Abstract：
:Phytosterols (PS) are naturally occurring compounds present in food products of plant origin. Due to reported positive health effects, some food products are also enriched with PS. In the same way as cholesterol is oxidised, PS also oxidise to a variety of oxidation products (POPs). The biological effects and safety aspects of POPs are still unclear. This study investigated whether POPs are genotoxic in vivo, using a flow cytometer-based micronucleus assay in mice. The highest dose of oxidation products administered was 67mg/kg b.w. for epoxides and 9.4mg/kg b.w. for triols. Synthesised and separated triols and epoxides from a mixture of sitosterol and campesterol were investigated. The frequency of micronucleated polychromatic erythrocytes (fMNPCE) in POP-exposed mice did not significantly differ from the control values in either of two experiments performed. The flow cytometer-based method also allows for restriction of the analysis to micronuclei with a high DNA content, indicating an aneugenic potency. Even with this approach, there was no significant increase in the frequency of micronucleated erythrocytes among POP-treated mice compared with control mice. Furthermore, no significant deviation in cell proliferation rate (%PCE) was observed.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Abramsson-Zetterberg L,Svensson M,Johnsson Ldoi
10.1016/j.toxlet.2007.07.006subject
Has Abstractpub_date
2007-09-10 00:00:00pages
132-9issue
2eissn
0378-4274issn
1879-3169pii
S0378-4274(07)00784-9journal_volume
173pub_type
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2011.06.026
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2007.03.004
更新日期：2007-05-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
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更新日期：2017-05-05 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.toxlet.2010.02.003
更新日期：2010-05-04 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(82)90151-5
更新日期：1982-05-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2012.07.010
更新日期：2012-09-03 00:00:00
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doi：10.1016/j.toxlet.2016.11.009
更新日期：2017-01-04 00:00:00
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更新日期：2012-05-20 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2006-10-10 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2004-03-14 00:00:00
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更新日期：1996-11-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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更新日期：2000-03-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2013-03-27 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2012.12.024
更新日期：2013-04-26 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2005.01.001
更新日期：2005-05-16 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(97)00112-4
更新日期：1998-01-31 00:00:00
abstract：:An in vivo micronucleus assay using Balb/C male mice was used to examine antigenotoxic effects of cimetidine (CM) on benzene (BZN) induced genotoxic effects. CM not only has therapeutic and immunomudolatory role, but it has also been shown to protect bone marrow stem cells from radiation induced clastogenic effects. T...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(98)00138-6
更新日期：1998-09-30 00:00:00
