abstract：Importance:Systemic and inhaled corticosteroids negatively affect bone remodeling and cause osteoporosis and bone fracture when given continuously or in high doses. However, risk of osteoporosis and major osteoporotic fracture (MOF) after application of topical corticosteroids (TCSs) is largely unexplored. Objective:T...

journal_title：JAMA dermatology

authors： Egeberg A,Schwarz P,Harsløf T,Andersen YMF,Pottegård A,Hallas J,Thyssen JP

更新日期：2021-01-20 00:00:00

abstract：Importance:In the US, incidence of and mortality due to anal carcinoma are rising faster than for most other cancers. Identifying populations who have a higher risk of developing anal cancers is critical to target preventive interventions. Objective:To assess the risk of developing anal carcinoma in adults living with...

journal_title：JAMA dermatology

authors： Arnold JD,Byrne ME,Monroe AK,Abbott SE,District of Columbia Cohort Executive Committee.

更新日期：2021-01-13 00:00:00

abstract：Importance:There is ongoing controversy about the adverse events of finasteride, a drug used in the management of alopecia and benign prostatic hyperplasia (BPH). In 2012, reports started emerging on men who had used finasteride and either attempted or completed suicide. Objective:To investigate the association of sui...

journal_title：JAMA dermatology

authors： Nguyen DD,Marchese M,Cone EB,Paciotti M,Basaria S,Bhojani N,Trinh QD

更新日期：2021-01-01 00:00:00

abstract：Importance:Although regression is commonly observed in cutaneous melanoma, it is uncertain whether it is associated with patient prognosis. Objective:To determine whether histologically confirmed regression was associated with better or worse survival in patients with primary cutaneous melanoma. Design, Setting, and ...

journal_title：JAMA dermatology

authors： El Sharouni MA,Aivazian K,Witkamp AJ,Sigurdsson V,van Gils CH,Scolyer RA,Thompson JF,van Diest PJ,Lo SN

更新日期：2020-12-23 00:00:00

abstract：Importance:Concerns have been raised about the use of radiotherapy (RT) by dermatologists. Little is known about temporal trends in payment for RT among dermatologists. Objective:To characterize changes in RT use and payment among dermatologists treating patients enrolled in Medicare. Design, Setting, and Participant...

journal_title：JAMA dermatology

authors： Nguyen KD,Chen HW,Adamson AS

更新日期：2020-12-23 00:00:00

abstract：Importance:Baricitinib, an oral selective Janus kinase 1 and 2 inhibitor, effectively reduced disease severity in moderate to severe atopic dermatitis (AD) in 2 phase 3 monotherapy studies. Objective:To assess the efficacy and safety of 4 mg and 2 mg of baricitinib in combination with background topical corticosteroid...

journal_title：JAMA dermatology

authors： Reich K,Kabashima K,Peris K,Silverberg JI,Eichenfield LF,Bieber T,Kaszuba A,Kolodsick J,Yang FE,Gamalo M,Brinker DR,DeLozier AM,Janes JM,Nunes FP,Thyssen JP,Simpson EL

更新日期：2020-12-01 00:00:00

abstract：Importance:Persistent radiation-induced alopecia (pRIA) and its management have not been systematically described. Objective:To characterize pRIA in patients with primary central nervous system (CNS) tumors or head and neck sarcoma. Design, Setting, and Participants:A retrospective cohort study of patients from Janua...

journal_title：JAMA dermatology

authors： Phillips GS,Freret ME,Friedman DN,Trelles S,Kukoyi O,Freites-Martinez A,Unger RH,Disa JJ,Wexler LH,Tinkle CL,Mechalakos JG,Dusza SW,Beal K,Wolden SL,Lacouture ME

更新日期：2020-09-01 00:00:00

abstract：Importance:How patients' mental health is associated with their satisfaction with physicians is rarely studied among adults with skin conditions. Objective:To examine the association between mental health comorbidities in patients with psoriasis and their satisfaction with physicians. Design, Setting, and Participant...

journal_title：JAMA dermatology

authors： Read C,Armstrong AW

更新日期：2020-07-01 00:00:00

abstract：Importance:The association between psoriasis and risk of cancer remains debatable. Objective:To evaluate the association and risk of cancer in patients with psoriasis or psoriatic arthritis, including risk of specific cancer subtypes. Data Sources:Two databases (PubMed and Embase) were screened from inception to Janu...

