Prostacyclin-dependent differences in TXA2 formation by platelets from normal and atherosclerotic rabbits.

abstract：:This study investigates the ability of a single, low dose of apolipoprotein (apo) A-I, the main lipoprotein of high density lipoproteins (HDL), to inhibit acute vascular inflammation in normocholesterolemic New Zealand White rabbits. Acute vascular inflammation was induced in the animals by placing a non-occlusive, si...

journal_title：Atherosclerosis

authors： Puranik R,Bao S,Nobecourt E,Nicholls SJ,Dusting GJ,Barter PJ,Celermajer DS,Rye KA

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Previous epidemiological studies have shown positive associations between serum calcium concentration and risk of cardiovascular disease (CVD), but results differ by definition of CVD. We examined the association of circulating calcium with incident and fatal CVD, myocardial infarction (MI), and str...

journal_title：Atherosclerosis

authors： Rohrmann S,Garmo H,Malmström H,Hammar N,Jungner I,Walldius G,Van Hemelrijck M

更新日期：2016-08-01 00:00:00

abstract：:The association between serum selenium concentration and a number of coronary heart disease risk factors is studied in 364 males from southern Italy participating in the Olivetti Heart Study. Selenium correlates positively and significantly with serum cholesterol (r = 0.120; P = 0.022), and this positive association p...

journal_title：Atherosclerosis

authors： Jossa F,Trevisan M,Krogh V,Farinaro E,Giumetti D,Fusco G,Galasso R,Panico S,Frascatore S,Mellone C

更新日期：1991-04-01 00:00:00

abstract：:The changes that occur with age in the distribution of atherosclerotic lesions around arterial branch points challenge accepted theories relating disease to haemodynamic stresses. We investigated whether flow near branch points changes with age in a way that can account for the different lesion distributions. Flow aro...

journal_title：Atherosclerosis

authors： Al-Musawi SL,Bishton J,Dean J,Williams S,Cremers SG,Weinberg PD

更新日期：2004-01-01 00:00:00

abstract：:Men with ankylosing spondylitis (AS) and females with systemic lupus erythematosus (SLE) were found to have low total serum lipid concentrations similar to results previously obtained in patients with rheumatoid arthritis (RA). In AS men total serum TG was about 50% of control values and in AS men and SLE women total ...

journal_title：Atherosclerosis

authors： Rössner S

更新日期：1978-09-01 00:00:00

abstract：OBJECTIVE:25-Hydroxycholesterol (25HC) and its sulfated metabolite, 25-hydroxycholesterol-3-sulfate (25HC3S), regulate certain aspects of lipid metabolism in opposite ways. Hence, the enzyme for the biosynthesis of 25HC3S, oxysterol sulfotransferase (SULT2B1b), may play a crucial role in regulating lipid metabolism. We...

journal_title：Atherosclerosis

authors： Bai Q,Xu L,Kakiyama G,Runge-Morris MA,Hylemon PB,Yin L,Pandak WM,Ren S

更新日期：2011-02-01 00:00:00

abstract：:Berberine, an alkaloid isolated from Chinese medicinal herbs, long been known for its anti-microbial activity and used to treat various infectious disorders in traditional Chinese medicine. In the present study, we have tested the hypothesis that berberine could inhibit vascular smooth muscle cell (VSMC) proliferation...

journal_title：Atherosclerosis

authors： Lee S,Lim HJ,Park HY,Lee KS,Park JH,Jang Y

更新日期：2006-05-01 00:00:00

abstract：:Evidence suggests low vitamin D and elevated parathyroid hormone (PTH) concentrations may increase risk for cardiovascular disease. However, little is known about the association between vitamin D or PTH and subclinical atherosclerosis. This cross-sectional study included 654 community-dwelling older adults aged 55-96...

journal_title：Atherosclerosis

authors： Reis JP,von Mühlen D,Michos ED,Miller ER 3rd,Appel LJ,Araneta MR,Barrett-Connor E

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:Deletion of inducible nitric oxide synthase (iNOS) in apolipoprotein E knockout mice was shown to mitigate the extent of arteriosclerosis. Oxidized low density lipoprotein (oxLDL) inhibits macrophage migration and traps foam cells, possibly through a mechanism involving oxidative stress. Here, we addressed wh...

journal_title：Atherosclerosis

authors： Huang H,Koelle P,Fendler M,Schröttle A,Czihal M,Hoffmann U,Conrad M,Kuhlencordt PJ

更新日期：2014-07-01 00:00:00

abstract：:It has been reported that total cholesterol (Chol) response to probucol is greater in familial hypercholesterolemic (FH) patients with apo E4 than in those without apo E4. We further examined the effect of probucol on plasma triglyceride (TG) and lipoprotein-Chol levels as well as total Chol levels in heterozygous FH ...

