Strain differences in susceptibility to di-2-ethylhexyl phthalate-induced testicular atrophy in mice.

abstract：:Lead (Pb) is a toxic heavy metal widespreadly used in industrial field. Prior studies showed that Pb exposure had detrimental effects on osteoblasts. The mechanisms underlying Pb-induced damage are complex. Autophagy can protect cells from various cytotoxic stimuli. In the present study, the aim of our research was to...

journal_title：Toxicology letters

authors： Lv XH,Zhao DH,Cai SZ,Luo SY,You T,Xu BL,Chen K

更新日期：2015-12-03 00:00:00

abstract：:Changes in the activities of antioxidant enzymes superoxide dismutase, catalase (CAT), glutathione peroxidase and heme oxygenase (HO) and changes in lipid peroxidation and reduced glutathione (GSH) levels were measured in the livers of control and Lewis lung carcinoma (LLC)-bearing mice 24 h after a single injection o...

journal_title：Toxicology letters

authors： Christova TY,Gorneva GA,Taxirov SI,Duridanova DB,Setchenska MS

更新日期：2003-03-03 00:00:00

abstract：:Several perfluoroalkyl compounds (PFCs) are ubiquitous environmental contaminants that can biomagnify in species at high trophic levels including wild birds. Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) have been detected in wild birds and are known to reduce hatching success of laboratory-expose...

journal_title：Toxicology letters

authors： O'Brien JM,Crump D,Mundy LJ,Chu S,McLaren KK,Vongphachan V,Letcher RJ,Kennedy SW

更新日期：2009-10-28 00:00:00

abstract：:Asthma is a common chronic inflammatory disease which severely reduces the quality of life in patients. Studies have demonstrated that both PM2.5 and cold stress contribute to the development of asthma. However, the combined effects of these two risking factors are unknown. In this study, we investigated the combined ...

journal_title：Toxicology letters

authors： Zhou J,Geng F,Xu J,Peng L,Ye X,Yang D,Zhao J,Sun Q

更新日期：2019-11-01 00:00:00

abstract：:Human saliva offers a unique noninvasive approach for populational study. Purposes of this study were to investigate the feasibility of using saliva manganese (Mn) concentration as a biomarker of Mn exposure among career welders and to study the variations of Mn, copper (Cu), zinc (Zn), cadmium (Cd), and lead (Pb) in ...

journal_title：Toxicology letters

authors： Wang D,Du X,Zheng W

更新日期：2008-01-04 00:00:00

abstract：:Troglitazone (TGZ) is an orally active hypoglycemic agent which is used for the treatment of non-insulin-dependent diabetes mellitus. It had been associated with severe drug-induced liver failure which resulted in its withdrawal from the market in 2000. While the exact mechanism of its toxicity remains unknown, it has...

journal_title：Toxicology letters

authors： Saha S,New LS,Ho HK,Chui WK,Chan EC

更新日期：2010-02-01 00:00:00

abstract：:The effects of four phthalates, i.e., di-2-ethylhexyl phthalate (DEHP), butyl benzyl phthalate (BBP), dibutyl phthalate (DBP) and diisobutyl phthalate (DIBP) on necrotic and apoptotic cell death, and production of reactive oxygen species (ROS) were studied on mouse macrophage cell line RAW 264.7. All the phthalates ca...

journal_title：Toxicology letters

authors： Naarala J,Korpi A

更新日期：2009-07-24 00:00:00

abstract：:The chronic toxic effects of chromium (2.6 mg/1) on the carbohydrate metabolism of a teleost fish, Channa punctatus were examined after 60 and 120 days of exposure. After 60 days the lactic acid content of blood and muscles was increased but liver lactic acid content decreased. Liver glycogen was also depleted. The ac...

journal_title：Toxicology letters

authors： Sastry KV,Sunita K

更新日期：1983-04-01 00:00:00

abstract：:Blood lead concentrations (Pb-B, microgram/100 ml) was measured in children and adults, both sexes, living in and around Liège (control group, n = 859) and in the urban center of Verviers (exposed group, n = 568) where houses with lead piping are supplied with corrosive drinking water. In control children, the mean Pb...

journal_title：Toxicology letters

authors： Sartor FA,Rondia D

更新日期：1981-01-01 00:00:00

abstract：:When pregnant mice were exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the average time to eye opening in the offspring was shortened by about a day. How acceleration of eye opening by TCDD occurs remains unknown. To reveal the underlying mechanisms of the accelerated eye opening, pregnant mice were intraperit...

journal_title：Toxicology letters

authors： Gin DW,Kim HR,Lee DM,Lee SH,Seong AR,Hwang JA,Park JH

更新日期：2010-07-01 00:00:00

abstract：:Methanol remains to be a major public and environmental health hazard. Formic acid is the toxic metabolite responsible for the metabolic acidosis observed in methanol poisoning in humans, in non-human primates and in folate-depleted rodents. Cytochrome oxidase inhibition by formate leads to lactic acid accumulation, w...

