Molecular biology of insecticide resistance.

abstract：:Asthma is a common chronic inflammatory disease which severely reduces the quality of life in patients. Studies have demonstrated that both PM2.5 and cold stress contribute to the development of asthma. However, the combined effects of these two risking factors are unknown. In this study, we investigated the combined ...

journal_title：Toxicology letters

authors： Zhou J,Geng F,Xu J,Peng L,Ye X,Yang D,Zhao J,Sun Q

更新日期：2019-11-01 00:00:00

abstract：RATIONALE:The popularity of new and emerging tobacco products such as E-cigarettes (E-cigs) is rapidly expanding worldwide. However, uncertainties surrounding the potential health consequences due to the use of such products exist and warrant further study. METHODS:Cultured A549 and Calu-3 airway epithelia were expose...

journal_title：Toxicology letters

authors： Zhang R,Jones MM,Dornsife RE,Wu T,Sivaraman V,Tarran R,Onyenwoke RU

更新日期：2021-02-01 00:00:00

abstract：:Male Swiss OF1 mice received a single oral dose of either 80 mg/kg hexachloro-1,3-butadiene (HCBD) or 80 mg/kg methyl mercury (MeHg). Examination of cryostat kidney sections stained for alkaline phosphatase (APP) revealed damage to about 50% of the proximal tubules after 8 h. Pretreatment with the gamma-glutamyltransp...

journal_title：Toxicology letters

authors： de Ceaurriz J,Ban M

更新日期：1990-02-01 00:00:00

abstract：:Tetrachlorobenzyltoluene (TCBT) (Ugilec 141) was investigated in induction experiments in male and female Wistar rats with long-term (50, 100 and 300 mg/kg p.o. daily for 28 days) and short-term administration (300 mg/kg once and 100 mg/kg daily for 4 days). The increase in total cytochrome P-450 did not exceed the fa...

journal_title：Toxicology letters

authors： von Meyerinck L,Hufnagel B,Schmoldt A,Benthe HF

更新日期：1990-04-01 00:00:00

abstract：:Environmental pollutants, such as dioxin-like (DL) PCBs, benzo(a) pyrene (B[a]P), and flavonoids are aryl hydrocarbon receptor (AHR) ligands and may be excreted in dairy milk. The expression of AHR-target genes, particularly those involved in xenobiotic biotransformation, and their modulation by two DL-PCBs, B[a]P, an...

journal_title：Toxicology letters

authors： Girolami F,Spalenza V,Manzini L,Carletti M,Nebbia C

更新日期：2015-01-05 00:00:00

abstract：:Letimide is a new efficient analgesic salicylate derivative. In this study we evaluated its cytogenetic and teratogenic potential. For chromosomal aberrations and sister chromatid exchange analysis we tested 250, 375, 500 and 625 micrograms/ml of letimide in human lymphocyte cultures in vitro, and for the in vivo cyto...

journal_title：Toxicology letters

authors： Díaz Barriga-Arceo S,Madrigal-Bujaidar E,Salazar M,Chamorro G

更新日期：1991-04-01 00:00:00

abstract：:In recent years physiologically based pharmacokinetic (PBPK) modeling has found frequent application in risk assessments where PBPK models serve as important adjuncts to studies on modes of action of xenobiotics. In this regard, studies on mode of action provide insight into both the sites/mechanisms of action and the...

journal_title：Toxicology letters

authors： Andersen ME

更新日期：2003-02-18 00:00:00

abstract：:In recent years, the detrimental effects of high iodine on intelligence are gaining tons of attention, but the relationship between high iodine and neurotoxicity is controversial. This study aimed to explore whether high iodine intake may impair intelligence and the roles of apoptosis and autophagy in high iodine-indu...

journal_title：Toxicology letters

authors： Cui Y,Zhang Z,Zhang B,Zhao L,Hou C,Zeng Q,Nie J,Yu J,Zhao Y,Gao T,Wang A,Liu H

更新日期：2018-11-01 00:00:00

abstract：:A single s.c. injection of 60 mg/kg of monocrotaline to rats induced pulmonary alterations characterized by hyaline thrombi of capillaries and arterioles, focal necrosis of alveolar walls, and medial thickening and intimal hyalinosis of arteries. Such pathological alterations became apparent 7 days after injection and...

journal_title：Toxicology letters

authors： Hayashi Y,Kokubo T,Takahashi M,Furukawa F,Otsuka H,Hashimoto K

更新日期：1984-04-01 00:00:00

abstract：:Occupational exposure to thallium (Tl+) is known to be responsible for severe neurological manifestations in humans, including ataxia and paralysis; however, little is known yet about the precise mechanism of toxicity elicited by this heavy metal at sublethal doses and its brain distribution after chronic or subchroni...

