听力与言语-语言病理学

行为科学

医学伦理学

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  • Effects of novel 17β-hydroxysteroid dehydrogenase type 10 inhibitors on mitochondrial respiration.

    abstract::Mitochondrial enzymes are targets of newly synthesized drugs being tested for the treatment of neurodegenerative disorders, such as Alzheimer's disease (AD). The enzyme 17β-hydroxysteroid dehydrogenase type 10 (HSD10) is a multifunctional mitochondrial protein that is thought to play a role in the pathophysiology of A...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.12.012

    authors: Fišar Z,Musílek K,Benek O,Hroch L,Vinklářová L,Schmidt M,Hroudová J,Raboch J

    更新日期:2021-03-15 00:00:00

  • A direct peptide reactivity assay using a high-throughput mass spectrometry screening platform for detection of skin sensitizers.

    abstract::Chemical-peptide conjugation is the molecular initiating event in skin sensitization. The OECD test guideline uses a high-performance liquid chromatography/ultraviolet (HPLC/UV) detection method to quantify chemical-peptide conjugation in a direct peptide reactivity assay (DPRA), which measures the depletion of two sy...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.12.002

    authors: Wei Z,Fang Y,Gosztyla ML,Li AJ,Huang W,LeClair CA,Simeonov A,Tao D,Xia M

    更新日期:2021-03-01 00:00:00

  • Estragole DNA adduct accumulation in human liver HepaRG cells upon repeated in vitro exposure.

    abstract::Accumulation of N2-(trans-isoestragol-3'-yl)-2'-deoxyguanosine (E-3'-N2-dG) DNA adducts derived from the alkenylbenzene estragole upon repeated dose exposure was investigated since the repair of this adduct was previously shown to be inefficient. To this end human HepaRG cells were exposed to repeating cycles of 2 h e...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.11.009

    authors: Yang S,Wesseling S,Rietjens IMCM

    更新日期:2021-02-01 00:00:00

  • JUUL e-liquid exposure elicits cytoplasmic Ca2+ responses and leads to cytotoxicity in cultured airway epithelial cells.

    abstract:RATIONALE:The popularity of new and emerging tobacco products such as E-cigarettes (E-cigs) is rapidly expanding worldwide. However, uncertainties surrounding the potential health consequences due to the use of such products exist and warrant further study. METHODS:Cultured A549 and Calu-3 airway epithelia were expose...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.11.017

    authors: Zhang R,Jones MM,Dornsife RE,Wu T,Sivaraman V,Tarran R,Onyenwoke RU

    更新日期:2021-02-01 00:00:00

  • The neuroprotective effect of oxytocin on vincristine-induced neurotoxicity in mice.

    abstract::Vincristine (VCR) is commonly used to treat a variety of hematological malignancies and solid tumors in pediatric and adult patients. However, peripheral neuropathy is a dose-limiting side effect that leaves some patients with functional disability and long-term pain. Oxytocin (OT) has demonstrated analgesic and anti-...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2021.01.008

    authors: Zhu J,Li Y,Liang J,Li J,Huang K,Li J,Liu C

    更新日期:2021-01-08 00:00:00

  • Glutathione is a potential therapeutic target for acrolein toxicity in the cornea.

    abstract::Toxic and volatile chemicals are widely used in household products and previously used as warfare agents, causing a public health threat worldwide. This study aimed to evaluate the extent of injury and mechanisms of acrolein toxicity in the cornea. Primary human corneal stromal fibroblasts cultures (hCSFs) from human ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2021.01.005

    authors: Gupta S,Kamil S,Sinha PR,Rodier JT,Chaurasia SS,Mohan RR

    更新日期:2021-01-06 00:00:00

  • Low doses of individual and combined deoxynivalenol and zearalenone in naturally moldy diets impair intestinal functions via inducing inflammation and disrupting epithelial barrier in the intestine of piglets.

