Cholestanol: a serum marker to guide LDL cholesterol-lowering therapy.

abstract：:The metabolic syndrome (MetS) is represented by the co-occurrence of multiple metabolic and physiologic risk factors for both type 2 diabetes mellitus and atherosclerotic cardiovascular diseases. In spite of its high frequency and association with morbidity and mortality in the adult population, very little is known a...

journal_title：Atherosclerosis

authors： Maggi S,Noale M,Zambon A,Limongi F,Romanato G,Crepaldi G,ILSA Working Group.

更新日期：2008-04-01 00:00:00

abstract：:Simvastatin, an inhibitor of HMG CoA reductase, lowers the plasma total cholesterol and LDL-cholesterol concentration in familial hypercholesterolemic patients. The efficacy of the drug shows considerable inter-individual variation, however. In this study we have assessed the influence of certain LDL-receptor gene mut...

journal_title：Atherosclerosis

authors： Jeenah M,September W,Graadt van Roggen F,de Villiers W,Seftel H,Marais D

更新日期：1993-01-04 00:00:00

abstract：BACKGROUND AND AIMS:The indications for carotid endarterectomy (CEA) are well established. The aim of the current study was to investigate sex and race-based disparities in the incidence of CEA after adjusting for carotid artery stenosis risk factors. METHODS:We conducted a prospective cohort analysis of 14,492 black ...

journal_title：Atherosclerosis

authors： Hicks CW,Daya NR,Black JH 3rd,Matsushita K,Selvin E

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:We investigated whether early atherosclerosis before calcified plaque appeared as assessed by carotid intima-media thickness (IMT) was associated with levels of the major carotenoids, and assessed the associations among these serum carotenoids, carotid IMT, and arterial stiffness. METHODS:The case-control st...

journal_title：Atherosclerosis

authors： Zou Z,Xu X,Huang Y,Xiao X,Ma L,Sun T,Dong P,Wang X,Lin X

更新日期：2011-12-01 00:00:00

abstract：:Two specific endothelial cell products, von Willebrand factor and soluble E-selectin, were measured together with serum lipids, lipoprotein(a), systolic and diastolic blood pressure (SHP, DBP) in a follow up study of 162 patients attending a dedicated lipid clinic. Patients were further classified by the presence or a...

journal_title：Atherosclerosis

authors： Blann AD,Miller JP,McCollum CN

更新日期：1997-07-25 00:00:00

abstract：BACKGROUND AND AIMS:The exact mechanism of premature atherosclerosis in diabetes is still unclear. Inappropriate activation of the renin-aldosterone-angiotensin system may be an important risk factor for cardiovascular disease. We investigated whether renin and aldosterone are associated with vasoactive peptides midreg...

journal_title：Atherosclerosis

authors： Then C,Rottenkolber M,Lechner A,Meisinger C,Heier M,Koenig W,Peters A,Rathmann W,Bidlingmaier M,Reincke M,Seissler J

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:Interruption of the enterohepatic circulation of bile acids induces hepatic bile acid synthesis, increases hepatic cholesterol demand, and increases clearance of apoB-containing lipoproteins in plasma. Based on these effects, bile acid sequestrants have been used for many years to treat hypercholesterolemia a...

journal_title：Atherosclerosis

authors： Lan T,Haywood J,Dawson PA

更新日期：2013-08-01 00:00:00

abstract：:Fifty-seven sections of human vessels, collected in the Pathobiological Determinants of Atherosclerosis in Youth study from individuals aged 25-34, were stained with two monoclonal antibodies to oxidatively-modified lysine. Intensity and extent of immunoreactivity were graded by three pathologists. Aorta from a Watana...

journal_title：Atherosclerosis

authors： Sloop GD,Fallon KB,Lipscomb G,Takei H,Zieske A

更新日期：2000-02-01 00:00:00

abstract：:We describe the cardiovascular state of a 60-year-old homozygous patient with familial HDL deficiency (Tangier disease). The patient was examined by coronary angiography and intravascular ultrasound because of chest pain at rest and on exertion. We found a normal left ventricular function, moderately diffuse coronary ...

journal_title：Atherosclerosis

authors： Walter M,Kerber S,Fechtrup C,Seedorf U,Breithardt G,Assmann G

更新日期：1994-10-01 00:00:00

abstract：PURPOSE:Metabolic Syndrome as defined by ATP III criteria, a constellation of risk factors associated with insulin resistance, predisposes to premature atherosclerosis and early coronary events. Whether that negative risk profile is associated with endothelial dysfunction remains to be established. MATERIALS AND METHO...

journal_title：Atherosclerosis

authors： Dell'Omo G,Penno G,Pucci L,Mariani M,Del Prato S,Pedrinelli R

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the relationship between brachial flow-mediated dilation (FMD) and carotid intima-media thickness (IMT) in a large multi-ethnic elderly cohort. BACKGROUND:Brachial flow-mediated dilation (FMD) is a physiologic measure and carotid IMT is an anatomic structural measure of...

