Fluvastatin therapy improves microcirculation in patients with hyperlipidaemia.

abstract：BACKGROUND:It is uncertain whether the novel single nucleotide polymorphisms (SNPs) that have recently been associated with coronary artery disease (CAD) in genome-wide studies also influence carotid atheroma and stroke risk. The mechanisms of their association with CAD are unknown; relationships to other cardiovascula...

journal_title：Atherosclerosis

authors： Cunnington MS,Mayosi BM,Hall DH,Avery PJ,Farrall M,Vickers MA,Watkins H,Keavney B

更新日期：2009-03-01 00:00:00

abstract：:AMO 1618 (2-isopropyl-4-dimethylamino-5-methylphenyl-1-piperidine carboxylate methyl chloride) was added to corn-soy based diets and fed to 9-week-old female chickens for 3 weeks to measure the inhibition of hepatic beta-hydroxy-beta-methylglutaryl coenzyme A (HMG-CoA) reductase and cholesterol 7 alpha-hydroxylase. Do...

journal_title：Atherosclerosis

authors： Qureshi AA,Abuirmeileh N,Burger WC,Din ZZ,Elson CE

更新日期：1983-02-01 00:00:00

abstract：:The effect of renal hypertension on dry defatted tissue mass and lipid accumulation in different segments of the aortic intima was studied in both normally-fed and cholesterol-fed rabbits. In normally-fed rabbits hypertension caused an increase in intimal dry weight in the aorta. The increase was greatest in the lower...

journal_title：Atherosclerosis

authors： Bretherton KN,Day AJ,Skinner SL

更新日期：1975-11-01 00:00:00

abstract：OBJECTIVE:Matrix metalloproteinases (MMPs) are implicated in the pathogenesis of atherosclerosis. However, the relationship between blood levels of MMPs and the extent of carotid atherosclerosis remains uncertain. We assessed blood levels of active MMPs in relation to the extent of carotid plaque formation and intima-m...

journal_title：Atherosclerosis

authors： Lien LM,Hsieh YC,Bai CH,Chen WH,Chiu HC,Hsieh FI,Shyu KG,Chiou HY,Hsu CY

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND AND AIM:In the general population lipid-rich plaques are prone to rupture and healing of the plaque involves calcification. Patients undergoing hemodialysis have a severe derangement of mineral metabolism and calcification of the arterial tree may have different implications. METHODS:Between 2004 and 2005, ...

journal_title：Atherosclerosis

authors： Bellasi A,Ferramosca E,Ratti C,Block G,Raggi P

更新日期：2016-07-01 00:00:00

abstract：:The change of acid cholesteryl ester hydrolase activity in mononuclear leukocyte following treatment of diabetes mellitus was studied in 21 patients with non-insulin-dependent diabetes mellitus (NIDDM). Enzyme activity before treatment in the patients was significantly lower than that in 14 age-matched healthy subject...

journal_title：Atherosclerosis

authors： Onuma T,Tsutsui M,Boku A,Yanada A,Ochiai S,Takebe K

更新日期：1992-02-01 00:00:00

abstract：:Enhanced and prolonged postprandial lipaemia is implicated in coronary and carotid artery disease. This study assessed the effects of atorvastatin, a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor, on postprandial plasma concentrations of triglyceride-rich lipoproteins (TRLs). Sixteen middle-aged men with combined...

journal_title：Atherosclerosis

authors： Boquist S,Karpe F,Danell-Toverud K,Hamsten A

更新日期：2002-05-01 00:00:00

abstract：INTRODUCTION:The possible cause of accelerated atherosclerosis in NAFLD may be the relationship with the MetS and its components. Our primary goal was to evaluate the relationship between NAFLD and subclinical atherosclerosis in adult male patients between 20 and 40 years of age. Moreover, we aimed to investigate the c...

journal_title：Atherosclerosis

authors： Ozturk K,Uygun A,Guler AK,Demirci H,Ozdemir C,Cakir M,Sakin YS,Turker T,Sari S,Demirbas S,Karslıoğlu Y,Saglam M

更新日期：2015-06-01 00:00:00

abstract：:Recent studies suggest that the beneficial effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins) in reducing cardiovascular events may in part, be independent of their capacity to lower plasma lipids. To test this hypothesis, simvastatin (50 mg/kg/d) was administered to 30-week-old ...

journal_title：Atherosclerosis

authors： Bea F,Blessing E,Shelley MI,Shultz JM,Rosenfeld ME

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:To clarify the potential mechanisms by which oxidized low-density lipoprotein (oxLDL) could contribute to the progression of aortic valve stenosis (AVS). METHODS:We investigated a total of 46 stenotic and 20 control human aortic valves. The mRNA expression levels of scavenger receptor class A type 1 (SR-A1),...

journal_title：Atherosclerosis

authors： Syväranta S,Alanne-Kinnunen M,Oörni K,Oksjoki R,Kupari M,Kovanen PT,Helske-Suihko S

