Chylomicron retention disease: exclusion of apolipoprotein B gene defects and detection of mRNA editing in an affected family.

abstract：BACKGROUND:There is increasing evidence that renin-angiotensin system (RAS) may play a major role in the actively regulated fibrocalcific process in aortic valve stenosis (AS), but the gene expression or function of (pro)renin receptor ((P)RR), prorenin and renin or angiotensin converting enzyme 2(ACE2)/angiotensin-(1-...

journal_title：Atherosclerosis

authors： Peltonen T,Näpänkangas J,Ohtonen P,Aro J,Peltonen J,Soini Y,Juvonen T,Satta J,Ruskoaho H,Taskinen P

更新日期：2011-05-01 00:00:00

abstract：:A sub-strain of male and female spontaneously hypertensive rats (SHR) capable of having massively obese or non-obese offspring were bred repeatedly or were maintained as virgin controls. When the male and female breeders had sired or given birth to 5 litters of young, they were autopsied along with their 10-month-old ...

journal_title：Atherosclerosis

authors： Wexler BC

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Exercise training (ET) helps treat atherosclerosis. However, many patients stop regular ET for various reasons. The effect of detraining on atherosclerosis is not well studied. We examined the effects of ET vs. short-term detraining on atheromatous matrix-metalloproteinase (MMP) activity in preexist...

journal_title：Atherosclerosis

authors： Kim J,Jang HJ,Schellingerhout D,Kang JW,Choi S,Oh H,Kim EJ,Lee SK,Lee JS,Kwon IC,Kim K,Koh YJ,Ryu WS,Kim DE

更新日期：2020-04-01 00:00:00

abstract：:We previously reported linkage for plasma levels of high-density lipoprotein cholesterol (HDL-C) on 15q21 in Caucasian families from the National Heart, Lung, and Blood Institute Family Heart Study (NHLBI FHS). Hepatic lipase gene (LIPC), which has a major role in lipoprotein metabolism, resides within the linkage reg...

journal_title：Atherosclerosis

authors： Feitosa MF,Myers RH,Pankow JS,Province MA,Borecki IB

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Uric acid is frequently elevated in hypertension. In addition to renal and metabolic disturbances, lower limb ischemia might contribute to hyperuricemia among hypertensives complicated by peripheral arterial disease (PAD). OBJECTIVE:To test the hypothesis that uric acid status is related to lower limb funct...

journal_title：Atherosclerosis

authors： Langlois M,De Bacquer D,Duprez D,De Buyzere M,Delanghe J,Blaton V

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVE:Serum adiponectin protects against incident ischemic heart disease (IHD). However, in patients with existing IHD, higher adiponectin levels are paradoxically associated with worse outcomes. We investigated this paradox by evaluating the relationship between adiponectin and cardiovascular events in patients wi...

journal_title：Atherosclerosis

authors： Beatty AL,Zhang MH,Ku IA,Na B,Schiller NB,Whooley MA

更新日期：2012-02-01 00:00:00

abstract：:Epidemiological and autopsy studies suggest a close link between aging and the clinical manifestation of atherosclerosis. Several experiments show increased arterial susceptibility to atherogenetic stimuli in aged subjects. All together, these findings support the concept that aging represents an independent atherogen...

journal_title：Atherosclerosis

authors： Orlandi A,Bochaton-Piallat ML,Gabbiani G,Spagnoli LG

更新日期：2006-10-01 00:00:00

abstract：:The detailed distribution of atherosclerotic lesions in the branching region of the left main coronary artery in man was studied. Tissue cubes of the hearts, containing the left coronary arteries, were removed, and 1.5-mm-thick parallel and consecutive slices were cut perpendicular to the main coronary artery. Histolo...

journal_title：Atherosclerosis

authors： Grøttum P,Svindland A,Walløe L

更新日期：1983-04-01 00:00:00

abstract：:This study sought to examine the association between cigarette smoking and serum bilirubin antioxidant concentrations in 715 middle-aged men undergoing coronary angiography. The study involved 153 current smokers, 251 who quit smoking and 311 who never smoked. Serum bilirubin concentrations were divided into the follo...

journal_title：Atherosclerosis

authors： Schwertner HA

更新日期：1998-02-01 00:00:00

abstract：:Using a simple, standardized denaturing gradient gel electrophoresis (DGGE) based mutation screening technique, a novel G-to-A mutation in the last base of the intron 12 splice acceptor site of the LDL receptor gene was found in 2 Danish families with familial hypercholesterolemia (FH). The mutation is shown to result...

