C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study.

abstract：UNLABELLED:Transglutaminases play an important role in vascular remodeling, calcification, cell adhesion and endothelial barrier function. In this study we investigate the influence of combined inhibition of both tissue-type transglutaminase (TG2) and the plasma transglutaminase FXIIIA on early lesion development. MET...

journal_title：Atherosclerosis

authors： Matlung HL,VanBavel E,van den Akker J,de Vries CJ,Bakker EN

更新日期：2010-11-01 00:00:00

abstract：:Endothelium plays a pivotal role in the development of atherosclerosis. Endothelial dysfunction participates in the course of acute coronary event. Using high-resolution ultrasound technique, endothelial dysfunction has been demonstrated in patients with atherosclerosis and risk factors for coronary disease, such as h...

journal_title：Atherosclerosis

authors： Zhang X,Zhao SP,Li XP,Gao M,Zhou QC

更新日期：2000-03-01 00:00:00

abstract：:Paraoxonase (PON) is an HDL-bound enzyme capable of hydrolyzing lipid peroxides and believed to be in part responsible for the protective effect of HDL against LDL oxidation. Its activity is mainly determined by a gene polymorphism of the PON 1 gene (Glu-Arg 192). Low activity has been related to an elevated incidence...

journal_title：Atherosclerosis

authors： Cao H,Girard-Globa A,Serusclat A,Bernard S,Bondon P,Picard S,Berthezene F,Moulin P

更新日期：1998-06-01 00:00:00

abstract：:The aortic endothelium of rabbits fed a stock diet containing 1 or 2% cholesterol for intervals of 1 day to 21 weeks was compared with that of normal rabbits on a stock diet without cholesterol. The endothelium was examined en face using the Häutchen technique. The aortic endothelium of the experimental animals reveal...

journal_title：Atherosclerosis

authors： Silkworth JB,McLean B,Stehbens WE

更新日期：1975-11-01 00:00:00

abstract：:Familial defective apolipoprotein B-100 (FDB) is a dominantly inherited disorder associated with hypercholesterolemia, in which substitution of the amino acid glutamine for arginine at position 3500 in the apoprotein B molecule results in LDL particles which bind poorly to the LDL receptor. To date, patients with FDB ...

journal_title：Atherosclerosis

authors： Schmidt EB,Illingworth DR,Bacon S,Mahley RW,Weisgraber KH

更新日期：1993-01-25 00:00:00

abstract：:Inflammation is thought to play a central role in the etiology and outcome of atherosclerosis. Animal studies as well as in vitro and in vivo human studies suggest that host factors modulate the magnitude and extent of inflammatory responses. We investigated familial aggregation of three systemic markers of inflammati...

journal_title：Atherosclerosis

authors： Pankow JS,Folsom AR,Cushman M,Borecki IB,Hopkins PN,Eckfeldt JH,Tracy RP

更新日期：2001-02-15 00:00:00

abstract：OBJECTIVE:To analyze the possible role of arachidonic acid (AA) in macrophage cholesterol biosynthesis and in PON2 expression. METHODS AND RESULTS:We used peritoneal macrophages (MPM) from the 6-DS KO mice that were fed a diet without or with AA. Macrophage cholesterol biosynthesis rate and HMGCoA-reductase mRNA level...

journal_title：Atherosclerosis

authors： Rosenblat M,Volkova N,Roqueta-Rivera M,Nakamura MT,Aviram M

更新日期：2010-06-01 00:00:00

abstract：:The importance of platelets for cardiovascular disease was established as early as the 19th century. Their therapeutic inhibition stands alongside the biggest achievements in medicine. Still, certain aspects of platelet pathophysiology remain unclear. This includes platelet resistance to antiplatelet therapy and the c...

journal_title：Atherosclerosis

authors： Gutmann C,Joshi A,Mayr M

更新日期：2020-08-01 00:00:00

abstract：:Five homozygous patients with familial hypercholesterolemia (FH) are described. Their serum cholesterol levels were between 603 and 907 mg/dl, with an average of 714 mg/dl. The mean value of serum cholesterol levels of the obligate heterozygous parents was 270 mg/dl. In the patient group, 87% of the serum cholesterol ...

journal_title：Atherosclerosis

authors： Cai HJ,Fan LM,Huang MG,Chen XY,Liu GQ,Chen Q

更新日期：1985-11-01 00:00:00

abstract：OBJECTIVE:Antiphospholipid antibodies are associated with increased risk of thrombosis, particularly as in antiphospholipid syndrome. This study aims to determine the acute effects of anticardiolipin antibodies on nitric oxide production and vascular function. METHODS:Ex vivo aortic rings from male Sprague Dawley rats...

journal_title：Atherosclerosis

authors： Alves JD,Clapp BR,Stidwill R,Chen PP,Hingorani AD,Singer M,Isenberg DA

更新日期：2006-04-01 00:00:00

abstract：:Modified lipoproteins induce autoimmune responses including the synthesis of autoantibodies with pro-inflammatory characteristics. Circulating modified lipoprotein autoantibodies combine with circulating antigens and form immune complexes (IC). We now report the results of a study investigating the role of circulating...

journal_title：Atherosclerosis

authors： Lopes-Virella MF,McHenry MB,Lipsitz S,Yim E,Wilson PF,Lackland DT,Lyons T,Jenkins AJ,Virella G,DCCT\/EDIC Research Group.