更新日期：2014-08-01 00:00:00

abstract：:The endothelium contributes to the regulation of vascular tone by producing nitric oxide (NO) and the endothelium-derived hyperpolarising factor (EDHF). In hypercholesterolemia, endothelium-dependent relaxation is impaired but can be restored by treatment with lovastatin (LOVAS). We investigated the effects of LOVAS o...

journal_title：Atherosclerosis

authors： Brandes RP,Behra A,Lebherz C,Böger RH,Bode-Böger SM,Mügge A

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:To study the influence of polyvascular atherothrombotic disease on stroke patient prognosis, its relation with inflammatory markers, and to analyze the progression of atherothrombotic disease. METHODS:MITICO is a multi-centered prospective observational study recruiting non-anticoagulated ischemic stroke pat...

journal_title：Atherosclerosis

authors： Blanco M,Sobrino T,Montaner J,Medrano V,Jiménez C,Masjuán J,Gómez-Escalonilla C,de Luis P,Arboix A,Castillo J,MITICO Study.

更新日期：2010-02-01 00:00:00

abstract：:Monocytes and macrophages synthesize tissue factor (TF) which plays a role in thrombogenicity in coronary artery disease. This study was conducted to investigate the effect of Rho/Rho-kinase inhibition on the synthesis of TF in cultured human monocytes. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibit...

journal_title：Atherosclerosis

authors： Nagata K,Ishibashi T,Sakamoto T,Ohkawara H,Shindo J,Yokoyama K,Sugimoto K,Sakurada S,Takuwa Y,Nakamura S,Teramoto T,Maruyama Y

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Oxidation processes play an important role in atherogenesis. Bilirubin IXalpha is recognised as a potent antioxidant. In the present study, we assessed the role of elevated serum bilirubin levels in the prevention of ischemic heart disease (IHD). METHODS:The occurrence of IHD was determined in Gilbert syndr...

journal_title：Atherosclerosis

authors： Vítek L,Jirsa M,Brodanová M,Kalab M,Marecek Z,Danzig V,Novotný L,Kotal P

更新日期：2002-02-01 00:00:00

abstract：:The present study focused on the role of blood flow in the formation of focal intimal hyperplasia in vein grafts, as well as the development of an engineering approach that can be used to eliminate disturbed blood flow and prevent blood flow-related focal intimal hyperplasia. A rat vein graft model was constructed by ...

journal_title：Atherosclerosis

authors： Liu SQ

更新日期：1998-10-01 00:00:00

abstract：:Oxidation of low density lipoprotein (LDL) leads to more rapid uptake by arterial wall macrophages and foam cell formation. Inhibiting LDL oxidation may impede these processes and offers a new mechanism to retard atherogenesis. The 21-aminosteroids, derived from methylprednisolone, are potent inhibitors of free radica...

journal_title：Atherosclerosis

authors： Fisher M,Levine PH,Doyle EM,Arpano MM,Hoogasian JJ

更新日期：1991-10-01 00:00:00

abstract：:The aim of this study was to examine whether the well-established effect of the common TaqIB polymorphism in intron 1 of the gene for cholesterol ester transfer protein (CETP) on high density lipoprotein cholesterol (HDL-C) concentration and increased risk of myocardial infarction (MI), could be explained by the recen...

journal_title：Atherosclerosis

authors： Eiriksdottir G,Bolla MK,Thorsson B,Sigurdsson G,Humphries SE,Gudnason V

更新日期：2001-11-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) has been proposed as a potential tool in the evaluation of atherosclerotic lesions. However, two basic difficulties have to date prevented the full exploitation of the potentials of this technique: the poor spatial resolution of the conventional tomographs and the wide variety of the l...

journal_title：Atherosclerosis

authors： Asdente M,Pavesi L,Oreste PL,Colombo A,Kuhn W,Tremoli E

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:We conducted the meta-analysis to compare the diagnostic accuracies of carotid plaque and carotid intima-media thickness (CIMT) measured by B-mode ultrasonography for the prediction of coronary artery disease (CAD) events. METHODS:Two reviewers independently searched electronic databases to identify relevan...

journal_title：Atherosclerosis

authors： Inaba Y,Chen JA,Bergmann SR

更新日期：2012-01-01 00:00:00

abstract：:Following injections of Evans blue (1-200 mg/kg) into rabbits, polyacrylamide gel disc electrophoresis showed that Evans blue binds to two protein fractions. The greater part was bound to albumin and the remainder to a plasma protein in the postalbumin fraction. Unbound Evans blue was present in each plasma sample ana...

journal_title：Atherosclerosis

authors： Lindner V,Heinle H

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:Lipoprotein Lp(a) has been shown to be an independent risk factor for coronary artery disease (CAD). However, its association with CAD burden in patients with ACS is largely unknown, as well as the association of Lp(a) with lipid rich plaques prone to rupture. AIM:We aim at assessing CAD burden by coronary ...

