Lp-PLA2 activity and mass for prediction of incident abdominal aortic aneurysms: A prospective longitudinal cohort study.


BACKGROUND AND AIMS:The pathogenesis of abdominal aortic aneurysm (AAA) shares several common pathways with atherosclerosis. Prospective clinical plasma biomarker studies in AAA have been hampered by the need for very large cohorts and long follow-up time. METHODS:We analyzed a prospective longitudinal cohort of middle-aged individuals from the cardiovascular cohort of the Malmö Diet and Cancer study (n = 5551; 1991-94). The plasma biomarkers lipoprotein-associated phospholipase A2 (Lp-PLA2 activity and mass), proneurotensin and C-reactive protein, and conventional risk factors at baseline were measured in patients with incident AAA during follow-up, and compared to individuals without a diagnosis of AAA. Subjects were followed until December 31st, 2013. Multivariable analyses were expressed in terms of hazard ratios (HR) per 1 standard deviation increment of each respective log-transformed plasma biomarker in the Cox proportional hazard models. RESULTS:Cumulative incidence of AAA was 1.5% (men 2.9%, women 0.5%) during a median follow-up period of 20.7 years. Overall, 84 individuals had an incident AAA, of whom 22 (26.2%) were operated on and 16 (19.0%) had ruptured. Mean age of individuals with incident AAA was 59.7 years at study entry and AAA was diagnosed on average 14 years later. When adjusting for age, gender, smoking, body mass index, hypertension, and diabetes mellitus, Lp-PLA2 activity (HR 1.40; 95% CI 1.15-1.72) and Lp-PLA2 mass (HR 1.23; 95% CI 1.00-1.51) were independently associated with incident AAA. CONCLUSIONS:The plasma biomarkers Lp-PLA2 activity and mass were markers of AAA risk and this implies that AAA is an athero-thrombotic related disease.






Acosta S,Taimour S,Gottsäter A,Persson M,Engström G,Melander O,Zarrouk M,Nilsson PM,Smith JG




Has Abstract


2017-07-01 00:00:00












  • Coronary artery calcium and cardiovascular risk in diabetes.

    abstract::Measurement of coronary artery calcium score (CACS) by electron beam tomography has been shown to a powerful predictor of coronary heart disease events in asymptomatic non-diabetic subjects. In type 2 diabetes, measurement of CACS was found to be a powerful predictor of cardiovascular events which could enhance predic...


    pub_type: 杂志文章,评审


    authors: Elkeles RS

    更新日期:2010-06-01 00:00:00

  • Type 2 diabetes is associated with impaired endothelium-dependent, flow-mediated dilation, but impaired glucose metabolism is not; The Hoorn Study.

    abstract:BACKGROUND:Type 2 diabetes (DM2) and impaired glucose metabolism (IGM) are associated with an increased cardiovascular disease risk. Impaired endothelial synthesis of nitric oxide (NO) is an important feature of atherothrombosis and can be estimated from endothelium-dependent flow-mediated dilation (FMD). It is controv...


    pub_type: 杂志文章


    authors: Henry RM,Ferreira I,Kostense PJ,Dekker JM,Nijpels G,Heine RJ,Kamp O,Bouter LM,Stehouwer CD

    更新日期:2004-05-01 00:00:00

  • Incremental diagnostic value of epicardial adipose tissue for the detection of functionally relevant coronary artery disease.

    abstract:BACKGROUND AND AIM:To determine the incremental diagnostic value of epicardial adipose tissue (EAT) volume in addition to the coronary artery calcium (CAC) score for detecting hemodynamic significant coronary artery disease (CAD). METHODS AND RESULTS:122 patients (mean age 61 ± 10 years, 61% male) without a previous c...


    pub_type: 杂志文章


    authors: Romijn MA,Danad I,Bakkum MJ,Stuijfzand WJ,Tulevski II,Somsen GA,Lammertsma AA,van Kuijk C,van de Ven PM,Min JK,Leipsic J,van Rossum AC,Raijmakers PG,Knaapen P

    更新日期:2015-09-01 00:00:00

  • Serum high density lipoprotein cholesterol and factors influencing its level in healthy Chinese.

