Abstract：
:Lack of physical activity appears to have deleterious effects on serum lipoproteins. Twenty-three patients who were completely immobilised by traumatic fracture of the spine had significantly lower (P < 0.001) plasma high density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I levels than normally mobile paired control subjects. The low density lipoprotein cholesterol (LDL-C) levels of the immobile patients were not different from those of controls but the LDL triglyceride (LDL-TG) of the patients was increased. The patients had a significantly higher LDL/HDL-C ratio and HDL-C/apoprotein A-I ratio than the controls. These results suggest that the increased risk of ischemic heart disease in physically inactive people is partially accounted for by low plasma HDL levels. On the other hand, caution is needed in the interpretation of HDL findings in clinical conditions where the physical activity of the patients is limited.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Nikkilä EA,Kuusi T,Myllynen Pdoi
10.1016/0021-9150(80)90151-3subject
Has Abstractpub_date
1980-11-01 00:00:00pages
457-62issue
3eissn
0021-9150issn
1879-1484pii
0021-9150(80)90151-3journal_volume
37pub_type
杂志文章相关文献
ATHEROSCLEROSIS文献大全abstract：:Pressure recordings in 120 patients, aged 0-35 years, undergoing operation for coarctation of the aorta, show a slow but steady rise in both systolic and diastolic peak pressures, the highest peak registered being in patients aged 16-18 years. The finding of significant morphological changes in the aorta in this age g...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(81)90023-x
更新日期：1981-06-01 00:00:00
abstract：:The possible mechanisms of action of probucol on the metabolism of low density lipoprotein and of high density lipoprotein were studied in 5 hyperlipidaemic subjects. The kinetics of LDL-B protein and of HDL-AI protein were determined by 2-pool analysis of specific radioactivity-time curves after reinjection of 131I-l...
journal_title：Atherosclerosis
pub_type： 临床试验,杂志文章
doi：10.1016/0021-9150(81)90117-9
更新日期：1981-01-01 00:00:00
abstract：:Small high density lipoproteins (HDL) with pre-beta electrophoretic mobility (pre-beta HDL) have recently been shown to be the primary acceptor of cholesterol from cultured cells. We studied the metabolism of these particles by incubating serum at 37 degrees C in the presence and absence of active lecithin: cholestero...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(91)90005-n
更新日期：1991-07-01 00:00:00
abstract：OBJECTIVES:To examine the longitudinal association between toenail selenium levels and subclinical atherosclerosis over an 18-year period. METHODS:Toenail selenium concentrations were examined among 3112 Americans age 20-32 years in 1987 and measured by instrumental neutron-activation analysis. Subclinical atheroscler...
journal_title：Atherosclerosis
pub_type： 杂志文章,多中心研究
doi：10.1016/j.atherosclerosis.2010.01.021
更新日期：2010-06-01 00:00:00
abstract：:Observational studies suggested that the progression of carotid atherosclerosis and plaques might be an independent risk factor for coronary artery disease (CAD) and stroke, prior researches of different dosage of statins therapy on the progression of carotid atherosclerosis in patients had small sample sizes and diff...
journal_title：Atherosclerosis
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.atherosclerosis.2004.08.005
更新日期：2004-12-01 00:00:00
abstract：:Histologic features of aortic fatty streaks were examined in male subjects aged 10-39 from Guatemala, Jamaica Negro, Durban Bantu, New Orleans Negro, New Orleans white, Lima and Santiago. These groups were selected from the 19 available in the IAP (International Atherosclerosis Project) because they represented the gr...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(75)90079-9
更新日期：1975-03-01 00:00:00
abstract：:Plasma high density lipoproteins (HDL) and their major protein, apolipoprotein (apo) A-I, are deficient in homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits. As the pathophysiology of subnormal HDL-apo A-I is unclear, we examined kinetic parameters of HDL-apo A-I in WHHL rabbits and normolipidemic Japanese W...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(89)90127-5
更新日期：1989-10-01 00:00:00
abstract：:The elevated carbon monoxide level found in tobacco smokers has been suggested as one etiologic factor linking it with atherosclerosis. Unquestionably carbon monoxide does induce some arterial wall hypoxia, which has been established as an atherogenic factor, but without knowing the extent and location of this hypoxia...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(78)90148-x
更新日期：1978-05-01 00:00:00
abstract：:Preclinical and clinical data on atorvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, indicate that it has superior activity in treating a variety of dyslipidemic disorders characterized by elevations in low-density lipoprotein cholesterol (LDL-C) and/or triglycerides. Results for p...
