当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > Brain microangiopathy and macroangiopathy share common risk factors and biomarkers.

Brain microangiopathy and macroangiopathy share common risk factors and biomarkers.

Abstract：

AIMS:Besides carotid or cardiac embolism, stroke can occur via microangiopathy (small arterial disease [SAD]) and macroangiopathy (intracranial atherosclerotic stroke [ICAS]) of the intracranial vasculature. There have been efforts to identify risk factors specific to microangiopathy and macroangiopathy, including vascular risk factors, and protein and genetic biomarkers. We hypothesized that despite the anatomic and pathophysiological differences between microvessels and macrovessels, microangiopathy and macroangiopathy share common risk factors during disease progression. METHODS:Among 714 patients with acute infarctions within middle cerebral artery territory, 126 with SAD and 116 with ICAS were included in this study. Subclinical microangiopathy (degree of leukoaraiosis) and macroangiopathy (number of tandem stenosis) was graded in each patient. Inflammatory biomarkers (C-reactive protein, E-selectin, and LpPLA2), endothelial dysfunction (asymmetric dimethylarginine, urinary albumin-to-creatinine ratio, endostatin, and homocysteine), atherogenesis (lipoprotein(a), adiponectin, and resistin), and renal function (creatinine clearance and estimated glomerular filtration rate) were assessed. RESULTS:Compared with the patients with isolated SAD, those with isolated ICAS were younger, were current smokers, and showed higher apoB levels (p < 0.05 in all cases). However, with the progression of subclinical microangiopathy, asymptomatic macroangiopathy worsened and vice versa. No significant differences in risk factors were observed between advanced SAD and ICAS. Decreased renal function was independently associated with progression of microangiopathy and macroangiopathy. Markers of endothelial dysfunction, but not the other markers, were significantly related to creatinine clearance level. CONCLUSIONS:Mild to moderate loss of renal function is strongly associated with both intracranial microangiopathy and macroangiopathy. Endothelial dysfunction may be associated with this relationship.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Bang OY,Chung JW,Ryoo S,Moon GJ,Kim GM,Chung CS,Lee KH

doi

10.1016/j.atherosclerosis.2015.12.040

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

71-7

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(15)30269-0

journal_volume

246

pub_type

杂志文章

相关文献

ATHEROSCLEROSIS文献大全
  • ABCA1 expression in humans is associated with physical activity and alcohol consumption.

    abstract：:Genetic variation in ABCA1 significantly affects HDL levels and atherosclerotic risk. The aim of this study was to examine lifestyle factors influencing ABCA1 expression in human leukocytes and skeletal muscle. A fasting venous blood sample and a vastus lateralis muscle biopsy were taken from 30 volunteers (53+/-1 yea...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.03.017

    authors： Hoang A,Tefft C,Duffy SJ,Formosa M,Henstridge DC,Kingwell BA,Sviridov D

    更新日期：2008-03-01 00:00:00

  • Association of glucose metabolism, smoking and cardiovascular risk factors with incident peripheral arterial disease: the DESIR study.

    abstract：AIMS:We determined the 6-year incidence of peripheral arterial disease (PAD) in a French population and assessed the association of glucose metabolism, smoking, cardiovascular risk factors and physical activity with incident PAD. METHODS:Participants from the French Data from a Epidemiological Study on the Insulin Res...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2006.02.017

    authors： Tapp RJ,Balkau B,Shaw JE,Valensi P,Cailleau M,Eschwege E,DESIR Study Group.

