听力与言语-语言病理学

行为科学

医学伦理学

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  • Impact of capsaicin concentration evoking coughs on clinical variables in patients with asthma.

    abstract:BACKGROUND:Inhaled capsaicin (8-methyl-N-vanillyl-6-nonenamide) has been used to induce cough in a safe and dose-dependent manner. Chronic cough is associated with an increased sensitivity to inhaled capsaicin in patients with asthma. The aim of this study was to evaluate clinical impact of capsaicin provocation test f...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2020.1834016

    authors: Park KH,Kim BG,Lee PH,Hong J,Lee J,Park SW,Kim DJ,Jang AS

    更新日期:2021-02-01 00:00:00

  • Acute and chronic effects of intravitreal bevacizumab on lung biomarkers of angiogenesis in the rat exposed to neonatal intermittent hypoxia.

    abstract:PURPOSE/AIM:Intravitreal bevacizumab (Avastin) is an irreversible vascular endothelial growth factor (VEGF) inhibitor used to treat severe retinopathy of prematurity (ROP) in extremely low gestational age neonates (ELGANs). ELGANs who are at the highest risk for developing severe ROP often experience brief intermittent...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2020.1866712

    authors: Duggan TJ,Cai CL,Aranda JV,Beharry KD

    更新日期:2020-12-30 00:00:00

  • In vitro and ex vivo expression of serum amyloid A3 in mouse lung epithelia.

    abstract:BACKGROUND AND PURPOSE:Serum amyloid A (SAA), an acute-phase protein whose level tracks infection and inflammation, is the precursor protein of amyloid A (AA) fibrils that is thought to cause AA amyloidosis in human and animals. SAA protein has several isoforms based on the difference of amino acid sequence, such as SA...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2020.1809750

    authors: Kawasaki H,Murakami T,Badr Y,Kamiya S,Shimizu K,Okada A,Inoshima Y

    更新日期:2020-11-01 00:00:00

  • Thymoquinone ameliorates the PM2.5-induced lung injury in rats.

    abstract:BACKGROUND:This study aims to explore the effect of thymoquinone (TQ) on particulate matter 2.5 (PM2.5)-induced lung injury. METHODS:The PM2.5 sample was provided by Shenyang Environment Monitor Central Station. Lung injury was established by intratracheal instillation PM2.5 (7.5 mg/kg) followed by TQ treatment (20 an...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2020.1801895

    authors: Mao M,Li J,Bi A,Jia H,Li Q,Liu Y,Jiang X,Huang D,Xia S

    更新日期:2020-10-01 00:00:00

  • Blocking protein phosphatase 2A with a peptide protects mice against bleomycin-induced pulmonary fibrosis.

    abstract::Emerging data indicate that endothelial-mesenchymal transition (EndMT) is involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF). A previous study noted that blocking the activity of protein phosphatase 2 A (PP2A) could attenuate EndMT. However, the treatment effects of PP2A inhibitors in pulmonary fibros...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2020.1774823

    authors: Yu J,Deng Y,Han M

    更新日期:2020-09-01 00:00:00

  • 14-3-3β Is necessary in the regulation of polarization and directional migration of alveolar myofibroblasts by lipopolysaccharide.

    abstract::Aims:Bronchopulmonary dysplasia (BPD) is characterized by alveolarization arrest. During alveolarization, alveolar myofibroblasts are thought to migrate into the septal tips and elongate secondary septa. Lipopolysaccharide (LPS) exposure has been reported to disrupt directional migration and final location of alveolar...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2019.1711464

    authors: Li J,Gong X

    更新日期:2020-01-01 00:00:00

  • Alpha 1-antitrypsin for treating ventilator-associated lung injury in acute respiratory distress syndrome rats.

    abstract::Purpose: Mechanical ventilation (MV) is an essential life support tool for patients with acute respiratory distress syndrome (ARDS). However, MV for ARDS can result in ventilator-induced lung injury (VILI). This study aimed to assess whether alpha 1-antitrypsin (AAT) can reduce VILI in ARDS rats. Materials and Methods...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2019.1642968

    authors: Wang X,Gong J,Zhu J,Jin Z,Gao W

    更新日期:2019-09-01 00:00:00

  • Schisandrin B inhibits TGF-β1-induced epithelial-mesenchymal transition in human A549 cells through epigenetic silencing of ZEB1.

