Abstract:
:The reliability of human scalp hair as an indicator of mercury vapour exposure is contentious. In this study mercury concentrations in hair were compared with those in blood and urine of 20 dental students during their first "occupational" exposure to mercury vapour. Samples were collected before, at the end of the technical course of operating dentistry which lasted 6 weeks, and 3 months later. Mercury was measured by cold vapour atomic absorption spectrometry. In all biological media studied, mercury levels significantly (P < 0.05) reflected exposure to mercury vapour. After the time period without exposure mercury content decreased. Hair mercury levels were correlated to those in erythrocytes at sampling times 1 and 3 (r = 0.686 and r = 0.492) and to the frequency of fish consumption at sampling time 1. It is concluded that hair may be used as an indicator of internal uptake of mercury provided that it was not externally exposed to mercury vapour. In cases of occupational exposure to mercury vapour, hair is an useful tool for monitoring external exposure.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Wilhelm M,Müller F,Idel Hdoi
10.1016/0378-4274(96)03741-1subject
Has Abstractpub_date
1996-11-01 00:00:00pages
221-6issue
1-3eissn
0378-4274issn
1879-3169pii
0378-4274(96)03741-1journal_volume
88pub_type
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2016.08.014
更新日期:2016-11-30 00:00:00
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journal_title:Toxicology letters
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doi:10.1016/j.toxlet.2009.04.031
更新日期:2009-11-12 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(82)90067-4
更新日期:1982-02-01 00:00:00
abstract::EDTA, 1,2-cyclohexylenediamine tetra-acetic acid (CDTA), hexamethylene 1,6-diamine N,N,N',N'-tetra-acetic acid (HDTA), diethylene-triamine pentaacetic acid (DTPA) and nitrilotriacetic acid (NTA) were examined for the removal of manganese-54(54Mn) from some organs of sham-operated and partially hepatectomized rats in e...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(84)90037-7
更新日期:1984-07-01 00:00:00
abstract::Untargeted metabolomic approaches offer new opportunities for a deeper understanding of the molecular events related to toxic exposure. This study proposes a metabolomic investigation of biochemical alterations occurring in urine as a result of dioxin toxicity. Urine samples were collected from Czech chemical workers ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2013.10.031
更新日期:2014-10-15 00:00:00
abstract::Women over 50 years of age in 32 cadmium(Cd)-polluted and 16 nonpolluted hamlets were studied. Itai-itai disease patients and proteinuria with glucosuria were used as indices of the effect of Cd on health. Unpolished rice samples were collected from 568 households in the same area and analyzed for Cd. The hamlet's ave...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(83)90236-9
更新日期:1983-07-01 00:00:00
abstract::In order to evaluate the possibility that the metabolism of pyridine may be important for its toxic actions, pyridine was compared with pyridine N-oxide, 2-hydroxypyridine, 3-hydroxypyridine, 4-hydroxypyridine and pyridinium methyliodide in rats given equal molar doses of the chemicals i.p. Hepatoxicity was assessed b...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(96)03660-0
更新日期:1996-06-01 00:00:00
abstract::Human epidermal keratinocytes which have been cultured were treated with the heavy metal ions of cadmium, mercury, copper and zinc. Cytotoxicity was measured either by protein estimation or by using the neutral red assay. Antioxidants were added in order to find out whether heavy metal-induced cytotoxicity is related ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(94)90170-8
更新日期:1994-04-01 00:00:00
abstract::Cisplatin is prescribed for the treatment of solid tumors and elicits toxicity to kidney tubules, which limits its clinical use. Nuclear factor erythroid 2-related factor 2 (Nrf2, NFE2L2) is a critical transcription factor that has been shown to protect against kidney injury through activation of antioxidant mechanism...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2016.07.021
