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Is uric acid protective or deleterious in acute ischemic stroke? A prospective cohort study.

Abstract：

:Contrasting observations have been made between serum urate and ischemic stroke outcomes in studies involving Caucasian populations. To assess the hypothesis that urate is associated with stroke outcomes, a prospective follow-up study was performed in a cohort of Asian patients with ischemic stroke. Patients diagnosed with transient ischemic attack, first or recurrent ischemic stroke were included in this study. Serum urate, measured using high-performance liquid chromatography, was correlated with 12-month functional and vascular stroke outcomes. Poor functional outcome was defined as a modified Rankin scale exceeding 2 and vascular outcome was defined as a composite of recurrent stroke, myocardial infarction or vascular death during the study period. A total of 503 patients of mean age 63 (SD 12) years were included. A U-shaped relationship between urate quartiles and poor functional outcomes was demonstrated. More patients with low (<280microM) and high (>410microM) urate levels had poor functional outcomes (36% and 27% respectively), compared to those with urate levels between 340 and 410microM (14%). No significant relationship was observed between urate and vascular outcomes. Depending on its level, serum urate may exhibit protective and deleterious effects on stroke outcomes.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Seet RC,Kasiman K,Gruber J,Tang SY,Wong MC,Chang HM,Chan YH,Halliwell B,Chen CP

doi

10.1016/j.atherosclerosis.2009.08.012

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

215-9

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(09)00637-6

journal_volume

209

pub_type

杂志文章

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