Abstract：
OBJECTIVE:We examined the association between increasing serum GGT levels and PAD in the US general population. METHODS:Cross-sectional study among 3941 National Health and Nutrition Examination Survey 1999-2002 participants aged >or=40 years. Main outcome-of-interest was PAD defined as ankle-brachial index <0.9 (n=219). RESULTS:Overall, serum GGT levels were positively associated with PAD among men but not women (p-interaction=0.0421). Among men, the multivariable odds ratio (OR) [95% confidence intervals (CI)] comparing the highest quartile of serum GGT (>35U/L) to the lowest quartile (<16U/L) was 4.25 (1.65-10.94); p-trend=0.0008. Also the observed positive association between GGT quartiles and PAD among men was predominantly present among non-Hispanic whites and current nondrinkers (multivariable OR [95% CI] comparing the highest quartile of serum GGT to the lowest quartile was 10.59 [2.31-48.55]; p-trend=0.0104). In contrast among women, the multivariable OR (95% CI) comparing the highest quartile of serum GGT to the lowest quartile was 0.76 (0.41-1.41); p-trend=0.8308. CONCLUSIONS:There was a positive association between serum GGT level and PAD among men, particularly non-Hispanic white and nondrinker men, but not among women. Future prospective studies are required to clarify the temporal nature of this relationship and to confirm the observed gender-specific nature of this association.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Shankar A,Li J,Klein BE,Nieto FJ,Klein Rdoi
10.1016/j.atherosclerosis.2007.10.009subject
Has Abstractpub_date
2008-07-01 00:00:00pages
102-9issue
1eissn
0021-9150issn
1879-1484pii
S0021-9150(07)00663-6journal_volume
199pub_type
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