In vitro toxicity of methyl mercury: effects on nerve growth factor (NGF)-responsive neurons and on NGF synthesis in fibroblasts.


:The effect of methyl mercury chloride (MeHgCl) on the chick sympathetic and sensory dorsal root ganglia was studied in a biological in vitro assay. These cultures were not affected by the addition of MeHg up to a concentration of 2 microM. However, after an addition of 4-5 microM MeHg the capability of the neurons to respond to added nerve growth factor (NGF) was completely inhibited. The effect of MeHg was also examined in a fibroblast cell line, mouse 3T3 cells. After the addition of mercury to the culture medium at concentrations as low as 0.1 microM, an elevated production of the NGF protein was observed. However, NGF mRNA measured in the individual fibroblast cells by in situ hybridization was found to be reduced to about 80% of the control in the low level at day 2 of exposure. These results suggest that the release of NGF is actively enhanced from the 3T3 cells by addition of low levels of mercury. The results thus show that MeHg at low to moderate concentrations has adverse effects on NGF responses in cultured neurons and moreover alter levels of NGF production in cells, suggestive of mechanisms for mercury toxicity in the developing nervous system.


Toxicol Lett


Toxicology letters


Söderström S,Ebendal T




Has Abstract


1995-01-01 00:00:00














  • Protein association of the neurotoxin and non-protein amino acid BMAA (β-N-methylamino-L-alanine) in the liver and brain following neonatal administration in rats.

    abstract::The environmental neurotoxin β-N-methylamino-L-alanine (BMAA) is not an amino acid that is normally found in proteins. Our previous autoradiographic study of (3)H-labeled BMAA in adult mice unexpectedly revealed a tissue distribution similar to that of protein amino acids. The aim of this study was to characterize the...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Karlsson O,Jiang L,Andersson M,Ilag LL,Brittebo EB

    更新日期:2014-04-07 00:00:00

  • One-month persistence of inflammation and alteration of fibrotic marker and cytoskeletal proteins in rat kidney after Cd-doped silica nanoparticle instillation.

    abstract::In vivo effects of model cadmium-containing silica nanoparticles (SiNPs-Cd, 1 mg/rat) were investigated by i.t. instillation in rats to evaluate potential effects on secondary target organ, e.g., kidney. Specific endpoints and pathological outcomes were focused to assess inflammation and fibrosis in renal tissue, 7 an...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Coccini T,Barni S,Mustarelli P,Locatelli C,Roda E

    更新日期:2015-01-22 00:00:00

  • No change in serum dopamine-beta-hydroxylase activity in workers exposed to trichloroethylene.

    abstract::To determine whether occupational exposure to trichloroethylene (TCE) influences sympathetic nerve activity, serum dopamine-beta-hydroxylase (DBH) activities were analyzed in 84 male workers exposed to TCE and 83 male age-matched controls. The workers were exposed to about 22 ppm TCE in air. There were no significant ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Nagaya T,Ishikawa N,Hata H

    更新日期:1990-12-01 00:00:00

  • An antimicrotubule agent, TZT-1027, does not induce neuropathologic alterations which are detected after administration of vincristine or paclitaxel in animal models.

    abstract::One of the major dose-limiting toxicities induced by antimicrotubule antitumor agents such as vinca alkaloids and taxanes is peripheral neuropathy. The neurotoxicity of TZT-1027 (a dolastatin 10 derivative antimicrotubule agent) was thus assessed using the animal models for antimicrotubule agent-induced neurotoxicity....

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Ogawa T,Mimura Y,Isowa K,Kato H,Mitsuishi M,Toyoshi T,Kuwayama N,Morimoto H,Murakoshi M,Nakayama T

    更新日期:2001-04-30 00:00:00

  • Convergence of air pollutant-induced redox-sensitive signals in the dendritic cells contributes to asthma pathogenesis.

    abstract::Exposure to airborne particulate matter (PM) is a major risk factor for allergic airway inflammation such as asthma. Many of the PM components (i.e., polycyclic aromatic hydrocarbons and metals) are redox-active and capable of inducing cellular oxidative stress and injuries including inflammation and cell death. Airwa...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Li N,Buglak N

    更新日期:2015-08-19 00:00:00

  • Skin absorption of aniline from aqueous solutions in man.