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVES:To examine whether serum concentrations of carotenoids are related to the risk of sudden cardiac death (SCD) in middle-aged men. METHODS:The study population consisted of 1031 Finnish men aged 46-65 years of the Kuopio Ischemic Heart Disease Risk Factor (KIHD) cohort. Serum concentrations of carotenoids wer...

journal_title：Atherosclerosis

authors： Karppi J,Laukkanen JA,Mäkikallio TH,Ronkainen K,Kurl S

更新日期：2013-01-01 00:00:00

abstract：:Studies on carotid artery atherosclerosis have been performed in order to understand the high risk for cardiovascular disease in chronic renal failure (CRF). The purpose of this study was to evaluate the extent and nature of carotid artery atherosclerosis in patients with CRF. Of the 135 patients with CRF (52 +/- 11 y...

journal_title：Atherosclerosis

authors： Leskinen Y,Lehtimäki T,Loimaala A,Lautamatti V,Kallio T,Huhtala H,Salenius JP,Saha H

更新日期：2003-12-01 00:00:00

abstract：:In the rabbit, dietary cholesterol downregulates the hepatic LDL receptor and concomitant treatment with 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors partly restores its expression. The aim of this study was to determine whether the LDL receptor activity of circulating mononuclear cells would r...

journal_title：Atherosclerosis

authors： Roach PD,Kerry NL,Whiting MJ,Nestel PJ

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:To investigate the hypothesis that COMP can influence the morphology, stability and size of murine atherosclerotic lesions. METHODS:ApoE- and ApoE/COMP-knockout mice were fed a high-fat diet to develop atherosclerotic plaques at lesion sites of three different types; inflammatory and fibrous plaques induced ...

journal_title：Atherosclerosis

authors： Bond AR,Hultgårdh-Nilsson A,Knutsson A,Jackson CL,Rauch U

更新日期：2014-10-01 00:00:00

abstract：AIMS:The ubiquitin-activating enzyme E1 (UBA1, E1), the apex of the ubiquitin proteasome pathway, plays a critical role in protein degradation and in pathological processes. Whether UBA1 participates the development of vascular restenosis remains unknown. This study aims to determine the role of UBA1 in the development...

journal_title：Atherosclerosis

authors： Qin Z,Cui B,Jin J,Song M,Zhou B,Guo H,Qian D,He Y,Huang L

更新日期：2016-04-01 00:00:00

abstract：:Extracellular-superoxide dismutase (EC-SOD) is the major SOD isozyme in the arterial wall and may be important for antioxidation capability of the vascular wall and normal vascular function. EC-SOD is expressed in various cell types in the vascular wall such as fibroblasts, smooth muscle cells and macrophages, and the...

journal_title：Atherosclerosis

authors： Adachi T,Hara H,Yamada H,Yamazaki N,Yamamoto M,Sugiyama T,Futenma A,Katagiri Y

更新日期：2001-12-01 00:00:00

abstract：:Gender is a strong predictor of coronary heart disease (CHD) susceptibility and reports indicate that males are more likely to develop CHD compared to age-matched premenopausal females. To test whether similar gender differences exist in hamsters, 16 male and 16 female F1B Golden Syrian hamsters, aged 10 weeks, were f...

journal_title：Atherosclerosis

authors： Wilson TA,Nicolosi RJ,Lawton CW,Babiak J

更新日期：1999-09-01 00:00:00

abstract：:We examined the interactive effect of oxidized low density lipoprotein (LDL) and ascorbic acid on collagen production in cultured smooth muscle cells (SMCs). Porcine aortic SMCs were incubated with 50-200 micrograms/ml of human LDL with/without 5 microM Cu2+ for 24 h. Collagen production was assayed by successive salt...

journal_title：Atherosclerosis

authors： Jimi S,Saku K,Uesugi N,Sakata N,Takebayashi S

更新日期：1995-07-01 00:00:00

abstract：:High level of plasma very low-density lipoprotein (VLDL) has been identified as a risk factor for coronary heart disease. Recent evidence suggests that excess VLDL induces inflammatory responses in macrophages and vascular endothelial cells. The Japan EPA Lipid Intervention Study (JELIS), a large scale clinical trial,...

