Autophagy mediates bronchial cell malignant transformation induced by chronic arsenic exposure via MEK/ERK1/2 pathway.

abstract：:The effects of lead exposure have been studied upon the behavioural and diuretic responses to the kappa-opioid receptor agonist U-50488H in neonatal rats. Lead was administered in the maternal drinking water (100, 300 and 1000 ppm) from conception to postnatal day 14. The hyperactivity, wall climbing behaviours and di...

journal_title：Toxicology letters

authors： Jackson HC,Kitchen I

更新日期：1990-01-01 00:00:00

abstract：:A protective effect of preadministration of the metals Cu, Bi, Zn, Hg, Cd, Ni or Co, against lethal toxicity of cis-diamminedichloroplatinum (Cisplatin; CDDP) was observed in mice. However, the protective effect seems not always to correlate with metallothionein (MT) levels in the liver and kidney of mice treated with...

journal_title：Toxicology letters

authors： Naganuma A,Satoh M,Koyama Y,Imura N

更新日期：1985-02-01 00:00:00

abstract：:Effective treatments for esophageal squamous cell carcinoma (ESCC), one of the most common cancers in China, are lacking. Longikaurin A (LK-A), an ent-kauranoid diterpenoid isolated from Isodon ternifolius, has been shown to have potent cytotoxic effects on ESCC cells both in vivo and in vitro, mainly by inducing apop...

journal_title：Toxicology letters

authors： Che Y,Wang J,Yuan Z,Li Y,Lu Z,Zhang Z,Zhang J,Wan J,Sun H,Chen Z,Pu J,He J

更新日期：2017-10-05 00:00:00

abstract：:Soman is a highly toxic organophosphorus chemical warfare compound that binds rapidly and irreversibility to a variety of serine active enzymes, i.e., butyryl- and acetyl-cholinesterases and carboxylesterase. The in vivo toxicity of soman has been reported to vary significantly in different animal species, such as rat...

journal_title：Toxicology letters

authors： Lenz DE,Cerasoli D,Maxwell DM

更新日期：2018-02-01 00:00:00

abstract：:Ursolic acid (UA), a pentacyclic triterpene acid, is reported to have inducing activity of hepatic metallothionein (MT) which responsible for the detoxification of heavy metals; however, the mechanism underlying its effects is poorly understood. To further determine the underlying mechanism of UA, this study investiga...

journal_title：Toxicology letters

authors： Jeong HG,Kim HG,Hwang YP

更新日期：2005-03-15 00:00:00

abstract：:An occupational health study was conducted on 45 acetone-exposed male workers in combination with 343 non-exposed men to examine the quantitative relationship between the intensity of acetone vapor exposure and the concentration of acetone in urine. The time-weighted average acetone concentrations were measured by mea...

journal_title：Toxicology letters

authors： Kawai T,Yasugi T,Mizunuma K,Horiguchi S,Iguchi H,Ikeda M

更新日期：1992-08-01 00:00:00

abstract：RATIONALE:The popularity of new and emerging tobacco products such as E-cigarettes (E-cigs) is rapidly expanding worldwide. However, uncertainties surrounding the potential health consequences due to the use of such products exist and warrant further study. METHODS:Cultured A549 and Calu-3 airway epithelia were expose...

journal_title：Toxicology letters

authors： Zhang R,Jones MM,Dornsife RE,Wu T,Sivaraman V,Tarran R,Onyenwoke RU

更新日期：2021-02-01 00:00:00

abstract：:Heptachlor is a major component of the insecticide, chlordane. It is a health hazard but is still in use in some countries of Southeast Asia. To elucidate the toxicity of heptachlor its effects on mice after oral and intraperitoneal administration were studied. A 3-day group, 92-day group and 180-day group were given ...

journal_title：Toxicology letters

authors： Izushi F,Ogata M

更新日期：1990-11-01 00:00:00

abstract：:Intraperitoneal injection of the iron-complex, ferric-nitrilotriacetate (Fe-NTA), induces renal proximal tubular damage associated with oxidative damage in vivo. Fe-NTA induced a time-dependent decrease of several polyunsaturated fatty acids (PUFA), together with increased conjugated diene values and decreased cellula...

journal_title：Toxicology letters

authors： Deiana M,Aruoma OI,Rosa A,Crobu V,Casu V,Piga R,Dessi MA

更新日期：2001-09-15 00:00:00

abstract：:The exposure to cuprizone (CPZ) leads to demyelination in the central nervous system in rodents. To examine the developmental effects of CPZ exposure on hippocampal neurogenesis, pregnant rats were treated with 0, 0.1 or 0.4% CPZ in the diet from gestational day 6 to day 21 after delivery. On postnatal day 21, male of...

