Biological monitoring of mercury vapour exposure by scalp hair analysis in comparison to blood and urine.

Abstract:

:The reliability of human scalp hair as an indicator of mercury vapour exposure is contentious. In this study mercury concentrations in hair were compared with those in blood and urine of 20 dental students during their first "occupational" exposure to mercury vapour. Samples were collected before, at the end of the technical course of operating dentistry which lasted 6 weeks, and 3 months later. Mercury was measured by cold vapour atomic absorption spectrometry. In all biological media studied, mercury levels significantly (P < 0.05) reflected exposure to mercury vapour. After the time period without exposure mercury content decreased. Hair mercury levels were correlated to those in erythrocytes at sampling times 1 and 3 (r = 0.686 and r = 0.492) and to the frequency of fish consumption at sampling time 1. It is concluded that hair may be used as an indicator of internal uptake of mercury provided that it was not externally exposed to mercury vapour. In cases of occupational exposure to mercury vapour, hair is an useful tool for monitoring external exposure.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Wilhelm M,Müller F,Idel H

doi

10.1016/0378-4274(96)03741-1

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

221-6

issue

1-3

eissn

0378-4274

issn

1879-3169

pii

0378-4274(96)03741-1

journal_volume

88

pub_type

杂志文章
  • Kinetics of chemotaxis, cytokine, and chemokine release of NR8383 macrophages after exposure to inflammatory and inert granular insoluble particles.

    abstract::Accumulation of macrophages and neutrophil granulocytes in the lung are key events in the inflammatory response to inhaled particles. The present study aims at the time course of chemotaxis in vitro in response to the challenge of various biopersistent particles and its functional relation to the transcription of infl...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2016.08.014

    authors: Schremmer I,Brik A,Weber DG,Rosenkranz N,Rostek A,Loza K,Brüning T,Johnen G,Epple M,Bünger J,Westphal GA

    更新日期:2016-11-30 00:00:00

  • General 4-week toxicity study with EMS in the rat.

    abstract::In this subacute toxicity study, ethyl methanesulfonate (EMS) was administered daily by oral gavage to SPF-bred Wistar rats of both sexes at dose levels of 20, 60 and 180/120 mg/kg body weight (bw)/day for a period of 28 days (for 19 days in the high-dose group). A control group was treated similarly with the vehicle,...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2009.04.031

    authors: Pfister T,Eichinger-Chapelon A

    更新日期:2009-11-12 00:00:00

  • Protection against mercuric chloride nephrotoxicity by cold exposure in rats.

    abstract::The influence of cold exposure (+ 1 degree C for 24 h) was studied in rats dosed i.p. with 0, 2.5 or 5.0 mumol HgCl2/kg. Cold exposure of controls caused an increased diuresis and solute elimination, except sodium, with almost no variations in urine alkaline phosphatase (ALP) and gammaglutamyl transferase (GGT). Proxi...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(82)90067-4

    authors: Burgat-Sacaze V,Braun JP,Benard P,Eghbali B,Rico A

    更新日期:1982-02-01 00:00:00

  • Influence of polyaminocarboxylic acids on the removal of manganese-54 from the body organs of sham-operated and partially hepatectomized rats.

    abstract::EDTA, 1,2-cyclohexylenediamine tetra-acetic acid (CDTA), hexamethylene 1,6-diamine N,N,N',N'-tetra-acetic acid (HDTA), diethylene-triamine pentaacetic acid (DTPA) and nitrilotriacetic acid (NTA) were examined for the removal of manganese-54(54Mn) from some organs of sham-operated and partially hepatectomized rats in e...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(84)90037-7

    authors: Kaur G,Srivastava UC,Dwivedi RS,Srivastava RC

    更新日期:1984-07-01 00:00:00

  • Human urinary biomarkers of dioxin exposure: analysis by metabolomics and biologically driven data dimensionality reduction.

    abstract::Untargeted metabolomic approaches offer new opportunities for a deeper understanding of the molecular events related to toxic exposure. This study proposes a metabolomic investigation of biochemical alterations occurring in urine as a result of dioxin toxicity. Urine samples were collected from Czech chemical workers ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2013.10.031

    authors: Jeanneret F,Boccard J,Badoud F,Sorg O,Tonoli D,Pelclova D,Vlckova S,Rutledge DN,Samer CF,Hochstrasser D,Saurat JH,Rudaz S

    更新日期:2014-10-15 00:00:00

  • The relationship between itai-itai disease among inhabitants of the Jinzu River basin and cadmium in rice.