journal_title：Toxicology letters

authors： Muthuvel A,Rajamani R,Sheeladevi R

更新日期：2006-02-20 00:00:00

abstract：:Tubule segments from defined stages of the mouse seminiferous epithelium were incubated for 4, 8 and 24 h in the presence of different concentrations of mono-2-ethylhexyl phthalate (MEHP), adriamycin, and N-ethyl-N-nitrosourea (ENU) to study the effects of these chemicals on germ cell apoptosis and DNA synthesis. Apop...

journal_title：Toxicology letters

authors： Suominen JS,Linderborg J,Nikula H,Hakovirta H,Parvinen M,Toppari J

更新日期：2003-07-20 00:00:00

abstract：:Dysglycemia and central nervous system (CNS) complications are the known adverse effects of fluoroquinolone antibiotics. Ciprofloxacin and levofloxacin are among the most prescribed antibiotics. In this study we demonstrate that ciprofloxacin and levofloxacin disturb glucose transport into HepG2 cells and such inhibit...

journal_title：Toxicology letters

authors： Ge DT,Law PY,Kong SK,Ho YY

更新日期：2009-01-30 00:00:00

abstract：:Pyrethroids are neurotoxic insecticides showing significant selective toxicity on insects over mammals, but effects on mammalian nervous system are not negligible. These substances act on the voltage-gated sodium channel, prolonging the duration of the open state. The present study focused on the effect of the pyrethr...

journal_title：Toxicology letters

authors： Varró P,Kovács M,Világi I

更新日期：2017-02-05 00:00:00

abstract：:The test based on measuring the RNA synthesis rate, already described on Hela S3 in culture (Fauris et al., Les colloques de l'INSERM 106 (1981) 455-463), has been adapted to a human hepatoma cell line Hep 3B which retains a certain capacity towards metabolising. These modifications make it easier to point to the pres...

journal_title：Toxicology letters

authors： Descampiaux B,Herno V,Brice A,Erb F

更新日期：1994-11-01 00:00:00

abstract：:cis-Diamminedichloroplatinum(II) (cisplatin) is one of the most effective antitumor agents currently available for cancer chemotherapy. Unfortunately, its clinical use is severely limited by its dose-dependent nephrotoxicity. Recently, it has been reported that this nephrotoxicity is associated with an increase in lip...

journal_title：Toxicology letters

authors： Sadzuka Y,Shoji T,Takino Y

更新日期：1991-07-01 00:00:00

abstract：:Pneumotoxicity of butylated hydroxytoluene (BHT) applied to the skin of CD-1 mice was investigated and compared with that of butylated hydroxyanisole (BHA). To 6 groups of 10 male mice and 10 female mice 0.1 ml of dimethylsulfoxide (DMSO) solutions containing 0, 5, 10, 20, or 30 mg of BHT or 30 mg of BHA were topicall...

journal_title：Toxicology letters

authors： Miyakawa Y,Takahashi M,Furukawa F,Toyoda K,Sato H,Hayashi Y

更新日期：1986-11-01 00:00:00

abstract：:Welding fumes contain various toxic metals including chromium (Cr), nickel (Ni) and manganese (Mn). An assessment of the risk to health of local and systemic exposure to welding fumes requires the assessment of both external and internal doses. The aims of this study were to test the relevance in small and medium size...

journal_title：Toxicology letters

authors： Persoons R,Arnoux D,Monssu T,Culié O,Roche G,Duffaud B,Chalaye D,Maitre A

更新日期：2014-12-01 00:00:00

abstract：:In order to study the effect of arsenic on DNA damage, Sprague-Dawley rats were dosed with sodium arsenite (10 mg/kg) with or without 800 microg of benzo(a)pyrene (BP) by intramammilary injection. The animals were sacrificed on day 1, 3, 5, 10 and 27 and the mammary gland tissues were collected for DNA adduct measurem...

journal_title：Toxicology letters

authors： Tran HP,Prakash AS,Barnard R,Chiswell B,Ng JC

更新日期：2002-07-07 00:00:00

abstract：:The influence of cold exposure (+ 1 degree C for 24 h) was studied in rats dosed i.p. with 0, 2.5 or 5.0 mumol HgCl2/kg. Cold exposure of controls caused an increased diuresis and solute elimination, except sodium, with almost no variations in urine alkaline phosphatase (ALP) and gammaglutamyl transferase (GGT). Proxi...

