Abstract：
:Children may be inherently more vulnerable than adults to the lethal effects associated with chemical warfare nerve agent (CWNA) exposure because of their closer proximity to the ground, smaller body mass, higher respiratory rate, increased skin permeability and immature metabolic systems. Unfortunately, there have only been a handful of studies on the effects of CWNA in pediatric animal models, and more research is needed to confirm this hypothesis. Using a stagewise, adaptive dose design, we estimated the 24h median lethal dose for subcutaneous exposure to seven CWNA in both male and female Sprague-Dawley rats at six different developmental times. Perinatal (postnatal day [PND] 7, 14 and 21) and adult (PND 70) rats were more susceptible than pubertal (PND 28 and 42) rats to the lethal effects associated with exposure to tabun, sarin, soman and cyclosarin. Age-related differences in susceptibility were not observed in rats exposed to VM, Russian VX or VX.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Wright LK,Lee RB,Vincelli NM,Whalley CE,Lumley LAdoi
10.1016/j.toxlet.2015.11.023subject
Has Abstractpub_date
2016-01-22 00:00:00pages
167-74eissn
0378-4274issn
1879-3169pii
S0378-4274(15)30118-1journal_volume
241pub_type
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