Abstract:
:Coronary heart disease (CHD) is one of the leading disorders with the highest mortality rate. Percutaneous angioplasty and stent implantation are the currently available standard methods for the treatment of obstructive coronary artery disease. However, the stent being an exogenous substance causes several complications by promoting the proliferation of vascular smooth muscle cells, immune responses and neointima formation after implantation, leading to post-stent restenosis (ISR) and late thrombosis. The prevention of these adverse vascular events is important to achieve long-term proper functioning of the heart after stent implantation. Non-coding ribonucleic acids (ncRNAs) are RNA molecules not translated into proteins, theyhave a great potential in regulating endothelial cell and vascular smooth muscle function as well as inflammatory reactions. In this review, we outline the regulatory functions of different classes of ncRNA in cardiovascular disease and propose ncRNAs as new targets for stent restonosis treatment.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Liu S,Yang Y,Jiang S,Tang N,Tian J,Ponnusamy M,Tariq MA,Lian Z,Xin H,Yu Tdoi
10.1016/j.atherosclerosis.2018.03.036subject
Has Abstractpub_date
2018-05-01 00:00:00pages
153-161eissn
0021-9150issn
1879-1484pii
S0021-9150(18)30164-3journal_volume
272pub_type
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