    更新日期：2007-01-01 00:00:00

  • Vascular NAD(P)H oxidase mediates endothelial dysfunction in basilar arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats.

    abstract：:We examined the responses of basilar arteries taken from Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a type 2 diabetes model. Both the nitric oxide (NO)-mediated relaxation and the cyclic 3',5'-guanosine monophosphate (cGMP) production elicited by acetylcholine (ACh) were much weaker in OLETF rats than in age-matc...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2006.06.005

    authors： Matsumoto T,Kobayashi T,Wachi H,Seyama Y,Kamata K

    更新日期：2007-05-01 00:00:00

  • Primary culture of endothelial cells from atherosclerotic human aorta. Part 1. Identification, morphological and ultrastructural characteristics of two endothelial cell subpopulations.

    abstract：:Endothelial cells (EC) were harvested by 0.1% collagenase treatment for adult human thoracic aortas obtained 1-3 h after sudden death. At least 35-70% of EC were removed from the intimal surface of aorta, 90-95% of them being viable. Plating efficiency was 70-80%. Monolayer formation was achieved at a seeding density ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(86)90027-4

    authors： Antonov AS,Nikolaeva MA,Klueva TS,Romanov YuA,Babaev VR,Bystrevskaya VB,Perov NA,Repin VS,Smirnov VN

    更新日期：1986-01-01 00:00:00

  • A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit.

    abstract：:Oxidant signalling and lipoprotein oxidation may play important roles in atherosclerotic lesion development. Given coincident localization of 15-lipoxygenase (15-LO), stereospecific products of 15-LO and epitopes of modified LDL in atherosclerotic lesions, we hypothesized that inhibition of 15-LO by PD146176, an inhib...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(97)00204-9

    authors： Bocan TM,Rosebury WS,Mueller SB,Kuchera S,Welch K,Daugherty A,Cornicelli JA

    更新日期：1998-02-01 00:00:00

  • The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese.

    abstract：:The newly identified apoprotein AV (apoAV) gene was suggested to have a significant effect on triglyceride (TG) metabolism in Caucasians. We studied the genetic effect of this gene on serum TG in a Japanese population. Participants (481 male and 412 female) were recruited at a health examination. A T/C single nucleoti...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(02)00252-6

    authors： Nabika T,Nasreen S,Kobayashi S,Masuda J

    更新日期：2002-12-01 00:00:00

  • Quantitative and qualitative pleiotropic differences between Simvastatin single and Vytorin combination therapy in hypercholesterolemic subjects.

    abstract：AIMS:This cross-sectional study tested the hypothesis that treatment with the combination of Ezetimibe/Simvastatin (Vytorin) leads to broader changes in the expression levels of immunomodulatory genes as compared to Simvastatin monotherapy. METHODS:Illumina's GenomeStudio gene expression module was used to compare gen...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.atherosclerosis.2013.09.031

    authors： Sternberg Z,Chichelli T,Sternberg D,Hojnacki D,Drake A,Liu S,Hu Q,Munschauer F

    更新日期：2013-12-01 00:00:00

  • Ursolic acid prevents angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice.

    abstract：BACKGROUND AND AIMS:Abdominal aortic aneurysms (AAA) is a chronic inflammatory disease in which signal transducer and activator of transcription 3 (STAT3), and disintegrin and metalloproteinase 17 (ADAM17) play important roles. However, it remains unclear whether ursolic acid (UA), a natural pentacyclic triterpenoid ca...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2018.02.022

    authors： Zhai M,Guo J,Ma H,Shi W,Jou D,Yan D,Liu T,Tao J,Duan J,Wang Y,Li S,Lv J,Li C,Lin J,Zhang C,Lin L

    更新日期：2018-04-01 00:00:00

  • Lipid lowering in healthy volunteers treated with multiple doses of MGL-3196, a liver-targeted thyroid hormone receptor-β agonist.

    abstract：:MGL-3196 is an oral, liver-targeted selective agonist for the thyroid hormone receptor-β (THR-β) that is being developed for the treatment of dyslipidemia. The safety profile and tolerability of THR-β agonist MGL-3196 was assessed in first-in humans studies, including a single ascending dose study (NCT01367873) in whi...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.atherosclerosis.2013.07.056

    authors： Taub R,Chiang E,Chabot-Blanchet M,Kelly MJ,Reeves RA,Guertin MC,Tardif JC

    更新日期：2013-10-01 00:00:00

  • Calcium deposition within coronary atherosclerotic lesion: Implications for plaque stability.

