Histamine as an activator of cell growth and extracellular matrix reconstruction for human vascular smooth muscle cells.

abstract：BACKGROUND AND AIM:To determine the incremental diagnostic value of epicardial adipose tissue (EAT) volume in addition to the coronary artery calcium (CAC) score for detecting hemodynamic significant coronary artery disease (CAD). METHODS AND RESULTS:122 patients (mean age 61 ± 10 years, 61% male) without a previous c...

journal_title：Atherosclerosis

authors： Romijn MA,Danad I,Bakkum MJ,Stuijfzand WJ,Tulevski II,Somsen GA,Lammertsma AA,van Kuijk C,van de Ven PM,Min JK,Leipsic J,van Rossum AC,Raijmakers PG,Knaapen P

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Carotid artery plaque is an established marker of subclinical atherosclerosis and common patho-mechanisms with coronary artery disease (CAD) are hypothesized. We aimed to identify genetic variants associated with carotid plaque and to examine the potential shared genetic basis with CAD. METHODS:Aft...

journal_title：Atherosclerosis

authors： Pott J,Burkhardt R,Beutner F,Horn K,Teren A,Kirsten H,Holdt LM,Schuler G,Teupser D,Loeffler M,Thiery J,Scholz M

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND AND AIMS:The mechanisms that drive atherosclerotic plaque progression and destabilization in humans remain largely unknown. Laboratory models are needed to study these mechanisms under controlled conditions. The aim of this study was to establish a new ex vivo model of human atherosclerotic plaques that pres...

journal_title：Atherosclerosis

authors： Lebedeva A,Vorobyeva D,Vagida M,Ivanova O,Felker E,Fitzgerald W,Danilova N,Gontarenko V,Shpektor A,Vasilieva E,Margolis L

更新日期：2017-12-01 00:00:00

abstract：:A total of 1200 patients with angina were cardiac catheterized establishing that 63% had 70-100% stenosis, 12% had 10-69% stenosis of one or more of their coronary arteries and 25% had microvascular angina listed as 0% stenosis. Prior to catheterization 10 ml of blood was drawn and the plasma subjected to analysis for...

journal_title：Atherosclerosis

authors： Kummerow FA,Olinescu RM,Fleischer L,Handler B,Shinkareva SV

更新日期：2000-03-01 00:00:00

abstract：:The molecular mechanisms underlying the atherogenic activity of cigarette smoke have yet to be fully elucidated. In the present study, genome-wide microarray analysis was performed on endothelial cells exposed to an aqueous cigarette smoke extract (CSE) for 3, 7, and 24 h, to obtain a better insight into how smoking m...

journal_title：Atherosclerosis

authors： Henderson B,Csordas A,Backovic A,Kind M,Bernhard D,Wick G

更新日期：2008-12-01 00:00:00

abstract：:Blood serum of most patients with coronary heart disease (CHD) caused a 2-5-fold increase in the total cholesterol content of smooth muscle cells cultured from unaffected human aortic intima, i.e. possessed an atherogenic potential manifested in culture. Removal of immunoglobulins G and M from an atherogenic serum bro...

journal_title：Atherosclerosis

authors： Tertov VV,Orekhov AN,Sayadyan KS,Serebrennikov SG,Kacharava AG,Lyakishev AA,Smirnov VN

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Diet and smoking expose the general population to cadmium (Cd), which is a toxic metal that accumulates in the arterial wall. In experimental studies, Cd causes reductions in proliferation of smooth muscle cells and cellular synthesis of procollagen. The aim of this study was to examine whether bloo...

journal_title：Atherosclerosis

authors： Fagerberg B,Borné Y,Sallsten G,Smith JG,Acosta S,Persson M,Melander O,Forsgard N,Gottsäter A,Hedblad B,Barregard L,Engström G

更新日期：2017-06-01 00:00:00

abstract：:Atherosclerosis is considered a chronic inflammatory disease of the arterial wall. Recently, compelling evidence has arisen for the role of monocytes and neutrophils and a particular protein complex that resides within these cells - the NLRP3 inflammasome - in atherosclerosis-associated inflammation. It is now also kn...

journal_title：Atherosclerosis

authors： Martínez GJ,Celermajer DS,Patel S

更新日期：2018-02-01 00:00:00

abstract：:Apolipoprotein F (ApoF) is a sialoglycoprotein that is a component of the HDL and LDL fractions of human serum. We sought to test the hypothesis that ApoF plays an important role in atherosclerosis in mice by modulating lipoprotein function. Atherosclerosis was assessed in male low density lipoprotein receptor knockou...

journal_title：Atherosclerosis

authors： Lagor WR,Fields DW,Bauer RC,Crawford A,Abt MC,Artis D,Wherry EJ,Rader DJ

更新日期：2014-03-01 00:00:00

abstract：:Chronic renal failure markedly accelerates atherogenesis in apolipoprotein E-deficient (apoE(-/-)) mice. To study the putative role of receptor for advanced glycation end products (RAGE) in development of uremic atherosclerosis, apoE(-/-) mice received intraperitoneal injections thrice weekly of a neutralizing murine ...