    abstract::The intestinal epithelium is the first barrier against food contaminants and is highly sensitive to Fusarium toxins, especially deoxynivalenol (DON) and zearalenone (ZEA). Here, we explored the effects of low doses of DON and/or ZEA in naturally moldy diets on intestinal functions in piglets, including inflammatory re...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.07.032

    authors: Jia R,Liu W,Zhao L,Cao L,Shen Z

    更新日期:2020-10-15 00:00:00

  • Urinary metabolites of furan in waterpipe tobacco smokers compared to non-smokers in home settings in the US.

    abstract:OBJECTIVES:Determine uptake of furan, a potential human carcinogen, in waterpipe tobacco (WPT) smokers in home settings. METHODS:We analysed data from a US convenience sample of 50 exclusive WPT smokers, mean age 25.3 years, and 25 non-smokers, mean age 25.5 years. For WPT smokers, data were collected at a home visit ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.08.002

    authors: Kassem NOF,Peterson LA,Liles S,Kassem NO,Zaki FK,Lui KJ,Vevang KR,Dodder NG,Hoh E,Hovell MF

    更新日期:2020-10-15 00:00:00

  • Differential coagulotoxicity of metalloprotease isoforms from Bothrops neuwiedi snake venom and consequent variations in antivenom efficacy.

    abstract::Bothrops (lance-head pit vipers) venoms are rich in weaponised metalloprotease enzymes (SVMP). These toxic enzymes are structurally diverse and functionally versatile. Potent coagulotoxicity is particularly important for prey capture (via stroke-induction) and relevant to human clinical cases (due to consumption of cl...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.08.009

    authors: Sousa LF,Bernardoni JL,Zdenek CN,Dobson J,Coimbra F,Gillett A,Lopes-Ferreira M,Moura-da-Silva AM,Fry BG

    更新日期:2020-10-15 00:00:00

  • Autophagy mediates bronchial cell malignant transformation induced by chronic arsenic exposure via MEK/ERK1/2 pathway.

    abstract::Chronic exposure to arsenic increases the risk of developing a variety of human cancers including lung carcinomas. However, the exact molecular mechanism underlying arsenic carcinogenicity remains largely unknown. Autophagy is a conserved catabolic process for maintaining cellular protein homeostasis whose defects mig...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.06.006

    authors: Wu L,Wang Z,Li X,He X,Han Y,Chen Y,Liu L,Fu L,Zhang T

    更新日期:2020-10-10 00:00:00

  • Dechlorination and demethylation of ochratoxin A enhance blocking activity of PXR activation, suppress PXR expression and reduce cytotoxicity.

    abstract::The pregnane X receptor (PXR) has been established to induce chemoresistance and metabolic diseases. Ochratoxin A (OTA), a mycotoxin, decreases the expression of PXR protein in human primary hepatocytes. OTA is chlorinated and has a methylated lactone ring. Both structures are associated with OTA toxicity. The study w...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.07.012

    authors: Shen Y,Shi Z,Fan JT,Yan B

    更新日期:2020-10-10 00:00:00

  • Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat.

    abstract::The relative toxicity of three legacy and six emerging brominated flame retardants* was studied in the male Harlan Sprague Dawley rat. The hepatocellular and thyroid toxicity of each flame retardant was evaluated following five-day exposure to each of the nine flame retardants (oral gavage in corn oil) at 0.1-1000 μmo...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.07.016

    authors: Shockley KR,Cora MC,Malarkey DE,Jackson-Humbles D,Vallant M,Collins BJ,Mutlu E,Robinson VG,Waidyanatha S,Zmarowski A,Machesky N,Richey J,Harbo S,Cheng E,Patton K,Sparrow B,Dunnick JK

    更新日期:2020-10-10 00:00:00

  • Pubertal fenvalerate exposure impairs cognitive and behavioral development partially through down-regulating hippocampal thyroid hormone receptor signaling.

    abstract::Fenvalerate, a synthetic pyrethroid insecticide, is an environmental endocrine disruptor and neurodevelopmental toxicant. An early report found that pubertal exposure to high-dose fenvalerate impaired cognitive and behavioral development. Here, we aimed to further investigate the effect of pubertal exposure to low-dos...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.07.020

    authors: Yang Y,Zhan F,Wang YC,Wang B,Shi MX,Guo C,Xu DX,Meng XH

    更新日期:2020-10-10 00:00:00

  • DNA reactivity of altertoxin II: Identification of two covalent guanine adducts formed under cell-free conditions.

