Abstract:
:In vivo effects of model cadmium-containing silica nanoparticles (SiNPs-Cd, 1 mg/rat) were investigated by i.t. instillation in rats to evaluate potential effects on secondary target organ, e.g., kidney. Specific endpoints and pathological outcomes were focused to assess inflammation and fibrosis in renal tissue, 7 and 30 days after exposure to SiNPs-Cd, as well as to equivalent amount of CdCl₂ or SiNPs. Immunohistochemistry was employed to investigate the presence/distribution of selected markers, i.e., (i) TGF-ß1, (ii) IL-6 (iii) collagen (type I), (iv) fibronectin, and (v) vimentin. An ongoing inflammatory process was demonstrated, together with a general overexpression of extracellular matrix components and alteration of cytoskeletal proteins, mainly in cortex and medulla, 7 days after SiNPs-Cd, lasting until 30th day. Less pronounced effects were observed after CdCl₂, while SiNPs did not cause any insult except for IL-6 expression increase. Briefly, engineered SiNPs-Cd cause long-lasting injury in rat kidney, following a single pulmonary exposure. Renal response may be due to (i) translocation, i.e., nanoparticles migration from lung to systemic circulation, or (ii) secondary organ changes, caused by circulating inflammatory factors (e.g., IL-6, TGF-ß1) released from lung following local insult, or (iii) direct renal action of cadmium ions released from the absorbed SiNPs-Cd.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Coccini T,Barni S,Mustarelli P,Locatelli C,Roda Edoi
10.1016/j.toxlet.2014.11.021subject
Has Abstractpub_date
2015-01-22 00:00:00pages
449-57issue
2eissn
0378-4274issn
1879-3169pii
S0378-4274(14)01473-8journal_volume
232pub_type
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