Framingham risk score is related to carotid artery intima-media thickness in both white and black young adults: the Bogalusa Heart Study.

abstract：BACKGROUND AND AIMS:Carbohydrates and fat intake have both been linked to development of atherosclerosis. We examined associations between glycemic index (GI) and fat intake with carotid atherosclerosis. METHODS:The Atherosclerosis Risk in Communities (ARIC) cohort enrolled participants during the period 1987-1989 and...

journal_title：Atherosclerosis

authors： Dearborn JL,Qiao Y,Guallar E,Steffen LM,Gottesman RF,Zhang Y,Wasserman BA

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:An elevated systolic blood pressure (SBP) response to a graded maximal exercise stress test (GEST) may be a predictor of endothelial dysfunction and hypertension. We examined relationships among the GEST peak SBP response and indicators of endothelial function. METHODS:Men (n=48, 43.7±1.4 yr) with high BP (145...

journal_title：Atherosclerosis

authors： Olson KM,Augeri AL,Seip RL,Tsongalis GJ,Thompson PD,Pescatello LS

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:CD36 signal transductions have been reported by a variety of lipid moiety of oxidized low-density lipoprotein (oxLDL), however, CD36 signal induced by 7-ketocholesteryl-9-carboxynonanoate (oxLig-1), a lipid moiety of oxLDL has not been elucidated. METHODS AND RESULTS:OxLig-1 leads to activation and recruitm...

journal_title：Atherosclerosis

authors： Li W,Wang D,Chi Y,Wang R,Zhang F,Ma G,Chen Z,Li J,Liu Z,Matsuura E,Liu Q

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:In chronic kidney disease (CKD), high FGF23 concentrations are associated with left ventricular hypertrophy (LVH), cardiovascular events, and death. The associations of FGF23 with left ventricular mass (LVM) and LVH in the general population and the influence of CKD remains uncertain. METHODS:C-terminal pla...

journal_title：Atherosclerosis

authors： Jovanovich A,Ix JH,Gottdiener J,McFann K,Katz R,Kestenbaum B,de Boer IH,Sarnak M,Shlipak MG,Mukamal KJ,Siscovick D,Chonchol M

更新日期：2013-11-01 00:00:00

abstract：:Expression of ATP binding cassette transporter A1 (ABCA1), a major regulator of high density lipoprotein (HDL) biogenesis, is known to be up-regulated by the transcription factor liver X receptor (LXR) alpha, and expression is further enhanced by activation of the peroxisome proliferator activated receptors (PPARs). W...

journal_title：Atherosclerosis

authors： Ogata M,Tsujita M,Hossain MA,Akita N,Gonzalez FJ,Staels B,Suzuki S,Fukutomi T,Kimura G,Yokoyama S

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVES:We examined the associations between HbA1c levels and various atherosclerotic vascular parameters among adults without diabetes from the general population. METHODS:A total of 6500 community-dwelling adults, who were free of type 2 diabetes and ≥50 years of age, were included. High-resolution B-mode ultraso...

journal_title：Atherosclerosis

authors： Lee YH,Shin MH,Choi JS,Rhee JA,Nam HS,Jeong SK,Park KS,Ryu SY,Choi SW,Kim BH,Oh GJ,Kweon SS

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:The association between cholesterol and endothelial dysfunction remains controversial. We tested the hypothesis that lipoprotein subclasses are associated with coronary endothelial dysfunction. METHODS AND RESULTS:Coronary endothelial function was assessed in 490 patients between November 1993 and February 2...

journal_title：Atherosclerosis

authors： Ford MA,McConnell JP,Lavi S,Rihal CS,Prasad A,Sandhu GS,Hartman SJ,Lerman LO,Lerman A

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:The apolipoprotein E mimetic peptide Ac-hE18A-NH(2), capable of reducing plasma cholesterol and possessing anti-inflammatory properties, was compared with the well-studied anti-atherogenic apoA-I mimetic peptide 4F for reducing lesion formation in female apoE null mice with already existing lesions. METHODS ...

journal_title：Atherosclerosis

authors： Nayyar G,Garber DW,Palgunachari MN,Monroe CE,Keenum TD,Handattu SP,Mishra VK,Anantharamaiah GM

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:Transplant vasculopathy consists of neointima formation in graft vasculature resulting from vascular smooth muscle cell recruitment and proliferation. Variation in the severity of vasculopathy has been demonstrated. Genetic predisposition is suggested as a putative cause of this variation, although cellular m...

journal_title：Atherosclerosis

authors： Onuta G,van Ark J,Rienstra H,Boer MW,Klatter FA,Bruggeman CA,Zeebregts CJ,Rozing J,Hillebrands JL

更新日期：2010-04-01 00:00:00

abstract：:Apolipoprotein E phenotypes and fasting lipid and other biochemical parameters were determined in 51 patients with recently diagnosed coronary heart disease (CHD) and 164 control subjects. The age of the participants was 62.5 +/- 6.6 (S.D.) and 63% were male. Forty-eight CHD cases and 51 control subjects were also stu...