    abstract::Purpose/Aim: More and more evidences suggest that airway remodeling of fibrotic lung diseases may be associated with epithelial-mesenchymal transition (EMT) of human A549 cells induced by transforming growth factor (TGF)-β1. Schisandrin B (Sch B) is the highest content of dibenzocyclooctadiene lignans in Schisandra ch...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2019.1631906

    authors: Zhuang W,Li Z,Dong X,Zhao N,Liu Y,Wang C,Chen J

    更新日期:2019-01-01 00:00:00

  • Biphasic changes in airway epithelial cell EGF receptor binding and phosphorylation induced by components of hogbarn dust.

    abstract:PURPOSE OF THE STUDY:Workers in enclosed hogbarns experience an increased incidence of airway inflammation and obstructive lung disease, and an aqueous hogbarn dust extract (HDE) induces multiple inflammation-related responses in cultured airway epithelial cells. Epidermal growth factor receptor (EGFR) phosphorylation ...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2019.1575931

    authors: Dodmane PR,Schulte NA,Heires AJ,Band H,Romberger DJ,Toews ML

    更新日期:2018-12-01 00:00:00

  • HMGB1 signaling blocking protects against carbapenem-resistant klebsiella pneumoniae in a murine model of infection.

    abstract:PURPOSE OF THE STUDY:Pulmonary infection with Klebsiella pneumoniae (KP) and carbapenem-resistant Klebsiella pneumoniae (CRKP) significantly contribute to morbidity and mortality in pneumonia. Recent studies have indicated that High-Mobility Group Box 1 Protein (HMGB1) plays an important role in the prevention and trea...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2018.1505976

    authors: Liming S,Guixia L,Wenxin S,Guirong T

    更新日期:2018-08-01 00:00:00

  • Regulation of eosinophil recruitment and allergic airway inflammation by heparan sulfate proteoglycan (HSPG) modifying enzymes.

    abstract:BACKGROUND:HSPGs are glycoproteins containing covalently attached heparan sulfate (HS) chains which bind to growth factors, chemokines, etc., and regulate various aspects of inflammation including cell recruitment. We previously showed that deletion of endothelial N-acetylglucosamine N-deacetylase-N-sulfotransferase-1 ...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2018.1451574

    authors: Ge XN,Bastan I,Ha SG,Greenberg YG,Esko JD,Rao SP,Sriramarao P

    更新日期:2018-03-01 00:00:00

  • Delivery of nucleic acids to ex vivo porcine airways using electrospray.

    abstract:AIM OF THE STUDY:Nucleic acid-based therapies have the potential to provide clinically meaningful benefit across a wide spectrum of lung disease. However, in vivo delivery remains a challenge. Here we examined the feasibility of using electrospray to deliver nucleic acids to both porcine tracheal tissue sections and wh...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2018.1563924

    authors: Riddell P,Gilbert JL,Molloy EL,Finnegan S,Egan JJ,O'Dea S

    更新日期:2018-01-01 00:00:00

  • The effect of captopril on lipopolysaccharide-induced lung inflammation.

    abstract:PURPOSE:As an angiotensin converting enzyme (ACE) inhibitor, the effects of captopril on inflammation has been previously examined. Captopril has been shown to have anti-inflammatory and antioxidant effects. Imbalance in the oxidant/antioxidant system is one of the major causes of inflammation. In the present study, th...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2018.1473530

    authors: Boskabadi J,Mokhtari-Zaer A,Abareshi A,Khazdair MR,Emami B,Mohammadian Roshan N,Hosseini M,Boskabady MH

    更新日期:2018-01-01 00:00:00

  • The effects of hydrogen peroxide and lipopolysaccharide on rat alveolar L2 cells.

    abstract:PURPOSE:This study aimed to investigate differential cell responses of alveolar epithelial cells (AECs) after treatments with lipopolysaccharide (LPS) and hydrogen peroxide (H2O2) to mimic the exposure to inflammation and oxidative stress and the mechanisms of a double-hit model of apoptosis. MATERIALS AND METHODS:AEC...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2017.1368738

    authors: Kang EK,Kim HS

    更新日期:2017-10-01 00:00:00

  • Radiation induced pulmonary fibrosis as a model of progressive fibrosis: Contributions of DNA damage, inflammatory response and cellular senescence genes.