    abstract::Women over 50 years of age in 32 cadmium(Cd)-polluted and 16 nonpolluted hamlets were studied. Itai-itai disease patients and proteinuria with glucosuria were used as indices of the effect of Cd on health. Unpolished rice samples were collected from 568 households in the same area and analyzed for Cd. The hamlet's ave...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(83)90236-9

    authors: Nogawa K,Yamada Y,Honda R,Ishizaki M,Tsuritani I,Kawano S,Kato T

    更新日期:1983-07-01 00:00:00

  • Comparison of the effects of pyridine and its metabolites on rat liver and kidney.

    abstract::In order to evaluate the possibility that the metabolism of pyridine may be important for its toxic actions, pyridine was compared with pyridine N-oxide, 2-hydroxypyridine, 3-hydroxypyridine, 4-hydroxypyridine and pyridinium methyliodide in rats given equal molar doses of the chemicals i.p. Hepatoxicity was assessed b...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(96)03660-0

    authors: Carlson GP

    更新日期:1996-06-01 00:00:00

  • Heavy metal-induced cytotoxicity to cultured human epidermal keratinocytes and effects of antioxidants.

    abstract::Human epidermal keratinocytes which have been cultured were treated with the heavy metal ions of cadmium, mercury, copper and zinc. Cytotoxicity was measured either by protein estimation or by using the neutral red assay. Antioxidants were added in order to find out whether heavy metal-induced cytotoxicity is related ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(94)90170-8

    authors: Kappus H,Reinhold C

    更新日期:1994-04-01 00:00:00

  • Bardoxolone methyl modulates efflux transporter and detoxifying enzyme expression in cisplatin-induced kidney cell injury.

    abstract::Cisplatin is prescribed for the treatment of solid tumors and elicits toxicity to kidney tubules, which limits its clinical use. Nuclear factor erythroid 2-related factor 2 (Nrf2, NFE2L2) is a critical transcription factor that has been shown to protect against kidney injury through activation of antioxidant mechanism...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2016.07.021

    authors: Atilano-Roque A,Aleksunes LM,Joy MS

    更新日期:2016-09-30 00:00:00

  • Lead exposure and changes in the renin-angiotensin-aldosterone system in man.

    abstract::We have studied the effects of chronic slight to moderate lead exposure on the renin-angiotensin-aldosterone system in normotensive man. Plasma renin activity (PRA), blood angiotensin I (AI) concentration, angiotensin converting enzyme (ACE) activity and aldosterone concentration were measured in 33 normotensive men, ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(85)90096-7

    authors: Campbell BC,Meredith PA,Scott JJ

    更新日期:1985-04-01 00:00:00

  • Histopathologic lens changes in mirex-exposed rats.

    abstract::The early histologic lesions and sequential changes in the development of mirex-induced cataracts were studied in the offspring of lactating female Sherman rats given oral doses of mirex for 5 consecutive days post partum. The earliest histologic change, seen at neonatal day 7, was slight swelling of the individual co...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(81)90163-6

    authors: Scotti TM,Chernoff N,Linder R,McElroy WK

    更新日期:1981-11-01 00:00:00

  • Lithocholic acid-sensitive mutant cells isolated from Chinese hamster ovary cells are cross-sensitive to cytoskeleton-disturbing agents.

    abstract::The lithocholic acid-sensitive mutant cells were isolated from CHO-9 cells mutagenized with ethylmethane sulfonate, through clonal selection on 96-well dishes. The isolated mutant cells (LSJ-11) were 3-fold more sensitive than controls in the survival to lithocholic acid and were also sensitive to other bile acids suc...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(93)90001-e

    authors: Kaneko M,Kodama M,Inoue F,Horikoshi J

    更新日期:1993-03-01 00:00:00

  • Curvi-linear relation between acetone in breathing zone air and acetone in urine among workers exposed to acetone vapor.

    abstract::An occupational health study was conducted on 45 acetone-exposed male workers in combination with 343 non-exposed men to examine the quantitative relationship between the intensity of acetone vapor exposure and the concentration of acetone in urine. The time-weighted average acetone concentrations were measured by mea...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(92)90081-t

    authors: Kawai T,Yasugi T,Mizunuma K,Horiguchi S,Iguchi H,Ikeda M

    更新日期:1992-08-01 00:00:00

  • The mutagenicity of urine fractions from patients administered antineoplastic therapy.

    abstract::A concern among hospital personnel is their exposure to mutagenic drugs and in the incidental exposures that could occur in caring for the patients. In a recent published study the mutagenicity of urine from patients administered antineoplastic drugs was determined and techniques were developed to chemically inactivat...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(88)90049-5

    authors: Monteith DK,Connor TH,Benvenuto JA,Fairchild EJ,Theiss JC

    更新日期:1988-03-01 00:00:00

  • Generic physiologically based kinetic modelling for farm animals: Part I. Data collection of physiological parameters in swine, cattle and sheep.