journal_title：Atherosclerosis

authors： Yeboah J,Burke GL,Crouse JR,Herrington DM

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:DJ-1-a multifunctional protein responding to oxidative stress-is a possible regulator of the inflammatory response that plays an important role in atherosclerosis. Stromal cell-derived factor (SDF)-1 and its receptor, chemokine receptor type 4 (CXCR4), have been implicated in the recruitment of inflammatory c...

journal_title：Atherosclerosis

authors： Jung SH,Won KJ,Lee KP,Lee DH,Yu S,Lee DY,Seo EH,Kang H,Park ES,Kim HJ,Lee SH,Kim B

更新日期：2014-08-01 00:00:00

abstract：:Monocyte chemoattractant protein-1 (MCP-1) recruits monocytes into atherosclerotic plaques. A single nucleotide polymorphism in the MCP-1 gene promoter (-2578A>G) results in greater production of MCP-1 protein. We examined the association of this polymorphism with occult coronary artery disease (CAD) and its interacti...

journal_title：Atherosclerosis

authors： Kim MP,Wahl LM,Yanek LR,Becker DM,Becker LC

更新日期：2007-08-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) migration and proliferation are critical events in the development of neointima following vascular injury. In this study, we found that CD9 is constitutively expressed in the VSMC of the neointima of injured carotid arteries. The in vitro migration and proliferation of human coronary...

journal_title：Atherosclerosis

authors： Kotha J,Zhang C,Longhurst CM,Lu Y,Jacobs J,Cheng Y,Jennings LK

更新日期：2009-04-01 00:00:00

abstract：:Apolipoprotein D (APOD, gene; apoD, protein) is a plasma high-density lipoprotein (HDL)-associated glycoprotein, with a putative role in the cholesterol (CHOL) transport pathway. An apoD protein polymorphism has been previously reported by us. The cathodically shifted pattern seen on isoelectric focusing gels, control...

journal_title：Atherosclerosis

authors： Desai PP,Bunker CH,Ukoli FA,Kamboh MI

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Atherosclerosis is a chronic lipid-driven inflammatory disease of the arterial wall. Interferon gamma (IFNγ) is an important immunomodulatory cytokine and a known pro-atherosclerotic mediator. However, cell-specific targeting of IFNγ or its signaling in atherosclerosis development has not been studi...

journal_title：Atherosclerosis

authors： Boshuizen MC,Neele AE,Gijbels MJ,van der Velden S,Hoeksema MA,Forman RA,Muller W,Van den Bossche J,de Winther MP

更新日期：2016-03-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of fluvastatin on the microcirculation of patients with hyperlipidaemia (low-density lipoprotein cholesterol > 160 mg/dL, triglycerides < 350 mg/dl) inadequately controlled by diet. After a dietary run-in of 4 weeks, patients were randomised in a double-blind stu...

journal_title：Atherosclerosis

authors： Haak E,Abletshauser C,Weber S,Goedicke C,Martin N,Hermanns N,Lackner K,Kusterer K,Usadel KH,Haak T

更新日期：2001-04-01 00:00:00

abstract：:We tested whether low high-density lipoprotein cholesterol (HDL-C) and/or high triglycerides are associated to abnormal HDL subclasses distribution and composition, and their relationships with fasting insulin and C-reactive protein (CRP). Four groups of adolescents were studied: group 1 (HDL-C< or =35 mg/dl+TG> or =1...

journal_title：Atherosclerosis

authors： Medina-Urrutia A,Juarez-Rojas JG,Martínez-Alvarado R,Jorge-Galarza E,Posadas-Sánchez R,Cardoso-Saldaña G,Caracas-Portilla N,Mendoza-Perez E,Posadas-Romero C

更新日期：2008-12-01 00:00:00

abstract：:Occlusive arterial disease stimulates compensatory growth of pre-existent and new arterial channels which help to maintain organ perfusion. Previous studies characterizing compensatory or collateral vascular growth have been performed in normocholesterolemic animals. Because hyperlipidemic states alter vascular regula...

journal_title：Atherosclerosis

authors： Bucay M,Nguy J,Barrios R,Chen CH,Henry PD

更新日期：1998-08-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) has been shown to participate in both experimental and human atherogenesis. Expression of MMP-9 has been shown to play a role in the instability of atherosclerotic plaque. Thus, we hypothesize that MIF may participate in the destabilization of atherosclerotic plaques by sti...

journal_title：Atherosclerosis

authors： Kong YZ,Yu X,Tang JJ,Ouyang X,Huang XR,Fingerle-Rowson G,Bacher M,Scher LA,Bucala R,Lan HY