    abstract::The skin absorption of aniline, aniline with 3% water content, and 1 and 2% aqueous aniline solutions was investigated in man. The time of exposure was 30 or 60 min. The absorbed amount of aniline was calculated on the basis of rho-aminophenol excretion in 24-h urine. The rate of aniline absorption from aqueous soluti...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Baranowska-Dutkeiwicz B

    更新日期:1982-03-01 00:00:00

  • Hepatic and muscle injuries in mice treated with heptachlor.

    abstract::Heptachlor is a major component of the insecticide, chlordane. It is a health hazard but is still in use in some countries of Southeast Asia. To elucidate the toxicity of heptachlor its effects on mice after oral and intraperitoneal administration were studied. A 3-day group, 92-day group and 180-day group were given ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Izushi F,Ogata M

    更新日期:1990-11-01 00:00:00

  • The role of NF-κB signaling pathway in polyhexamethylene guanidine phosphate induced inflammatory response in mouse macrophage RAW264.7 cells.

    abstract::Polyhexamethylene guanidine (PHMG) phosphate is a competitive disinfectant with strong antibacterial activity. However, epidemiologists revealed that inhaled PHMG-phosphate may increase the risk of pulmonary fibrosis associated with inflammation, resulting in the deaths of many people, including infants and pregnant w...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Kim HR,Shin DY,Chung KH

    更新日期:2015-03-04 00:00:00

  • Measuring problems in estimating the exposure to passive smoking using the excretion of cotinine.

    abstract::Quality control studies on cotinine measurements following low level environmental tobacco smoke (ETS) exposure are rare. The exposure to ETS was controlled and systematically changed in a series of experiments in a climatic chamber. Healthy nonsmoking volunteers were exposed to ETS simultaneously. The duration and le...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Letzel H,Fischer-Brandies A,Johnson LC,Uberla K,Biber A

    更新日期:1987-01-01 00:00:00

  • Genotoxicity of the isoflavones genistein, daidzein and equol in V79 cells.

    abstract::Hormonally active chemicals in the human diet, such as man-made estrogenic chemicals or plant-derived compounds (phytoestrogens), have become a matter of public concern. A significant part of human exposure to phytoestrogens is attributable to soy isoflavones. Besides their estrogenic properties, soy isoflavones also ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Di Virgilio AL,Iwami K,Wätjen W,Kahl R,Degen GH

    更新日期:2004-06-15 00:00:00

  • Effect of DI-n-pentyl phthalate treatment on testicular steroidogenic enzymes and cytochrome P-450 in the rat.

    abstract::Treatment of young male rats with dipentyl phthalate (DPP) produced significant decreases in testicular cytochrome P-450, cytochrome P-450 dependent microsomal steroidogenic enzymes (17 alpha-hydroxylase, 17-20 lyase) and in the maximal binding of a natural substrate (progesterone) to testis microsomes. No effect was ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Foster PM,Thomas LV,Cook MW,Walters DG

    更新日期:1983-02-01 00:00:00

  • Vehicle-dependent oral absorption and target tissue dosimetry of chloroform in male rats and female mice.

    abstract::Chloroform-induced toxicity in rodents depends on oral dose regimen. We evaluated the absorption and tissue dosimetry of chloroform after gavage administration in various vehicles to male Fischer 344 rats and female B6C3F1 mice. Animals received a single dose of chloroform in corn oil, water, or aqueous 2% emulphor at...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Dix KJ,Kedderis GL,Borghoff SJ

    更新日期:1997-05-16 00:00:00

  • Acute toxicity of latex microspheres.

    abstract::The distribution and acute lethality of i.v. administered 3 micrometers latex spheres were determined in rats. The results extend previous studies demonstrating the similarity between dog and rat in the dynamics of microspheres in these species and the inverse relationship between sphere diameter and hemodynamic toxic...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Yokel RA,Sabo JP,Simmons GH,DeLuca PP

    更新日期:1981-10-01 00:00:00

  • Predicting dermal permeability of biocides in commercial cutting fluids using a LSER approach.

    abstract::The aim of this study is to predict dermal permeability of four phenolic biocides in four different formulations using a linear solvation energy relationship (LSER) approach, with a calibrated flow through diffusion cell system. Mathematical descriptors were determined in the laboratory, by mathematical computations, ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Vijay V,Yeatts JL Jr,Riviere JE,Baynes RE