    abstract::Serum HDL-cholesterol (HDLc) levels were studied on 2399 healthy urban inhabitants, from newborn to 78 years of age, in Shanghai. The results were as follows. (1) Frequency distribution of serum HDLc levels in most groups was approximately normal after age 20. (2) The serum HDLc levels and HDLc/total cholesterol ratio...


    pub_type: 杂志文章


    authors: Chen H,Zhuang H,Han Q

    更新日期:1983-07-01 00:00:00

  • Effect of exposure of rats to cigarette smoke on the metabolism of lipids.

    abstract::Prolonged exposure of rats to cigarette smoke resulted in significant alterations in the metabolism of lipids. There was a significant increase in the concentration of cholesterol, triglycerides and phospholipids in most of the tissues, particularly the heart, aorta and lungs. Cholesterol, triglycerides and phospholip...


    pub_type: 杂志文章


    authors: Latha MS,Vijayammal PL,Kurup PA

    更新日期:1988-04-01 00:00:00

  • Simvastatin inhibits expression of tissue factor in advanced atherosclerotic lesions of apolipoprotein E deficient mice independently of lipid lowering: potential role of simvastatin-mediated inhibition of Egr-1 expression and activation.

    abstract::Recent studies suggest that the beneficial effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins) in reducing cardiovascular events may in part, be independent of their capacity to lower plasma lipids. To test this hypothesis, simvastatin (50 mg/kg/d) was administered to 30-week-old ...


    pub_type: 杂志文章


    authors: Bea F,Blessing E,Shelley MI,Shultz JM,Rosenfeld ME

    更新日期:2003-04-01 00:00:00

  • Correlates of endothelial function and the peak systolic blood pressure response to a graded maximal exercise test.

    abstract:PURPOSE:An elevated systolic blood pressure (SBP) response to a graded maximal exercise stress test (GEST) may be a predictor of endothelial dysfunction and hypertension. We examined relationships among the GEST peak SBP response and indicators of endothelial function. METHODS:Men (n=48, 43.7±1.4 yr) with high BP (145...


    pub_type: 杂志文章


    authors: Olson KM,Augeri AL,Seip RL,Tsongalis GJ,Thompson PD,Pescatello LS

    更新日期:2012-05-01 00:00:00

  • Effects of nitric oxide and superoxide on relaxation in human artery and vein.

    abstract::Endothelium-derived relaxing and contracting factors play an important role in atherosclerosis, re-stenosis and graft survival. Internal thoracic artery (ITA) and saphenous vein (SV) are used as conduit vessels in coronary artery bypass graft surgery (CABG). The long-term graft patency rate is higher with ITA than SV....


    pub_type: 杂志文章


    authors: Hamilton CA,Berg G,Mcintyre M,Mcphaden AR,Reid JL,Dominiczak AF

    更新日期:1997-08-01 00:00:00

  • Oxidized cholesterol in oxidized low density lipoprotein may be responsible for the inhibition of LPS-induced nitric oxide production in macrophages.

    abstract::Previous work has shown that oxidized low density lipoprotein (Ox-LDL) inhibited lipopolysacchride (LPS)-induced nitric oxide (NO) production in macrophages. In this paper, the role of different components of Ox-LDL in the inhibitory effect was studied by measuring nitrite in media. Ox-LDL inhibited LPS-induced NO pro...


    pub_type: 杂志文章


    authors: Liu SX,Chen Y,Zhou M,Wan J

    更新日期:1998-01-01 00:00:00

  • Increased atherosclerosis following treatment with a dual PPAR agonist in the ApoE knockout mouse.

    abstract:OBJECTIVE:Recent reports have suggested that dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonists are associated with adverse cardiovascular events. This study aimed to investigate the actions of the non-thiazolidinedione PPARalpha/gamma agonist, compound 3q, on plaque development in the apolipop...


    pub_type: 杂志文章


    authors: Calkin AC,Allen TJ,Lassila M,Tikellis C,Jandeleit-Dahm KA,Thomas MC

    更新日期:2007-11-01 00:00:00

  • Diabetes mellitus abolishes ethnic differences in cardiovascular risk factors: lessons from a multi-ethnic population.

