Associations of non-invasive measures of arterial structure and function, and traditional indicators of cardiovascular risk in adults with cerebral palsy.


BACKGROUND:Persons with cerebral palsy (CP) have mobility limitations and may be at increased risk for cardiovascular disease (CVD). AIMS:To determine the feasibility of assessing novel CVD risk indicators and to identify predictors of CVD risk in a clinic-based group of adults with CP. METHODS:In an observational study, we examined 42 adults with CP (mean age 33.5 ± 12.3 yr). Traditional (resting blood pressure, smoking status and lipids) and novel CVD risk indicators (endothelial function, arterial stiffness, and carotid wall thickness) were assessed. RESULTS:Measures of endothelial function and central arterial stiffness were conducted in 100% and 83% of participants, respectively. Age was the strongest independent predictor of vascular health (cIMT, Age, R square = 0.576, p = 0.001). CONCLUSION:Non-invasive measures of arterial structure and function are feasible to assess and may assist in the prediction of CVD risk in adults with CP.






McPhee PG,Gorter JW,Cotie LM,Timmons BW,Bentley T,MacDonald MJ




Has Abstract


2015-12-01 00:00:00














  • Effect of probucol on the composition of lipoproteins and on VLDL apoprotein B turnover.

    abstract::We studied the effect of probucol on lipoprotein composition and VLDL apo B turnover. In 7 hypercholesterolemic subjects, probucol therapy lowered mean total cholesterol, HDL cholesterol and HDL triglycerides, raised LDL triglycerides and did not change LDL cholesterol. LDL cholesterol:LDL triglycerides mass ratios fe...


    pub_type: 杂志文章


    authors: Lock DR,Kuisk I,Gonen B,Patsch W,Schonfeld G

    更新日期:1983-06-01 00:00:00

  • Histamine promotes the differentiation of macrophages from CD11b+ myeloid cells and formation of foam cells through a Stat6-dependent pathway.

    abstract:BACKGROUND AND AIMS:The enzyme histidine decarboxylase (Hdc), which generates histamine, is highly expressed in CD11b+Gr-1+ myeloid cells that play a critical role in infection, inflammation and tumorigenesis. The aim of this study was to explore the role of Hdc-expressing CD11b+ myeloid cells or histamine in atherogen...


    pub_type: 杂志文章


    authors: Xu L,Cheng D,Huang Z,Ding S,Zhang W,Tan H,Shi H,Chen R,Zou Y,Wang TC,Yang X,Ge J

    更新日期:2017-08-01 00:00:00

  • Impact of retrograde shear rate on brachial and superficial femoral artery flow-mediated dilation in older subjects.

    abstract:UNLABELLED:An inverse, dose-dependent relationship between retrograde shear rate and brachial artery endothelial function exists in young subjects. This relationship has not been investigated in older adults, who have been related to lower endothelial function, higher resting retrograde shear rate and higher risk of ca...


    pub_type: 杂志文章


    authors: Schreuder TH,Green DJ,Hopman MT,Thijssen DH

    更新日期:2015-07-01 00:00:00

  • Elevated triglycerides and low HDL cholesterol in transgenic mice expressing human apolipoprotein A-I(Milano).

    abstract::In general, plasma concentrations of high density lipoproteins (HDL) are inversely related to the incidence of coronary artery disease. One exception to this trend is individuals with apolipoprotein A-I(Milano) (apo A-IM), a molecular variant of apo A-I, which results in very low plasma apo A-I and HDL-cholesterol lev...


    pub_type: 杂志文章


    authors: Chiesa G,Stoltzfus LJ,Michelagnoli S,Bielicki JK,Santi M,Forte TM,Sirtori CR,Franceschini G,Rubin EM

    更新日期:1998-01-01 00:00:00

  • Contribution of platelet glycoprotein VI to the thrombogenic effect of collagens in fibrous atherosclerotic lesions.