    更新日期:2007-12-10 00:00:00

  • Exposure of 19 substances to lung A549 cells at the air liquid interface or under submerged conditions reveals high correlation between cytotoxicity in vitro and CLP classifications for acute lung toxicity.

    abstract::In vivo experiments are still widely used for the testing of lung toxicity but there is an ethical and legal obligation to replace, reduce and refine animal testing. Lung A549 cells could serve as an in vitro indicator for acute lung toxicity but little data about the correlation of the cytotoxicity in A549 cells and ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Gohlsch K,Mückter H,Steinritz D,Aufderheide M,Hoffmann S,Gudermann T,Breit A

    更新日期:2019-11-01 00:00:00

  • Calcitonin inhibits the increase in bone acid phosphatase activity by high dose of zinc in rats.

    abstract::The activity of femoral-epiphyseal acid phosphatase, a marker enzyme of bone resorption induced by parathyroid hormone, was increased by a single oral dose of Zn 100 mg/kg to rats. This increase was completely inhibited by calcitonin which has antagonistic effect on the action of parathyroid hormone on bone, thus supp...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Yamaguchi M,Takahashi K

    更新日期:1983-10-01 00:00:00

  • Anti-arthritic effect and subacute toxicological evaluation of Baccharis genistelloides aqueous extract.

    abstract::This work studies the potential subacute toxicological effects of the aqueous extract of Baccharis genistelloides (AEBg) and demonstrates a new anti-arthritic therapeutic effect. The treatment of the collagen-induced arthritis (CIA) group with 4.2 mg/kg AEBg induced an important decrease (75%) in CIA severity in all a...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Coelho MG,Reis PA,Gava VB,Marques PR,Gayer CR,Laranja GA,Felzenswalb I,Sabino KC

    更新日期:2004-12-01 00:00:00

  • The effects of mono-2-ethylhexyl phathalate, adriamycin and N-ethyl-N-nitrosourea on stage-specific apoptosis and DNA synthesis in the mouse spermatogenesis.

    abstract::Tubule segments from defined stages of the mouse seminiferous epithelium were incubated for 4, 8 and 24 h in the presence of different concentrations of mono-2-ethylhexyl phthalate (MEHP), adriamycin, and N-ethyl-N-nitrosourea (ENU) to study the effects of these chemicals on germ cell apoptosis and DNA synthesis. Apop...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Suominen JS,Linderborg J,Nikula H,Hakovirta H,Parvinen M,Toppari J

    更新日期:2003-07-20 00:00:00

  • Manganese in exhaled breath condensate: a new marker of exposure to welding fumes.

    abstract:OBJECTIVE:To evaluate manganese in exhaled breath condensate (Mn-EBC) as an indicator of exposure to fumes from metal inert gas welding process. METHODS:We collected EBC and urine from 17 welders and 16 unexposed control subjects after 5 days exposure. Concentrations of manganese (Mn), nickel (Ni), iron (Fe) and chrom...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Hulo S,Chérot-Kornobis N,Howsam M,Crucq S,de Broucker V,Sobaszek A,Edme JL

    更新日期:2014-04-07 00:00:00

  • Reprint of "In utero exposure to benzo[a]pyrene increases adiposity and causes hepatic steatosis in female mice, and glutathione deficiency is protective".

    abstract::Polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene (BaP), are ubiquitous environmental pollutants found in tobacco smoke, air pollution, and grilled foods. Reactive metabolites and reactive oxygen species generated during PAH metabolism are detoxified by reactions involving glutathione (GSH). Early life...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Ortiz L,Nakamura B,Li X,Blumberg B,Luderer U

    更新日期:2014-10-15 00:00:00

  • Disruption of male sex hormones with regard to pesticides: pathophysiological and regulatory aspects.

    abstract::Several pesticides used as herbicides, insecticides and fungicides are known to be endocrine disrupting chemicals (EDCs). In three pair-matched studies we found changes in sex hormone concentrations and T-lymphocytes in relation to acute and chronic pesticide exposure. After acute exposure, 1 day later the concentrati...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Straube E,Straube W,Krüger E,Bradatsch M,Jacob-Meisel M,Rose HJ

    更新日期:1999-06-30 00:00:00

  • Importance of species selection in drug toxicity testing.

    abstract::The development of efficacious and safe new human pharmaceuticals continues to be highly dependent on well-designed and carefully executed animal toxicology studies. Although the protocols of most toxicology studies now conform to a standard format, careful selection of the most appropriate and relevant laboratory spe...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Morton DM