journal_title：Atherosclerosis

authors： Bro S,Flyvbjerg A,Binder CJ,Bang CA,Denner L,Olgaard K,Nielsen LB

更新日期：2008-12-01 00:00:00

abstract：:Atherosclerotic calcification may weaken the aorta wall and thereby lead to rupture of the vessel. The mechanism whereby aortas undergo calcification remains unclear. Previous reports in this laboratory showed that, after 2 months of cholesterol-supplemental feeding, an increase in calcifiability of membrane vesicles ...

journal_title：Atherosclerosis

authors： Hsu HH,Camacho NC,Tawfik O,Sun F

更新日期：2002-03-01 00:00:00

abstract：:A recent study has suggested that symptoms of chronic bronchitis predict the risk of coronary disease independently of the known major cardiovascular risk factors. High serum levels of lipoprotein(a) (Lp(a)) have also been considered as an independent risk factor for coronary heart disease. Therefore, the aim of the p...

journal_title：Atherosclerosis

authors： Basili S,Ferroni P,Vieri M,Cardelli P,Ceci F,Paradiso M,Labbadia G,Gazzaniga PP,Cordova C,Alessandri C

更新日期：1999-12-01 00:00:00

abstract：:Previous work has shown that oxidized low density lipoprotein (Ox-LDL) inhibited lipopolysacchride (LPS)-induced nitric oxide (NO) production in macrophages. In this paper, the role of different components of Ox-LDL in the inhibitory effect was studied by measuring nitrite in media. Ox-LDL inhibited LPS-induced NO pro...

journal_title：Atherosclerosis

authors： Liu SX,Chen Y,Zhou M,Wan J

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:There is increasing evidence that renin-angiotensin system (RAS) may play a major role in the actively regulated fibrocalcific process in aortic valve stenosis (AS), but the gene expression or function of (pro)renin receptor ((P)RR), prorenin and renin or angiotensin converting enzyme 2(ACE2)/angiotensin-(1-...

journal_title：Atherosclerosis

authors： Peltonen T,Näpänkangas J,Ohtonen P,Aro J,Peltonen J,Soini Y,Juvonen T,Satta J,Ruskoaho H,Taskinen P

更新日期：2011-05-01 00:00:00

abstract：:Various oils have been used as vehicles for cholesterol in diets used to produce atherosclerosis in rabbits. Because such oils may affect the physico-chemical properties of the beta-VLDL produced in response to cholesterol feeding, we have studied the physico-chemical characteristics of beta-VLDL isolated from cholest...

journal_title：Atherosclerosis

authors： Waugh DA,Tercyak AM,Small DM

更新日期：1989-04-01 00:00:00

abstract：AIM:The present clinical study tested the hypothesis that oil-rich fish consumption improves CHD risk factors. METHODS:Forty-eight (16 men) non-obese, healthy adults aged 20-55, consumed 125 g/day of salmon for a 4-week period followed by a 4-week period with no-fish (41 completers). Subjects were instructed to mainta...

journal_title：Atherosclerosis

authors： Lara JJ,Economou M,Wallace AM,Rumley A,Lowe G,Slater C,Caslake M,Sattar N,Lean ME

更新日期：2007-07-01 00:00:00

abstract：:Polar coordinate mapping was used to determine the rate of growth of individual sudanophilic lesions on the aortic wall around several major branches of the aortae of cholesterol fed rabbits. Four groups, with 6 8-month old male albino white rabbits in each, were used in the study. One group served as a control and th...

journal_title：Atherosclerosis

authors： Roach MR,Fletcher J,Cornhill JF

更新日期：1976-10-01 00:00:00

abstract：:Regulation of expression of the genes for the low density lipoprotein receptor (LDLR) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) is of central importance in the control of cholesterol metabolism and thus in influencing the concentration of low density lipoprotein in the plasma. This can be studied by i...

journal_title：Atherosclerosis

authors： Le Cras TD,Gherardi E,Bowyer DE

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:The influence of the quality of dietary fat on some aspects of lipid metabolism-i.e. lipoprotein concentrations, post-prandial lipids and LDL size-is not completely understood, especially in healthy individuals. OBJECTIVES:Aim of this study was to evaluate the effects of different types of dietary fat (mono...

journal_title：Atherosclerosis

authors： Rivellese AA,Maffettone A,Vessby B,Uusitupa M,Hermansen K,Berglund L,Louheranta A,Meyer BJ,Riccardi G

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Vasa vasorum (VV) and lymphatic vasa vasorum (LVV) form their own networks in the adventitia. VV supply the aorta with nutrition and oxygen; however, the distribution and role of LVV remains to be determined. The purpose of this study was to investigate differences in the distribution of VV and LVV ...