journal_title：Toxicology letters

authors： Abe H,Tanaka T,Kimura M,Mizukami S,Imatanaka N,Akahori Y,Yoshida T,Shibutani M

更新日期：2015-05-05 00:00:00

abstract：:In Europe and the USA the prevalence of certain forms of allergic disease is rising; an increase that can not be reconciled simply on the basis of changes in diagnostic fashion. The changes observed have been too rapid to be explained by alterations in the gene pool and, as a consequence, there has been a growing inte...

journal_title：Toxicology letters

authors： Kimber I

更新日期：1998-12-28 00:00:00

abstract：:A considerable body of research over the past fifteen years establishes that in laboratory animals the Ah (aromatic hydrocarbon) receptor (AhR) mediates most, if not all, toxic effects of halogenated aromatic hydrocarbons such as polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polyhalogenated bip...

journal_title：Toxicology letters

authors： Okey AB,Riddick DS,Harper PA

更新日期：1994-01-01 00:00:00

abstract：:Exposure of humans to xenobiotic mixtures is a continuous state during their everyday routine. However, the majority of toxicological studies assess the in vivo effects of individual substances rather than mixtures. Therefore, our main objective was to evaluate the impact of the 12- and 18-month exposure of rats to a ...

journal_title：Toxicology letters

authors： Fountoucidou P,Veskoukis AS,Kerasioti E,Docea AO,Taitzoglou IA,Liesivuori J,Tsatsakis A,Kouretas D

更新日期：2019-12-15 00:00:00

abstract：:There is sufficient evidence for pulmonary carcinogenicity of inhaled cadmium (Cd) compounds in rats whereas no such evidence was found in mice and hamsters, indicating significant species differences in the pulmonary response to inhaled Cd. We hypothesized that expression of metallothionein (MT) protein in the lung a...

journal_title：Toxicology letters

authors： Oberdörster G,Cherian MG,Baggs RB

更新日期：1994-06-01 00:00:00

abstract：:The phototoxic potentials of quinolone derivatives and the possibility of free radical contribution to their phototoxicity were investigated by measuring increments in ear thickness. Balb/c mice, fasted overnight, were orally administered ofloxacin (OFLX), lomefloxacin (LMFX), enoxacin (ENX), ciprofloxacin (CPFX) and ...

journal_title：Toxicology letters

authors： Wagai N,Tawara K

更新日期：1991-10-01 00:00:00

abstract：:Phytosterols (PS) are naturally occurring compounds present in food products of plant origin. Due to reported positive health effects, some food products are also enriched with PS. In the same way as cholesterol is oxidised, PS also oxidise to a variety of oxidation products (POPs). The biological effects and safety a...

journal_title：Toxicology letters

authors： Abramsson-Zetterberg L,Svensson M,Johnsson L

更新日期：2007-09-10 00:00:00

abstract：:Primary renal neoplasms in the rats are uncommon. Nephroblastoma is the only renal embryonal tumor of the rat; all other tumors are reported in older rats. The occurrence of spontaneous nephroblastoma in rats has been reported. However, metastasis from the nephroblastoma in rat is extremely rare. Data from 2669 Spragu...

journal_title：Toxicology letters

authors： Chandra M,Carlton WW

更新日期：1992-09-01 00:00:00

abstract：:We examined the ability of the multidrug resistance-associated protein 1 (MRP1/ABCC1) to transport pesticides, as this transporter mediates the cellular efflux of a variety of xenobiotics, typically as glucuronide, sulfate, or glutathione conjugates. NIH3T3 cells stably expressing MRP1 were 3.37-fold more resistant to...

journal_title：Toxicology letters

authors： Tribull TE,Bruner RH,Bain LJ

更新日期：2003-04-30 00:00:00

abstract：:1,2-Dioxetanes, very reactive and high energy molecules, are involved as labile intermediates in dioxygenase-activated aerobic metabolism and in physiological processes. Various toxicological tests reveal that dioxetanes are indeed genotoxic. In supercoiled DNA of bacteriophage PM2 they induce endonuclease-sensitive s...

journal_title：Toxicology letters

authors： Adam W,Ahrweiler M,Saha-Möller CR,Sauter M,Schönberger A,Epe B,Müller E,Schiffmann D,Stopper H,Wild D

更新日期：1993-04-01 00:00:00

abstract：:Male rats are the most frequently used experimental animals in drug toxicity tests. However, there are clear sex-related differences in toxicity of various drugs and chemicals in rats. These differences, in most cases, are closely connected with the sex-related differences in hepatic drug metabolisms. Recent studies i...