    abstract::Purpose/Aim of Study: Studies of pulmonary fibrosis (PF) have resulted in DNA damage, inflammatory response, and cellular senescence being widely hypothesized to play a role in the progression of the disease. Utilizing these aforementioned terms, genomics databases were interrogated along with the term, "pulmonary fib...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2017.1318975

    authors: Beach TA,Johnston CJ,Groves AM,Williams JP,Finkelstein JN

    更新日期:2017-04-01 00:00:00

  • Characteristic plethysmographic findings in a guinea pig model of COPD.

    abstract:AIM OF THE STUDY:Long-term exposure to cigarette smoke generates chronic obstructive pulmonary disease (COPD) in guinea pigs, but a comprehensive evaluation of changes in lung function, as assessed by barometric whole body plethysmography (WBP), is lacking. MATERIALS AND METHODS:Female guinea pigs were exposed to the ...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2017.1294632

    authors: Ramírez-Ramírez E,Torres-Ramírez A,Alquicira-Mireles J,Cañavera-Constantino A,Segura-Medina P,Montaño-Ramírez M,Ramos-Abraham C,Vargas MH,Arreola-Ramírez JL

    更新日期:2017-03-01 00:00:00

  • Exposure to cigarette smoke extract and lipopolysaccharide modifies cytoskeleton organization in bronchial epithelial cells.

    abstract::The integrity of the respiratory epithelium is crucial for airway homeostasis. Tobacco smoke exposure and recurrent infections of the airways play a crucial role in the progression and in the decline of the respiratory function in chronic obstructive pulmonary disease (COPD). The aim of this study was to detect differ...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2017.1377784

    authors: D'Anna C,Cigna D,Di Sano C,Di Vincenzo S,Dino P,Ferraro M,Bini L,Bianchi L,Di Gaudio F,Gjomarkaj M,Pace E

    更新日期:2017-01-01 00:00:00

  • Effect of nintedanib on airway inflammation and remodeling in a murine chronic asthma model.

    abstract:INTRODUCTION:Nintedanib is a multi-tyrosine kinase receptor inhibitor recently approved for treatment of idiopathic pulmonary fibrosis. Although angiogenesis is a key process involved in airway structural changes in patients with bronchial asthma, the effect of nintedanib targeting the angiokinase pathway on airway inf...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2017.1339141

    authors: Lee HY,Hur J,Kim IK,Kang JY,Yoon HK,Lee SY,Kwon SS,Kim YK,Rhee CK

    更新日期:2017-01-01 00:00:00

  • Alteration of TGF-β-ALK-Smad signaling in hyperoxia-induced bronchopulmonary dysplasia model of newborn rats.

    abstract:BACKGROUND:Bronchopulmonary dysplasia (BPD) is a main chronic lung disease commonly occurs in preterm infants. BPD is characterized by impaired alveolarization and vascularization of the developing lung. Transforming growth factor-β (TGF-β) signaling pathway is known to play an important role during lung vascular devel...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2016.1226448

    authors: Jin M,Lee J,Lee KY,Jin Z,Pak JH,Kim HS

    更新日期:2016-09-01 00:00:00

  • Effect of tranilast in comparison with beclomethasone in chronic murine model of asthma.

    abstract:AIM OF THE STUDY:The current investigation was taken to scrutinize the action of tranilast on the airway remodeling in chronic asthma in mice. MATERIALS AND METHODS:Intraperitoneal injection of ovalbumin was applied to mice for sensitization and subsequent inhalation of 1% ovalbumin three times week for 10 weeks for c...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2016.1207727

    authors: Nader MA,Gameil N,Abdelaziz RR,Zalata KR,Osman A,Zedan MM,Abo-Elkheir N,Elsiddig AA,Zedan M

    更新日期:2016-08-01 00:00:00

  • Erythropoietin may attenuate lung inflammation in a rat model of meconium aspiration syndrome.

