Molecular biology of insecticide resistance.


:The widespread use of insecticides has amounted to a large scale 'experiment' in natural selection of insects by chemicals of toxicological importance to humans. Specific examples in which the molecular basis of insecticide resistance has been studied in detail are presented here. The biochemical/physiological mechanisms of resistance can be categorized as target site insensitivity, increased metabolic detoxification and sequestration or lowered availability of the toxicant. These are achieved at the molecular level by: point mutations in the ion channel portion of a GABA receptor subunit (cyclodiene insecticides); point mutations in the vicinity of the acetylcholinesterase (AChE) active site (organophosphorus and carbamate insecticide resistance); amplification of esterase genes (organophosphorus and carbamate insecticides); mutations linked genetically to a sodium channel gene (DDT and pyrethroid insecticides); and yet uncharacterized mutations leading to the up-regulation of detoxification enzymes, such as cytochrome P450 and glutathione S-transferases (many classes of insecticides). In several cases, the selection of a precisely homologous mutation has been observed in different insect species.


Toxicol Lett


Toxicology letters


Feyereisen R




Has Abstract


1995-12-01 00:00:00












  • Genotoxicity--threshold or not? Introduction of cases of industrial chemicals.

    abstract::Many industrially and environmentally important industrial carcinogens display effects that lead them to be viewed and regulated as 'genotoxic compounds'. Some of these chemicals cause experimental tumours only at high or toxic doses. The current view is that non-threshold principles should be applied for risk assessm...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Bolt HM

    更新日期:2003-04-11 00:00:00

  • Immunotoxicity of poly-drug use: abnormalities in the active and high-affinity CD2 antigen (E-rosette receptor) bearing T-lymphocytes.

    abstract::The E-rosetting profiles of T-cells were studied in 47 subjects with a history of poly-drug and alcohol abuse, and compared with 15 normal controls. No change was evident in numbers of total rosette-forming cells (TRFC). However, there was reduction in active and high-affinity rosette-forming cells (ARFC and HARFC). T...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Nair BS,Erickson JR,Pillai R,Estrada A,Watson RR

    更新日期:1991-08-01 00:00:00

  • Lack of effect of perinatal lead exposure on kappa-opioid receptor function.

    abstract::The effects of lead exposure have been studied upon the behavioural and diuretic responses to the kappa-opioid receptor agonist U-50488H in neonatal rats. Lead was administered in the maternal drinking water (100, 300 and 1000 ppm) from conception to postnatal day 14. The hyperactivity, wall climbing behaviours and di...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Jackson HC,Kitchen I

    更新日期:1990-01-01 00:00:00

  • Cadmium-induced non-apoptotic cell death mediated by oxidative stress under the condition of sulfhydryl deficiency.

    abstract::Cadmium (Cd), which accumulates primarily in the liver and the kidney, induces apoptosis and also causes necrotic cell death in certain pathophysiologic situations. Previously, we have shown that Cd activated mitogen-activated protein kinases and that sulfur amino acid deficiency potentiated Cd-induced cytotoxicity vi...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Kim SC,Cho MK,Kim SG

    更新日期:2003-10-15 00:00:00

  • Urinary N-acetyl-beta-D-glucosaminidase and beta 2-microglobulin in 'itai-itai' disease.

    abstract::N-acetyl-beta-D-glucosaminidase (NAG) activity in urine was measured in patients with 'itai-itai' disease, from chronically advanced cadmium poisoning. Elevation of NAG activity, however, was not so marked as that of beta 2-microglobulin (beta 2-MG) in the urine of patients and suspected patients. We conclude that the...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Nogawa K,Yamada Y,Honda R,Tsuritani I,Ishizaki M,Sakamoto M

    更新日期:1983-05-01 00:00:00

  • Unexpected nephrotoxicity induced by tetrabromobisphenol A in newborn rats.

    abstract::The repeated dose toxicity of tetrabromobisphenol A (TBBPA), a flame retardant, was examined in male and female newborn rats given TBBPA orally at 0, 40, 200, or 600 mg/kg per day for 18 days from 4 days of age until weaning at 21 days of age. Half the rats in each dose group were sacrificed for a full gross necropsy ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Fukuda N,Ito Y,Yamaguchi M,Mitumori K,Koizumi M,Hasegawa R,Kamata E,Ema M

    更新日期:2004-04-21 00:00:00

  • Programmed cell death and its protective role with particular reference to apoptosis.