journal_title：Toxicology letters

authors： Galván-Arzate S,Martínez A,Medina E,Santamaría A,Ríos C

更新日期：2000-07-27 00:00:00

abstract：:Inorganic arsenic has strong human carcinogenic potential, but the availability of an animal model to study toxicity is extremely limited. Here, we used the transgenic zebrafish line Tg(k18(2.9):RFP) as an animal model to study arsenite toxicity. This line was chosen because the red fluorescent protein (RFP) is expres...

journal_title：Toxicology letters

authors： Wang YH,Chen YH,Wu TN,Lin YJ,Tsai HJ

更新日期：2006-06-01 00:00:00

abstract：:The antioxidant activity of genistein is associated with preventing atherosclerosis; however, the underlying mechanisms are not fully understood. In this study, human umbilical vein endothelial cells (HUVECs) were pretreated with genistein at different concentrations (10nM, 100nM and 1000nM) for 6h and then exposed to...

journal_title：Toxicology letters

authors： Zhang H,Zhao Z,Pang X,Yang J,Yu H,Zhang Y,Zhou H,Zhao J

更新日期：2017-08-05 00:00:00

abstract：BACKGROUND:Oxidative stress is one of the main pathogenic mechanisms in vancomycin-induced nephrotoxicity (VIN). Some studies suggest proximal renal tubular cell necrosis by vancomycin accumulation as a mechanism of nephrotoxicity, and other studies demonstrate that cilastatin has protective effects against drug-induce...

journal_title：Toxicology letters

authors： Im DS,Shin HJ,Yang KJ,Jung SY,Song HY,Hwang HS,Gil HW

更新日期：2017-08-05 00:00:00

abstract：:Hepatic and renal microsomal electron transport components and erythrocyte delta-aminolevulinate dehydratase were investigated in adult male rats exposed to 0, 50, 200 and 600 ppm tetrachloroethylene for 4 weeks. Body weight and liver weight showed a significant decrease only in the 600 ppm group. A dose-dependent dec...

journal_title：Toxicology letters

authors： Soni M,Nomiyama H,Nomiyama K

更新日期：1990-12-01 00:00:00

abstract：:2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental pollutant that could induce serious toxic effects in both humans and rodents. Some studies suggested that TCDD exposure may facilitate the activation of hepatic stellate cells (HSCs) and liver injury. However, the underlying molecular mechanism b...

journal_title：Toxicology letters

authors： Han M,Liu X,Liu S,Su G,Fan X,Chen J,Yuan Q,Xu G

更新日期：2017-05-05 00:00:00

abstract：:The aim of this study was to establish a methodology to analyze estrogen quinone-derived adducts, including 17β-estradiol-2,3-quinone (E2-2,3-Q) and 17β-estradiol-3,4-quinone (E2-3,4-Q), in human hemoglobin (Hb). The methodology was then used to measure the levels of these adducts in Hb derived from female breast canc...

journal_title：Toxicology letters

authors： Lin C,Hsieh WC,Chen DR,Kuo SJ,Yu WF,Hu SW,Sue HJ,Ko MH,Juan CH,Chung KS,Lin PH

更新日期：2014-03-21 00:00:00

abstract：:Cigarette smoking is the strongest risk factor for lung cancer (LC), but genetically determined variations in pulmonary metabolism of tobacco-derived carcinogens may affect individual risk. Results from a case-control study on LC patients demonstrated the pronounced effect of tobacco smoke on pulmonary xenobiotic meta...

journal_title：Toxicology letters

authors： Bartsch H,Castegnaro M,Rojas M,Camus AM,Alexandrov K,Lang M

更新日期：1992-12-01 00:00:00

abstract：:The repeated use of the nerve agent sarin against civilians in Syria in 2013 emphasizes the continuing threat by chemical warfare agents. Multiple studies demonstrated a limited efficacy of standard atropine-oxime treatment in nerve agent poisoning and called for the development of alternative and more effective treat...

journal_title：Toxicology letters

authors： Worek F,Thiermann H,Wille T

更新日期：2016-02-26 00:00:00

abstract：:Upon entering the body, nerve agents can bind active amino acid residues to form phosphonylated adducts. Tabun derivatives (O-alkyl-N,N-dialkyl phosphoroamidocyanidates) have strikingly different structural features from other G-series nerve agents, such as sarin and soman. Here, we investigate the binding mechanism f...

journal_title：Toxicology letters

authors： Fu F,Liu H,Gao R,Zhao P,Lu X,Zhang R,Wang L,Wang H,Pei C

更新日期：2020-03-15 00:00:00

abstract：:The effect of a single intravenous (i.v.) injection of cadmium nitrate was investigated in livers of male Wistar rats. A significant increase in liver weight, accompanied by an elevation of total hepatic DNA content was observed. DNA synthesis as measured by the incorporation of [3H]thymidine, was found to be 6 times ...