    更新日期:1998-12-28 00:00:00

  • Activation of styrene to styrene oxide in hepatocytes and subcellular fractions of rat liver.

    abstract::The oxidation of styrene to styrene oxide and the hydration of this metabolite to styrene glycol was investigated in hepatocytes, 9000 x g supernatant (S9) and the microsomal fraction from rat liver. Similar amounts of free styrene oxide were found in microsomes, hepatocytes and S9. However, on the basis of the format...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Belvedere G,Elovaara E,Vainio H

    更新日期:1984-11-01 00:00:00

  • In vitro reconstituted tissue as an alternative to human respiratory tract.

    abstract::The data obtained from in vitro systems utilizing human cells and tissues should form a basic part of the information necessary for risk assessment. The most important thing for such systems is, therefore, to simulate the structures and functions of cells and tissues in the native organ as closely as possible. In desi...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Emura M,Ochiai A,Hirohashi S

    更新日期:1996-11-01 00:00:00

  • An in vitro investigation on the cytotoxic and nuclear receptor transcriptional activity of the mycotoxins fumonisin B1 and beauvericin.

    abstract::Fumonisin B1 (FB1) and beauvericin (BEA) are secondary metabolites of filamentous fungi, which under appropriate temperature and humidity conditions may develop on various foods and feeds. To date few studies have been performed to evaluate the toxicological and endocrine disrupting effects of FB1 and BEA. The present...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Fernández-Blanco C,Frizzell C,Shannon M,Ruiz MJ,Connolly L

    更新日期:2016-08-22 00:00:00

  • Unexpected nephrotoxicity induced by tetrabromobisphenol A in newborn rats.

    abstract::The repeated dose toxicity of tetrabromobisphenol A (TBBPA), a flame retardant, was examined in male and female newborn rats given TBBPA orally at 0, 40, 200, or 600 mg/kg per day for 18 days from 4 days of age until weaning at 21 days of age. Half the rats in each dose group were sacrificed for a full gross necropsy ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Fukuda N,Ito Y,Yamaguchi M,Mitumori K,Koizumi M,Hasegawa R,Kamata E,Ema M

    更新日期:2004-04-21 00:00:00

  • Susceptibility to the cytogenetic effects of dichloromethane is related to the glutathione S-transferase theta phenotype.

    abstract::The carcinogenicity of dichloromethane (DCM) has been demonstrated by mutagenicity studies using bacteria and yeasts and using animal bioassays. Epidemiological studies indicate that exposure to DCM increases the incidences of liver and pancreas cancers. In the present study, we determine whether DCM generates DNA dam...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Olvera-Bello AE,Estrada-Muñiz E,Elizondo G,Vega L

    更新日期:2010-12-15 00:00:00

  • Effect of fructose-1, 6-diphosphate versus diphenhydramine on mortality in compound 48/80-induced shock.

    abstract::Fructose-1,6-diphosphate (FDP) has a salutary effect on hemorrhagic, traumatic and endotoxic shock. The role of FDP on compound 48/80-induced shock was therefore investigated. Sprague Dawley aged male rats (448+/-7.4 gm body weight) were randomly assigned into three groups and treated intraperitoneally with diphenhydr...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Figueroa AH,Stone RH,Cohly HH,Lehan PH,Markov AK

    更新日期:2001-06-20 00:00:00

  • In vitro metabolism of benzo[a]pyrene and dibenzo[def,p]chrysene in rodent and human hepatic microsomes.

    abstract::Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous and often carcinogenic contaminants released into the environment during natural and anthropogenic combustion processes. Benzo[a]pyrene (B[a]P) is the prototypical carcinogenic PAH, and dibenzo[def,p]chrysene (DBC) is a less prevalent, but highly potent transplace...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Crowell SR,Hanson-Drury S,Williams DE,Corley RA

    更新日期:2014-07-03 00:00:00

  • Pathogenic factors in aminoglycoside-induced nephrotoxicity.

    abstract::Aminoglycoside antibiotics play an integral role in antimicrobial chemotherapy. Unfortunately, these drugs are known to cause nephrotoxicity in man and experimental animals. In fact, the incidence of renal dysfunction during the course of clinical treatment with aminoglycoside antibiotics is approximately 10%. Over th...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Kacew S,Bergeron MG

    更新日期:1990-05-01 00:00:00