    abstract::Physiologically based kinetic (PBK) models for farm animals are of growing interest in food and feed safety with key applications for regulated compounds including quantification of tissue concentrations, kinetic parameters and the setting of safe exposure levels on an internal dose basis. The development and applicat...

    journal_title:Toxicology letters

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.toxlet.2019.10.021

    authors: Lautz LS,Dorne JLCM,Oldenkamp R,Hendriks AJ,Ragas AMJ

    更新日期:2020-02-01 00:00:00

  • Effect of trimethyltin on ornithine decarboxylase in various regions of the mouse brain.

    abstract::Male C57B1/6N mice, 8-10 weeks old were given a single oral dose of 0, 1.0 or 3.0 mg/kg body weight of trimethyltin hydroxide (TMT). Levels of ornithine decarboxylase (ODC) activity were measured in several brain areas, 1, 2 and 7 days later. The lower dose of TMT produced a decrease of ODC in the caudate nucleus and ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(87)90042-7

    authors: Ali SF,Newport GD,Slikker W Jr,Bondy SC

    更新日期:1987-03-01 00:00:00

  • Cadmium effects on hypothalamic activity and pituitary hormone secretion in the male.

    abstract::Cadmium specifically modify amine metabolism at the central nervous system and pituitary hormone secretions. Thus, the physiological functions controlled by these hormones can be modulated by cadmium. This xenobiotic is associated with deleterious effects on the gonadal function and with changes in the secretory patte...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-4274(99)00159-9

    authors: Lafuente A,Esquifino AI

    更新日期:1999-11-22 00:00:00

  • Interlaboratory evaluation of a cow's milk allergy mouse model to assess the allergenicity of hydrolysed cow's milk based infant formulas.

    abstract::This study describes two phases of a multi-phase project aiming to validate a mouse model for cow's milk allergy to assess the potential allergenicity of hydrolysed cow's milk based infant formulas (claim support EC-directive 2006/141/E). The transferability and the discriminatory power of this model was evaluated in ...

    journal_title:Toxicology letters

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.toxlet.2013.04.008

    authors: van Esch BC,van Bilsen JH,Jeurink PV,Garssen J,Penninks AH,Smit JJ,Pieters RH,Knippels LM

    更新日期:2013-06-20 00:00:00

  • Subchronic administration of sublethal doses of thallium to rats: effects on distribution and lipid peroxidation in brain regions.

    abstract::Occupational exposure to thallium (Tl+) is known to be responsible for severe neurological manifestations in humans, including ataxia and paralysis; however, little is known yet about the precise mechanism of toxicity elicited by this heavy metal at sublethal doses and its brain distribution after chronic or subchroni...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(00)00200-9

    authors: Galván-Arzate S,Martínez A,Medina E,Santamaría A,Ríos C

    更新日期:2000-07-27 00:00:00

  • Elevation of metallothionein level in preneoplastic lesions during chemical hepatocarcinogenesis of the Fischer 344 rat.

    abstract::Metallothionein (MT) is inducible by various stimuli such as metals and physiological stress. Although elevated MT expression in certain type of tumors has been reported, there are few data available on the roles of MT in tumor formation. In this study, we immunohistochemically examined MT expression in gluthathione S...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(99)00127-7

    authors: Sawaki M,Enomoto K,Hattori A,Tsuzuki N,Sawada N,Mori M

    更新日期:1999-07-30 00:00:00

  • Evaluation of the antigenicity of hydrolyzed cow's milk protein formulas using the mouse basophil activation test.

    abstract::Hypoallergenic infant formulas are widely used for infants with cow's milk allergy. The aim of this study was to assess the utility of the mouse basophil activation test (BAT) in the evaluation of residual antigenicity in these formulas. Whole blood samples derived from β-lactoglobulin- or casein-immunized mice were i...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2015.11.024

    authors: Iwamoto H,Matsubara T,Nakazato Y,Namba K,Takeda Y

    更新日期:2016-02-03 00:00:00

  • Indomethacin induces small intestinal damage and inhibits amitrole-associated thyroid carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.

    abstract::Effects of intestinal damage on thyroid carcinogenesis due to amitrole (AT) were examined in F344 male rats initiated with N-bis(2-hydroxypropyl)nitrosamine (DHPN). In experiment 1, rats were provided with diet containing 0.03% AT for 20 weeks after a single subcutaneous injection of DHPN (2800 mg/kg body weight), and...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2005.11.012

    authors: Imai T,Onose J,Hasumura M,Takizawa T,Hirose M

    更新日期:2006-06-20 00:00:00

  • Glycochenodeoxycholic acid impairs transcription factor E3 -dependent autophagy-lysosome machinery by disrupting reactive oxygen species homeostasis in L02 cells.