    abstract::Fungi of the genus Alternaria infest many agricultural crops and produce numerous mycotoxins, of which altertoxin II (ATX II) is one of the most mutagenic metabolites. ATX II carries an epoxide group but the formation of DNA adducts has not been demonstrated to date. We report now that ATX II gives rise to two covalen...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.05.018

    authors: Soukup ST,Fleck SC,Pfeiffer E,Podlech J,Kulling SE,Metzler M

    更新日期:2020-10-01 00:00:00

  • Glycochenodeoxycholic acid impairs transcription factor E3 -dependent autophagy-lysosome machinery by disrupting reactive oxygen species homeostasis in L02 cells.

    abstract::Cholestasis represents pathophysiologic syndromes defined as impaired bile flow from the liver. As an outcome, bile acids accumulate and promote hepatocyte injury, followed by liver cirrhosis and liver failure. Glycochenodeoxycholic acid (GCDCA) is relatively toxic and highly concentrated in bile and serum after chole...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.05.017

    authors: Lan W,Chen Z,Chen Y,Tan M,Chen Y,Chen J,Chi X,Chen Y

    更新日期:2020-10-01 00:00:00

  • Ambient PM2.5 chronic exposure leads to cognitive decline in mice: From pulmonary to neuronal inflammation.

    abstract::Fine particulate matter 2.5 (PM2.5), one of the main components of air pollutants, seriously threatens human health. Possible neuronal dysfunction induced by PM2.5 has received extensive attention. However, there is little evidence for the specific biochemical mechanism of neuronal injury induced by PM2.5. Moreover, t...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.06.014

    authors: Shou Y,Zhu X,Zhu D,Yin H,Shi Y,Chen M,Lu L,Qian Q,Zhao D,Hu Y,Wang H

    更新日期:2020-10-01 00:00:00

  • Urinary biomonitoring of subjects with different smoking habits. Part II: an untargeted metabolomic approach and the comparison with the targeted measurement of mercapturic acids.

    abstract:BACKGROUND:Although thousands of different chemicals have been identified in cigarette smoke, the characterization of their urinary metabolites still requires significant research. The aim of this work was to perform an untargeted metabolomic approach to a pilot cross-sectional study conducted on subjects with differen...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.03.020

    authors: Frigerio G,Mercadante R,Campo L,Polledri E,Boniardi L,Olgiati L,Missineo P,Nash WJ,Dunn WB,Fustinoni S

    更新日期:2020-09-01 00:00:00

  • Preclinical safety profile of disitamab vedotin:a novel anti-HER2 antibody conjugated with MMAE.

    abstract::The HER2 pathway plays a pivotal role in cell proliferation and differentiation, while the receptor overexpression caused by amplification of HER2 gene is associated with the growth of several tumors. Previously published clinical trials have demonstrated that antibody-conjugated drugs (ADCs) remarkably improved clini...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.12.027

    authors: Jiang J,Li S,Shan X,Wang L,Ma J,Huang M,Dong L,Chen F

    更新日期:2020-05-15 00:00:00

  • Metal environmental contamination within different human exposure context- specific and non-specific biomarkers.

    abstract::Exposure to high levels of persistent pollutants, such as metal mixtures, is commonly encountered by the general population especially in industrialized countries. The aim of this work was to evaluate how metal pollution in contaminated areas is reflected in terms of biomarkers (BMs) of exposure and effect in human su...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.12.022

    authors: de Andrade VL,Cota M,Serrazina D,Mateus ML,Aschner M,Dos Santos APM

    更新日期:2020-05-15 00:00:00

  • Endoplasmic reticulum stress, an important factor in the development of Parkinson's disease.