    abstract:BACKGROUND:Inflammation is believed to play a key role in the pathophysiology of meconium aspiration syndrome (MAS). PURPOSE OF THE STUDY:The objective was to determine whether the recombinant human Erythropoietin (rhEPO) pretreatment could attenuate meconium-induced inflammation. MATERIALS AND METHODS:In this study,...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.1080/01902148.2016.1190424

    authors: Turhan AH,Atici A,Muşlu N,Polat A,Sungur MA

    更新日期:2016-05-01 00:00:00

  • N-acetylcysteine and azithromycin affect the innate immune response in cystic fibrosis bronchial epithelial cells in vitro.

    abstract:BACKGROUND AND OBJECTIVE:We have previously reported that N-acetylcysteine (NAC), ambroxol and azithromycin (AZM) (partially) correct the chloride efflux dysfunction in cystic fibrosis bronchial epithelial (CFBE) cells with the ΔF508 homozygous mutation in vitro. METHODS:In the present paper, we further investigated p...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.3109/01902148.2014.934411

    authors: Hussain S,Varelogianni G,Särndahl E,Roomans GM

    更新日期:2015-06-01 00:00:00

  • Neuron-derived orphan receptor 1 promoted human pulmonary artery smooth muscle cells proliferation.

    abstract:AIMS:As a transcription factor of the nuclear receptor superfamily, neuron-derived orphan receptor 1 (NOR1) is induced rapidly in response to various extracellular stimuli. But, it is still unclear its role in pulmonary artery smooth muscle cells proliferation. MATERIALS AND METHODS:Human PASMCs were cultured in vitro...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.3109/01902148.2014.993776

    authors: Wang CG,Lei W,Li C,Zeng DX,Huang JA

    更新日期:2015-05-01 00:00:00

  • Interleukin-10 modulates pulmonary neutrophilic inflammation induced by cigarette smoke exposure.

    abstract:AIM OF THE STUDY:Interleukin (IL)-10 is an anti-inflammatory cytokine, but its role in cigarette smoke (CS)-induced inflammation and chronic obstructive pulmonary disease (COPD) has not been fully elucidated. The purpose of this study was to investigate the effect of IL-10 deficiency on CS-induced pulmonary inflammatio...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.3109/01902148.2015.1096315

    authors: Higaki M,Wada H,Mikura S,Yasutake T,Nakamura M,Niikura M,Kobayashi F,Kamma H,Kamiya S,Ito K,Barnes PJ,Goto H,Takizawa H

    更新日期:2015-01-01 00:00:00

  • Effects of different concentrations of isoflurane pretreatment on respiratory mechanics, oxygenation and hemodynamics in LPS-induced acute respiratory distress syndrome model of juvenile piglets.

    abstract:PURPOSE:This study was prospectively designed to investigate the effects of different concentrations of isoflurane (ISO) pretreatment on respiratory mechanics, oxygenation, and hemodynamics in lipopolysaccharide (LPS)-induced acute respiratory distress syndrome (ARDS) model of juvenile piglets. METHODS:Twenty-four pig...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.3109/01902148.2015.1054530

    authors: Fu H,Sun M,Miao C

    更新日期:2015-01-01 00:00:00

  • PPAR-α activation reduced LPS-induced inflammation in alveolar epithelial cells.

    abstract:PURPOSE OF THE STUDY:Acute respiratory distress syndrome (ARDS) represents a major cause of mortality in intensive care patients. Activation of peroxisome proliferator-activated receptor-α (PPAR-α) by fibrates, such as WY-14643 (WY), has been described to beneficially influence inflammation and experimental lung injury...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.3109/01902148.2015.1046200

    authors: Hecker M,Behnk A,Morty RE,Sommer N,Vadász I,Herold S,Seeger W,Mayer K

    更新日期:2015-01-01 00:00:00

  • Mechanical stretch induces lung α-epithelial Na(+) channel expression.

    abstract::ABSTRACT During fetal development physiological stretching helps drive lung growth and maturation. At birth, the α-subunit of the alveolar epithelial sodium channel (α-ENaC) is a critical factor in helping to facilitate clearance of lung fluid during the perinatal period. The effects of stretch, however, on α-ENaC exp...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.3109/01902148.2014.934410

    authors: Mustafa SB,Isaac J,Seidner SR,Dixon PS,Henson BM,DiGeronimo RJ

    更新日期:2014-10-01 00:00:00

  • Regulation of silicosis formation by lysophosphatidic acid and its receptors.