journal_title：Atherosclerosis

authors： Eto M,Sato T,Watanabe K,Iwashima Y,Makino I

更新日期：1990-09-01 00:00:00

abstract：:Short-term exercise training has been associated with improved endothelial-dependent vasodilation, but the impact of long-term habitual physical activity on vascular reactivity is not established. We studied the correlation between self-reported, habitual physical activity and vasoreactivity in non-smoking, non-diabet...

journal_title：Atherosclerosis

authors： McKechnie R,Rubenfire M,Mosca L

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND AND AIMS:The role of circular RNAs (circRNAs) in coronary artery disease (CAD) remains elusive. The aim of the present study was to profile circRNAs expression in CAD patients and assess diagnostics biomarkers for CAD. METHODS:The circRNA profiles of 24 CAD patients and 7 controls were assessed by microarra...

journal_title：Atherosclerosis

authors： Wang L,Shen C,Wang Y,Zou T,Zhu H,Lu X,Li L,Yang B,Chen J,Chen S,Lu X,Gu D

更新日期：2019-07-01 00:00:00

abstract：:Apolipoprotein E phenotypes and fasting lipid and other biochemical parameters were determined in 51 patients with recently diagnosed coronary heart disease (CHD) and 164 control subjects. The age of the participants was 62.5 +/- 6.6 (S.D.) and 63% were male. Forty-eight CHD cases and 51 control subjects were also stu...

journal_title：Atherosclerosis

authors： Dart A,Sherrard B,Simpson H

更新日期：1997-04-01 00:00:00

abstract：AIMS:To assess efficacy and safety of HMG-CoA reductase inhibitor (statin) treatment in children and adolescents with heterozygous familial hypercholesterolaemia. METHODS:MEDLINE, EMBASE, COCHRANE and Current Controlled Trials databases were searched. Study design, efficacy, and safety outcome-measures were extracted....

journal_title：Atherosclerosis

authors： Arambepola C,Farmer AJ,Perera R,Neil HA

更新日期：2007-12-01 00:00:00

abstract：:Sitostanol (24-ethyl-5 alpha-cholestan-3 beta-ol), a hydrogenated derivative of sitosterol, was administered in a low dose (1.5 g/day) for 4 weeks to 6 patients with hypercholesterolemia. Total cholesterol was reduced significantly after 3 and 4 weeks by 10 and 15%, respectively. The reduction of total cholesterol was...

journal_title：Atherosclerosis

authors： Heinemann T,Leiss O,von Bergmann K

更新日期：1986-09-01 00:00:00

abstract：:The effect of immunological injury upon the early in vivo changes in aortic connective tissue metabolism was studied. It was found that a single antigen (bovine serum albumin), when administered in multiple doses, activated collagen synthesis and increased the rate of lgycosaminoglycan synthesis in the arterial wall. ...

journal_title：Atherosclerosis

authors： Rokosova B,Bentley JP

更新日期：1979-04-01 00:00:00

abstract：OBJECTIVE:Epidemiological, biological and clinical links between periodontal and cardiovascular diseases are now well established. Several human studies have detected bacterial DNA corresponding to periodontal pathogens in cardiovascular samples. Intraplaque hemorrhage has been associated with a higher risk of atherosc...

journal_title：Atherosclerosis

authors： Rangé H,Labreuche J,Louedec L,Rondeau P,Planesse C,Sebbag U,Bourdon E,Michel JB,Bouchard P,Meilhac O

更新日期：2014-10-01 00:00:00

abstract：:A marked reduction of serum cholesterol was obtained by treatment with probucol in heterozygous as well as in homozygous cases of familial hypercholesterolemia. A strict dietary regimen (low-fat, low-calories) intensified the hypocholesterolemic effect of the drug. The drug was also useful in diminishing the rebound o...

journal_title：Atherosclerosis

authors： Yamamoto A,Matsuzawa Y,Kishino B,Hayashi R,Hirobe K,Kikkawa T

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND AND AIMS:High concentrations of low density lipoprotein (LDL) triglycerides have been associated with prevalent angiographic coronary artery disease. The present analysis was designed to investigate the association of LDL triglycerides with cardiovascular mortality and to explore possible mechanisms that may...

journal_title：Atherosclerosis

authors： Silbernagel G,Scharnagl H,Kleber ME,Delgado G,Stojakovic T,Laaksonen R,Erdmann J,Rankinen T,Bouchard C,Landmesser U,Schunkert H,März W,Grammer TB

更新日期：2019-03-01 00:00:00

abstract：:Quantitative assessment of atherosclerosis during its natural history and following therapeutic interventions is important, as cardiovascular disease remains the most significant cause of morbidity and mortality in industrial societies. While coronary angiography delineates the vessel lumen, permitting only the indire...