    abstract::Collagens (types I and III) are among the strongest thrombus-forming components of the vascular subendothelium. We compared the thrombogenic effects of four collagen-containing advanced atherosclerotic lesions with those of purified types I and III collagen fibers. Cell-free homogenates from the human plaques effectiv...


    pub_type: 杂志文章


    authors: Cosemans JM,Kuijpers MJ,Lecut C,Loubele ST,Heeneman S,Jandrot-Perrus M,Heemskerk JW

    更新日期:2005-07-01 00:00:00

  • The discrete and combined effect of SREBP-2 and SCAP isoforms in the control of plasma lipids among familial hypercholesterolaemia patients.

    abstract:BACKGROUND AND AIM:Hypercholesterolaemia is a major risk factor for atherosclerosis. Cholesterol is modulated by genetic and environmental factors. An important regulatory pathway is controlled by the sterol-regulatory element-binding proteins (SREBPs) and the SREBP cleavage-activating protein (SCAP). Both SREBP-2 and ...


    pub_type: 杂志文章,多中心研究


    authors: Durst R,Jansen A,Erez G,Bravdo R,Butbul E,Ben Avi L,Shpitzen S,Lotan C,Leitersdorf E,Defesche J,Friedlander Y,Meiner V,Miserez AR

    更新日期:2006-12-01 00:00:00

  • ABCA1 expression in humans is associated with physical activity and alcohol consumption.

    abstract::Genetic variation in ABCA1 significantly affects HDL levels and atherosclerotic risk. The aim of this study was to examine lifestyle factors influencing ABCA1 expression in human leukocytes and skeletal muscle. A fasting venous blood sample and a vastus lateralis muscle biopsy were taken from 30 volunteers (53+/-1 yea...


    pub_type: 杂志文章


    authors: Hoang A,Tefft C,Duffy SJ,Formosa M,Henstridge DC,Kingwell BA,Sviridov D

    更新日期:2008-03-01 00:00:00

  • Effect of gemfibrozil on composition of lipoproteins and distribution of LDL subspecies.

    abstract::We studied the effect of gemfibrozil on the compositions of VLDL, LDL and distribution of LDL subspecies in type II hyperlipidemic patients. Gemfibrozil significantly lowered serum triglyceride levels in this group of patients who had normal to moderately elevated triglyceride prior to therapy. Gemfibrozil also change...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Tsai MY,Yuan J,Hunninghake DB

    更新日期:1992-07-01 00:00:00

  • Association of smoking and low serum bilirubin antioxidant concentrations.

    abstract::This study sought to examine the association between cigarette smoking and serum bilirubin antioxidant concentrations in 715 middle-aged men undergoing coronary angiography. The study involved 153 current smokers, 251 who quit smoking and 311 who never smoked. Serum bilirubin concentrations were divided into the follo...


    pub_type: 杂志文章


    authors: Schwertner HA

    更新日期:1998-02-01 00:00:00

  • Predictive value of preprocedural fibrinogen concerning coronary stenting.

    abstract::Elevated fibrinogen levels after coronary balloon angioplasty have been reported to be useful in predicting restenosis. Therefore, we sought to evaluate the relationship between preprocedural fibrinogen levels and the 6-12-month outcomes of patients undergoing coronary stenting. Plasma levels of fibrinogen were measur...


    pub_type: 杂志文章


    authors: Otsuka M,Hayashi Y,Ueda H,Imazu M,Kohno N

    更新日期:2002-10-01 00:00:00

  • Apolipoprotein A-I gene polymorphisms: frequency in patients with coronary artery disease and healthy controls and association with serum apo A-I and HDL-cholesterol concentration.

    abstract::We have investigated the association between serum high density lipoprotein-cholesterol (HDL-C) and apo A-I concentration and the PstI and XmnI restriction fragment length polymorphisms of the apolipoprotein AI-CIII-AIV multigene complex. Two groups of subjects were examined. The first comprised 174 unrelated male pat...