    abstract::Similar to other types of neuronal degeneration, Parkinson's disease (PD) is characterized by the aggregation of a pathological protein, α-synuclein. The endoplasmic reticulum (ER) is the principal site of protein synthesis, quality control and degradation. Genetic mutants, environmental insults and other factors dist...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.toxlet.2020.01.019

    authors: Mou Z,Yuan YH,Zhang Z,Song LK,Chen NH

    更新日期:2020-05-15 00:00:00

  • α-asarone induces cardiac defects and QT prolongation through mitochondrial apoptosis pathway in zebrafish.

    abstract::α-asarone is a natural phenylpropene found in several plants, which are widely used for flavoring foods and treating diseases. Previous studies have demonstrated that α-asarone has many pharmacological functions, while some reports indicated its toxicity. However, little is known about its cardiovascular effects. This...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.02.003

    authors: Shang X,Ji X,Dang J,Wang L,Sun C,Liu K,Sik A,Jin M

    更新日期:2020-05-15 00:00:00

  • Dried blood microsamples: Suitable as an alternative matrix for the quantification of paracetamol-protein adducts?

    abstract::Paracetamol (acetaminophen, APAP) is the most frequently used analgesic drug worldwide. However, patients in several specific populations can have an increased exposure to toxic APAP metabolites. Therefore, APAP-protein adducts have been proposed as an alternative marker for the assessment of APAP intoxications and as...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.02.001

    authors: Delahaye L,Dhont E,De Cock P,De Paepe P,Stove CP

    更新日期:2020-05-15 00:00:00

  • Classification, hepatotoxic mechanisms, and targets of the risk ingredients in traditional Chinese medicine-induced liver injury.

    abstract::Traditional Chinese medicine (TCM) has become a crucial cause of drug-induced liver injury (DILI). Differ from chemical medicines, TCM feature more complex and mostly indefinite components. This review aimed to clarify the classification, underlying mechanisms and targets of the risk components in TCM-induced liver in...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.toxlet.2020.01.026

    authors: Pan X,Zhou J,Chen Y,Xie X,Rao C,Liang J,Zhang Y,Peng C

    更新日期:2020-05-01 00:00:00

  • Reactive oxygen species production by BP-1,6-quinone and its effects on the endothelial dysfunction: Involvement of the mitochondria.

    abstract::Strong epidemiological evidence supports the association between increased air pollution and the risk of developing atherosclerotic cardiovascular diseases (CVDs). However, the mechanism remains unclear. As an environmental air pollutant and benzo-a-pyrene (BP) metabolite, BP-1,6-quinone (BP-1,6-Q) is present in the p...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.01.011

    authors: Shukla H,Chitrakar R,Bibi HA,Gaje G,Koucheki A,Trush MA,Zhu H,Li YR,Jia Z

    更新日期:2020-04-01 00:00:00

  • Protein adduct binding properties of tabun-subtype nerve agents after exposure in vitro and in vivo.

    abstract::Upon entering the body, nerve agents can bind active amino acid residues to form phosphonylated adducts. Tabun derivatives (O-alkyl-N,N-dialkyl phosphoroamidocyanidates) have strikingly different structural features from other G-series nerve agents, such as sarin and soman. Here, we investigate the binding mechanism f...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.12.014

    authors: Fu F,Liu H,Gao R,Zhao P,Lu X,Zhang R,Wang L,Wang H,Pei C

    更新日期:2020-03-15 00:00:00

  • Comparison of the toxic mechanism of T-2 toxin and deoxynivalenol on human chondrocytes by microarray and bioinformatics analysis.

    abstract::T-2 toxin and deoxynivalenol (DON) are two representative mycotoxins that are commonly found in cereals and agricultural products. As T-2 toxin and DON are considered the cause of Kashin-Beck disease, a special osteoarticular disease, chondrocytes would be a vital target site for these toxins. To fully understand the ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.12.024

    authors: Yang L,Wang S,Zhao G,Wang X,Guo X

    更新日期:2020-03-15 00:00:00

  • Encapsulation of oxime K027 into cucurbit[7]uril: In vivo evaluation of safety, absorption, brain distribution and reactivation effectiveness.

