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Regulation of arginase pathway in response to wall shear stress.

Abstract：

OBJECTIVE:Alterations of wall shear stress can predispose the endothelium to the development of atherosclerotic plaques. Ample evidence indicates that arginase expression and/or activity correlates with several risk factors for cardiovascular disease including atherosclerosis. We investigated the regulation of arginase pathway in response to distinct patterns of wall shear stress. METHODS:Isolated porcine endothelial cells and carotid arterial segments were perfused under unidirectional high shear stress (HSS) or oscillatory shear stress (OSS) for 1 and 3 days. Arginase I and II expression, cellular localization and enzyme activity were, respectively, assessed by Western blot, immunohistochemistry and colorimetric determination of urea. The contribution of arginase to the processes of endothelial dysfunction, cell proliferation and arterial remodeling induced by OSS was evaluated by administration of the arginase inhibitor N-omega-hydroxy-nor-l-arginine (nor-Noha). RESULTS:Only arginase II isoform was detected on porcine carotid endothelial cells and on carotid artery. Exposure of arteries to OSS increased arginase II expression and activity as compared to HSS. Inhibition of arginase by nor-Noha improved NO-dependent endothelial function and decreased total vascular ROS formation in arteries submitted to OSS. In addition, inhibition of arginase activity decreased smooth muscle cell proliferation rate with no effect on collagen content after OSS. CONCLUSIONS:Exposure of carotid artery to oscillatory flow induced a more pronounced activation of arginase as compared to HSS. Inhibition of arginase in arteries exposed to OSS improved NO-dependent endothelial function and decrease smooth muscle cell proliferation rate, both processes are important for the focal development of atherosclerotic plaque.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Thacher TN,Gambillara V,Riche F,Silacci P,Stergiopulos N,da Silva RF

doi

10.1016/j.atherosclerosis.2009.10.031

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

63-70

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(09)00905-8

journal_volume

210

pub_type

杂志文章

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