journal_title：Atherosclerosis

authors： von Birgelen C,Slager CJ,Di Mario C,de Feyter PJ,Serruys PW

更新日期：1995-12-01 00:00:00

abstract：:Increased aortic and liver prolyl hydroxylase activity has been suggested as an early biochemical indicator of the fibrotic changes which occur in rabbits with injury induced arteriosclerosis. Daily administration of epinephrine (0.025-0.050 mg/kg, i.v.) and thyroxine (0.050 mg/kg, i.p.) to rabbits for 3 weeks produce...

journal_title：Atherosclerosis

authors： Fuller GC,Matoney AL,Fisher DO,Fausto N,Cardinale GJ

更新日期：1976-09-01 00:00:00

abstract：:Arterial specimens were obtained from 12 patients during arterial repair surgery and 3 patients during nephrectomy following a bolus injection of autologous radio-iodinated very low density lipoprotein (VLDL) up to 30 h before surgery. Radioactivity in apoprotein B (apo B) was determined in lipoprotein fractions isola...

journal_title：Atherosclerosis

authors： Nicoll A,Duffield R,Lewis B

更新日期：1981-05-01 00:00:00

abstract：:Numerous epidemiological studies have shown that lipoprotein(a) (Lp(a)) is an independent risk factor for the premature development of cardiovascular disease. In spite of such evidence, the structural and functional features of this atherogenic, cholesterol-rich particle are not clearly understood. We have demonstrate...

journal_title：Atherosclerosis

authors： Huby T,Chapman J,Thillet J

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:We investigated the separate impact of metabolic syndrome (MS) and altered glucose tolerance on early markers of vascular injuries. METHODS:Intima-media thickness (IMT) and pulse wave analysis (PWA), were evaluated in 132 overweight or obese subjects, with (MS(+)) or without (MS(-)) MS; subjects were further...

journal_title：Atherosclerosis

authors： Di Pino A,Alagona C,Piro S,Calanna S,Spadaro L,Palermo F,Urbano F,Purrello F,Rabuazzo AM

更新日期：2012-08-01 00:00:00

abstract：:Hypercholesterolemia (HC) induces alterations in systemic vascular reactivity, which can manifest as an attenuated endothelium-dependent relaxation, partly consequent to an impairment in nitric oxide (NO) activity. To determine whether experimental HC has a similar effect on renal vascular function, renal artery segme...

journal_title：Atherosclerosis

authors： Stulak JM,Lerman A,Caccitolo JA,Wilson SH,Romero JC,Schaff HV,Rodriguez Porcel M,Lerman LO

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Dyslipidemia has been linked to vascular complications of Type 1 diabetes (T1DM). We investigated the prospective associations of nuclear magnetic resonance-determined lipoprotein subclass profiles (NMR-LSP) and conventional lipid profiles with carotid intima-media thickness (IMT) in T1DM. METHODS:NMR-LSP a...

journal_title：Atherosclerosis

authors： Basu A,Jenkins AJ,Zhang Y,Stoner JA,Klein RL,Lopes-Virella MF,Garvey WT,Lyons TJ,DCCT\/EDIC Research Group.

更新日期：2016-01-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea results in nocturnal intermittent hypoxia (IH) as a main trigger for cardiovascular morbidity, including atherosclerosis. IH induces hemodynamic, hormono-metabolic and also immuno-inflammatory alterations that could differentially contribute to atherosclerosis. Our study aimed at exami...

journal_title：Atherosclerosis

authors： Arnaud C,Poulain L,Lévy P,Dematteis M

更新日期：2011-12-01 00:00:00

abstract：:Vascular calcification is associated with increased risk of cardiovascular events that are the most common cause of death in patients with end-stage renal disease. Clinical and experimental studies indicate that hyperphosphatemia is a risk factor for vascular calcification and cardiovascular mortality in these patient...

journal_title：Atherosclerosis

authors： Li X,Yang HY,Giachelli CM

更新日期：2008-08-01 00:00:00

abstract：:High level of plasma very low-density lipoprotein (VLDL) has been identified as a risk factor for coronary heart disease. Recent evidence suggests that excess VLDL induces inflammatory responses in macrophages and vascular endothelial cells. The Japan EPA Lipid Intervention Study (JELIS), a large scale clinical trial,...

journal_title：Atherosclerosis

authors： Jinno Y,Nakakuki M,Kawano H,Notsu T,Mizuguchi K,Imada K

更新日期：2011-12-01 00:00:00

abstract：:Oxidation of low density lipoprotein (LDL) leads to more rapid uptake by arterial wall macrophages and foam cell formation. Inhibiting LDL oxidation may impede these processes and offers a new mechanism to retard atherogenesis. The 21-aminosteroids, derived from methylprednisolone, are potent inhibitors of free radica...

journal_title：Atherosclerosis

authors： Fisher M,Levine PH,Doyle EM,Arpano MM,Hoogasian JJ

更新日期：1991-10-01 00:00:00