    abstract::Oxime-based acetylcholinesterase reactivators (briefly oximes) regenerate organophosphate-inactivated acetylcholinesterase and restore its function. Poor blood-brain-barrier passage and fast elimination from blood limit their actual use in treatment of patients exposed to organophosphates. Previous in vitro results im...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.11.021

    authors: Zdarova Karasova J,Hepnarova V,Andrys R,Lisa M,Jost P,Muckova L,Pejchal J,Herman D,Jun D,Kassa J,Kuca K

    更新日期:2020-03-01 00:00:00

  • Screening of chiral shift reagents suitable to generically separate the enantiomers of V-agents by 31P-NMR spectroscopy.

    abstract::Fourteen amino acids protected at the N-terminal and at their side chains were screened for resolving the enantiomers of V-agents by NMR. While none of the shift reagents tested showed really effective separation in proton NMR, two of them (BOC-Gln(Xan)-OH, 16, and Z-Arg(Z)2-OH), 21, with 16 superior to 21) were found...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.12.004

    authors: Koller M,Thiermann H,Worek F

    更新日期:2020-03-01 00:00:00

  • Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis.

    abstract::Transcription factor activator protein (AP)-1 can be activated in nitrogen-mustard-injured mouse skin, and is thought to participate in the inflammatory response. AP-1 consists of homo- or heterodimers of Fos [c-Fos, Fos-B, fos-related antigen (Fra)-1 and Fra-2] and Jun (c-Jun, JunB and JunD) family members, and infor...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.10.006

    authors: Ye F,Zeng Q,Dan G,Dong X,Chen M,Sai Y,Lin H,Zou Z

    更新日期:2020-02-01 00:00:00

  • Generic physiologically based kinetic modelling for farm animals: Part I. Data collection of physiological parameters in swine, cattle and sheep.

    abstract::Physiologically based kinetic (PBK) models for farm animals are of growing interest in food and feed safety with key applications for regulated compounds including quantification of tissue concentrations, kinetic parameters and the setting of safe exposure levels on an internal dose basis. The development and applicat...

    journal_title:Toxicology letters

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.toxlet.2019.10.021

    authors: Lautz LS,Dorne JLCM,Oldenkamp R,Hendriks AJ,Ragas AMJ

    更新日期:2020-02-01 00:00:00

  • Combinatory estrogenic effects of bisphenol A in mixtures with alternariol and zearalenone in human endometrial cells.

    abstract::Humans are typically exposed to mixtures of substances, whereby their bioactivity can be significantly altered by co-occurring compounds. Thus, over the last years, research on combinatory effects has gained increasing attention. In particular, several xenoestrogens have been recently reported to interact synergistica...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.10.025

    authors: Aichinger G,Pantazi F,Marko D

    更新日期:2020-02-01 00:00:00

  • The effect of α-synuclein and Tau in methamphetamine induced neurotoxicity in vivo and in vitro.

    abstract::The upregulated α-synuclein (α-syn) and Tau co-occur in methamphetamine (METH) abusers' brains. Here, we designed experiments mainly to investigate whether α-syn and Tau interact in METH exposure. We detected the expression of α-syn, total Tau, and phosphorylation of Tau at Serine 396 (pSer396 Tau) under in vitro and ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.11.028

    authors: Ding J,Lian Y,Meng Y,He Y,Fan H,Li C,Qiu P

    更新日期:2020-02-01 00:00:00

  • Rotenone and 3-bromopyruvate toxicity impacts electrical and structural cardiac remodeling in rats.

    abstract::3-Bromopyruvate (3-BrPA) is a promising agent that has been widely studied in the treatment of cancer and pulmonary hypertension. Rotenone is a pesticide commonly used on farms and was shown to have anti-cancer activity and delay fibrosis progression in chronic kidney disease in a recent study. However, there are few ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.09.024

    authors: Zhan C,Liu G,Li J,Li G,Li T,Zhao H,Li L,Yang W,Bai N,Zheng M,Yang J,Li W

    更新日期:2020-01-01 00:00:00

  • Generic physiologically based kinetic modelling for farm animals: Part II. Predicting tissue concentrations of chemicals in swine, cattle, and sheep.