    abstract::Apoptosis is a type of programmed cell death involved in growth control of tissues. It is considered as a cellular suicide functionally opposite to mitosis. It may serve to remove "unwanted" damaged or dangerous, e.g. precancerous, cells. Chemical compounds can interfere with the regulatory network which controls apop...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Schulte-Hermann R,Bursch W,Kraupp-Grasl B,Oberhammer F,Wagner A

    更新日期:1992-12-01 00:00:00

  • Effect of acute and repeated chlordimeform treatment on rat hepatic microsomal drug metabolizing enzymes.

    abstract::The effect of chlordimeform (CDM) treatment on the hepatic microsomal drug metabolizing enzymes was examined in male and female rats following either acute or repeated treatment. After acute administration of chlordimeform (100 mg/kg, i.p., 1 hour before killing) differential effects were observed in various parameter...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Budris DM,Yim GK,Carlson GP,Schnell RC

    更新日期:1983-08-01 00:00:00

  • Protective effects of the thiol compounds GSH and NAC against sulfur mustard toxicity in a human keratinocyte cell line.

    abstract::Sulfur mustard (SM) is a chemical warfare agent causing blistering, inflammation and ulceration of the skin. Thiol compounds such as glutathione (GSH) and N-acetylcysteine (NAC) have been suggested as potential antidotes. We investigated SM toxicity in a human keratinocyte cell line (HaCaT) and used GSH and NAC to cou...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Balszuweit F,Menacher G,Schmidt A,Kehe K,Popp T,Worek F,Thiermann H,Steinritz D

    更新日期:2016-02-26 00:00:00

  • Human eosinophils are direct targets to nanoparticles: Zinc oxide nanoparticles (ZnO) delay apoptosis and increase the production of the pro-inflammatory cytokines IL-1β and IL-8.

    abstract::Zinc oxide NPs (ZnO) have been recently proposed as novel candidates for the treatment of allergic inflammatory diseases. Paradoxically, recent data suggested that ZnO could cause eosinophilic airway inflammation in rodents. Despite the above observations, there are currently no studies reporting direct interaction be...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Silva LR,Girard D

    更新日期:2016-09-30 00:00:00

  • Linoleic acid epoxide promotes the maintenance of mitochondrial function and active Na+ transport following hypoxia.

    abstract::Low concentrations of arachidonic acid monoepoxides protect against ischemia/reperfusion injury. This study examined whether low concentrations of the linoleic acid monoepoxide, cis-12,13-epoxy-9-octadecenoic acid (12,13-EOA), protect renal cells against decreases in mitochondrial and transport functions induced by hy...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Nowak G,Grant DF,Moran JH

    更新日期:2004-03-01 00:00:00

  • Research chemicals marketed as legal highs: the case of pipradrol derivatives.

    abstract::Between 1997 and 2011, more than 200 new substances were notified through the early-warning system, with the record number of 49 novel molecules reported in 2011. The pattern of acute toxicity associated with the consumption of these new substances is generally similar to that seen with traditional drugs of abuse. Rec...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Coppola M,Mondola R

    更新日期:2012-07-07 00:00:00

  • The effects of mono-2-ethylhexyl phathalate, adriamycin and N-ethyl-N-nitrosourea on stage-specific apoptosis and DNA synthesis in the mouse spermatogenesis.

    abstract::Tubule segments from defined stages of the mouse seminiferous epithelium were incubated for 4, 8 and 24 h in the presence of different concentrations of mono-2-ethylhexyl phthalate (MEHP), adriamycin, and N-ethyl-N-nitrosourea (ENU) to study the effects of these chemicals on germ cell apoptosis and DNA synthesis. Apop...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Suominen JS,Linderborg J,Nikula H,Hakovirta H,Parvinen M,Toppari J

    更新日期:2003-07-20 00:00:00

  • The integration of data on physico-chemical properties, in vitro-derived toxicity data and physiologically based kinetic and dynamic as modelling a tool in hazard and risk assessment. A commentary.

    abstract::Toxicity of a compound for an organism is dependent on the route of exposure, the amount (or concentration), the way in which the compound is taken up, distributes and is eliminated from the organism (ADME, kinetics) and the intrinsic properties (reactivity; mode of action, dynamics) of the compound towards the organi...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Blaauboer BJ

    更新日期:2003-02-18 00:00:00

  • Promutagen activation in partially hepatectomized mice.