journal_title：Atherosclerosis
pub_type： 杂志文章,评审
doi：10.1016/s0021-9150(97)06066-8
更新日期：1997-05-01 00:00:00
abstract：PURPOSE:Metabolic Syndrome as defined by ATP III criteria, a constellation of risk factors associated with insulin resistance, predisposes to premature atherosclerosis and early coronary events. Whether that negative risk profile is associated with endothelial dysfunction remains to be established. MATERIALS AND METHO...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2003.11.013
更新日期：2004-02-01 00:00:00
abstract：:Endothelial cells (EC) were harvested by 0.1% collagenase treatment for adult human thoracic aortas obtained 1-3 h after sudden death. At least 35-70% of EC were removed from the intimal surface of aorta, 90-95% of them being viable. Plating efficiency was 70-80%. Monolayer formation was achieved at a seeding density ...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(86)90027-4
更新日期：1986-01-01 00:00:00
abstract：:Polar coordinate mapping was used to determine the rate of growth of individual sudanophilic lesions on the aortic wall around several major branches of the aortae of cholesterol fed rabbits. Four groups, with 6 8-month old male albino white rabbits in each, were used in the study. One group served as a control and th...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(76)90043-5
更新日期：1976-10-01 00:00:00
abstract：BACKGROUND AND AIMS:The mechanisms that drive atherosclerotic plaque progression and destabilization in humans remain largely unknown. Laboratory models are needed to study these mechanisms under controlled conditions. The aim of this study was to establish a new ex vivo model of human atherosclerotic plaques that pres...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2017.10.003
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:The CAV1 gene encodes caveolin-1 expressed in cell types relevant to atherosclerosis. Cav-1-null mice showed a protective effect on atherosclerosis under the ApoE(-/-) background. However, it is unknown whether CAV1 is linked to CAD and MI in humans. In this study we analyzed a tagSNP for CAV1 in intron 2, r...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2016.01.008
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVE:Evidence has demonstrated profound influence of genetic background on cardiovascular phenotypes. Murine models in Marfan syndrome (MFS) have shown that genetic background-related variations affect thoracic aortic aneurysm formation, rupture, and lifespan of mice. MFS mice with C57Bl/6 genetic background are l...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2015.10.006
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:We investigated whether early atherosclerosis before calcified plaque appeared as assessed by carotid intima-media thickness (IMT) was associated with levels of the major carotenoids, and assessed the associations among these serum carotenoids, carotid IMT, and arterial stiffness. METHODS:The case-control st...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2011.08.006
更新日期：2011-12-01 00:00:00
abstract：:The aim of this study was to examine whether the well-established effect of the common TaqIB polymorphism in intron 1 of the gene for cholesterol ester transfer protein (CETP) on high density lipoprotein cholesterol (HDL-C) concentration and increased risk of myocardial infarction (MI), could be explained by the recen...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(01)00489-0
更新日期：2001-11-01 00:00:00
abstract：:The risk factors for cardiovascular disease are related directly or indirectly in women, as in men, to lipid and lipoprotein levels. But women have the advantage of the beneficial effects of either endogenous or exogenous estrogen on these levels throughout most of their lives. Behaviors such as smoking or diseases su...