    abstract::The development of three generic multi-compartment physiologically based kinetic (PBK) models is described for farm animal species, i.e. cattle, sheep, and swine. The PBK models allow one to quantitatively link external dose and internal dose for risk assessment of chemicals relevant to food and feed safety. Model per...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.10.008

    authors: Lautz LS,Hoeks S,Oldenkamp R,Hendriks AJ,Dorne JLCM,Ragas AMJ

    更新日期:2020-01-01 00:00:00

  • A mixture of routinely encountered xenobiotics induces both redox adaptations and perturbations in blood and tissues of rats after a long-term low-dose exposure regimen: The time and dose issue.

    abstract::Exposure of humans to xenobiotic mixtures is a continuous state during their everyday routine. However, the majority of toxicological studies assess the in vivo effects of individual substances rather than mixtures. Therefore, our main objective was to evaluate the impact of the 12- and 18-month exposure of rats to a ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.09.015

    authors: Fountoucidou P,Veskoukis AS,Kerasioti E,Docea AO,Taitzoglou IA,Liesivuori J,Tsatsakis A,Kouretas D

    更新日期:2019-12-15 00:00:00

  • A new photosafety screening strategy based on in chemico photoreactivity and in vitro skin exposure for dermally-applied chemicals.

    abstract::This study involved an attempt to establish a new photosafety screening system for dermally-applied chemicals consisting of a reactive oxygen species (ROS) assay and an in vitro skin permeation test. The ROS assay was undertaken to evaluate photoreactivity of six test compounds, acridine (ACD), furosemide (FSM), hexac...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.09.016

    authors: Iyama Y,Sato H,Seto Y,Onoue S

    更新日期:2019-12-15 00:00:00

  • Mitochondrial dysfunction is associated with Miro1 reduction in lung epithelial cells by cigarette smoke.

    abstract::Cigarette smoke (CS) is known to cause mitochondrial dysfunction leading to cellular senescence in lung cells. We determined the mechanism of mitochondrial dysfunction by CS in lung epithelial cells. CS extract (CSE) treatment differentially affected mitochondrial function, such as membrane potential, mitochondrial re...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.09.022

    authors: Sundar IK,Maremanda KP,Rahman I

    更新日期:2019-12-15 00:00:00

  • The protective effect of lithocholic acid on the intestinal epithelial barrier is mediated by the vitamin D receptor via a SIRT1/Nrf2 and NF-κB dependent mechanism in Caco-2 cells.

    abstract::Lithocholic acid (LCA) is both a secondary bile acid and a vitamin D receptor (VDR) ligand. The VDR is activated by 1,25-dihydroxy vitamin D3 and plays an important role in maintaining integrity of the intestinal mucosal barrier. LCA can also substitute for vitamin D to carry out the in vivo functions of vitamin D. Ho...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.08.024

    authors: Yao B,He J,Yin X,Shi Y,Wan J,Tian Z

    更新日期:2019-11-01 00:00:00

  • PM2.5 exposure and cold stress exacerbates asthma in mice by increasing histone acetylation in IL-4 gene promoter in CD4+ T cells.

    abstract::Asthma is a common chronic inflammatory disease which severely reduces the quality of life in patients. Studies have demonstrated that both PM2.5 and cold stress contribute to the development of asthma. However, the combined effects of these two risking factors are unknown. In this study, we investigated the combined ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.09.011

    authors: Zhou J,Geng F,Xu J,Peng L,Ye X,Yang D,Zhao J,Sun Q

    更新日期:2019-11-01 00:00:00

  • Exposure of 19 substances to lung A549 cells at the air liquid interface or under submerged conditions reveals high correlation between cytotoxicity in vitro and CLP classifications for acute lung toxicity.

    abstract::In vivo experiments are still widely used for the testing of lung toxicity but there is an ethical and legal obligation to replace, reduce and refine animal testing. Lung A549 cells could serve as an in vitro indicator for acute lung toxicity but little data about the correlation of the cytotoxicity in A549 cells and ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.09.014

    authors: Gohlsch K,Mückter H,Steinritz D,Aufderheide M,Hoffmann S,Gudermann T,Breit A

    更新日期:2019-11-01 00:00:00

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