journal_title：JAMA dermatology

authors： Vaengebjerg S,Skov L,Egeberg A,Loft ND

更新日期：2020-04-01 00:00:00

abstract：Importance:Necrobiotic xanthogranuloma (NXG) is a non-Langerhans cell histiocytosis classically associated with paraproteinemia attributable to plasma-cell dyscrasias or lymphoproliferative disorders. Despite the morbidity of NXG, the literature is limited to case reports and small studies, and diagnostic criteria are ...

journal_title：JAMA dermatology

authors： Nelson CA,Zhong CS,Hashemi DA,Ashchyan HJ,Brown-Joel Z,Noe MH,Imadojemu S,Micheletti RG,Vleugels RA,Wanat KA,Rosenbach M,Mostaghimi A

更新日期：2020-03-01 00:00:00

abstract：Importance:The dupilumab regimen of 300 mg every 2 weeks is approved for uncontrolled, moderate to severe atopic dermatitis (AD). Objective:To assess the efficacy and safety of different dupilumab regimens in maintaining response after 16 weeks of initial treatment. Design, Setting, and Participants:The Study to Conf...

journal_title：JAMA dermatology

authors： Worm M,Simpson EL,Thaçi D,Bissonnette R,Lacour JP,Beissert S,Kawashima M,Ferrándiz C,Smith CH,Beck LA,Chan KC,Chen Z,Akinlade B,Hultsch T,Staudinger H,Gadkari A,Eckert L,Davis JD,Rajadhyaksha M,Graham NMH,Pirozzi

更新日期：2020-02-01 00:00:00

abstract：Importance:High-cost biologic therapies have transformed the management of immune-mediated inflammatory diseases. To optimize outcomes and reduce costs, dose adjustment informed by measurement of circulating drug levels has been shown to be effective in various settings. However, limited evidence exists for this approa...

journal_title：JAMA dermatology

authors： Tsakok T,Wilson N,Dand N,Loeff FC,Bloem K,Baudry D,Duckworth M,Pan S,Pushpa-Rajah A,Standing JF,de Vries A,Alsharqi A,Becher G,Murphy R,Wahie S,Wright A,Griffiths CEM,Reynolds NJ,Barker J,Warren RB,Burden AD,Ris

更新日期：2019-09-18 00:00:00

abstract：Importance:Breslow thickness is a 1-dimensional surrogate prognostic feature for tumor size, yet tissue sections have 2 dimensions. Therefore, a 2-dimensional feature, calculated tumor area (CTA), was devised. Objective:To determine CTA precision and prognostic value. Design, Setting, and Participants:This retrospect...

journal_title：JAMA dermatology

authors： Saldanha G,Yarrow J,Elsheikh S,O'Riordan M,Uraiby H,Bamford M

更新日期：2019-06-26 00:00:00

abstract：Importance:Previous studies suggest that depression and anxiety are common in patients with hidradenitis suppurativa (HS), more so than other dermatological conditions. Yet, to the authors' knowledge, no previous systematic review or meta-analysis has estimated the prevalence or odds ratio (OR) for those psychiatric co...

journal_title：JAMA dermatology

authors： Machado MO,Stergiopoulos V,Maes M,Kurdyak PA,Lin PY,Wang LJ,Shyu YC,Firth J,Koyanagi A,Solmi M,Alavi A,Piguet V,Carvalho AF

更新日期：2019-06-05 00:00:00

abstract：Importance:A phase 2 trial comparing talimogene laherparepvec plus ipilimumab vs ipilimumab monotherapy in patients with advanced unresectable melanoma found no differential benefit in progression-free survival (PFS) but noted objective response rates (ORRs) of 38.8% (38 of 98 patients) vs 18.0% (18 of 100 patients), r...

journal_title：JAMA dermatology

authors： Almutairi AR,Alkhatib NS,Oh M,Curiel-Lewandrowski C,Babiker HM,Cranmer LD,McBride A,Abraham I