journal_title：Atherosclerosis

authors： Jinno Y,Nakakuki M,Kawano H,Notsu T,Mizuguchi K,Imada K

更新日期：2011-12-01 00:00:00

abstract：:Retinoic acid modulates cell growth and differentiation of the vascular system. Vascular endothelial growth factor (VEGF) is known as a vascular permeability factor and a potent mitogen for vascular endothelial cells. In the present study, we investigated whether retinoic acid induces VEGF release in aortic smooth mus...

journal_title：Atherosclerosis

authors： Tanabe K,Hirade K,Ishisaki A,Shu E,Suga H,Kitajima Y,Katagiri Y,Dohi S,Kozawa O

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:Effective systemic drugs against restenosis upon percutaneous transluminal coronary angioplasty (PTCA) are largely lacking. Polyphenols have been suggested to ameliorate post-angioplasty restenosis. Hawthorn (Crataegus spp.) extracts, which are among the most frequently used herbal medicinal products against ...

journal_title：Atherosclerosis

authors： Fürst R,Zirrgiebel U,Totzke F,Zahler S,Vollmar AM,Koch E

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND AND AIMS:The pathogenesis of abdominal aortic aneurysm (AAA) shares several common pathways with atherosclerosis. Prospective clinical plasma biomarker studies in AAA have been hampered by the need for very large cohorts and long follow-up time. METHODS:We analyzed a prospective longitudinal cohort of middl...

journal_title：Atherosclerosis

authors： Acosta S,Taimour S,Gottsäter A,Persson M,Engström G,Melander O,Zarrouk M,Nilsson PM,Smith JG

更新日期：2017-07-01 00:00:00

abstract：:Oxidation of low density lipoproteins (LDL) is considered a key event in the pathogenesis of atherosclerotic lesions. Disturbed generation of coagulatory and anticoagulatory factors by endothelial cells contributes to thrombosis and the progression of atherosclerosis in coronary arteries. In this study, the effects of...

journal_title：Atherosclerosis

authors： Gräfe M,Auch-Schwelk W,Hertel H,Terbeek D,Steinheider G,Loebe M,Fleck E

更新日期：1998-03-01 00:00:00

abstract：:Fractional esterification rate of cholesterol in high density lipoprotein (HDL) (FER[HDL]) can predict the size distribution and physicochemical characteristics of HDL in plasma. In the present study, we investigated the correlation of FER(HDL) with the particle size of low density lipoprotein (LDL) (LDL-size) in 111 ...

journal_title：Atherosclerosis

authors： Ohta T,Saku K,Takata K,Nagata N,Maung KK,Matsuda I

更新日期：1997-12-01 00:00:00

abstract：:Obesity is commonly associated with high rates of cardiovascular disease (CVD). Weight loss in obese subjects reduces risk factors for CVD but this response is not uniform. Genetic factors could be involved in this variability. The 360His polymorphism of apolipoproteinA-IV (apoA-IV) influences the lipid response to fa...

journal_title：Atherosclerosis

authors： Heilbronn LK,Noakes M,Morris AM,Kind KL,Clifton PM

更新日期：2000-05-01 00:00:00

abstract：:We present the case of a 42-year-old male with familial hypercholesterolemia (FH) who had received long-term low-density lipoprotein (LDL)-apheresis before death occurred, presumably from an arrhythmia. He had been treated with double filtration plasmapheresis (DFPP) for 4 years and selective LDL adsorbent plasmaphere...

journal_title：Atherosclerosis

authors： Koga N,Iwata Y

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND AND AIMS:South Asians are at increased risk for cardiovascular disease (CVD). Aortic valve calcium (AVC) is associated with CVD risk and aortic stenosis. Elevated Lp(a) is a heritable risk factor for CVD and AVC. AVC prevalence and its association with Lp(a) have not been studied in South Asians. METHODS:Am...

journal_title：Atherosclerosis

authors： Makshood M,Joshi PH,Kanaya AM,Ayers C,Budoff M,Tsai MY,Blaha M,Michos ED,Post WS

更新日期：2020-11-01 00:00:00

abstract：:Serum triglycerides, cholesterol, HDL-C and LDL-C levels as well as the LDL/HDL cholesterol ratio were determined in 11 patients suffering from hyperthyroidism and 7 patients suffering from hypothyroidism, and compared with those of 19 sex-and age-matched controls. In hypothyroidism a net increase of all lipid values ...

journal_title：Atherosclerosis

authors： Raziel A,Rosenzweig B,Botvinic V,Beigel I,Landau B,Blum I

更新日期：1982-02-01 00:00:00

abstract：:Oxidative stress is associated with atherosclerosis. Familial combined hyperlipidemia (FCH) is considered as a human model of primary dyslipidemia and atherosclerosis frequently associated with insulin resistance (IR), but there are few data on its possible relation to oxidative stress. The objective of this study was...

journal_title：Atherosclerosis

authors： Martinez-Hervas S,Fandos M,Real JT,Espinosa O,Chaves FJ,Saez GT,Salvador A,Cerdá C,Carmena R,Ascaso JF

更新日期：2008-08-01 00:00:00