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ACE insert/delete polymorphism and atherosclerosis.

Abstract：

:We report on the results of a large autopsy study focusing upon the hypothesis that deletion of the Alu insert in the angiotensin converting enzyme (ACE) gene is associated with: (a) greater prevalence or extent of atherosclerosis in the aorta and coronary arteries; and (b) microscopic qualities of established atherosclerotic plaques in the coronary arteries. This study was conducted in young US black (n=290) and white (n=379) males using available materials and data from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study, a multi-center cooperative autopsy study organized in 1985 to explore the relationships of known cardiovascular risk factors to atherosclerosis in victims of accidents, homicides, or suicides in the age range of 15-34 years. The results provide strong evidence that ACE genotype may not be a predictor of either the prevalence or the extent of the lesions of atherosclerosis in the right coronary artery or the aorta of young adults, an observation that confirms previous studies that estimated the prevalence and extent of atherosclerosis using coronary angiography. In addition, the results suggest that ACE genotype does not contribute to the formation of atherosclerotic lesions that have the characteristics of vulnerable plaques in the left anterior descending coronary artery of young adults.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Scheer WD,Boudreau DA,Hixson JE,McGill HC,Newman WP 3rd,Tracy RE,Zieske AW,Strong JP

doi

10.1016/j.atherosclerosis.2004.09.019

keywords:

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

241-7

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(04)00496-4

journal_volume

178

pub_type

杂志文章

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