更新日期：2019-01-01 00:00:00

abstract：Importance:Pyoderma gangrenosum and necrotizing Sweet syndrome are diagnostically challenging variants of neutrophilic dermatosis that can clinically mimic the cutaneous and systemic features of necrotizing fasciitis. Improved characterization of these rare variants is needed, as improper diagnosis may lead to inapprop...

journal_title：JAMA dermatology

authors： Sanchez IM,Lowenstein S,Johnson KA,Babik J,Haag C,Keller JJ,Ortega-Loayza AG,Cohen J,McCalmont TH,Demer AM,Mansh MD,Hylwa SA,Liu J,Shinkai K

更新日期：2019-01-01 00:00:00

abstract：Importance:Granuloma faciale (GF) is a rare, benign inflammatory dermatosis of unknown cause. Some reports have suggested that it could be part of the spectrum of IgG4-related sclerosing diseases. Granuloma faciale is characterized by single or multiple red-brown nodules, most frequently occurring on the face, and it c...

journal_title：JAMA dermatology

authors： Morgado-Carrasco D,Giavedoni P,Mascaró JM Jr,Iranzo P

更新日期：2018-11-01 00:00:00

abstract：Importance:Exercise is recommended as an adjuvant treatment for venous leg ulceration (VLU) to improve calf muscle pump function. However, the association of exercise with VLU healing has not been properly aggregated, and the effectiveness of different exercise interventions has not been characterized. Objective:To su...

journal_title：JAMA dermatology

authors： Jull A,Slark J,Parsons J

更新日期：2018-11-01 00:00:00

abstract：Importance:Despite the growing popularity of cosmetic procedures, the sociocultural and quality-of-life factors that motivate patients to undergo such procedures are not well understood. Objective:To estimate the relative importance of factors that motivate patients to seek minimally invasive cosmetic procedures. Des...

journal_title：JAMA dermatology

authors： Maisel A,Waldman A,Furlan K,Weil A,Sacotte K,Lazaroff JM,Lin K,Aranzazu D,Avram MM,Bell A,Cartee TV,Cazzaniga A,Chapas A,Crispin MK,Croix JA,DiGiorgio CM,Dover JS,Goldberg DJ,Goldman MP,Green JB,Griffin CL,Haimo

更新日期：2018-10-01 00:00:00

abstract：Importance:There are limited data among young adults on sunscreen use during childhood and adulthood and on the association of sunscreen use with melanoma risk. Objective:To assess correlates of early-life sunscreen use and the association between sunscreen use and risk of cutaneous melanoma before age 40 years. Desi...

journal_title：JAMA dermatology

authors： Watts CG,Drummond M,Goumas C,Schmid H,Armstrong BK,Aitken JF,Jenkins MA,Giles GG,Hopper JL,Mann GJ,Cust AE

更新日期：2018-09-01 00:00:00

abstract：Importance:Advanced practice professionals (APPs) such as nurse practitioners and physician assistants independently perform a large number and variety of dermatologic procedures, but little is known about how the number and scope of these procedures have changed over time. Objective:To examine the trends in scope and...

journal_title：JAMA dermatology

authors： Zhang M,Zippin J,Kaffenberger B

更新日期：2018-09-01 00:00:00

abstract：Importance:Psoriasis is a chronic inflammatory disease. The Mediterranean diet has been shown to reduce chronic inflammation and has a positive effect on the risk of metabolic syndrome and cardiovascular events. Thus, we hypothesized a positive effect on the onset and/or severity of psoriasis. Objective:To assess the ...

journal_title：JAMA dermatology

authors： Phan C,Touvier M,Kesse-Guyot E,Adjibade M,Hercberg S,Wolkenstein P,Chosidow O,Ezzedine K,Sbidian E

更新日期：2018-09-01 00:00:00

abstract：Importance:Staged excision of lentigo maligna (LM) often requires multiple stages and can result in significant cosmetic morbidity. Imiquimod cream has been used off-label as monotherapy in the treatment of LM and may be used in the neoadjuvant setting prior to staged excision as a strategy to reduce the size of the su...

journal_title：JAMA dermatology

authors： Donigan JM,Hyde MA,Goldgar DE,Hadley ML,Bowling M,Bowen GM

更新日期：2018-08-01 00:00:00

abstract：Importance:Hemophagocytic lymphohistiocytosis (HLH) has been reported as a serious complication of cutaneous T-cell lymphoma (CTCL). Despite available diagnostic guidelines, it remains a diagnostic and therapeutic challenge in this patient population. Objectives:To examine the characteristics of CTCL associated with H...