    abstract::Silicosis is a serious occupational disease characterized by lung fibrosis that is caused by long-term inhalation of silica-containing fine particles. Lysophosphatidic acid (LPA) and LPA1/3 plays a role in lung fibrosis. Until recently, there has been little research investigating the role of LPA and LPA receptors (LP...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.3109/01902148.2014.920438

    authors: Cong C,Mao L,Zhang Y,Zhao Z,Xu X,Zhao J

    更新日期:2014-09-01 00:00:00

  • Combined effects of sivelestat and resveratrol on severe acute pancreatitis-associated lung injury in rats.

    abstract::Despite extensive research and clinical efforts made in the management of acute pancre-atitis during the past few decades, to date no effective cure is available and the mortality from severe acute pancre-atitis remains high. Given that lung is the primary cause of early death in acute pancreatitis patients, novel the...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.3109/01902148.2014.908249

    authors: Wang H,Wang S,Tang A,Gong H,Ma P,Chen L

    更新日期:2014-08-01 00:00:00

  • A new adaptive controller for volume-controlled mechanical ventilation in small animals.

    abstract:BACKGROUND:This study aimed to develop and evaluate an adaptive control system for volume-controlled ventilation (VCV) in small animals to guarantee accurate delivery of tidal volume (VT) in the presence of changes in lung mechanics. METHODS:The adaptive control system to control the Harvard Inspira ventilator was des...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.3109/01902148.2014.900156

    authors: Huhle R,Spieth PM,Güldner A,Koch T,de Abreu MG

    更新日期:2014-04-01 00:00:00

  • The inhibitory effect of salvianolic acid B on TGF-β1-induced proliferation and differentiation in lung fibroblasts.

    abstract::Salvianolic acid B (Sal B), one of the major water-soluble compounds of Danshen (a popular Chinese herb), possesses many of the biological activities, such as antifibrogenic effect in liver and renal diseases. Transforming growth factor-β1 (TGF-β1) plays a central role in the development of pulmonary fibrosis by stimu...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.3109/01902148.2014.895070

    authors: Zhang M,Cao SR,Zhang R,Jin JL,Zhu YF

    更新日期:2014-04-01 00:00:00

  • Lung response after subchronic glass fiber intratracheal instillation: an experimental study on rats.

    abstract::The aim of the study was to identify the effects on the lung after subchronic glass fiber intratracheal instillation study on rats. We evaluated the toxicological effects on the lung: persistent inflammatory reaction, cell proliferation, and pulmonary fibrosis on histopathological examination. We performed a glass fib...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.3109/01902148.2013.860568

    authors: Domokos-Hancu B,Man MA,Liana H,Pop CM

    更新日期:2014-03-01 00:00:00

  • Effect of invariant natural killer T cells with IL-5 and activated IL-6 receptor in ventilator-associated lung injury in mice.

    abstract::Mechanical ventilation (MV) is well known to potentially cause ventilator-associated lung injury (VALI). It has also been reported recently that activation of invariant natural killer T (iNKT) cells is involved in the onset/progression of airway inflammation. We analyzed the roles of inflammatory cells, including iNKT...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.3109/01902148.2013.854518

    authors: Shiga Y,Sugamata R,Iwamura C,Nagao T,Zao J,Kawakami K,Kawachi S,Nakayama T,Suzuki K

    更新日期:2014-02-01 00:00:00

  • Temporal determination of lung NO system and COX-2 upregulation following ischemia-reperfusion injury.

    abstract:BACKGROUND:Pulmonary ischemia-reperfusion (IR) is a biopathological event detectable in several clinical conditions, including lung transplantation, cardiopulmonary bypass, resuscitation, and pulmonary embolism. The understanding behind the activation of various inflammatory mediators regulating the apoptotic pathways ...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.3109/01902148.2013.858196

    authors: Dolkart O,E A,S S,S M,P G,Aa W

    更新日期:2014-02-01 00:00:00

  • Differential expression and activation of epidermal growth factor receptor 1 (EGFR1), ERK, AKT, STAT3, and TWIST1 in nonsmall cell lung cancer (NSCLC).