更新日期：2005-01-01 00:00:00

abstract：:Mevinolin (MK-803) is a potent inhibitor of HMG-CoA reductase. After a placebo run-in period, mevinolin 5,15 or 50 mg, or placebo was given twice daily for 7-11 days under double -blind conditions ot 4 groups of 6 normocholesterolemic male volunteers. After 7 days, mean serum cholesterol fell 14%, 25% and 24% on 5, 15...

journal_title：Atherosclerosis

authors： Tobert JA,Hitzenberger G,Kukovetz WR,Holmes IB,Jones KH

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) have been implicated in development of atherosclerosis. MMPs are activated in patients with acute coronary syndrome (ACS). However, little data exist regarding the correlation between circulating levels of MMPs and plaque volume (PV) in patients with ACS. We therefore evaluat...

journal_title：Atherosclerosis

authors： Ogita M,Miyauchi K,Morimoto T,Daida H,Kimura T,Hiro T,Nakagawa Y,Yamagishi M,Ozaki Y,Matsuzaki M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Parental history (PH) and genetic risk scores (GRSs) are separately associated with coronary heart disease (CHD), but evidence regarding their combined effects is lacking. We aimed to evaluate the joint associations and predictive ability of PH and GRSs for incident CHD. METHODS:Data for 4283 Cauca...

journal_title：Atherosclerosis

authors： Antiochos P,Marques-Vidal P,McDaid A,Waeber G,Vollenweider P

更新日期：2016-01-01 00:00:00

abstract：:83 pairs of twins, aged 50-74 years, were studied with respect to their serum apoproteins (A-I, A-II, B, C-II, C-III and E) and cholesterol concentrations. Each of the variables showed a higher intraclass correlation in the MZ twins than in the DZ twins. HDL cholesterol showed the highest intraclass correlation among ...

journal_title：Atherosclerosis

authors： Hayakawa K,Shimizu T,Ohba Y,Tomioka S

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:It is uncertain whether the novel single nucleotide polymorphisms (SNPs) that have recently been associated with coronary artery disease (CAD) in genome-wide studies also influence carotid atheroma and stroke risk. The mechanisms of their association with CAD are unknown; relationships to other cardiovascula...

journal_title：Atherosclerosis

authors： Cunnington MS,Mayosi BM,Hall DH,Avery PJ,Farrall M,Vickers MA,Watkins H,Keavney B

更新日期：2009-03-01 00:00:00

abstract：:A major gene hypothesis for heparin releasable plasma lipoprotein lipase (PH-LPL) activity was assessed using segregation analyses of data on 495 members in 98 normolipidemic sedentary families of Caucasian descent who participated in the HERITAGE Family Study. Segregation analyses were performed on PH-LPL adjusted fo...

journal_title：Atherosclerosis

authors： Hong Y,Rice T,Després JP,Gagnon J,Nadeau A,Bergeron J,Pérusse L,Bouchard C,Leon AS,Skinner JS,Wilmore JH,Rao DC

更新日期：1999-06-01 00:00:00

abstract：:High circulating levels of carotenoids have been thought to exhibit a protective function in the development of atherosclerosis. We investigated whether aortic atherosclerosis was associated with lower levels of the major serum carotenoids in alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein, lycopene, and zea...

journal_title：Atherosclerosis

authors： Klipstein-Grobusch K,Launer LJ,Geleijnse JM,Boeing H,Hofman A,Witteman JC

更新日期：2000-01-01 00:00:00

abstract：:Acyl-coenzyme A:cholesterol acyltransferase (ACAT) esterifies free cholesterol and stores cholesteryl esters in lipid droplets. Macrophage ACAT1 deficiency results in increased atherosclerotic lesion area in hyperlipidemic mice via disrupted cholesterol efflux, increased lipoprotein uptake, accumulation of intracellul...

journal_title：Atherosclerosis

authors： Dove DE,Su YR,Swift LL,Linton MF,Fazio S

更新日期：2006-06-01 00:00:00

abstract：:Statins produce cholesterol-independent, anti-inflammatory effects, which result at least in part from increased endothelial nitric oxide production. These effects may be modulated by polymorphisms in the endothelial nitric oxide synthase (eNOS) gene. Here, we examined whether the T-786C polymorphism of eNOS gene affe...

journal_title：Atherosclerosis

authors： Souza-Costa DC,Sandrim VC,Lopes LF,Gerlach RF,Rego EM,Tanus-Santos JE

更新日期：2007-08-01 00:00:00

abstract：:Various oils have been used as vehicles for cholesterol in diets used to produce atherosclerosis in rabbits. Because such oils may affect the physico-chemical properties of the beta-VLDL produced in response to cholesterol feeding, we have studied the physico-chemical characteristics of beta-VLDL isolated from cholest...

journal_title：Atherosclerosis

authors： Waugh DA,Tercyak AM,Small DM

更新日期：1989-04-01 00:00:00