Abstract：
:Results of health survey and biological monitoring in pesticide formulators exposed to a combination of pesticides, an organophosphorus (OP) insecticide (phorate) and a persistent chlorinated insecticide (technical hexachlorocyclohexane; HCH; BHC) are reported. Exposure of 160 workers to a combination of pesticides (malathion, parathion, DDT and HCH) resulted in 73% of the workers showing toxic signs and symptoms. Formulators showed marked inhibition of whole blood, plasma and red blood cell cholinesterase (ChE) activity and slightly higher concentrations of DDT and HCH in serum. An interesting observation was that over 25% of the formulators showed ECG aberrations. The ECG changes were not related to whole blood ChE activity. Exposure to the chlorinated insecticide HCH in 19 workers engaged in the manufacture of technical HCH resulted in toxic signs and symptoms in over 90% of the subjects. The HCH concentrations in serum showed a ten-fold increase. Changes in the liver enzymes ornithine carbamyl transferase (OCT), gamma-glutamyl transpeptidase (GGTP), leucine aminopeptidase (LAP) and in immunoglobulin M(IgM) showed possible effects on liver and humoral immunity. ECG monitoring showed evidence of cardiac effects. Exposure of 40 formulators to a highly toxic OP insecticide (phorate) showed that over 60% of the workers suffered from toxic effects in spite of using a complete set of protective clothing. A marked and progressive inhibition in whole blood and plasma ChE activity was found during the two weeks of exposure to phorate. An appreciable recovery in ChE activity was observed 10 days after cessation of exposure. These surveys have established the need to practice and develop biological monitoring techniques to assess exposure and predict health risks in workers occupationally exposed to pesticides.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Kashyap SKdoi
10.1016/0378-4274(86)90075-5subject
Has Abstractpub_date
1986-10-01 00:00:00pages
107-14issue
1-3eissn
0378-4274issn
1879-3169pii
0378-4274(86)90075-5journal_volume
33pub_type
杂志文章abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a proven animal carcinogen. Occupational cohorts with the highest exposures imply that there is a small risk of all cancers combined, but it is difficult to pinpoint the confounding effect of the main chemicals. Studies after major accidents do not unequivocally confirm th...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
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更新日期：2012-05-05 00:00:00
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doi：10.1016/0378-4274(87)90093-2
更新日期：1987-01-01 00:00:00
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更新日期：1984-10-01 00:00:00
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pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1990-02-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1995-10-01 00:00:00
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更新日期：1983-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2006-04-10 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2013.11.022
更新日期：2014-03-03 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2009.04.001
更新日期：2009-07-24 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2012.09.020
更新日期：2012-11-23 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(91)90117-o
更新日期：1991-06-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(92)90236-d
更新日期：1992-12-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(96)03827-1
更新日期：1997-01-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/0378-4274(89)90113-6
更新日期：1989-03-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/0378-4274(92)90245-f
更新日期：1992-12-01 00:00:00
abstract：:Amiodarone is an effective antidysrhythmic agent, restricted in use by the development of pulmonary toxicity. Several in vivo animal models have been used to study amiodarone-induced pulmonary toxicity. Intratracheal administration of amiodarone to the hamster has been used as a model for the critical amiodarone-induc...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(94)90073-6
更新日期：1994-10-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2007.11.002
更新日期：2008-01-30 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2007.09.006
更新日期：2008-01-04 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2004.03.004
更新日期：2004-07-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/j.toxlet.2003.12.073
更新日期：2004-06-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(95)03528-1
更新日期：1995-12-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2012-06-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2017.05.019
更新日期：2017-10-20 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(85)90084-0
更新日期：1985-05-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2018.07.017
更新日期：2018-10-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(00)00277-0
更新日期：2001-01-03 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/s0378-4274(02)00375-2
更新日期：2003-02-18 00:00:00
abstract：:Computer simulation can be used to integrate existing toxicity information within a biologically realistic framework. Simulation models calculate relevant measures of target tissue dose based on physiological, biochemical and physicochemical properties and readily support the dose, route, species and interchemical ext...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/0378-4274(89)90029-5
更新日期：1989-12-01 00:00:00
abstract：:Acetylcholinesterase (AChE)-induced chewing movements, tremors, convulsions and hind limb abduction at doses of 50-85% LD50 in rats were monitored in order to determine whether the severity of these different signs would correlate with brain AChE levels and the time course of such a relationship. 30 min after subcutan...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(86)90094-9
更新日期：1986-02-01 00:00:00
