Abstract:
INTRODUCTION:It has been proposed that reactive oxygen species (ROS) generated during myocardial ischemia-reperfusion modify the N-terminus of serum albumin resulting in ischemia-modified albumin (IMA) formation. Likewise, several recent publications provide evidence that melatonin, a circadian endogenously produced indolamine, is a direct scavenger of ROS. We sought to investigate the relationship between IMA and melatonin in ST- elevation myocardial infarction (STEMI). METHODS:We compared IMA and melatonin levels in 27 patients with STEMI undergoing primary angioplasty and 20 age- and gender-matched healthy normal subjects. Blood samples were drawn at 02:00h (night period) and 09:00h (day period) while patients were resting, to assess IMA and melatonin. RESULTS:In both groups, melatonin concentrations maintained a diurnal variation, but the difference between nocturnal and diurnal levels was less in the STEMI-patients than in the control group (p<0.001). In contrast to findings about melatonin, IMA levels showed no diurnal variations in control subjects. However, the STEMI group showed a diurnal fluctuation with significantly higher levels at 02:00h (p<0.01). The association between IMA and melatonin remained statistically significant after adjustment for cardiovascular risk factors. An inverse correlation between IMA and melatonin at 02:00h and at 09:00h was observed, with respective r-values of -0.42 (p<0.03) and -0.57 (p<0.002). CONCLUSIONS:Circulating IMA is negatively correlated to melatonin in STEMI-patients. Our results suggest that melatonin might exert a beneficial effect as a radical scavenger in a human model of myocardial ischemia-reperfusion.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Dominguez-Rodriguez A,Abreu-Gonzalez P,Garcia-Gonzalez MJ,Samimi-Fard S,Reiter RJ,Kaski JCdoi
10.1016/j.atherosclerosis.2007.10.019subject
Has Abstractpub_date
2008-07-01 00:00:00pages
73-8issue
1eissn
0021-9150issn
1879-1484pii
S0021-9150(07)00674-0journal_volume
199pub_type
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