journal_title：Atherosclerosis
pub_type： 杂志文章,评审
doi：10.1016/0021-9150(94)90154-6
更新日期：1994-08-01 00:00:00
abstract：:In general, plasma concentrations of high density lipoproteins (HDL) are inversely related to the incidence of coronary artery disease. One exception to this trend is individuals with apolipoprotein A-I(Milano) (apo A-IM), a molecular variant of apo A-I, which results in very low plasma apo A-I and HDL-cholesterol lev...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(97)00195-0
更新日期：1998-01-01 00:00:00
abstract：:In monocyte-derived macrophages from both normal and familial hypercholesterolaemic (FH) subjects, degradation of low density lipoprotein (LDL) through non-saturable pathways produced the same fall in 3-hydroxy-3-methylglutaryl-CoA reductase activity as receptor-mediated degradation of acetylated LDL, yet did not lead...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(87)90238-3
更新日期：1987-04-01 00:00:00
abstract：:Conjugated linoleic acid (CLA) refers to a group of positional and geometric isomers of linoleic acid and has been shown to suppress the development of atherosclerosis in experimental models. However, the mechanism involved is unclear although it is believed it may act as a cyclooxygenase inhibitor or as an agonist of...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2005.08.024
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND:Tissue proportions of long chain n-6 [especially arachidonic acid (AA)] and n-3 fatty acids [FA; eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) acids], or some ratio of these may be markers of risk for coronary heart disease (CHD). The purpose of this paper is to evaluate the published associatio...
journal_title：Atherosclerosis
pub_type： 杂志文章,评审
doi：10.1016/j.atherosclerosis.2007.03.018
更新日期：2007-07-01 00:00:00
abstract：:High density lipoproteins (HDL) induce prostacyclin (PGI(2)) release in vascular smooth muscle cells (VSMC) by up-regulation of cyclooxygenase-2 (Cox-2). Our goal was to analyse the mechanisms underlying this effect, and its potential modulation by HMG-CoA reductase inhibition in human VSMC. The contribution of mitoge...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2004.01.037
更新日期：2004-06-01 00:00:00
abstract：:A combined gross and histologic study carried out on 270 selected male subjects with the common type of distribution of the coronary arteries revealed a natural resistance to intimal thickening and plaque development exhibited by the left main coronary artery and by the first centimeter of the right coronary artery. T...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(84)90020-0
更新日期：1984-02-01 00:00:00
abstract：:Hypercholesterolemia (HC) induces alterations in systemic vascular reactivity, which can manifest as an attenuated endothelium-dependent relaxation, partly consequent to an impairment in nitric oxide (NO) activity. To determine whether experimental HC has a similar effect on renal vascular function, renal artery segme...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(00)00462-7
更新日期：2001-01-01 00:00:00
abstract：:Endothelial cell lipotoxicity mediated by accumulation of free fatty acids is an early event in the pathogenesis of atherosclerosis. The energy-sensor AMP-activated protein kinase (AMPK) is a key regulator of endothelial cell lipid metabolism. To test the hypothesis that bradykinin (BK) regulates AMPK and fatty acid o...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2007.12.003
更新日期：2008-09-01 00:00:00
abstract：:Inflammatory response genes may influence life span or quality at advanced ages. Using data from the population-based cardiovascular health study (CHS) cohort, we examined the associations between promoter polymorphisms of several inflammation and thrombosis genes with longevity. We ascertained genotypes for interleuk...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2005.01.028
更新日期：2005-07-01 00:00:00
abstract：:Studies were performed to determine if serum bilirubin, when combined with various lipid and lipoprotein risk factors, enhances our ability to predict coronary artery disease (CAD). This hypothesis was tested in a retrospective study of 644 middle-aged males who had undergone coronary angiography. The traditional risk...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(99)00387-1
更新日期：2000-06-01 00:00:00
abstract：:To study the association of alcohol consumption and lipid-based cardiovascular risk factors among middle-age women, cross-sectional analysis among 274 middle-aged healthy women with different drinking habits and a follow-up analysis of alcoholic women during abstinence was performed. Serum total cholesterol, low and h...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(00)00369-5
更新日期：2000-10-01 00:00:00
abstract：:This study investigates the ability of a single, low dose of apolipoprotein (apo) A-I, the main lipoprotein of high density lipoproteins (HDL), to inhibit acute vascular inflammation in normocholesterolemic New Zealand White rabbits. Acute vascular inflammation was induced in the animals by placing a non-occlusive, si...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2007.05.008
更新日期：2008-01-01 00:00:00
