Abstract：
BACKGROUND AND AIMS:Low ankle-brachial index (ABI) calculated using systolic blood pressure (SBP) is associated with poor prognosis. However, there is no study assessing ABI calculated using mean artery pressure (MAP) and diastolic blood pressure (DBP) in predicting mortality. METHODS:Two cohort populations were enrolled. The first population comprised 379 patients (106 patients with angiography-proved peripheral artery disease (PAD) and 273 relative normal patients) to evaluate the best cutoff values of ABImbp and ABIdbp for prediction of PAD. The second population included 941 patients undergoing echocardiographic examinations to assess the ability of different ABIs in predicting mortality. ABIs were measured using an ABI-form device. RESULTS:The best cutoff values of ABImbp and ABIdbp for prediction of PAD were 0.92 and 0.88. In our second population, median follow-up to mortality was 93 months. There were 87 cardiovascular and 228 overall deaths. Multivariable analysis showed ABIsbp, ABImap, ABIdbp, ABIsbp <0.9, and ABImap <0.92 could predict overall and cardiovascular mortality (all p < 0.001). ABIdbp <0.88 could only predict CV mortality (p = 0.033). In a direct comparison of 6 multivariable models, the basic model consisting of significant variables in the univariable analysis plus ABImap <0.92 had the highest predictive value for overall and cardiovascular mortality (all p < 0.001). CONCLUSIONS:In a direct comparison of 6 multivariable models, the basic model + ABImap < 0.92 was the best model in predicting overall and cardiovascular mortality. Hence, calculation of ABI using MAP except SBP might provide extra benefit in survival prediction.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Hsu PC,Lee WH,Chen YC,Lee MK,Tsai WC,Chu CY,Lee CS,Yen HW,Lin TH,Voon WC,Lai WT,Sheu SH,Su HMdoi
10.1016/j.atherosclerosis.2020.04.005subject
Has Abstractpub_date
2020-07-01 00:00:00pages
57-63eissn
0021-9150issn
1879-1484pii
S0021-9150(20)30200-8journal_volume
304pub_type
杂志文章相关文献
ATHEROSCLEROSIS文献大全abstract：:This study sought to examine the association between cigarette smoking and serum bilirubin antioxidant concentrations in 715 middle-aged men undergoing coronary angiography. The study involved 153 current smokers, 251 who quit smoking and 311 who never smoked. Serum bilirubin concentrations were divided into the follo...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(97)00232-3
更新日期：1998-02-01 00:00:00
abstract：OBJECTIVE:We examined the risk of cardiovascular disease, stroke, ischaemic heart disease, and diabetes with the metabolic syndrome according to the new harmonised definition and its components using a national longitudinal data set from an Asian population. METHODS:Data of 9791 men and women aged 20+ from 1998 and 20...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2010.09.009
更新日期：2010-12-01 00:00:00
abstract：:Paraoxanase (PON 1), a high-density lipoprotein-associated enzyme, exerts an antiatherogenic effect by protecting low-density lipoproteins (LDL) against oxidation. A common polymorphism at codon 192(Q/R) of the PON 1 gene has been shown to be associated with an adverse lipoprotein profile and increased coronary artery...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2004.06.013
更新日期：2004-11-01 00:00:00
abstract：:Coronary arteries with and without atheroma are compared histologically to ask what kind of artery encourages atheroma. When atheroma obliterates the structures that preceded and invited its intrusion, the sites remaining for observation form a censored data set. How to assess media-like island effects using the censo...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2004.08.011
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:The CHA(2)DS(2)-VASc (congestive heart failure, hypertension, age ≥ 75 years (doubled), type 2 diabetes, previous stroke, transient ischemic attack, or thromboembolism (doubled), vascular disease, age 65-75 years, and sex category) score was published as a predictive scoring model for stroke in atrial fibril...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2012.10.025
更新日期：2012-12-01 00:00:00
abstract：:Reconstituted high-density lipoprotein (rHDL) has been shown to produce a rapid regression of atherosclerosis in animal models and humans. Sphingosine-1-phosphate (S1P), which is a bioactive lipid in HDL, plays a role in mitogenesis, endothelial cell motility, and cell survival, as well as organization and differentia...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2006.10.020
更新日期：2007-09-01 00:00:00
abstract：INTRODUCTION:The apolipoproteinB (apoB)/apolipoproteinA-I (apoA-I) ratio mirrors the number of pro-atherogenic and anti-atherogenic lipoprotein particles. This ratio may carry more information on risk for atherosclerosis than LDL in cohorts with impaired glucose tolerance. The aim was to examine the association between...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2007.01.017
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND AND AIMS:Galectin-3 binding protein (Gal-3BP) is a secreted protein associated with inflammation and carotid atherosclerosis. We hypothesized that high Gal-3BP levels may indicate unfavorable plaque morphology and outcome in coronary artery disease (CAD). METHODS:Gal-3BP plasma levels were measured by ELISA...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2016.06.002
更新日期：2016-08-01 00:00:00
abstract：:The ultrastructure of the aortic intima and serum lipid levels in Fischer 344 rats were examined at the ages of 12, 18 and 24 months after feeding the animals an atherogenic diet (2% cholesterol, 0.25% sodium cholate, 5% beef fat) for 6 months. Structural changes in the intima were noticeable only at the age of 24 mon...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(89)90114-7
更新日期：1989-10-01 00:00:00
abstract：:Ezetimibe (Zetia(®), Ezetrol(®), Merck, Whitehouse Station, NJ) is a potent inhibitor of sterol absorption, which selectively blocks the uptake of biliary and dietary cholesterol in the small intestine. Clinical trials have demonstrated the beneficial effects of ezetimibe on the reduction of atherogenic lipoproteins a...