journal_title：Atherosclerosis

authors： Niccoli G,Cin D,Scalone G,Panebianco M,Abbolito S,Cosentino N,Jacoangeli F,Refaat H,Gallo G,Salerno G,Volpe M,Crea F,De Biase L

更新日期：2016-03-01 00:00:00

abstract：:Copper mediated oxidative modification of high density lipoprotein (HDL) diminishes its capacity to promote cholesterol efflux from cells in culture. In the present study, HDL was isolated from eight subjects before and after a 10 day administration of the antioxidant vitamins C and E. After incubation HDL (1.25 mg pr...

journal_title：Atherosclerosis

authors： Rifici VA,Khachadurian AK

更新日期：1996-11-15 00:00:00

abstract：:The ATP-binding cassette transporters, ABCA1 and ABCG1, are LXR-target genes that participate in the removal of cholesterol from lipid-laden macrophages, a crucial anti-atherogenic mechanism. Statins are currently the most efficacious therapy for the treatment of hypercholesterolemia and cardiovascular disease. We and...

journal_title：Atherosclerosis

authors： Wong J,Quinn CM,Gelissen IC,Jessup W,Brown AJ

更新日期：2008-01-01 00:00:00

abstract：:Deficit sialylation of vascular endothelium, circulating cells and macromolecules has been associated with the development of atherosclerosis. On the other hand, an elevated serum level of sialic acid is a long-lasting marker of atherosclerosis and complications from atherosclerosis. One may speculate that the inverse...

journal_title：Atherosclerosis

authors： Lindberg G

更新日期：2007-06-01 00:00:00

abstract：:Inducible nitric oxide synthase (iNOS) has recently been shown to be present in human atherosclerotic lesions and to promote the formation of deleterious peroxynitrite. Allicin and ajoene are discussed as active compounds with regard to the beneficial effects of garlic in atherosclerosis. The aim of this study was to ...

journal_title：Atherosclerosis

authors： Dirsch VM,Kiemer AK,Wagner H,Vollmar AM

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolaemia (FH) is a powerful risk factor for cardiovascular (CV) events. High levels of low-density lipoprotein cholesterol (LDL-C) since birth are linked to the early onset of atherosclerotic disease. A genetic mutation determining FH is present in about one subject out of 250;...

journal_title：Atherosclerosis

authors： Gulizia MM,Maggioni AP,Abrignani MG,Bilato C,Mangiacapra F,Sanchez FA,Piovaccari G,Montagna L,Marini M,De Biasio M,Averna M,Casula M,Colivicchi F,Fabbri G,Lucci D,Zampoleri V,Catapano AL,POSTER Investigators.

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND AIMS:The role of circular RNAs (circRNAs) in coronary artery disease (CAD) remains elusive. The aim of the present study was to profile circRNAs expression in CAD patients and assess diagnostics biomarkers for CAD. METHODS:The circRNA profiles of 24 CAD patients and 7 controls were assessed by microarra...

journal_title：Atherosclerosis

authors： Wang L,Shen C,Wang Y,Zou T,Zhu H,Lu X,Li L,Yang B,Chen J,Chen S,Lu X,Gu D

更新日期：2019-07-01 00:00:00

abstract：:Extracellular-superoxide dismutase (EC-SOD) is the major SOD isozyme in the arterial wall and may be important for antioxidation capability of the vascular wall and normal vascular function. EC-SOD is expressed in various cell types in the vascular wall such as fibroblasts, smooth muscle cells and macrophages, and the...

journal_title：Atherosclerosis

authors： Adachi T,Hara H,Yamada H,Yamazaki N,Yamamoto M,Sugiyama T,Futenma A,Katagiri Y

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Molecular imaging with 18Fluorodeoxyglucose (FDG) and 18F-sodium-fluoride (NaF) captures arterial inflammation and micro-calcification and can reveal potentially unstable atherosclerotic plaques. METHODS:We performed FDG and NaF PET/CT imaging in two clinically similar cohorts of patients living wi...

journal_title：Atherosclerosis

authors： Guaraldi G,Milic J,Prandini N,Ligabue G,Esposito F,Ciusa G,Malagoli A,Scaglioni R,Besutti G,Beghetto B,Nardini G,Roncaglia E,Mussini C,Raggi P

更新日期：2020-03-01 00:00:00

abstract：:Arterial specimens were obtained from 12 patients during arterial repair surgery and 3 patients during nephrectomy following a bolus injection of autologous radio-iodinated very low density lipoprotein (VLDL) up to 30 h before surgery. Radioactivity in apoprotein B (apo B) was determined in lipoprotein fractions isola...

journal_title：Atherosclerosis

authors： Nicoll A,Duffield R,Lewis B

更新日期：1981-05-01 00:00:00