journal_title：JAMA dermatology

authors： Lee DE,Martinez-Escala ME,Serrano LM,Zhou XA,Kaplan JB,Pro B,Choi J,Guitart J

更新日期：2018-07-01 00:00:00

abstract：Importance:Patients with vascular malformations (VAMs) and vascular overgrowth syndromes have lower health-related quality of life (HRQoL) attributable to social stigmatization, poor mental health, severity, and pain. However, the factors that contribute to this decreased HRQoL are not clear. Objective:To perform a sy...

journal_title：JAMA dermatology

authors： Nguyen HL,Bonadurer GF 3rd,Tollefson MM

更新日期：2018-06-01 00:00:00

abstract：Importance:Psoriasis of the scalp, palms and/or soles, and nails is challenging to treat. Objective:To evaluate the effect of guselkumab on psoriasis in specific body regions. Design, Setting, and Participants:VOYAGE 1 and VOYAGE 2 were, double-blind, placebo- and adalimumab-controlled studies of guselkumab conducted...

journal_title：JAMA dermatology

authors： Foley P,Gordon K,Griffiths CEM,Wasfi Y,Randazzo B,Song M,Li S,Shen YK,Blauvelt A

更新日期：2018-06-01 00:00:00

abstract：Importance:Increased rates of autoimmune conditions have been reported in association with systemic lupus erythematosus (SLE). Little is known about coexisting autoimmune conditions in patients with cutaneous lupus erythematosus (CLE) without SLE. Objective:To determine the prevalence and risk factors of having coexis...

journal_title：JAMA dermatology

authors： Kunzler E,Hynan LS,Chong BF

更新日期：2018-06-01 00:00:00

abstract：Importance:Cutaneous squamous cell carcinoma (cSCC) has metastatic potential, but the prognostic value of current staging systems in nonselected patients is uncertain. Objective:To assess the effect of risk factors for metastasis and to evaluate validity and usefulness of 4 staging systems for cSCC using population-ba...

journal_title：JAMA dermatology

authors： Roscher I,Falk RS,Vos L,Clausen OPF,Helsing P,Gjersvik P,Robsahm TE

更新日期：2018-04-01 00:00:00

abstract：Importance:The US Food and Drug Administration approves Class III medical devices via the premarket approval pathway, often requiring clinical data on safety and efficacy. Manufacturers can submit incremental device changes via supplemental applications, which are not subjected to such vetting measures and can cause un...

journal_title：JAMA dermatology

authors： Ezaldein HH,Scott JF,Yin ES,Ventura A,DeRuyter NP,Leffell DJ

更新日期：2018-03-01 00:00:00

abstract：Importance:Melanoma treatment has been revolutionized with the development of immune-based therapies that offer durable clinical responses in a subset of patients. Clinical outcomes after treatment by immunotherapy can be influenced by the host's immune system. The immune system is modified with age by age-related immu...

journal_title：JAMA dermatology

authors： Perier-Muzet M,Gatt E,Péron J,Falandry C,Amini-Adlé M,Thomas L,Dalle S,Boespflug A

更新日期：2018-01-01 00:00:00

abstract：Importance:Hidradenitis suppurativa (HS) places a significant burden on the health-related quality of life (HRQOL) of patients, many of whom have depression. Resilience can play a role in mitigating the negative stressors, such as the symptoms of HS, on patients' mental health. Objective:To investigate the correlation...

journal_title：JAMA dermatology

authors： Kirby JS,Butt M,Esmann S,Jemec GBE

更新日期：2017-12-01 00:00:00

abstract：Importance:Chronic urticaria (CU) affects 0.1% to 0.3% of children. Most cases have no identifiable trigger and are classified as chronic spontaneous urticaria (CSU). At least half of patients with CSU may have an autoimmune etiology that can be determined in vitro using the basophil activation test (BAT). While 30% to...