journal_title：Atherosclerosis

authors： Nissen H,Hansen AB,Guldberg P,Petersen NE,Hansen TS,Hørder M

更新日期：1997-01-03 00:00:00

abstract：BACKGROUND:Vascular calcification is a common finding in abdominal aortic aneurysms (AAA) however whether it predicts aneurysm expansion is controversial. OBJECTIVES:1) To establish a reproducible method of assessing AAA calcification using computed tomography (CT); 2) To investigate the association between AAA calcif...

journal_title：Atherosclerosis

authors： Hendy K,Gunnarsson R,Cronin O,Golledge J

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:To investigate the statin eligibility and the predictabilities for cardiovascular disease between AHA/ACC and ATPIII guidelines, comparing those results to concomitant coronary artery calcium scores (CACS) in a large cohort of Korean individuals who met statin-eligibility criteria. METHODS:Among 19,920 parti...

journal_title：Atherosclerosis

authors： Rhee EJ,Park SE,Oh HG,Park CY,Oh KW,Park SW,Blankstein R,Plutzky J,Lee WY

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:As apoE(-/-) and LDL-Receptor(-/-) mice are commonly used in atherosclerosis research; our objective was to point out the differences in HDL metabolism between mice and humans regarding the roles of apoE and LDLR. METHODS:We examined HDL particles obtained from wild type (WT), LDLR(-/-), and apoE(-/-) mice, ...

journal_title：Atherosclerosis

authors： Tani M,Matera R,Horvath KV,Hasan TS,Schaefer EJ,Asztalos BF

更新日期：2014-03-01 00:00:00

abstract：:Lysosomal acid lipase deficiency (LAL-D) is a rare autosomal recessive lysosomal storage disease caused by deleterious mutations in the LIPA gene. The age at onset and rate of progression vary greatly and this may relate to the nature of the underlying mutations. Patients presenting in infancy have the most rapidly pr...

journal_title：Atherosclerosis

authors： Reiner Ž,Guardamagna O,Nair D,Soran H,Hovingh K,Bertolini S,Jones S,Ćorić M,Calandra S,Hamilton J,Eagleton T,Ros E

更新日期：2014-07-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) has been shown to participate in both experimental and human atherogenesis. Expression of MMP-9 has been shown to play a role in the instability of atherosclerotic plaque. Thus, we hypothesize that MIF may participate in the destabilization of atherosclerotic plaques by sti...

journal_title：Atherosclerosis

authors： Kong YZ,Yu X,Tang JJ,Ouyang X,Huang XR,Fingerle-Rowson G,Bacher M,Scher LA,Bucala R,Lan HY

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Urinary cystatin C (u-CysC) is a new biomarker for acute tubular kidney dysfunction and may also indicate chronic tubular dysfunction. Chronic kidney disease is an important cardiovascular risk factor, however it is not known if u-CysC is a risk marker for cardiovascular death. METHODS:The association betwe...

journal_title：Atherosclerosis

authors： Helmersson-Karlqvist J,Ärnlöv J,Carlsson AC,Härmä J,Larsson A

更新日期：2014-05-01 00:00:00

abstract：:The single nucleotide polymorphisms (SNPs) apolipoprotein E (APOE) epsilon3/epsilon2/epsilon4, cholesteryl ester transfer protein (CETP) TaqIB, and apolipoprotein C3 (APOC3) -482 C>T have been associated with an atherogenic lipid profile and, in some studies, with increased cardiovascular risk. However, no data exist ...

journal_title：Atherosclerosis

authors： Muendlein A,Saely CH,Marte T,Schmid F,Koch L,Rein P,Langer P,Aczel S,Drexel H

更新日期：2008-07-01 00:00:00

abstract：:Low density lipoproteins (LDL) isolated by ultracentrifugation induce cytotoxic changes in cultured human endothelial cells (EC) and fibroblasts if the ratio between LDL cholesterol and the final protein concentration of the culture medium exceeds 0.10-0.12 mmol/g protein. In order to investigate if reactive oxygen sp...

journal_title：Atherosclerosis

authors： Evensen SA,Galdal KS,Nilsen E

更新日期：1983-10-01 00:00:00

abstract：:The ultrastructural effects of a single brief intra-arterial infusion of palmitic, linoleic and acetoacetic acid on the arterial endothelium of the rat were investigated, and the following results obtained: (1) Palmitic acid, infused at a concentration of 4 mM/l, damaged the arterial lining by producing large cytoplas...

journal_title：Atherosclerosis

authors： Constantinides P,Kiser M

更新日期：1981-02-01 00:00:00

abstract：:Five homozygous patients with familial hypercholesterolemia (FH) are described. Their serum cholesterol levels were between 603 and 907 mg/dl, with an average of 714 mg/dl. The mean value of serum cholesterol levels of the obligate heterozygous parents was 270 mg/dl. In the patient group, 87% of the serum cholesterol ...