    abstract::Mutagenic activity of aflatoxin B1 (AFB1) was followed in the Ames Salmonella/microsome test using liver S-9 from control and partially hepatectomized (PH) mice. The S-9 preparations from the PH mice were capable of inducing significantly greater AFB1 mutagenic activity to strain TA100 than S-9 preparations from eithe...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Vandewaa EA,Barney CC,Gentile JM

    更新日期:1982-12-01 00:00:00

  • The effects of ascorbic acid on the induction of urothelial lesions in mice by 2-acetylaminofluorene.

    abstract::288 BALB/c male mice were allocated to: Group 1-control; Group 2-500 ppm of 2-acetylaminofluorene (2-AAF) in the food, with control water; Group 4-500 ppm of 2-AAF in the food and 250 mg/100 ml of vitamin C in the water; and Group 3-control food and 250 mg% of vitamin C in the water. Major histopathologic changes at t...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Frith CH,Rule J,Kodell RL

    更新日期:1980-09-01 00:00:00

  • Direct oxidation of polyunsaturated cis-parinaric fatty acid by phenoxyl radicals generated by peroxidase/H2O2 in model systems and in HL-60 cells.

    abstract::Reactivity of phenoxyl radicals towards biomolecules (proteins, nucleic acids and lipids) is essential for antioxidant (protective) versus prooxidant (cytotoxic) effects of phenolic compounds (antioxidants, phytochemicals, environmental pollutants and toxic chemicals). The present study demonstrates for the first time...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Ritov VB,Menshikova EV,Goldman R,Kagan VE

    更新日期:1996-10-01 00:00:00

  • Upper respiratory tract nociceptor stimulation and stress response following acute and repeated Cyfluthrin inhalation in normal and pregnant rats: Physiological rat-specific adaptions can easily be misunderstood as adversities.

    abstract::This paper reviews the results from past regulatory and mechanistic inhalation studies in rats with the type II pyrethroid Cyfluthrin. Apart from many chemical irritants, Cyfluthrin was shown to be a neuroexcitatory agent without any inherent tissue-destructive or irritant property. Thus, any Cyfluthrin-induced neuroe...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Pauluhn J

    更新日期:2018-01-05 00:00:00

  • Multiple signal transduction pathways alterations during nerve agent toxicity.

    abstract::Nerve agent toxicity is primarily due to the synaptic build up of toxic levels of acetylcholine. The acute lethal effects of the nerve agents are generally attributed to respiratory failure caused by a combination of effects at both central and peripheral levels and are further complicated by copious secretions, muscl...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: RamaRao G,Bhattacharya BK

    更新日期:2012-01-05 00:00:00

  • Subchronic oral toxicity of turmeric and ethanolic turmeric extract in female mice and rats.

    abstract::Subchronic oral toxicity of turmeric and ethanolic turmeric extract was studied in female Swiss mice and Wistar rats fed turmeric (0, 1 and 5%) and ethanolic turmeric extract (0, 0.05 and 0.25%) through diet for 14 and/or 90 days. The administration of a high dose of turmeric (5%) for longer duration (90 days) showed ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Deshpande SS,Lalitha VS,Ingle AD,Raste AS,Gadre SG,Maru GB

    更新日期:1998-05-01 00:00:00

  • Urinary excretion of heptanones, heptanoles and 2,5-heptanedione after controlled acute exposure of volunteers to n-heptane.

    abstract::A lack of well-established parameters and assessment values currently impairs biomonitoring of n-heptane exposure. Using controlled inhalation experiments, we collected information on urinary n-heptane metabolite concentrations and the time course of metabolite excretion. Relationships between external and internal ex...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Rossbach B,Kegel P,Letzel S

    更新日期:2018-12-01 00:00:00

  • Mouse model of human poisonings with tetramethylenedisulfotetramine: Characterization of the effect of exposure route on syndrome outcomes.

    abstract::Tetramethylenedisulfotetramine (TMDT) is a synthetic neurotoxic rodenticide and potential chemical threat agent. Signs of TMDT poisoning include convulsions which can progress into status epilepticus and death. Although clinical reports clearly show that poisoning via food and drink is the main route of exposure, expe...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Lauková M,Pervez S,Rosman R,Velíšková J,Velíšek L,Shakarjian MP

    更新日期:2019-06-15 00:00:00

  • Effects of salinomycin on human bone marrow-derived mesenchymal stem cells in vitro.