journal_title：Toxicology letters

authors： Kato R,Yamazoe Y

更新日期：1992-12-01 00:00:00

abstract：:Tubule segments from defined stages of the mouse seminiferous epithelium were incubated for 4, 8 and 24 h in the presence of different concentrations of mono-2-ethylhexyl phthalate (MEHP), adriamycin, and N-ethyl-N-nitrosourea (ENU) to study the effects of these chemicals on germ cell apoptosis and DNA synthesis. Apop...

journal_title：Toxicology letters

authors： Suominen JS,Linderborg J,Nikula H,Hakovirta H,Parvinen M,Toppari J

更新日期：2003-07-20 00:00:00

abstract：:A major issue of inhalation toxicity is that of dose. An inhaled dose is more difficult to determine than the dose from other routes of administration. Via oral or parenteral routes, a discrete amount of test substance is given in a bolus. In inhalation toxicology, the delivered dose depends on the exposure concentrat...

journal_title：Toxicology letters

authors： Pauluhn J

更新日期：2003-04-11 00:00:00

abstract：:Transcription factor NF-E2-related factor 2 (NRF2) plays a crucial role in the cellular defense against oxidative/electrophilic stress by up-regulating multiple antioxidant genes. Numerous studies with genetically modified animals have demonstrated that Nrf2 is a sensitivity determining factor upon the exposure to env...

journal_title：Toxicology letters

authors： Jung KA,Choi BH,Nam CW,Song M,Kim ST,Lee JY,Kwak MK

更新日期：2013-03-27 00:00:00

abstract：:Heart rate (HR) and body core temperature (Tco) were monitored in unanesthetized, unrestrained adult Sprague-Dawley rats following intraperitoneal administration of 0, 10, 30, or 60 mg/kg of the pesticide chlordimeform (CDM). Significant non-dose-related decreases were observed in both HR and Tco in all treated groups...

journal_title：Toxicology letters

authors： Watkinson WP,Gordon CJ

更新日期：1987-02-01 00:00:00

abstract：:Effects of vitamin E on cell morphology and cellular protein thiols under oxidative stress was investigated in cultured rat hepatocytes with different vitamin E status. Hepatocytes were incubated in the presence or absence of 100 microM alpha-tocopherol succinate for 24 h then treated with 1.5 mM t-butyl hydroperoxide...

journal_title：Toxicology letters

authors： Wang ST,Kuo JH,Chou RG,Lii CK

更新日期：1996-12-16 00:00:00

abstract：:Accumulation of N2-(trans-isoestragol-3'-yl)-2'-deoxyguanosine (E-3'-N2-dG) DNA adducts derived from the alkenylbenzene estragole upon repeated dose exposure was investigated since the repair of this adduct was previously shown to be inefficient. To this end human HepaRG cells were exposed to repeating cycles of 2 h e...

journal_title：Toxicology letters

authors： Yang S,Wesseling S,Rietjens IMCM

更新日期：2021-02-01 00:00:00

abstract：:The effects of menadione on activities and expression of cytochrome P450 (CYP) 1A subfamily (CYP1A) isozymes in rat hepatic tissue were examined. When rats were treated orally with 15 mg/kg menadione for 4 days, the elevation of hepatic CYP1A1/1A2 specific activities in microsomal preparations was detected with approx...

journal_title：Toxicology letters

authors： Sidorova YA,Grishanova AY,Lyakhovich VV

更新日期：2005-02-15 00:00:00

abstract：:Organophosphates are chemical pollutants that are existed widely in the environment, but the reactions of these agents with blood proteins are still not fully clarified. The current story was to analyze the static and dynamic interactions between human serum albumin (HSA) and phenthoate and then uncover the impact of ...

journal_title：Toxicology letters

authors： Ding F,Peng W,Peng YK,Liu BQ

更新日期：2019-10-10 00:00:00

abstract：:Paraquat poisoning results in damages of multiple organs including liver, kidney and lung, and antioxidants have been proven to have protective effects. As a novel free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), was introduced to clinical use recently, its protective effect was studied on acute ...

journal_title：Toxicology letters

authors： Saibara T,Toda K,Wakatsuki A,Ogawa Y,Ono M,Onishi S

更新日期：2003-06-05 00:00:00

abstract：:Nuclear accumulation of the tumorsuppressor protein p53 indicates the occurrence of chromatin injury (J. Cancer Res. Clin. Oncol. 1991, 117, 30; Oncogene 1993, 8, 307) and may be used as an analytical tool to detect genotoxic agents. This mechanism was used to evaluate the DNA-damaging potency (clastogenicity) of the ...

journal_title：Toxicology letters

authors： Hess RD,Brandner G

更新日期：1996-11-01 00:00:00