journal_title：Atherosclerosis

authors： Dart A,Sherrard B,Simpson H

更新日期：1997-04-01 00:00:00

abstract：:Inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) have been implicated in atherogenesis. However, the precise role of TNF-alpha in atherogenesis is still unclear. To examine the effect of TNF-alpha on atherogenesis, we generated compound-deficient mice in apolipoprotein E (apoE) and TNF-alpha (...

journal_title：Atherosclerosis

authors： Ohta H,Wada H,Niwa T,Kirii H,Iwamoto N,Fujii H,Saito K,Sekikawa K,Seishima M

更新日期：2005-05-01 00:00:00

abstract：:Methodological differences and variations in health care regulations among countries often preclude direct comparisons of cost-effectiveness studies. A projected risk model was applied, designed to determine the economic value in the United States of pravastatin in the secondary prevention of coronary heart disease (C...

journal_title：Atherosclerosis

authors： Muls E,Van Ganse E,Closon MC

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:Sarcopenia of legs is an important cause of physical dysfunctions, frailty and dependence. Many predisposing and underlying mechanisms of sarcopenia, including age, sedentary life style, oxidative stress, insulin resistance, and low testosterone levels, are also known to be related to atherosclerosis, which i...

journal_title：Atherosclerosis

authors： Ochi M,Kohara K,Tabara Y,Kido T,Uetani E,Ochi N,Igase M,Miki T

更新日期：2010-09-01 00:00:00

abstract：UNLABELLED:Transglutaminases play an important role in vascular remodeling, calcification, cell adhesion and endothelial barrier function. In this study we investigate the influence of combined inhibition of both tissue-type transglutaminase (TG2) and the plasma transglutaminase FXIIIA on early lesion development. MET...

journal_title：Atherosclerosis

authors： Matlung HL,VanBavel E,van den Akker J,de Vries CJ,Bakker EN

更新日期：2010-11-01 00:00:00

abstract：:We have previously reported that mouse peritoneal macrophages have three types of modified low density lipoprotein (LDL) receptors. One is specific for acetylated LDL (Ac-LDL), the second is for oxidized LDL (Ox-LDL), and the third recognizes both (Arai, H. et al. (1989) Biochem. Biophys. Res. Commun. 159, 1375-1382)....

journal_title：Atherosclerosis

authors： Ueda Y,Arai H,Kawashima A,Nagano Y,Cho M,Tanaka M,Kita T

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND AND AIMS:The enzyme histidine decarboxylase (Hdc), which generates histamine, is highly expressed in CD11b+Gr-1+ myeloid cells that play a critical role in infection, inflammation and tumorigenesis. The aim of this study was to explore the role of Hdc-expressing CD11b+ myeloid cells or histamine in atherogen...

journal_title：Atherosclerosis

authors： Xu L,Cheng D,Huang Z,Ding S,Zhang W,Tan H,Shi H,Chen R,Zou Y,Wang TC,Yang X,Ge J

更新日期：2017-08-01 00:00:00

abstract：:We measured 381 genomewide markers and performed genetic linkage analyses in search of loci influencing coronary artery calcification (CAC), a measure of atherosclerosis determined by electron beam computed tomography, in 948 non-Hispanic white siblings (mean age [+/-standard deviation] = 59.6 +/- 9.9 years; 73.7% hyp...

journal_title：Atherosclerosis

authors： Turner ST,Peyser PA,Kardia SL,Bielak LF,Sheedy PF 3rd,Boerwinkle E,de Andrade M

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Recent studies have unveiled an association between ADAMTS7 gene variation and coronary artery disease (CAD) caused by atherosclerosis. We investigated if the ADAMTS7 Serine214-to-Proline substitution arising from a CAD-associated variant affected angiogenesis, since neovascularization plays an impo...

journal_title：Atherosclerosis

authors： Pu X,Chan K,Yang W,Xiao Q,Zhang L,Moore AD,Liu C,Webb TR,Caulfield MJ,Samani NJ,Zhu J,Ye S

更新日期：2020-03-01 00:00:00

abstract：:Low-density lipoprotein cholesterol (LDL-C) and the small dense LDL (SdLDL) phenotype are both predictors for ischemic heart disease. We examined whether cholesterol of SdLDL (SdLDL-C) is more closely associated with carotid artery intima-media thickness (CA-IMT), a surrogate measure of atherosclerosis, than LDL-C and...

journal_title：Atherosclerosis

authors： Shoji T,Hatsuda S,Tsuchikura S,Shinohara K,Kimoto E,Koyama H,Emoto M,Nishizawa Y

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Evidence suggests that delayed re-endothelialization is responsible for in-stent thrombosis. Probucol inhibits neointimal thickening in animals via enhanced re-endothelialization and is the only oral drug that consistently inhibits restenosis after coronary angioplasty in humans. Here, we examined the effect...