journal_title：Atherosclerosis
pub_type： 杂志文章,评审
doi：10.1016/j.atherosclerosis.2011.02.010
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:Sleep-disordered breathing (SDB) is associated with clinical cardiovascular disease (CVD), but its relation to subclinical atherosclerosis remains to be determined. METHODS:We analyzed the cross-sectional associations of SDB, measured by the respiratory disturbance index (RDI), a hypoxemia index, and an aro...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2007.02.029
更新日期：2008-03-01 00:00:00
abstract：:Baroreceptor sensitivity was studied in twelve young normotensive subjects and forty hypertensive patients, separated into two groups according to their age, severity of hypertension and signs of severe atherosclerotic vascular disease. Under stabilized circulatory conditions, the changes of pulse rate in response to ...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(76)90079-4
更新日期：1976-07-01 00:00:00
abstract：OBJECTIVE:The objective of this article is to review the current literature on Wnt5a and its signaling mechanism, along with its role in atherosclerosis. In addition, the significance of Wnt5a as a diagnostic marker and a potential therapeutic target is reviewed. Wnt5a, a secreted glycoprotein, belongs to a family of h...
journal_title：Atherosclerosis
pub_type： 杂志文章,评审
doi：10.1016/j.atherosclerosis.2014.08.027
更新日期：2014-11-01 00:00:00
abstract：:Intermittent claudication (IC) is defined by leg muscle pain, cramping and fatigue brought on by ambulation/exercise; relieved on rest; and caused by inadequate blood supply and is the primary symptom of peripheral arterial disease (PAD). PAD has a detrimental effect on the quality of life. PAD is a debilitating ather...
journal_title：Atherosclerosis
pub_type： 杂志文章,评审
doi：10.1016/j.atherosclerosis.2005.11.027
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVE:Recent data suggests that cholesteryl ester transfer protein (CETP) activity may interact with acute stress conditions via inflammatory-oxidative response and thrombogenesis. We investigated this assumption in patients with ST-elevation myocardial infarction (STEMI). METHODS:Consecutive patients with STEMI (...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2014.10.104
更新日期：2014-12-01 00:00:00
abstract：:Rabbits were fed a semipurified diet containing soy protein for 4 weeks and subsequently transferred to a semipurified diet containing soy protein plus cholesterol (2 g/kg), or a semipurified diet containing casein as protein source. One group of rabbits was fed the soy protein diet throughout the entire experimental ...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(82)90055-7
更新日期：1982-07-01 00:00:00
abstract：:To clarify age-related and lipid-related hemostatic abnormalities in the elderly, we measured the plasma levels of active PAI-1 antigen (aPAI-1), tPA-PAI-1 complex (TPC), plasminogen, alpha 2-plasmin inhibitor (alpha 2-PI), plasmin-alpha 2-PI complex (PIC), and D-dimer, together with the plasma levels of fibrinogen, f...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(93)90256-t
更新日期：1993-11-01 00:00:00
abstract：:The number of low density platelets was found to be increased in patients with hypercholesterolemia, as compared with the number in controls. The percentage increase of the low density platelet subpopulation was even more pronounced in patients with hypercholesterolemia when compared with that in patients suffering fr...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(94)05448-r
更新日期：1995-03-01 00:00:00
abstract：BACKGROUND AND AIMS:We aimed to identify a blood-based gene expression score (GES) to predict the severity of coronary artery stenosis in patients with known or suspected coronary artery disease (CAD) by integrative use of gene network construction, Support Vector Machine (SVM) algorithm, and multi-cohort validation. ...