    abstract：:Atherosclerotic lesion progression is associated with intimal calcification. The earliest lesion that shows calcification is pathologic intimal thickening in which calcifications appear as microcalcifications that vary in size from <0.5 to 15 μm. The calcifications become larger as plaques progress, becoming punctate ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2020.05.017

    authors： Jinnouchi H,Sato Y,Sakamoto A,Cornelissen A,Mori M,Kawakami R,Gadhoke NV,Kolodgie FD,Virmani R,Finn AV

    更新日期：2020-08-01 00:00:00

  • Platelet-derived MIF: a novel platelet chemokine with distinct recruitment properties.

    abstract：OBJECTIVE:Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine with chemokine-like functions that plays a role in several inflammatory diseases including atherosclerosis. We recently demonstrated that in addition to macrophages and endothelial cells, platelets are a source of MIF. However, the funct...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.12.039

    authors： Wirtz TH,Tillmann S,Strüßmann T,Kraemer S,Heemskerk JW,Grottke O,Gawaz M,von Hundelshausen P,Bernhagen J

    更新日期：2015-03-01 00:00:00

  • Lysolecithin-dependent release of cholesterol from rat plasma.

    abstract：:We studied the effect of lysolecithin on the clearing of plasma cholesterol. The immediate and maximal conversion of plasma lecithin to lysolecithin was produced in rats by intravenous injection of phospholipase A. The changes which took place in the converted lysolecithin and of cholesterol were followed in rats whic...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(75)90047-7

    authors： Dobiásová M,Faltová E,Marek J,Obenberger J

    更新日期：1975-05-01 00:00:00

  • Inverse linear associations between liver aminotransferases and incident cardiovascular disease risk: The PREVEND study.

    abstract：BACKGROUND:Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) have been linked with an increased risk of type 2 diabetes, but their relationships with cardiovascular disease (CVD) are uncertain. We aimed to assess the associations of ALT and AST with CVD risk and determine their potential utility for C...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2015.09.006

    authors： Kunutsor SK,Bakker SJ,Kootstra-Ros JE,Blokzijl H,Gansevoort RT,Dullaart RP

    更新日期：2015-11-01 00:00:00

  • Atherosclerosis in vascular grafts for peripheral vascular disease. Part 1. Autogenous vein grafts.

    abstract：:29 autogenous vein grafts, from 26 patients with peripheral arterial disease, were studied. 4 grafts of Group I (less than 3 months duration) were patent and removed for reasons other than graft failure. These showed 'arterialisation' only; 4 grafts of Group II (duration 5-18 months) showed thrombotic occlusion; 21 gr...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(85)90153-4

    authors： Walton KW,Slaney G,Ashton F

    更新日期：1985-01-01 00:00:00

  • Mediterranean diet and carotid atherosclerosis in the Northern Manhattan Study.

    abstract：OBJECTIVE:Adherence to a Mediterranean-style diet (MeDi) may protect against clinical vascular events by reducing atherosclerosis, but data is limited. This is the first observational study of the association between MeDi adherence and carotid plaque thickness and area. METHODS:The study included 1374 participants of ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.03.011

    authors： Gardener H,Wright CB,Cabral D,Scarmeas N,Gu Y,Cheung K,Elkind MS,Sacco RL,Rundek T

    更新日期：2014-06-01 00:00:00

  • Long non-coding RNAs in the atherosclerotic plaque.

    abstract：BACKGROUND AND AIMS:Genetic and environmental factors are important components of the development of atherosclerosis. Long non-coding RNA (lncRNAs) have emerged as regulators of multiple pathophysiological pathways in the cardiovascular system. Here, we investigated potential associations between lncRNAs and atheroscle...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2017.10.012

    authors： Arslan S,Berkan Ö,Lalem T,Özbilüm N,Göksel S,Korkmaz Ö,Çetin N,Devaux Y,Cardiolinc™ network.