    abstract::Lung cancer is the leading cause of death of both men and women across the world. Overexpression and activating mutations of the epidermal growth factor receptor-1 (EGFR1) are frequently observed and associated with poor prognosis. To inhibit the function of EGFR1, multiple antibodies and small-molecule tyrosine kinas...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.3109/01902148.2013.831960

    authors: Gorgisen G,Ozes D,Pehlivanoglu S,Erdogan A,Dertsiz L,Ozbilim G,Ozbudak IH,Savas B,Ozes ON

    更新日期:2013-11-01 00:00:00

  • Thrombin induces epithelial-mesenchymal transition via PAR-1, PKC, and ERK1/2 pathways in A549 cells.

    abstract::Thrombin activates protease-activated receptor (PAR)-1 and induces a myofibroblast phenotype in normal lung fibroblasts. The origins of myofibroblasts are resident fibroblasts, fibrocytes, and epithelial-mesenchymal transition (EMT). We investigated the effects of thrombin, an important mediator of interstitial lung f...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.3109/01902148.2013.820809

    authors: Song JS,Kang CM,Park CK,Yoon HK

    更新日期:2013-10-01 00:00:00

  • Mesenchymal stem cell therapy in lung disorders: pathogenesis of lung diseases and mechanism of action of mesenchymal stem cell.

    abstract::Lung disorders such as asthma, acute respiratory distress syndrome (ARDS), chronic obstructive lung disease (COPD), and interstitial lung disease (ILD) show a few common threads of pathogenic mechanisms: inflammation, aberrant immune activity, infection, and fibrosis. Currently no modes of effective treatment are avai...

    journal_title:Experimental lung research

    pub_type: 杂志文章,评审

    doi:10.3109/01902148.2013.816803

    authors: Inamdar AC,Inamdar AA

    更新日期:2013-10-01 00:00:00

  • Two single nucleotide polymorphisms in TSLP gene are associated with asthma susceptibility in Chinese Han population.

    abstract:BACKGROUND:Asthma is a chronic inflammatory disease of the airway that is mediated by T-helper 2(TH2) cells. Thymic stromal lymphopoietin (TSLP) can aggravate asthmatic lung inflammation by activating dendritic cells (DCs) to promote TH2 differentiation. TSLP promoter polymorphisms are associated with susceptibility to...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.3109/01902148.2012.714840

    authors: Liu W,Xu LS,Liu QJ,Dong FZ,Qiu RF,Wen MC,Han YL,Tang NB,Kang LJ,Wu JX,Liu F,Zhao JP,Yang MM,Wang JF,Ding MJ,Sun YM,Fei WJ,Dong L

    更新日期:2012-10-01 00:00:00

  • Lung remodeling in a porcine model of cyanotic congenital heart defect with decreased pulmonary blood flow.

    abstract:BACKGROUND:Hypoperfusion of the pulmonary vascular bed under the condition of congenital cardiac malformations may lead to progressive pulmonary vascular disease. To improve the mechanistic understanding of this disease, we examined the biochemical and morphological changes of the lung in a relevant animal model and pr...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.3109/01902148.2012.708385

    authors: Xu Y,Liu Y,Li Z,Su J,Li G,Sun L

    更新日期:2012-09-01 00:00:00

  • Stress amplifies lung tissue mechanics, inflammation and oxidative stress induced by chronic inflammation.

    abstract:BACKGROUND:Mechanisms linking behavioral stress and inflammation are poorly understood, mainly in distal lung tissue. OBJECTIVE:We have investigated whether the forced swim stress (FS) could modulate lung tissue mechanics, iNOS, cytokines, oxidative stress activation, eosinophilic recruitment, and remodeling in guinea...

    journal_title:Experimental lung research

    pub_type: 杂志文章

    doi:10.3109/01902148.2012.704484

    authors: Reis FG,Marques RH,Starling CM,Almeida-Reis R,Vieira RP,Cabido CT,Silva LF,Lanças T,Dolhnikoff M,Martins MA,Leick-Maldonado EA,Prado CM,Tibério IF

    更新日期:2012-09-01 00:00:00

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