    pub_type: 杂志文章


    authors: Wile DB,Barbir M,Gallagher J,Myant NB,Ritchie CD,Thompson GR,Humphries SE

    更新日期:1989-07-01 00:00:00

  • Impact of evolocumab treatment on low-density lipoprotein cholesterol levels in heterozygous familial hypercholesterolemic patients withdrawing from regular apheresis.

    abstract:BACKGROUND AND AIMS:Low-density lipoprotein (LDL) apheresis has been used to treat refractory hyperlipidemia such as familial hypercholesterolemia (FH). Evolocumab, a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor used in clinical settings, can reduce LDL cholesterol (LDL-C) levels by >70%. Therefore, ...


    pub_type: 杂志文章,多中心研究


    authors: Kawashiri MA,Nohara A,Higashikata T,Tada H,Nakanishi C,Okada H,Konno T,Sakata K,Hayashi K,Inazu A,Mabuchi H,Yamagishi M

    更新日期:2017-10-01 00:00:00

  • 5'-nitro-indirubinoxime inhibits inflammatory response in TNF-alpha stimulated human umbilical vein endothelial cells.

    abstract::Inflammation plays a critical role in the development of atherosclerosis and TNF-alpha, a major inflammatory cytokine, induces inflammatory responses by enhancing the expression of adhesion molecules and the secretion of inflammatory mediators. Indirubin is an active compound of Polygonum tinctorium Lour (P. tinctoriu...


    pub_type: 杂志文章


    authors: Kim EJ,Park WH,Ahn SG,Yoon JH,Kim SW,Kim SA

    更新日期:2010-07-01 00:00:00

  • The effect of chronic consumption of red wine on cardiovascular disease risk factors in postmenopausal women.

    abstract:BACKGROUND:Moderate red wine has been shown to reduce cardiovascular disease (CVD) risk, however the effects on certain CVD risk factors are unclear. In this study we have investigated the effects of dealcoholised red wine (DRW) and full-complement red wine (RW) on several cardiovascular risk factors in mildly hypercho...


    pub_type: 杂志文章,随机对照试验


    authors: Naissides M,Mamo JC,James AP,Pal S

    更新日期:2006-04-01 00:00:00

  • Expression of transcriptional repressor ATF3/LRF1 in human atherosclerosis: colocalization and possible involvement in cell death of vascular endothelial cells.

    abstract::Vascular endothelial cell death contributes to the progression of atherosclerotic lesion, and several transcriptional regulators are involved in the process. Activating transcription factor 3/liver regenerating factor-1 (ATF3/LRF-1), a stress-inducible transcriptional repressor, was shown to be highly expressed in vas...


    pub_type: 杂志文章


    authors: Nawa T,Nawa MT,Adachi MT,Uchimura I,Shimokawa R,Fujisawa K,Tanaka A,Numano F,Kitajima S

    更新日期:2002-04-01 00:00:00

  • The state of macrophage differentiation determines the TNF alpha response to nitrated lipoprotein uptake.

    abstract::Inflammatory cytokine synthesis by monocyte-macrophages in the developing plaque represents an important amplification point in atherosclerotic disease progression. Here we have investigated whether the state of monocyte-macrophage differentiation can influence TNF alpha synthesis in response to scavenged modified low...


    pub_type: 杂志文章


    authors: Smythe CD,Skinner VO,Bruckdorfer KR,Haskard DO,Landis RC

    更新日期:2003-10-01 00:00:00

  • Apolipoprotein A-I and apolipoprotein B containing lipoprotein particles in coronary patients treated with extracorporal low density lipoprotein precipitation (HELP).

    abstract::Evidence for chemical and biological heterogeneity of human plasma lipoprotein density classes has been steadily accumulating over the last 15 years. Furthermore, several recent reports have indicated potential clinical significance of certain lipoprotein subspecies as either atherogenic or antiatherogenic. It is gene...