journal_title：Atherosclerosis

authors： Sano M,Unno N,Sasaki T,Baba S,Sugisawa R,Tanaka H,Inuzuka K,Yamamoto N,Sato K,Konno H

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVES:To evaluate the pharmacokinetics and effects of the first immediate-release (IR) niacin-aspirin prodrug (ST0702) on lipid, prostaglandin and thromboxane levels in non-human primates (NHPs). METHODS:We compared 28 mg/kg crystalline IR niacin, equimolar doses of crystalline IR ST0702 and control on low densit...

journal_title：Atherosclerosis

authors： Ledwidge MT,Ryan F,Kerins DM,O'Connell D,Cefali G,Harmon S,Jones M,Gilmer JF

更新日期：2012-04-01 00:00:00

abstract：:We investigated the influence of fish oil on cholesterol induced atherosclerosis in rabbits. Group I, a control group was fed a cholesterol-free diet, group II was fed a diet supplemented with 1.5% cholesterol, group III received in addition to cholesterol supplementation a purified fish oil concentrate (Maxepa, 2 ml/...

journal_title：Atherosclerosis

authors： Thiery J,Seidel D

更新日期：1987-01-01 00:00:00

abstract：:Enhanced and prolonged postprandial lipaemia is implicated in coronary and carotid artery disease. This study assessed the effects of atorvastatin, a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor, on postprandial plasma concentrations of triglyceride-rich lipoproteins (TRLs). Sixteen middle-aged men with combined...

journal_title：Atherosclerosis

authors： Boquist S,Karpe F,Danell-Toverud K,Hamsten A

更新日期：2002-05-01 00:00:00

abstract：:Statins have been the mainstay of lipid-lowering therapy since their introduction. However, as lower LDL cholesterol targets are sought, adjunct therapies are becoming increasingly important. Few patients reach new targets with statin monotherapy. We propose that the cholestanol:cholesterol ratio can be used to guide ...

journal_title：Atherosclerosis

authors： Hoenig MR,Rolfe BE,Campbell JH

更新日期：2006-02-01 00:00:00

abstract：:Hypertension is associated with an increased incidence of generalized vascular disease. Antihypertensive drug therapy, while decreasing overall mortality due to cerebral hemorrhage, myocardial hypertrophy or renal failure, paradoxically does not appear to reduce the incidence of coronary atherosclerosis. This study in...

journal_title：Atherosclerosis

authors： Bailey JM,Randazzo R

更新日期：1977-01-01 00:00:00

abstract：:Trained people exhibit low plasma concentrations of triacylglcyeride (TAG) in both fasted and postprandial states. This mainly reflects enhanced uptake of TAG into skeletal muscle, via enhanced activity of lipoprotein lipase, the rate-limiting step in TAG removal. Endurance athletes possess a large, well-vascularised ...

journal_title：Atherosclerosis

authors： Hardman AE

更新日期：1998-12-01 00:00:00

abstract：:The proliferation of aortic smooth muscle cells (ASMC) of Wistar rats, impaired by risk factors such as arterial hypertension, diabetes mellitus, atherogenic diet and staphylolysin injections and of normal Wistar rats treated with antirheumatic drugs such as prednisolone and acetylsalicylic acid was investigated. The ...

journal_title：Atherosclerosis

authors： Hauss WH,Mey J,Schulte H

更新日期：1979-10-01 00:00:00

abstract：BACKGROUND:The identification of mutations in PCSK9 (proprotein convertase subtilisin kexin9) in autosomal dominant hypercholesterolemia (ADH), has revealed the existence of a new player in cholesterol homeostasis. PCSK9 has been shown to enhance the degradation of the LDL receptor (LDLR) at the cell surface. Gain-of-f...

journal_title：Atherosclerosis

authors： Abifadel M,Guerin M,Benjannet S,Rabès JP,Le Goff W,Julia Z,Hamelin J,Carreau V,Varret M,Bruckert E,Tosolini L,Meilhac O,Couvert P,Bonnefont-Rousselot D,Chapman J,Carrié A,Michel JB,Prat A,Seidah NG,Boileau C

更新日期：2012-08-01 00:00:00

abstract：:The effects of insulin and insulin-like growth factor I (IGF-I) on migration, proliferation and tube-forming activity of endothelial cells were investigated, by using bovine carotid artery endothelial cells. Migration was assayed by a filter membrane technique and tube formation was assayed by a quantitative angiogene...

journal_title：Atherosclerosis

authors： Nakao-Hayashi J,Ito H,Kanayasu T,Morita I,Murota S

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVE:Recent data suggest the involvement of dectin-1 in atherosclerosis through regulation of local reactive oxygen species production. The aim of the current study was to assess the effect of dectin-1 deficiency on atherosclerotic plaque development. METHODS:Using immunohistochemistry dectin-1 expression was obs...

journal_title：Atherosclerosis

authors： Szilagyi K,Gijbels MJ,van der Velden S,Heinsbroek SE,Kraal G,de Winther MP,van den Berg TK

更新日期：2015-04-01 00:00:00