Associations of non-invasive measures of arterial structure and function, and traditional indicators of cardiovascular risk in adults with cerebral palsy.

Abstract:

BACKGROUND:Persons with cerebral palsy (CP) have mobility limitations and may be at increased risk for cardiovascular disease (CVD). AIMS:To determine the feasibility of assessing novel CVD risk indicators and to identify predictors of CVD risk in a clinic-based group of adults with CP. METHODS:In an observational study, we examined 42 adults with CP (mean age 33.5 ± 12.3 yr). Traditional (resting blood pressure, smoking status and lipids) and novel CVD risk indicators (endothelial function, arterial stiffness, and carotid wall thickness) were assessed. RESULTS:Measures of endothelial function and central arterial stiffness were conducted in 100% and 83% of participants, respectively. Age was the strongest independent predictor of vascular health (cIMT, Age, R square = 0.576, p = 0.001). CONCLUSION:Non-invasive measures of arterial structure and function are feasible to assess and may assist in the prediction of CVD risk in adults with CP.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

McPhee PG,Gorter JW,Cotie LM,Timmons BW,Bentley T,MacDonald MJ

doi

10.1016/j.atherosclerosis.2015.09.035

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

462-5

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(15)30146-5

journal_volume

243

pub_type

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