journal_title：Atherosclerosis
pub_type： 杂志文章,多中心研究
doi：10.1016/j.atherosclerosis.2019.10.001
更新日期：2019-12-01 00:00:00
abstract：:Known cytochrome P450-dependent oxygenase inhibitor ketoconazole (5-50 microM) blocked the murine macrophage-mediated modification of human low density lipoprotein (LDL) as measured by production of thiobarbituric acid-reactive substance, stimulation of [125I]LDL degradation in a fresh set of macrophages and LDL elect...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(94)05456-s
更新日期：1995-04-07 00:00:00
abstract：OBJECTIVE:Although many studies have reported that elevated serum triglycerides to high-density lipoprotein cholesterol (TG-HDL) ratios constitute a risk for insulin resistance and increased arterial stiffness, no study has clarified as yet the association, in terms of the TG-HDL ratio, between diabetes and increased a...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2013.03.021
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVE:Recent reports of animal models have shown that growth factors have stimulating effect on brain perfusion via the development of blood vessels. However, studies on the effect of growth factors on brain perfusion in humans are lacking. The aim of our study was to prospectively investigate in humans the relatio...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2006.11.041
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:Plaque with dense inflammatory cells, including macrophages, thin fibrous cap and superficial necrotic/lipid core is thought to be prone-to-rupture. We report a time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) technique for detection of such markers of plaque vulnerability in human plaques. ME...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2008.08.035
更新日期：2009-05-01 00:00:00
abstract：:Platelet-derived growth factor (PDGF) A-chain contributes to the pathogenesis of cardiovascular proliferative diseases, such as hypertensive vascular disease, atherosclerosis, and re-stenosis of an artery after angioplasty. To develop a ribozyme against human PDGF A-chain mRNA as a gene therapy for human arterial prol...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(01)00451-8
更新日期：2001-10-01 00:00:00
abstract：:Interleukin-8 is a cytokine produced by mononuclear cells that is involved in polymorphonuclear neutrophil leukocyte (PMN) recruitment and activation. Several studies have previously demonstrated a leukocyte activation during hypercholesterolemia and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(99)00160-4
更新日期：1999-10-01 00:00:00
abstract：:We investigated the influence of fish oil on cholesterol induced atherosclerosis in rabbits. Group I, a control group was fed a cholesterol-free diet, group II was fed a diet supplemented with 1.5% cholesterol, group III received in addition to cholesterol supplementation a purified fish oil concentrate (Maxepa, 2 ml/...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(87)90081-5
更新日期：1987-01-01 00:00:00
abstract：:Sixty-two subjects from 23 families were evaluated by serum lipid analyses and tissue culture biochemistry in skin fibroblasts. In 53 cases from 19 families with proven familial hypercholesterolemia (FHC), fibroblast cultures were successful. In 45 of these cases (85%) the clinical diagnosis of hyper- or normocholeste...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(81)90088-5
更新日期：1981-04-01 00:00:00
abstract：BACKGROUND:The putative association between the novel oxidized low-density lipoprotein markers, serum amyloid A-LDL (SAA-LDL) and alpha1-antitrypsin-LDL (AT-LDL), and obesity and the metabolic syndrome (MetS) has not been previously studied. In the present report, we investigated the levels of SAA-LDL and AT-LDL in rel...
journal_title：Atherosclerosis
pub_type： 杂志文章,多中心研究
doi：10.1016/j.atherosclerosis.2008.09.017
更新日期：2009-06-01 00:00:00
abstract：BACKGROUND:Anemia has been shown to be a risk factor for coronary artery disease and mortality. The involvement of body iron stores in the development of CAD remains controversial. So far, studies that examined hemoglobin and parameters of iron metabolism simultaneously do not exist. METHODS AND RESULTS:Hemoglobin and...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2014.07.002
更新日期：2014-10-01 00:00:00
abstract：:Since VLDL and LDL are involved in atherogenesis, their response to dietary modification was studied in 15 normal male prisoners. A 3-month reference diet (P/S ratio 0.3, daily cholesterol intake 370 mg) was compared with a modified fat diet (P/S 1.0, 250 mg) given for further 3 months. The decrement in serum choleste...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(83)90143-0
更新日期：1983-12-01 00:00:00