journal_title：Toxicology letters

authors： Ledda-Columbano GM,Columbano A,Coni PP,Vargiu M,Liguori C,Pani P

更新日期：1984-12-01 00:00:00

abstract：:Recently published studies suggest a weak positive correlation between increased dietary acrylamide intake and the increased risk of endometrial and ovarian cancer. However, risk assessment of acrylamide remains difficult because the carcinogenic mechanisms are still unknown and in particular the molecular effects of ...

journal_title：Toxicology letters

authors： Ehlers A,Lenze D,Broll H,Zagon J,Hummel M,Lampen A

更新日期：2013-02-27 00:00:00

abstract：:The development of efficacious and safe new human pharmaceuticals continues to be highly dependent on well-designed and carefully executed animal toxicology studies. Although the protocols of most toxicology studies now conform to a standard format, careful selection of the most appropriate and relevant laboratory spe...

journal_title：Toxicology letters

authors： Morton DM

更新日期：1998-12-28 00:00:00

abstract：:Identification of genetic polymorphisms responsible for reduced DNA repair capacity may allow better cancer prevention. We examined whether variations in genes involved in base-excision (hOGG1, XRCC1) and double strand break (XRCC3) DNA repair contribute to inter-individual differences in genotoxic effects induced in ...

journal_title：Toxicology letters

authors： Mateuca R,Aka PV,De Boeck M,Hauspie R,Kirsch-Volders M,Lison D

更新日期：2005-04-10 00:00:00

abstract：:An in vivo micronucleus assay using Balb/C male mice was used to examine antigenotoxic effects of cimetidine (CM) on benzene (BZN) induced genotoxic effects. CM not only has therapeutic and immunomudolatory role, but it has also been shown to protect bone marrow stem cells from radiation induced clastogenic effects. T...

journal_title：Toxicology letters

authors： Mozdarani H,Kamali S

更新日期：1998-09-30 00:00:00

abstract：:The tobacco smoking habit interferes with the innate host defence system against infections. Recurrent infections accelerated the functional respiratory decline. The present study assessed the effects of ceftaroline on TLR2 and TLR4 and on pro-inflammatory responses in airway epithelial cells (16HBE cell line and prim...

journal_title：Toxicology letters

authors： Pace E,Ferraro M,Di Vincenzo S,Siena L,Gjomarkaj M

更新日期：2016-09-06 00:00:00

abstract：:The role of intra- and extracellular calcium in the activation of human polymorphonuclear leukocytes (PMNL) to produce reactive oxygen metabolites (ROM) were studied by using soluble, formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol myristate acetate (PMA), or particulate stimuli, quartz or chrysotile. A calciu...

journal_title：Toxicology letters

authors： Ruotsalainen M,Naarala J,Savolainen KM

更新日期：1995-08-01 00:00:00

abstract：:The effect of tri- and hexavalent chromium after intraperitoneal administration for 5 consecutive days on testicular histopathology and epididymal sperm number was assessed. Treatment with hexavalent chromium induced testicular atrophy and a reduction in epididymal sperm number after 60 days. No effect was seen after ...

journal_title：Toxicology letters

authors： Ernst E

更新日期：1990-05-01 00:00:00

abstract：:Results of health survey and biological monitoring in pesticide formulators exposed to a combination of pesticides, an organophosphorus (OP) insecticide (phorate) and a persistent chlorinated insecticide (technical hexachlorocyclohexane; HCH; BHC) are reported. Exposure of 160 workers to a combination of pesticides (m...

journal_title：Toxicology letters

authors： Kashyap SK

更新日期：1986-10-01 00:00:00

abstract：:The skin is highly sensitive to the chemical warfare agent in mustard gas, sulfur mustard (SM) that initiates a delayed injury response characterized by erythema, inflammation and severe vesication (blistering). Although SM poses a continuing threat, used as recently as in the Syrian conflict, no mechanism-based antid...

journal_title：Toxicology letters

authors： Achanta S,Chintagari NR,Brackmann M,Balakrishna S,Jordt SE

更新日期：2018-09-01 00:00:00

abstract：:Due to the massive reduction of air-change rates in modern, energy-saving houses and dwellings, the contribution of volatile organic compound (VOCs) emissions from wood-based materials to indoor air quality has become increasingly important. To evaluate toxicity of VOC mixtures typically emitted from pine wood and ori...

journal_title：Toxicology letters

authors： Gminski R,Tang T,Mersch-Sundermann V

更新日期：2010-06-16 00:00:00