更新日期:2016-09-30 00:00:00
abstract::We have studied the effects of chronic slight to moderate lead exposure on the renin-angiotensin-aldosterone system in normotensive man. Plasma renin activity (PRA), blood angiotensin I (AI) concentration, angiotensin converting enzyme (ACE) activity and aldosterone concentration were measured in 33 normotensive men, ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(85)90096-7
更新日期:1985-04-01 00:00:00
abstract::The early histologic lesions and sequential changes in the development of mirex-induced cataracts were studied in the offspring of lactating female Sherman rats given oral doses of mirex for 5 consecutive days post partum. The earliest histologic change, seen at neonatal day 7, was slight swelling of the individual co...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(81)90163-6
更新日期:1981-11-01 00:00:00
abstract::The lithocholic acid-sensitive mutant cells were isolated from CHO-9 cells mutagenized with ethylmethane sulfonate, through clonal selection on 96-well dishes. The isolated mutant cells (LSJ-11) were 3-fold more sensitive than controls in the survival to lithocholic acid and were also sensitive to other bile acids suc...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(93)90001-e
更新日期:1993-03-01 00:00:00
abstract::An occupational health study was conducted on 45 acetone-exposed male workers in combination with 343 non-exposed men to examine the quantitative relationship between the intensity of acetone vapor exposure and the concentration of acetone in urine. The time-weighted average acetone concentrations were measured by mea...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(92)90081-t
更新日期:1992-08-01 00:00:00
abstract::A concern among hospital personnel is their exposure to mutagenic drugs and in the incidental exposures that could occur in caring for the patients. In a recent published study the mutagenicity of urine from patients administered antineoplastic drugs was determined and techniques were developed to chemically inactivat...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(88)90049-5
更新日期:1988-03-01 00:00:00
abstract::Physiologically based kinetic (PBK) models for farm animals are of growing interest in food and feed safety with key applications for regulated compounds including quantification of tissue concentrations, kinetic parameters and the setting of safe exposure levels on an internal dose basis. The development and applicat...
journal_title:Toxicology letters
pub_type: 杂志文章,meta分析
doi:10.1016/j.toxlet.2019.10.021
更新日期:2020-02-01 00:00:00
abstract::Male C57B1/6N mice, 8-10 weeks old were given a single oral dose of 0, 1.0 or 3.0 mg/kg body weight of trimethyltin hydroxide (TMT). Levels of ornithine decarboxylase (ODC) activity were measured in several brain areas, 1, 2 and 7 days later. The lower dose of TMT produced a decrease of ODC in the caudate nucleus and ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(87)90042-7
更新日期:1987-03-01 00:00:00
abstract::Cadmium specifically modify amine metabolism at the central nervous system and pituitary hormone secretions. Thus, the physiological functions controlled by these hormones can be modulated by cadmium. This xenobiotic is associated with deleterious effects on the gonadal function and with changes in the secretory patte...
journal_title:Toxicology letters
pub_type: 杂志文章,评审
doi:10.1016/s0378-4274(99)00159-9
更新日期:1999-11-22 00:00:00
abstract::This study describes two phases of a multi-phase project aiming to validate a mouse model for cow's milk allergy to assess the potential allergenicity of hydrolysed cow's milk based infant formulas (claim support EC-directive 2006/141/E). The transferability and the discriminatory power of this model was evaluated in ...
journal_title:Toxicology letters
pub_type: 杂志文章,多中心研究
doi:10.1016/j.toxlet.2013.04.008
更新日期:2013-06-20 00:00:00
abstract::Occupational exposure to thallium (Tl+) is known to be responsible for severe neurological manifestations in humans, including ataxia and paralysis; however, little is known yet about the precise mechanism of toxicity elicited by this heavy metal at sublethal doses and its brain distribution after chronic or subchroni...
journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2000-07-27 00:00:00
abstract::Metallothionein (MT) is inducible by various stimuli such as metals and physiological stress. Although elevated MT expression in certain type of tumors has been reported, there are few data available on the roles of MT in tumor formation. In this study, we immunohistochemically examined MT expression in gluthathione S...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(99)00127-7
更新日期:1999-07-30 00:00:00
abstract::Hypoallergenic infant formulas are widely used for infants with cow's milk allergy. The aim of this study was to assess the utility of the mouse basophil activation test (BAT) in the evaluation of residual antigenicity in these formulas. Whole blood samples derived from β-lactoglobulin- or casein-immunized mice were i...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2015.11.024
更新日期:2016-02-03 00:00:00
abstract::Effects of intestinal damage on thyroid carcinogenesis due to amitrole (AT) were examined in F344 male rats initiated with N-bis(2-hydroxypropyl)nitrosamine (DHPN). In experiment 1, rats were provided with diet containing 0.03% AT for 20 weeks after a single subcutaneous injection of DHPN (2800 mg/kg body weight), and...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2005.11.012
更新日期:2006-06-20 00:00:00
abstract::Cholestasis represents pathophysiologic syndromes defined as impaired bile flow from the liver. As an outcome, bile acids accumulate and promote hepatocyte injury, followed by liver cirrhosis and liver failure. Glycochenodeoxycholic acid (GCDCA) is relatively toxic and highly concentrated in bile and serum after chole...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2020.05.017
更新日期:2020-10-01 00:00:00
abstract::Anti-androgenic chemicals alter sexual differentiation by a variety of mechanisms, and the mechanisms between phthalate esters and p,p'-DDE are considered to be different. We performed an in utero through lactational exposure assay using dicyclohexyl phthalate and p,p'-DDE to investigate the sexual differentiation of ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2009.04.023
更新日期:2009-08-25 00:00:00
abstract::Acrylonitrile (AN) showed spectral interaction with hepatic microsomes from mouse, rat and man. Whereas human and rat liver microsomes resulted in ligand AN-binding spectra, mouse liver microsomes behaved differently. Hepatic microsomes from phenobarbital-treated mice with AN showed a type I substrate binding; ligand ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(81)90057-6
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:Vitamin A is widely used in cosmetic preparations. Given that oral Vitamin A and its metabolites present a potential reproductive risk, the present study investigated the effect of topical Vitamin A on human endogenous plasma levels of Vitamin A and its metabolites. METHODS:Two groups of 14 female volunteer...
journal_title:Toxicology letters
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.toxlet.2005.09.029
更新日期:2006-05-05 00:00:00
abstract::After toxicological studies with nitrate/nitrite in rats it was observed with nuclear magnetic resonance that N-methylnicotinamide (NMN), a metabolite of tryptophan was increased. The use of NMN as a biomarker for nitrate/nitrite exposure was investigated further in additional experiments with rats and in a human stud...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(95)03306-8
更新日期:1995-05-01 00:00:00
abstract::Cigarette smoking is the strongest risk factor for lung cancer (LC), but genetically determined variations in pulmonary metabolism of tobacco-derived carcinogens may affect individual risk. Results from a case-control study on LC patients demonstrated the pronounced effect of tobacco smoke on pulmonary xenobiotic meta...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(92)90222-6
更新日期:1992-12-01 00:00:00
abstract::Benzene is an occupational and environmental toxicant. The major health concern for humans is acute myelogenous leukemia. To exert its toxic effects, benzene must be metabolized by cytochrome P450 to phenol and subsequently to catechol and hydroquinone. Previous research has implicated CYP2E1 in the metabolism of phen...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(01)00441-6
更新日期:2001-12-15 00:00:00
abstract::This study demonstrates an intraspecies difference in elimination of methylmercury between two genetic variant strains of mice. Following a single non-toxic dose of 203Hg labeled methylmercury (0.5 mg Hg/kg i.p.), the half-time of 203Hg elimination in the CBA/J inbred strain was 7.4 days compared to 3.0 days in the CF...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(80)90114-9
更新日期:1980-10-01 00:00:00