    更新日期：2017-11-01 00:00:00

  • Nitric oxide synthase II (NOS II) gene expression correlates with atherosclerotic intimal thickening. Preventive effects of HMG-CoA reductase inhibitors.

    abstract：:HMG-CoA reductase inhibitors have been shown to be effective in primary and secondary prevention of coronary heart disease. Their mechanism of action is attributed to their cholesterol lowering activity but recent results seem to indicate additional effects related to the modulation of other processes that regulate th...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(99)00084-2

    authors： Alfon J,Guasch JF,Berrozpe M,Badimon L

    更新日期：1999-08-01 00:00:00

  • Micro-ultrasound imaging assessment of carotid plaque characteristics in apolipoprotein-E knockout mice.

    abstract：:This study was aimed to test the hypothesis that noninvasive assessment of carotid plaques can be achieved by high-resolution micro-ultrasound imaging in apolipoprotein-E knockout (apoE-KO) mice. Forty-two male apoE-KO mice were fed a high-fat diet and atherosclerotic lesions in the left common carotid artery were ind...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.07.039

    authors： Ni M,Zhang M,Ding SF,Chen WQ,Zhang Y

    更新日期：2008-03-01 00:00:00

  • Animal models for Chlamydia pneumoniae infection.

    abstract：:Animal models are used extensively in the ongoing investigation of a possible causal link between Chlamydia pneumoniae infection and conditions such as asthma and cardiovascular disease. Respiratory infections have been studied in monkeys, while mouse and rabbit models have been used to study both respiratory and card...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/s0021-9150(98)00115-4

    authors： Saikku P,Laitinen K,Leinonen M

    更新日期：1998-10-01 00:00:00

  • Effects of high-cholesterol diet on the interendothelial clefts and the associated junctional complexes in rat aorta.

    abstract：:The arterial endothelial intercellular cleft (AEC) and its associated junctional complex (JC) are the determinants of permeability to macromolecules. This study analyzed frequencies of AEC and JC profile types in the rat thoracic aorta at 1 and 12 months after feeding the animals with a normal or a high-cholesterol di...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(00)00578-5

    authors： Lee WC,Chao WT,Yang VC

    更新日期：2001-04-01 00:00:00

  • Effects of bezafibrate on the expression of endothelial nitric oxide synthase gene and its mechanisms in cultured bovine endothelial cells.

    abstract：OBJECTIVE:Peroxisome proliferator-activated receptors alpha (PPARalpha) is a target gene for atherosclerosis and cardiovascular diseases. However, effects of PPARalpha on endothelial nitric oxide synthase (eNOS) remain unknown. We investigated the eNOS regulation by bezafibrate, a ligand of PPARalpha, and involved sign...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2005.09.008

    authors： Wang Y,Wang Y,Yang Q,Yan JT,Zhao C,Cianflone K,Wang DW

    更新日期：2006-08-01 00:00:00

  • SR-PSOX at sites predisposed to atherosclerotic lesion formation mediates monocyte-endothelial cell adhesion.

    abstract：OBJECTIVE:The scavenger receptor SR-PSOX/CXCL16, which is identical to the chemokine CXCL16, is thought to be involved in atherogenesis. However, the presence and function of SR-PSOX/CXCL16 in the endothelium of atherosclerotic arteries has not been substantiated. METHODS AND RESULTS:In rabbit aorta immunocytochemistr...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.04.021

    authors： Hofnagel O,Engel T,Severs NJ,Robenek H,Buers I

    更新日期：2011-08-01 00:00:00

  • Atorvastatin and gemfibrozil metabolites, but not the parent drugs, are potent antioxidants against lipoprotein oxidation.

    abstract：:Increased atherosclerosis risk in hyperlipidemic patients may be a result of the enhanced oxidizability of their plasma lipoproteins. We have previously shown that hypocholesterolemic drug therapy, including the 3-hydroxy-3-methyl-glutaryl CoenzymeA (HMG-CoA) reductase inhibitors, and the hypotriglyceridemic drug beza...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(98)00032-x

    authors： Aviram M,Rosenblat M,Bisgaier CL,Newton RS

    更新日期：1998-06-01 00:00:00

  • Prevalence and predictors of lipid abnormalities in patients treated with statins in the UK general practice.