    pub_type: 杂志文章


    authors: Koren E,Armstrong VW,Mueller G,Wilson PR,Schuff-Werner P,Thiery J,Eisenhauer T,Alaupovic P,Seidel D

    更新日期:1992-08-01 00:00:00

  • Tissue plasminogen activator on admission is an important predictor of 30-day mortality in patients with acute myocardial infarction undergoing primary angioplasty.

    abstract::Tissue plasminogen activator (tPA) is emerging as an important risk factor for coronary heart disease, but the association between tPA concentration and mortality in acute myocardial infarction (AMI) remains uncertain. We studied the relationship between tPA antigen level on admission and 30-day mortality in 226 conse...


    pub_type: 杂志文章


    authors: Lee CW,Ahn JM,Park DW,Kim YH,Hong MK,Song JK,Kim JJ,Park SW,Chi HS,Park SJ

    更新日期:2008-01-01 00:00:00

  • Homocysteine and cerebral small vessel disease in patients with symptomatic atherosclerotic disease. The SMART-MR study.

    abstract:OBJECTIVE:High homocysteine level is a risk factor for atherosclerosis and has been associated with lacunar infarcts (LIs), white matter lesions (WML) and cognitive dysfunction. It is unclear whether homocysteine is associated with cerebral small vessel disease (cSVD) on top of pre-existent atherosclerosis. We evaluate...


    pub_type: 杂志文章


    authors: Kloppenborg RP,Nederkoorn PJ,van der Graaf Y,Geerlings MI

    更新日期:2011-06-01 00:00:00

  • Platelet aggregability in rats with early atherosclerotic changes induced by parenterally-administered lipid emulsions.

    abstract::The present study is the first work to evaluate thrombin-, ADP-, and collagen-induced platelet aggregation in laboratory rats receiving alimentation with the parenterally-administered lipid emulsion, Lipofundin-S, in doses sufficient to induce early atherosclerotic changes in the aorta. The aggregometry parameters of ...


    pub_type: 杂志文章


    authors: Saladino CF,Fox RL,Yeh Q,Karpowicz F,Feffer SE,Jonas EA

    更新日期:1987-07-01 00:00:00

  • Linoleic acid increases monocyte deformation and adhesion to endothelium.

    abstract::Fatty acids have been implicated in having both anti- or pro-inflammatory actions, which may contribute to the progression and severity of atherosclerosis. Linoleic acid has been shown by others to decrease CD18 expression and leukocyte adhesion under static conditions. We investigated the effect of steric acid (18:0)...


    pub_type: 杂志文章


    authors: Rinker KD,Kirkpatrick AP,Ting-Beall HP,Shepherd RD,Levin JD,Irick J,Thomas JL,Truskey GA

    更新日期:2004-12-01 00:00:00

  • The relationship between cholesteryl ester transfer protein levels and risk factor profile in patients with familial hypercholesterolemia.

    abstract:BACKGROUND:Cholesteryl ester transfer protein (CETP) mediates the transfer of neutral lipids between lipoproteins. The role of CETP in atherogenesis is controversial. To better understand the relationships between plasma CETP levels, lipoproteins and atherosclerosis, we assessed these parameters in patients with an enh...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: de Grooth GJ,Smilde TJ,Van Wissen S,Klerkx AH,Zwinderman AH,Fruchart JC,Kastelein JJ,Stalenhoef AF,Kuivenhoven JA

    更新日期:2004-04-01 00:00:00

  • The effect of acute exercise on high density lipoprotein-cholesterol and the subfractions in females.

    abstract::The effect of an acute exercise session on high density lipoprotein-cholesterol (HDL-C) and the subfractions HDL2-C and HDL3-C was determined for 9 healthy females (VO2max = 46.62 +/- 4.82 ml X kg-1 min-1). Each subject underwent a continuous 40-min run on a treadmill at a workload corresponding to 70% of VO2max. A ve...