    abstract::Various hypotheses on the origin of cancer stem cells (CSCs) exist, including that CSCs develop from transformed human bone marrow mesenchymal stem cells (hBMSC). Since the polyether antibiotic salinomycin selectively kills CSCs, the present study aims to elucidate the effects of salinomycin on normal hBMSC. The immun...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Scherzed A,Hackenberg S,Froelich K,Rak K,Technau A,Radeloff A,Nöth U,Koehler C,Hagen R,Kleinsasser N

    更新日期:2013-04-26 00:00:00

  • Effect of diet on colonic-programmed cell death: molecular mechanism of action.

    abstract::Colon cancer evolves from a progressive inhibition of apoptosis and is influenced strongly by diet. Among dietary factors, butyrate (derived from fermentable fibers) may have utility as a chemopreventive agent because of its ability to promote apoptosis. Because CD95 (APO-1/Fas) transduces signals resulting in apoptos...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Chapkin RS,Fan Y,Lupton JR

    更新日期:2000-03-15 00:00:00

  • Methylmercury impairs motor function in early development and induces oxidative stress in cerebellar granule cells.

    abstract::Environmental toxicants such as methylmercury play a critical role in the pathogenesis of many neurodevelopmental disorders. Environmental exposure to methylmercury frequently occurs at low doses, most frequently through fish consumption. Although the general population is at risk for exposure, pregnant women and youn...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Patel E,Reynolds M

    更新日期:2013-10-09 00:00:00

  • Is propylene oxide induced cell proliferation in rat nasal respiratory epithelium mediated by a severe depletion of water-soluble non-protein thiol?

    abstract::Propylene oxide (PO) concentrations >or=300 ppm induced cell proliferation and tumors in rat nasal respiratory epithelium (NRE). Cell proliferation was suggested to result from depletion of glutathione (GSH) in NRE. In order to substantiate this hypothesis, cell proliferation - measured by bromodeoxyuridine incorporat...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Khan MD,Klein D,Mossbrugger I,Oesterle D,Csanády GA,Quintanilla-Martinez L,Filser JG

    更新日期:2009-03-28 00:00:00

  • Urinary trehalase activity and renal brush-border damage in inhabitants of a cadmium-polluted area (Jinzu River basin).

    abstract::Elevated urinary trehalase activity was observed in the inhabitants of the Jinzu River basin. Urinary trehalase activity was correlated with other urinalysis components, such as beta 2-microglobulin, glucose, amino nitrogen, and cadmium, of which a high level was observed in cadmium-polluted areas as compared with the...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Nakano M,Aoshima K,Katoh T,Teranishi H,Kasuya M

    更新日期:1986-12-01 00:00:00

  • The therapeutic effects of Longikaurin A, a natural ent-kauranoid, in esophageal squamous cell carcinoma depend on ROS accumulation and JNK/p38 MAPK activation.

    abstract::Effective treatments for esophageal squamous cell carcinoma (ESCC), one of the most common cancers in China, are lacking. Longikaurin A (LK-A), an ent-kauranoid diterpenoid isolated from Isodon ternifolius, has been shown to have potent cytotoxic effects on ESCC cells both in vivo and in vitro, mainly by inducing apop...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Che Y,Wang J,Yuan Z,Li Y,Lu Z,Zhang Z,Zhang J,Wan J,Sun H,Chen Z,Pu J,He J

    更新日期:2017-10-05 00:00:00

  • Toxicological aspects of interesterified fat: Brain damages in rats.

    abstract::In recent years, interesterified fat (IF) has been used to replace hydrogenated vegetable fat (HVF), rich in trans isomers, being found in processed foods. Studies involving IF have shown deleterious influences on the metabolic system, similarly to HVF, whereas no studies regarding its influence on the central nervous...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: D'avila LF,Dias VT,Vey LT,Milanesi LH,Roversi K,Emanuelli T,Bürger ME,Trevizol F,Maurer HL

    更新日期:2017-07-05 00:00:00

  • Effect of ethanol on the in vivo covalent binding and in vitro metabolism of aflatoxin B1 in rats.

    abstract::The binding of [3H]aflatoxin B1 (AFB1) to the DNA, RNA and protein of liver after i.p. administration to rats with and without ethanol pretreatment was studied. The quantities of AFB1 binding to DNA and RNA were significantly increased by ethanol pretreatment but the formation of protein adducts was not affected. AFB1...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Toskulkao C,Glinsukon T

    更新日期:1986-02-01 00:00:00