    abstract:AIMS:To compare cardiovascular risk factors in diabetic subjects of different ethnic groups, and between new and known diabetic subjects, in the Singapore National Health Survey '92. METHODS:Disproportionate stratified sampling followed by systematic sampling were used in 3568 (total) respondents of whom 2743 were non...


    pub_type: 杂志文章


    authors: Tan CE,Emmanuel SC,Tan BY,Tai ES,Chew SK

    更新日期:2001-03-01 00:00:00

  • Effects of low-dose pravastatin sodium on plasma cholesterol levels and aortic atherosclerosis of heterozygous WHHL rabbits fed a low cholesterol (0.03%) enriched diet for one year.

    abstract::The aim of this study was to evaluate the cholesterol-lowering and antiatherosclerotic effect of the HMG-CoA reductase inhibitor pravastatin sodium at a dosage comparable to human therapy. Twelve heterozygous WHHL rabbits (13 months old) were fed 100 g per day of a low cholesterol (0.03%) enriched diet for 12 months. ...


    pub_type: 杂志文章


    authors: Harsch M,Braesen JH,Niendorf A

    更新日期:1997-02-10 00:00:00

  • Alterations in very low density lipoprotein subfractions in normotriglyceridemic non-insulin-dependent diabetics.

    abstract::Lipid and apoprotein composition of four very low density lipoprotein (VLDL) subfractions decreasing in Sf value were evaluated in the fasting state in 12 normolipidemic Pima Indians (6 M, 6 F, age 39 +/- 1.7 yrs) (mean +/- SEM) with non-insulin-dependent diabetes mellitus (NIDDM) in poor glycemic control (HbA1 9.8 +/...


    pub_type: 杂志文章


    authors: Patti L,Swinburn B,Riccardi G,Rivellese AA,Howard BV

    更新日期:1991-11-01 00:00:00

  • Evidence for a reversal with age in the pattern of near-wall blood flow around aortic branches.

    abstract::The changes that occur with age in the distribution of atherosclerotic lesions around arterial branch points challenge accepted theories relating disease to haemodynamic stresses. We investigated whether flow near branch points changes with age in a way that can account for the different lesion distributions. Flow aro...


    pub_type: 杂志文章


    authors: Al-Musawi SL,Bishton J,Dean J,Williams S,Cremers SG,Weinberg PD

    更新日期:2004-01-01 00:00:00

  • Urinary cysteinyl leukotrienes in one-year follow-up of percutaneous transluminal angioplasty for peripheral arterial occlusive disease.

    abstract:BACKGROUND AND AIMS:Treatment of severe peripheral arterial occlusive disease requires percutaneous revascularization. However, little is known about risk factors or predictors for reocclusion/restenosis. Cysteinyl leukotrienes are highly bioactive lipid mediators of inflammation. Their intravascular production may tak...


    pub_type: 杂志文章


    authors: Maga P,Sanak M,Rewerska B,Maga M,Jawien J,Wachsmann A,Rewerski P,Szczeklik W,Celejewska-Wójcik N

    更新日期:2016-06-01 00:00:00

  • Lipoprotein particle distribution and size, insulin resistance, and metabolic syndrome in Alaska Eskimos: the GOCADAN study.

    abstract:BACKGROUND:Metabolic syndrome (MS) is associated with dyslipidemia, and insulin resistance (IR) may be a main determinant of this dyslipidemia. OBJECTIVE:To determine how lipoprotein particle concentration and size are related to MS and IR in a population-based sample of Alaska Eskimos. DESIGN:Participants underwent ...


    pub_type: 杂志文章


    authors: Rivellese AA,Patti L,Kaufman D,Zhu J,Annuzzi G,Vaccaro O,Ebbesson SO,Howard WJ,Riccardi G,Howard BV

    更新日期:2008-10-01 00:00:00

  • High prevalence of small dense LDL in diabetic nephropathy is not directly associated with kidney damage: a possible role of postprandial lipemia.

    abstract::To determine whether high prevalence of small dense low-density lipoprotein (LDL) in non-insulin-dependent diabetes (NIDDM) with nephropathy is directly associated with kidney damage, we measured LDL particle size by non-denaturing 2-16% gradient polyacrylamide gel electrophoresis in non-diabetic patients with primary...