journal_title：Atherosclerosis

authors： Tanous D,Bräsen JH,Choy K,Wu BJ,Kathir K,Lau A,Celermajer DS,Stocker R

更新日期：2006-12-01 00:00:00

abstract：:Colesevelam hydrochloride is a novel, potent, non-absorbed lipid-lowering agent previously shown to reduce low density lipoprotein (LDL) cholesterol. To examine the efficacy and safety of coadministration of colesevelam and atorvastatin, administration of these agents alone or in combination was examined in a double-b...

journal_title：Atherosclerosis

authors： Hunninghake D,Insull W Jr,Toth P,Davidson D,Donovan JM,Burke SK

更新日期：2001-10-01 00:00:00

abstract：:Estrogen use is associated with protection from cardiovascular disease in postmenopausal women. This benefit appears to be magnified among women with pre-existing heart disease. The possible bias of intrinsically better health in women using estrogen has not been ruled out in observational studies. Therefore, two doub...

journal_title：Atherosclerosis

authors： Knopp RH,Zhu X,Bonet B

更新日期：1994-10-01 00:00:00

abstract：:The effect of triiodothyronine (T3) on prostacyclin production in rat aortic smooth muscle cells was investigated by using an intact cell assay system. T3 at its physiological concentrations has no significant effect on smooth muscle cell proliferation, but it does significantly stimulate prostacyclin production by th...

journal_title：Atherosclerosis

authors： Nakao J,Chang WC,Murota S,Orimo H

更新日期：1981-07-01 00:00:00

abstract：:The newly identified apoprotein AV (apoAV) gene was suggested to have a significant effect on triglyceride (TG) metabolism in Caucasians. We studied the genetic effect of this gene on serum TG in a Japanese population. Participants (481 male and 412 female) were recruited at a health examination. A T/C single nucleoti...

journal_title：Atherosclerosis

authors： Nabika T,Nasreen S,Kobayashi S,Masuda J

更新日期：2002-12-01 00:00:00

abstract：:Oxidized low-density lipoproteins (LDL) impair endothelium-dependent dilation and constrict arteries. This study examined possible relation of the circulating plasma levels of Ox-LDL to coronary spastic angina (CSA). The plasma levels of Ox-LDL were measured by ELISA in 37 consecutive patients with CSA and normal coro...

journal_title：Atherosclerosis

authors： Kugiyama K,Sugiyama S,Soejima H,Kawano H,Sakamoto T,Takazoe K,Ogawa H,Doi H,Yasue H

更新日期：2001-02-01 00:00:00

abstract：:The mechanism(s) by which doxazosin, an alpha 1 inhibitor, regulates plasma low density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) levels were investigated in 'normocholesterolemic' (average total cholesterol (TC) of 218 mg/dl) and 'hypercholesterolemic' (average TC of 350 mg/dl) cynomolgus monkeys. ...

journal_title：Atherosclerosis

authors： Stucchi AF,Vespa DB,Terpstra AH,Nicolosi RJ

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Oxidative stress-induced endothelial dysfunction is considered to exert a vital role in the development of atherosclerotic coronary heart disease (CHD). NRF2 is a key transcriptional factor against oxidative stress through activation of multiple ARE-mediated genes. Z-Lig is derived from the Ligustic...

journal_title：Atherosclerosis

authors： Zhu Y,Zhang Y,Huang X,Xie Y,Qu Y,Long H,Gu N,Jiang W

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:Increased lipid accumulation in cells and tissues is a key phenomenon in the development of obesity, insulin resistance, and atherosclerosis. In the regulation of lipid content of cells and tissues the SREBPs play a dominant role as transcription factors. METHODS:Since growth hormone (GH) affects lipid metab...

journal_title：Atherosclerosis

authors： Kotzka J,Knebel B,Avci H,Jacob S,Nitzgen U,Jockenhovel F,Heeren J,Haas J,Muller-Wieland D

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to estimate circulating oxidized low-density lipoprotein (oxLDL) levels in postmenopausal women and evaluate their association with obesity and smoking status. DESIGN AND METHODS:The study included 135 postmenopausal women aged 52-75 years. Forty of them were overweight (BMI ...

journal_title：Atherosclerosis

authors： Kassi E,Dalamaga M,Faviou E,Hroussalas G,Kazanis K,Nounopoulos Ch,Dionyssiou-Asteriou A

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:Interleukin (IL)-6 is a key modulator of the acute phase response (APR), and while both are implicated in atherosclerosis, the pathological role of specific IL-6 signalling cascades is ill-defined. Since IL-6 employs the cytokine receptor gp130 to primarily activate the STAT3 pathway, here we evaluate whether...

journal_title：Atherosclerosis

authors： Jones GW,McLeod L,Kennedy CL,Bozinovski S,Najdovska M,Jenkins BJ

更新日期：2015-02-01 00:00:00