Abstract:
:29 autogenous vein grafts, from 26 patients with peripheral arterial disease, were studied. 4 grafts of Group I (less than 3 months duration) were patent and removed for reasons other than graft failure. These showed 'arterialisation' only; 4 grafts of Group II (duration 5-18 months) showed thrombotic occlusion; 21 grafts of Group III (duration greater than 2 years) showed impaired graft patency and lipid identifiable as apolipoprotein B-containing-lipoproteins (LpB), and fibrinogen-related antigens (FRA) were seen as intramural deposits in the thickened grafts. LpB was also seen in a perifibrous distribution on the collagen of organised thrombi. Complicated lesions in some Group III grafts showed stenosis or occlusion, ulceration, calcification or aneurysm formation. These features suggest that a process indistinguishable from 'true' atherosclerosis affects vein grafts of long duration. The ways in which such changes may: contribute to graft failure; and improve our understanding of the basic processes involved in atherogenesis, are discussed.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Walton KW,Slaney G,Ashton Fdoi
10.1016/0021-9150(85)90153-4subject
Has Abstractpub_date
1985-01-01 00:00:00pages
49-64issue
1eissn
0021-9150issn
1879-1484pii
0021-9150(85)90153-4journal_volume
54pub_type
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