journal_title：Atherosclerosis

authors： Cai HJ,Fan LM,Huang MG,Chen XY,Liu GQ,Chen Q

更新日期：1985-11-01 00:00:00

abstract：:Inflammatory response genes may influence life span or quality at advanced ages. Using data from the population-based cardiovascular health study (CHS) cohort, we examined the associations between promoter polymorphisms of several inflammation and thrombosis genes with longevity. We ascertained genotypes for interleuk...

journal_title：Atherosclerosis

authors： Reiner AP,Diehr P,Browner WS,Humphries SE,Jenny NS,Cushman M,Tracy RP,Walston J,Lumley T,Newman AB,Kuller LH,Psaty BM

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:Recent studies have suggested that circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL) is a useful marker for the identification of patients with coronary artery disease (CAD). However, the role of MDA-LDL in atherogenic mechanisms has not yet been fully determined. METHOD AND RESULTS:We i...

journal_title：Atherosclerosis

authors： Miyazaki T,Shimada K,Sato O,Kotani K,Kume A,Sumiyoshi K,Sato Y,Ohmura H,Watanabe Y,Mokuno H,Daida H

更新日期：2005-03-01 00:00:00

abstract：:The purpose of this study was to determine the extent and sources of oxidative stress within skeletal muscle following an acute bout of contractile claudication. Twenty-four hours after unilateral ligation of the femoral artery, rat hind limbs were stimulated in vivo for 30 min, and force production measured. One-hour...

journal_title：Atherosclerosis

authors： Judge AR,Dodd SL

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:Alterations of wall shear stress can predispose the endothelium to the development of atherosclerotic plaques. Ample evidence indicates that arginase expression and/or activity correlates with several risk factors for cardiovascular disease including atherosclerosis. We investigated the regulation of arginase...

journal_title：Atherosclerosis

authors： Thacher TN,Gambillara V,Riche F,Silacci P,Stergiopulos N,da Silva RF

更新日期：2010-05-01 00:00:00

abstract：:The effect of chlorthalidone treatment on serum lipids and lipoproteins was investigated in 21 hypertensive patients. Chlorthalidone caused an increase in total serum and low density lipoprotein (LDL) cholesterol, but not in high density lipoprotein (HDL) cholesterol. Serum and lipoprotein triglycerides also increased...

journal_title：Atherosclerosis

authors： Rosenthal T,Holtzman E,Segal P

更新日期：1980-05-01 00:00:00

abstract：:Mild hyperhomocysteinemia is considered an important risk factor for vascular disease. A common polymorphism (677C-->T) in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with a decreased enzyme activity and consequent higher circulating levels of homocysteine. We hypothesized that the serum levels ...

journal_title：Atherosclerosis

authors： Pisciotta L,Cortese C,Gnasso A,Liberatoscioli L,Pastore A,Mannucci L,Irace C,Federici G,Bertolini S

更新日期：2005-04-01 00:00:00

abstract：:Several studies indicate that the inter-individual variation in plasma concentrations of lipoprotein(a) (Lp(a)) is mainly under genetic control. To define the effect of three DNA polymorphisms on apolipoprotein(a) (apo(a)) expression, we have determined plasma Lp(a) concentrations, apo(a) isoform size, KpnI allele siz...

journal_title：Atherosclerosis

authors： Valenti K,Aveynier E,Leauté S,Laporte F,Hadjian AJ

更新日期：1999-11-01 00:00:00

abstract：:Paraoxanase (PON 1), a high-density lipoprotein-associated enzyme, exerts an antiatherogenic effect by protecting low-density lipoproteins (LDL) against oxidation. A common polymorphism at codon 192(Q/R) of the PON 1 gene has been shown to be associated with an adverse lipoprotein profile and increased coronary artery...

journal_title：Atherosclerosis

authors： Srinivasan SR,Li S,Chen W,Tang R,Bond MG,Boerwinkle E,Berenson GS

更新日期：2004-11-01 00:00:00

abstract：:The importance of platelets for cardiovascular disease was established as early as the 19th century. Their therapeutic inhibition stands alongside the biggest achievements in medicine. Still, certain aspects of platelet pathophysiology remain unclear. This includes platelet resistance to antiplatelet therapy and the c...

journal_title：Atherosclerosis

authors： Gutmann C,Joshi A,Mayr M

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:The relationship between alcohol consumption and ischemic stroke or aortic atherosclerosis is unclear, but a protective effect of moderate consumption on stroke risk has been suggested. We conducted a cross-sectional analysis in a population-based sample to evaluate the possible association between alcohol c...

journal_title：Atherosclerosis

authors： Kohsaka S,Jin Z,Rundek T,Homma S,Sacco RL,Di Tullio MR

更新日期：2011-12-01 00:00:00