journal_title：Toxicology letters

authors： Burgat-Sacaze V,Braun JP,Benard P,Eghbali B,Rico A

更新日期：1982-02-01 00:00:00

abstract：:N-(3,5-Dichlorophenyl)succinimide (NDPS) induces nephrotoxicity via one or more metabolites which arise from oxidation of the succinimide ring. The purpose of this study was to examine the nephrotoxic potential of N-(3,5-dichlorophenyl)-3-hydroxysuccinamic acid (3-NDHSA), a potential metabolite of NDPS and a positiona...

journal_title：Toxicology letters

authors： Rankin GO,Shih H,Teets VJ,Nicoll DW,Brown PI

更新日期：1989-09-01 00:00:00

abstract：:Pyrethroids, a group of insecticides with high efficiency, low toxicity and wide spectrum, are used for pest control in agriculture. Here, we administered two representative pyrethroids (cypermethrin and deltamethrin) and an equal volume of vehicle (corn oil) to the pregnant ICR mice. This study investigated the effec...

journal_title：Toxicology letters

authors： Guo J,Xu J,Zhang J,An L

更新日期：2018-05-01 00:00:00

abstract：:Benzene is a human leukemogen, and a bone marrow toxin and carcinogen in experimental animals. The reactive intermediates involved in benzene toxicity and their mechanism(s) of action have not been clearly delineated. We have investigated the clastogenic and cytotoxic effects of trans,trans-muconaldehyde (MUC), a reac...

journal_title：Toxicology letters

authors： Oshiro Y,Balwierz PS,Witz G

更新日期：2001-05-19 00:00:00

abstract：:Male C57B1/6N mice, 8-10 weeks old were given a single oral dose of 0, 1.0 or 3.0 mg/kg body weight of trimethyltin hydroxide (TMT). Levels of ornithine decarboxylase (ODC) activity were measured in several brain areas, 1, 2 and 7 days later. The lower dose of TMT produced a decrease of ODC in the caudate nucleus and ...

journal_title：Toxicology letters

authors： Ali SF,Newport GD,Slikker W Jr,Bondy SC

更新日期：1987-03-01 00:00:00

abstract：:Cadmium (Cd) has been reported to induce hypertension in both humans and animals; however, its mechanism has not been clearly elucidated. Vascular tone is one of the factors contributing to hypertension. This study was conducted to investigate the effects of Cd exposure on vascular muscarinic receptor responses to ace...

journal_title：Toxicology letters

authors： Yoopan N,Watcharasit P,Wongsawatkul O,Piyachaturawat P,Satayavivad J

更新日期：2008-01-30 00:00:00

abstract：:Between 1997 and 2011, more than 200 new substances were notified through the early-warning system, with the record number of 49 novel molecules reported in 2011. The pattern of acute toxicity associated with the consumption of these new substances is generally similar to that seen with traditional drugs of abuse. Rec...

journal_title：Toxicology letters

authors： Coppola M,Mondola R

更新日期：2012-07-07 00:00:00

abstract：:The dose-response curve obtained in toxicity testing is a mirror image of the susceptibility distribution in the treated population, i.e. it follows increasing tolerance of the individuals to the adverse effects of the chemical under investigation. Defining a dose as a maximum tolerated exposure level, therefore, spli...

journal_title：Toxicology letters

authors： Lutz WK

更新日期：2002-02-07 00:00:00

abstract：:The effects of sodium tellurite 0.1 and 0.4 mg/kg were assessed in the Morris water maze. Two days after treatment rats were tested for acquisition (posttreatment days 3-6) and on seventh day on a spatial retention task. Tellurium treatment was found to cause significant impairment in retention of the spatial learning...

journal_title：Toxicology letters

authors： Widy-Tyszkiewicz E,Piechal A,Gajkowska B,Smiałek M

更新日期：2002-05-28 00:00:00

abstract：:Female SWR mice were treated with 1,2-dimethylhydrazine (DMH: 6.8 mg/kg i.p. injection) once weekly for up to 10 weeks, a dosing regime that produced tumours principally within the distal colon (Jackson et al., 1999. Carcinogenesis 20, 509-513). O(6)-Methylguanine (O(6)-MeG) levels, measured using a simple [3H]-based ...

journal_title：Toxicology letters

authors： Jackson PE,Cooper DP,Meyer TA,Wood M,Povey AC,Margison GP

更新日期：2000-06-05 00:00:00

abstract：:Benzophenone-3 (2-hydroxy-4-methoxybenzophenone, BZ-3) is a UV absorber that is used extensively in medicine, cosmetics and industry as a sunscreen and color fastener. Exposure to the chemical is through the dermal and oral route. Bioavailability of the chemical absorbed through the skin is different from that seen th...

journal_title：Toxicology letters

authors： Okereke CS,Abdel-Rhaman MS,Friedman MA

更新日期：1994-08-01 00:00:00