    abstract：OBJECTIVE:To identify the prevalence and predictors of lipid abnormalities in statin-treated patients in the UK. METHODS:A retrospective cohort study was performed using the UK General Practice Research Database. Patients >or=35 years of age were included if they received first-ever statin between January 2000 and Dec...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2008.03.016

    authors： Phatak H,Wentworth C,Sazonov V,Burke T

    更新日期：2009-01-01 00:00:00

  • A normotriglyceridemic, low HDL-cholesterol phenotype is characterised by elevated oxidative stress and HDL particles with attenuated antioxidative activity.

    abstract：OBJECTIVE:Low levels of high density lipoprotein-cholesterol (HDL-C) are highly prevalent in subjects presenting premature atherosclerosis. It is indeterminate as to whether high cardiovascular risk in low HDL-C subjects occurs concomitantly with elevated oxidative stress and/or with biologically dysfunctional HDL part...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2005.03.001

    authors： Kontush A,de Faria EC,Chantepie S,Chapman MJ

    更新日期：2005-10-01 00:00:00

  • Cholesterol absorption efficiency and sterol metabolism in obesity.

    abstract：:Role of enterohepatic cholesterol metabolism in obesity-induced increase of cholesterol synthesis was studied in healthy lean (BMI <24) and overweight (BMI >31) subjects by measuring serum lipids (including plant sterols, cholestanol and cholesterol precursors), cholesterol absorption % (double-label method), sterol b...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(00)00404-4

    authors： Miettinen TA,Gylling H

    更新日期：2000-11-01 00:00:00

  • Genomic loci with pleiotropic effects on coronary artery calcification.

    abstract：:We measured 381 genomewide markers and performed genetic linkage analyses in search of loci influencing coronary artery calcification (CAC), a measure of atherosclerosis determined by electron beam computed tomography, in 948 non-Hispanic white siblings (mean age [+/-standard deviation] = 59.6 +/- 9.9 years; 73.7% hyp...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2005.06.010

    authors： Turner ST,Peyser PA,Kardia SL,Bielak LF,Sheedy PF 3rd,Boerwinkle E,de Andrade M

    更新日期：2006-04-01 00:00:00

  • The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation.

    abstract：:Atherosclerosis is considered a chronic inflammatory disease of the arterial wall. Recently, compelling evidence has arisen for the role of monocytes and neutrophils and a particular protein complex that resides within these cells - the NLRP3 inflammasome - in atherosclerosis-associated inflammation. It is now also kn...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2017.12.027

    authors： Martínez GJ,Celermajer DS,Patel S

    更新日期：2018-02-01 00:00:00

  • Increased number of high sensitive platelets in hypercholesterolemia, cardiovascular diseases, and after incubation with cholesterol.

    abstract：:The number of low density platelets was found to be increased in patients with hypercholesterolemia, as compared with the number in controls. The percentage increase of the low density platelet subpopulation was even more pronounced in patients with hypercholesterolemia when compared with that in patients suffering fr...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(94)05448-r

    authors： Opper C,Clement C,Schwarz H,Krappe J,Steinmetz A,Schneider J,Wesemann W

    更新日期：1995-03-01 00:00:00

  • Chronic hyperbaric oxygen treatment elicits an anti-oxidant response and attenuates atherosclerosis in apoE knockout mice.

    abstract：:We previously demonstrated that hyperbaric oxygen (HBO) treatment inhibits diet-induced atherosclerosis in New Zealand White rabbits. In the present study we investigate the mechanisms that might be involved in the athero-protective effect of HBO treatment in a well-accepted model of atherosclerosis, the apoE knockout...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2006.08.018

    authors： Kudchodkar BJ,Pierce A,Dory L

    更新日期：2007-07-01 00:00:00