    abstract::Cholestasis represents pathophysiologic syndromes defined as impaired bile flow from the liver. As an outcome, bile acids accumulate and promote hepatocyte injury, followed by liver cirrhosis and liver failure. Glycochenodeoxycholic acid (GCDCA) is relatively toxic and highly concentrated in bile and serum after chole...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.05.017

    authors: Lan W,Chen Z,Chen Y,Tan M,Chen Y,Chen J,Chi X,Chen Y

    更新日期:2020-10-01 00:00:00

  • Effects of in utero through lactational exposure to dicyclohexyl phthalate and p,p'-DDE in Sprague-Dawley rats.

    abstract::Anti-androgenic chemicals alter sexual differentiation by a variety of mechanisms, and the mechanisms between phthalate esters and p,p'-DDE are considered to be different. We performed an in utero through lactational exposure assay using dicyclohexyl phthalate and p,p'-DDE to investigate the sexual differentiation of ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2009.04.023

    authors: Yamasaki K,Okuda H,Takeuchi T,Minobe Y

    更新日期:2009-08-25 00:00:00

  • Interaction of acrylonitrile with hepatic microsomes of rats and men.

    abstract::Acrylonitrile (AN) showed spectral interaction with hepatic microsomes from mouse, rat and man. Whereas human and rat liver microsomes resulted in ligand AN-binding spectra, mouse liver microsomes behaved differently. Hepatic microsomes from phenobarbital-treated mice with AN showed a type I substrate binding; ligand ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(81)90057-6

    authors: Appel KE,Peter H,Bolt M,Bolt HM

    更新日期:1981-02-01 00:00:00

  • Repeated topical treatment, in contrast to single oral doses, with Vitamin A-containing preparations does not affect plasma concentrations of retinol, retinyl esters or retinoic acids in female subjects of child-bearing age.

    abstract:BACKGROUND:Vitamin A is widely used in cosmetic preparations. Given that oral Vitamin A and its metabolites present a potential reproductive risk, the present study investigated the effect of topical Vitamin A on human endogenous plasma levels of Vitamin A and its metabolites. METHODS:Two groups of 14 female volunteer...

    journal_title:Toxicology letters

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.toxlet.2005.09.029

    authors: Nohynek GJ,Meuling WJ,Vaes WH,Lawrence RS,Shapiro S,Schulte S,Steiling W,Bausch J,Gerber E,Sasa H,Nau H

    更新日期:2006-05-05 00:00:00

  • A new physiological biomarker for nitrate exposure in humans.

    abstract::After toxicological studies with nitrate/nitrite in rats it was observed with nuclear magnetic resonance that N-methylnicotinamide (NMN), a metabolite of tryptophan was increased. The use of NMN as a biomarker for nitrate/nitrite exposure was investigated further in additional experiments with rats and in a human stud...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(95)03306-8

    authors: Jansen EH,van den Berg RH,Boink AB,Hegger C,Meulenbelt J

    更新日期:1995-05-01 00:00:00

  • Expression of pulmonary cytochrome P4501A1 and carcinogen DNA adduct formation in high risk subjects for tobacco-related lung cancer.

    abstract::Cigarette smoking is the strongest risk factor for lung cancer (LC), but genetically determined variations in pulmonary metabolism of tobacco-derived carcinogens may affect individual risk. Results from a case-control study on LC patients demonstrated the pronounced effect of tobacco smoke on pulmonary xenobiotic meta...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(92)90222-6

    authors: Bartsch H,Castegnaro M,Rojas M,Camus AM,Alexandrov K,Lang M

    更新日期:1992-12-01 00:00:00

  • Cytochrome P450 isozymes involved in the metabolism of phenol, a benzene metabolite.

    abstract::Benzene is an occupational and environmental toxicant. The major health concern for humans is acute myelogenous leukemia. To exert its toxic effects, benzene must be metabolized by cytochrome P450 to phenol and subsequently to catechol and hydroquinone. Previous research has implicated CYP2E1 in the metabolism of phen...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(01)00441-6

    authors: Powley MW,Carlson GP

    更新日期:2001-12-15 00:00:00

  • Differences in elimination rates of methylmercury between two genetic variant strains of mice.

    abstract::This study demonstrates an intraspecies difference in elimination of methylmercury between two genetic variant strains of mice. Following a single non-toxic dose of 203Hg labeled methylmercury (0.5 mg Hg/kg i.p.), the half-time of 203Hg elimination in the CBA/J inbred strain was 7.4 days compared to 3.0 days in the CF...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(80)90114-9

    authors: Kostyniak PJ

    更新日期:1980-10-01 00:00:00