Abstract:
:The widespread use of insecticides has amounted to a large scale 'experiment' in natural selection of insects by chemicals of toxicological importance to humans. Specific examples in which the molecular basis of insecticide resistance has been studied in detail are presented here. The biochemical/physiological mechanisms of resistance can be categorized as target site insensitivity, increased metabolic detoxification and sequestration or lowered availability of the toxicant. These are achieved at the molecular level by: point mutations in the ion channel portion of a GABA receptor subunit (cyclodiene insecticides); point mutations in the vicinity of the acetylcholinesterase (AChE) active site (organophosphorus and carbamate insecticide resistance); amplification of esterase genes (organophosphorus and carbamate insecticides); mutations linked genetically to a sodium channel gene (DDT and pyrethroid insecticides); and yet uncharacterized mutations leading to the up-regulation of detoxification enzymes, such as cytochrome P450 and glutathione S-transferases (many classes of insecticides). In several cases, the selection of a precisely homologous mutation has been observed in different insect species.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Feyereisen Rdoi
10.1016/0378-4274(95)03470-6subject
Has Abstractpub_date
1995-12-01 00:00:00pages
83-90eissn
0378-4274issn
1879-3169pii
0378-4274(95)03470-6journal_volume
82-83pub_type
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
pub_type: 杂志文章,评审
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2018.08.020
更新日期:2018-11-01 00:00:00
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更新日期:1984-04-01 00:00:00
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journal_title:Toxicology letters
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更新日期:2000-07-27 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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journal_title:Toxicology letters
pub_type: 杂志文章
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2017-08-05 00:00:00
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journal_title:Toxicology letters
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更新日期:1990-12-01 00:00:00
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doi:10.1016/j.toxlet.2017.03.013
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2014.01.004
更新日期:2014-03-21 00:00:00
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doi:10.1016/0378-4274(92)90222-6
更新日期:1992-12-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章,评审
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更新日期:2016-02-26 00:00:00
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journal_title:Toxicology letters
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更新日期:1984-12-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2013-02-27 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1998-12-28 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2004.12.002
更新日期:2005-04-10 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(98)00138-6
更新日期:1998-09-30 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2016.06.2105
更新日期:2016-09-06 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(95)03255-j
更新日期:1995-08-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(90)90069-x
更新日期:1990-05-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1986-10-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2018.03.007
更新日期:2018-09-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2010.03.015
更新日期:2010-06-16 00:00:00