journal_title：JAMA dermatology

authors： Netchiporouk E,Sasseville D,Moreau L,Habel Y,Rahme E,Ben-Shoshan M

更新日期：2017-12-01 00:00:00

abstract：Importance:Because moisturizer use is critical for the prevention and treatment of numerous dermatological conditions, patients frequently request product recommendations from dermatologists. Objective:To determine the product performance characteristics and ingredients of best-selling moisturizers. Design and Settin...

journal_title：JAMA dermatology

authors： Xu S,Kwa M,Lohman ME,Evers-Meltzer R,Silverberg JI

更新日期：2017-11-01 00:00:00

abstract：Importance:Pubic hair grooming is a common practice that can lead to injury and morbidity. Objective:To identify demographic and behavioral risk factors associated with pubic hair grooming-related injuries to characterize individuals with high risk of injury and develop recommendations for safe grooming practices. De...

journal_title：JAMA dermatology

authors： Truesdale MD,Osterberg EC,Gaither TW,Awad MA,Elmer-DeWitt MA,Sutcliffe S,Allen I,Breyer BN

更新日期：2017-11-01 00:00:00

abstract：Importance:Melanoma risk factors and incidence in renal transplant recipients can inform decision making for both patients and clinicians. Objective:To determine risk factors and characteristics of renal transplant recipients who develop melanoma. Design, Setting, and Participants:This cohort study of a large nationa...

journal_title：JAMA dermatology

authors： Ascha M,Ascha MS,Tanenbaum J,Bordeaux JS

更新日期：2017-11-01 00:00:00

abstract：Importance:Use of systemic therapies for moderate to severe psoriasis in children is increasing, but comparative data on their use and toxicities are limited. Objective:To assess patterns of use and relative risks of systemic agents for moderate to severe psoriasis in children. Design, Setting, and Participants:A ret...

journal_title：JAMA dermatology

authors： Bronckers IMGJ,Seyger MMB,West DP,Lara-Corrales I,Tollefson M,Tom WL,Hogeling M,Belazarian L,Zachariae C,Mahé E,Siegfried E,Philipp S,Szalai Z,Vleugels RA,Holland K,Murphy R,Baselga E,Cordoro K,Lambert J,Alexopoulos

更新日期：2017-11-01 00:00:00

abstract：Importance:Protective effects of UV-B radiation against nonmelanoma skin cancer (NMSC) are exerted via signaling mechanisms involving the vitamin D receptor (VDR). Recent studies have examined single-nucleotide polymorphisms (SNPs) in the VDR, resulting in contradictory findings as to whether these polymorphisms increa...

journal_title：JAMA dermatology

authors： Burns EM,Guroji P,Ahmad I,Nasr HM,Wang Y,Tamimi IA,Stiefel E,Abdelgawwad MS,Shaheen A,Muzaffar AF,Bush LM,Hurst CB,Griffin RL,Elmets CA,Yusuf N

更新日期：2017-10-01 00:00:00

abstract：Importance:Population-level disease metrics are critical to guide the distribution of resources and implementation of public health initiatives. Internet search data reflect population interest in health topics and may be an alternative metric of disease characteristics when traditional sources are lacking, such as in ...

journal_title：JAMA dermatology

authors： Wehner MR,Nead KT,Linos E

更新日期：2017-09-01 00:00:00

abstract：Importance:Atopic dermatitis (AD) and allergic contact dermatitis (ACD) have a dynamic relationship not yet fully understood. Investigation has been limited thus far by a paucity of data on the overlap of these disorders in pediatric patients. Objective:To use data from the Pediatric Contact Dermatitis Registry to elu...

journal_title：JAMA dermatology

authors： Jacob SE,McGowan M,Silverberg NB,Pelletier JL,Fonacier L,Mousdicas N,Powell D,Scheman A,Goldenberg A

更新日期：2017-08-01 00:00:00

abstract：Importance:The risk for skin cancer has been well characterized in white organ transplant recipients (OTRs); however, most patients on the waiting list for organ transplant in the United States are nonwhite. Little is known about cutaneous disease and skin cancer risk in this OTR population. Objective:To compare the i...

journal_title：JAMA dermatology

authors： Chung CL,Nadhan KS,Shaver CM,Ogrich LM,Abdelmalek M,Cusack CA,Malat GE,Pritchett EN,Doyle A

更新日期：2017-06-01 00:00:00