    pub_type: 杂志文章


    authors: Swank AM,Robertson RJ,Deitrich RW,Bates M

    更新日期:1987-02-01 00:00:00

  • Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study.

    abstract:OBJECTIVE:Common variants at the 2q36.3-IRS1 locus are associated with insulin resistance (IR), type 2 diabetes (T2D) and coronary artery disease (CAD) in large-scale association studies. We tested the hypothesis that variants at this locus are associated with subclinical atherosclerosis traits. METHODS:We studied 274...


    pub_type: 杂志文章


    authors: Lim S,Hong J,Liu CT,Hivert MF,White CC,Murabito JM,O'Donnell CJ,Dupuis J,Florez JC,Meigs JB

    更新日期:2013-07-01 00:00:00

  • Comparison of plasma levels of different species of trans fatty acids in Japanese male patients with acute coronary syndrome versus healthy men.

    abstract:BACKGROUND AND AIMS:It remains unclear how trans fatty acid (TFA) at low-level intake affect lipid levels and the development of acute coronary syndrome (ACS). The study aimed to investigate how plasma TFA composition differs between male patients with ACS and healthy men. METHODS:Plasma fatty acid (FA) composition (a...


    pub_type: 杂志文章


    authors: Koba S,Takao T,Shimizu F,Ogawa M,Ishii Y,Yokota Y,Furuyama F,Tsunoda F,Shoji M,Harris WS,Takada A

    更新日期:2019-05-01 00:00:00

  • Acidic glycosaminoglycan, lipid and water contents in human coronary arterial branches.

    abstract::The acidic glycosaminoglycans (AGAG) of the human coronary arterial tree (the main left and right branches and their distal portions) were analyzed by enzymatic methods employing chondroitinases, hyaluronidase and heparitinase. The AGAG content of human coronary arteries was highest in the left branch, intermediate in...


    pub_type: 杂志文章


    authors: Murata K,Yokoyama Y

    更新日期:1982-10-01 00:00:00

  • A novel method for the rapid separation of plasma lipoproteins using self-generating gradients of iodixanol.

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    pub_type: 杂志文章


    authors: Graham JM,Higgins JA,Gillott T,Taylor T,Wilkinson J,Ford T,Billington D

    更新日期:1996-07-01 00:00:00

  • Circulating levels of MCP-1 and eotaxin are not associated with presence of atherosclerosis or previous myocardial infarction.

    abstract::The chemokines are a family of signalling proteins that participate in regulation of the immune system and have been implicated in the pathogenesis of vascular diseases. Deleting the gene encoding the chemokine MCP-1 in mouse models of atherosclerosis reduces lipid lesion formation and circulating chemokines are upreg...


    pub_type: 杂志文章


    authors: Mosedale DE,Smith DJ,Aitken S,Schofield PM,Clarke SC,McNab D,Goddard H,Gale CR,Martyn CN,Bethell HW,Barnard C,Hayns S,Nugent C,Panicker A,Grainger DJ

    更新日期:2005-12-01 00:00:00

  • HDL cholesterol, leptin and interleukin-6 predict high risk coronary anatomy assessed by CT angiography in patients with stable chest pain.

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    pub_type: 杂志文章


    authors: Caselli C,De Graaf MA,Lorenzoni V,Rovai D,Marinelli M,Del Ry S,Giannessi D,Bax JJ,Neglia D,Scholte AJ

    更新日期:2015-07-01 00:00:00

  • Pioglitazone improves endothelial and adipose tissue dysfunction in pre-diabetic CAD subjects.

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    pub_type: 杂志文章,随机对照试验


    authors: Rizza S,Cardellini M,Porzio O,Pecchioli C,Savo A,Cardolini I,Senese N,Lauro D,Sbraccia P,Lauro R,Federici M

    更新日期:2011-03-01 00:00:00