    pub_type: 杂志文章


    authors: Hirano T,Oi K,Sakai S,Kashiwazaki K,Adachi M,Yoshino G

    更新日期:1998-11-01 00:00:00

  • Efficacy of clinical diagnostic criteria for familial hypercholesterolemia genetic testing in Poland.

    abstract:BACKGROUND AND AIMS:Familial hypercholesterolemia (FH), which leads to premature cardiovascular events, still remains underrecognized and undertreated in most countries. Untreated FH individuals aged 20-39 years are at 100-fold higher risk of mortality from coronary heart disease compared to those of a general populati...


    pub_type: 杂志文章


    authors: Mickiewicz A,Chmara M,Futema M,Fijalkowski M,Chlebus K,Galaska R,Bandurski T,Pajkowski M,Zuk M,Wasag B,Limon J,Rynkiewicz A,Gruchala M

    更新日期:2016-06-01 00:00:00

  • Deuterium-reinforced polyunsaturated fatty acids protect against atherosclerosis by lowering lipid peroxidation and hypercholesterolemia.

    abstract:BACKGROUND AND AIMS:Oxidative modification of lipoproteins is a crucial step in atherosclerosis development. Isotopic-reinforced polyunsaturated fatty acids (D-PUFAs) are more resistant to reactive oxygen species-initiated chain reaction of lipid peroxidation than regular hydrogenated (H-)PUFAs. We aimed at investigati...


    pub_type: 杂志文章


    authors: Berbée JFP,Mol IM,Milne GL,Pollock E,Hoeke G,Lütjohann D,Monaco C,Rensen PCN,van der Ploeg LHT,Shchepinov MS

    更新日期:2017-09-01 00:00:00

  • Endogenous sex hormones impact the progression of subclinical atherosclerosis in women during the menopausal transition.

    abstract:OBJECTIVE:To determine whether endogenous sex hormones (estradiol (E2), testosterone (T), sex hormone binding globulin (SHBG), and follicle stimulating hormone (FSH)) are longitudinally associated with progression of atherosclerosis among women at midlife. METHODS:249 Pre- or early peri-menopausal women (42-57 years) ...


    pub_type: 杂志文章


    authors: El Khoudary SR,Wildman RP,Matthews K,Thurston RC,Bromberger JT,Sutton-Tyrrell K

    更新日期:2012-11-01 00:00:00

  • Atorvastatin markedly improves type III hyperlipoproteinemia in association with reduction of both exogenous and endogenous apolipoprotein B-containing lipoproteins.

    abstract::Remnant lipoproteins are known to promote atherosclerosis especially in patients with type III hyperlipoproteinemia (HLP). In the current study, the effects of atorvastatin were investigated with special reference to the exogenous and endogenous apolipoprotein (apo) B-containing lipoprotein metabolism in type III HLP....


    pub_type: 杂志文章


    authors: Ishigami M,Yamashita S,Sakai N,Hirano K,Hiraoka H,Nakamura T,Matsuzawa Y

    更新日期:2003-06-01 00:00:00

  • An investigation of the role of lecithin:cholesterol acyltransferase and triglyceride-rich lipoproteins in the metabolism of pre-beta high density lipoproteins.

    abstract::Small high density lipoproteins (HDL) with pre-beta electrophoretic mobility (pre-beta HDL) have recently been shown to be the primary acceptor of cholesterol from cultured cells. We studied the metabolism of these particles by incubating serum at 37 degrees C in the presence and absence of active lecithin: cholestero...


    pub_type: 杂志文章


    authors: Neary R,Bhatnagar D,Durrington P,Ishola M,Arrol S,Mackness M

    更新日期:1991-07-01 00:00:00

  • Framingham risk score is related to carotid artery intima-media thickness in both white and black young adults: the Bogalusa Heart Study.

    abstract::The Framingham risk score (FRS), developed in a white cohort aged 30-74 years, is increasingly used in the early risk identification for coronary artery disease (CAD). This study examines the relationship between FRS and carotid artery intima-media thickness (IMT), a surrogate marker of coronary atherosclerosis, in bl...


    pub_type: 杂志文章


    authors: Kieltyka L,Urbina EM,Tang R,Bond MG,Srinivasan SR,Berenson GS

    更新日期:2003-09-01 00:00:00

  • Comparison of various lipid, lipoprotein, and bilirubin combinations as risk factors for predicting coronary artery disease.

    abstract::Studies were performed to determine if serum bilirubin, when combined with various lipid and lipoprotein risk factors, enhances our ability to predict coronary artery disease (CAD). This hypothesis was tested in a retrospective study of 644 middle-aged males who had undergone coronary angiography. The traditional risk...


    pub_type: 杂志文章


    authors: Schwertner HA,Fischer JR Jr

    更新日期:2000-06-01 00:00:00

  • Elevated HDL is a risk factor for recurrent coronary events in a subgroup of non-diabetic postinfarction patients with hypercholesterolemia and inflammation.

    abstract::Recent studies demonstrate important roles for inflammation in development of atherosclerosis with current attention focusing on interactions of inflammation with traditional lipoprotein risk factors. Since the nature of such relationships is largely unknown, we sought to investigate interactions of inflammation with ...


    pub_type: 杂志文章


    authors: Corsetti JP,Zareba W,Moss AJ,Rainwater DL,Sparks CE

    更新日期:2006-07-01 00:00:00

  • Effects of soy protein and casein in low cholesterol diets on plasma lipoproteins in normolipidemic subjects.

    abstract::Dietary plant proteins may lower plasma cholesterol and LDL concentrations in hypercholesterolemic patients when substituted for animal proteins, particularly in diets with low cholesterol and saturated fat content. Plant protein diets appear, however, to be without effect on plasma lipoprotein levels in normal subjec...


    pub_type: 杂志文章


    authors: Meinertz H,Faergeman O,Nilausen K,Chapman MJ,Goldstein S,Laplaud PM

    更新日期:1988-07-01 00:00:00

  • A study of DNA polymorphism in the apolipoprotein B gene in a Japanese population.

    abstract::A Japanese group comprising 53 hyperlipidemic and 54 normolipidemic subjects was genotyped for DNA restriction fragment length polymorphisms (RFLPs) at the apo B gene locus. The polymorphisms with XbaI and PvuII were present at allelic frequencies of 0.04 (X1 allele) and 0.96 (X2 allele), 0.94 (P1 allele) and 0.06 (P2...


    pub_type: 杂志文章


    authors: Aburatani H,Matsumoto A,Itoh H,Yamada N,Murase T,Takaku F,Itakura H

    更新日期:1988-07-01 00:00:00

  • Metformin-induced changes in serum lipids, lipoproteins, and apoproteins in non-insulin-dependent diabetes mellitus.

    abstract::Forty patients with NIDDM and hyperlipoproteinemia were selected for a 12-week double-blind placebo-controlled trial to study the effects of metformin on lipoprotein concentration and composition. A significant decrease occurred in VLDL-apo B and all lipid components of VLDL, indicating a decreased number of circulati...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Schneider J,Erren T,Zöfel P,Kaffarnik H

    更新日期:1990-05-01 00:00:00

  • Lower bone mass is associated with subclinical atherosclerosis, endothelial dysfunction and carotid thickness in the very elderly.

    abstract:BACKGROUND AND AIMS:Osteoporosis and coronary heart disease (CHD) are very common conditions among elderly people, and both represent a public health concern due to their prognostic consequences. Osteoporosis and CHD share many risk factors and pathophysiological mechanisms, such as calcification pathways. Clinical evi...


    pub_type: 杂志文章


    authors: Campos-Staffico AM,Freitas WM,Carvalho LSF,Coelho-Filho OR,Nadruz W Jr,Oliveira RB,Sposito AC,Brasilia Study on Healthy Aging and Brasilia Heart Study.

    更新日期:2020-01-01 00:00:00

  • Arteriosclerosis in the African elephant: Part 2. Medial sclerosis.

    abstract:SUMMARY:A type of spontaneous arteriosclerosis, described as medial sclerosis and quite distinct from atherosclerosis, was found in the aortas, coronary arteries and aortic branch arteries of free-living elephants (Loxodonta africana) in Uganda and Kenya. The lesions took the form of calcified fibrotic plaques in the i...


    pub_type: 杂志文章


    authors: McCullagh KG

    更新日期:1975-01-01 00:00:00