Molecular biology of insecticide resistance.

abstract：:Many industrially and environmentally important industrial carcinogens display effects that lead them to be viewed and regulated as 'genotoxic compounds'. Some of these chemicals cause experimental tumours only at high or toxic doses. The current view is that non-threshold principles should be applied for risk assessm...

journal_title：Toxicology letters

authors： Bolt HM

更新日期：2003-04-11 00:00:00

abstract：:The E-rosetting profiles of T-cells were studied in 47 subjects with a history of poly-drug and alcohol abuse, and compared with 15 normal controls. No change was evident in numbers of total rosette-forming cells (TRFC). However, there was reduction in active and high-affinity rosette-forming cells (ARFC and HARFC). T...

journal_title：Toxicology letters

authors： Nair BS,Erickson JR,Pillai R,Estrada A,Watson RR

更新日期：1991-08-01 00:00:00

abstract：:The effects of lead exposure have been studied upon the behavioural and diuretic responses to the kappa-opioid receptor agonist U-50488H in neonatal rats. Lead was administered in the maternal drinking water (100, 300 and 1000 ppm) from conception to postnatal day 14. The hyperactivity, wall climbing behaviours and di...

journal_title：Toxicology letters

authors： Jackson HC,Kitchen I

更新日期：1990-01-01 00:00:00

abstract：:Cadmium (Cd), which accumulates primarily in the liver and the kidney, induces apoptosis and also causes necrotic cell death in certain pathophysiologic situations. Previously, we have shown that Cd activated mitogen-activated protein kinases and that sulfur amino acid deficiency potentiated Cd-induced cytotoxicity vi...

journal_title：Toxicology letters

authors： Kim SC,Cho MK,Kim SG

更新日期：2003-10-15 00:00:00

abstract：:N-acetyl-beta-D-glucosaminidase (NAG) activity in urine was measured in patients with 'itai-itai' disease, from chronically advanced cadmium poisoning. Elevation of NAG activity, however, was not so marked as that of beta 2-microglobulin (beta 2-MG) in the urine of patients and suspected patients. We conclude that the...

journal_title：Toxicology letters

authors： Nogawa K,Yamada Y,Honda R,Tsuritani I,Ishizaki M,Sakamoto M

更新日期：1983-05-01 00:00:00

abstract：:The repeated dose toxicity of tetrabromobisphenol A (TBBPA), a flame retardant, was examined in male and female newborn rats given TBBPA orally at 0, 40, 200, or 600 mg/kg per day for 18 days from 4 days of age until weaning at 21 days of age. Half the rats in each dose group were sacrificed for a full gross necropsy ...

journal_title：Toxicology letters

authors： Fukuda N,Ito Y,Yamaguchi M,Mitumori K,Koizumi M,Hasegawa R,Kamata E,Ema M

更新日期：2004-04-21 00:00:00

abstract：:Apoptosis is a type of programmed cell death involved in growth control of tissues. It is considered as a cellular suicide functionally opposite to mitosis. It may serve to remove "unwanted" damaged or dangerous, e.g. precancerous, cells. Chemical compounds can interfere with the regulatory network which controls apop...

journal_title：Toxicology letters

authors： Schulte-Hermann R,Bursch W,Kraupp-Grasl B,Oberhammer F,Wagner A

更新日期：1992-12-01 00:00:00

abstract：:The effect of chlordimeform (CDM) treatment on the hepatic microsomal drug metabolizing enzymes was examined in male and female rats following either acute or repeated treatment. After acute administration of chlordimeform (100 mg/kg, i.p., 1 hour before killing) differential effects were observed in various parameter...

journal_title：Toxicology letters

authors： Budris DM,Yim GK,Carlson GP,Schnell RC

更新日期：1983-08-01 00:00:00

abstract：:Sulfur mustard (SM) is a chemical warfare agent causing blistering, inflammation and ulceration of the skin. Thiol compounds such as glutathione (GSH) and N-acetylcysteine (NAC) have been suggested as potential antidotes. We investigated SM toxicity in a human keratinocyte cell line (HaCaT) and used GSH and NAC to cou...

journal_title：Toxicology letters

authors： Balszuweit F,Menacher G,Schmidt A,Kehe K,Popp T,Worek F,Thiermann H,Steinritz D

更新日期：2016-02-26 00:00:00

abstract：:Zinc oxide NPs (ZnO) have been recently proposed as novel candidates for the treatment of allergic inflammatory diseases. Paradoxically, recent data suggested that ZnO could cause eosinophilic airway inflammation in rodents. Despite the above observations, there are currently no studies reporting direct interaction be...

journal_title：Toxicology letters

authors： Silva LR,Girard D

更新日期：2016-09-30 00:00:00

abstract：:Low concentrations of arachidonic acid monoepoxides protect against ischemia/reperfusion injury. This study examined whether low concentrations of the linoleic acid monoepoxide, cis-12,13-epoxy-9-octadecenoic acid (12,13-EOA), protect renal cells against decreases in mitochondrial and transport functions induced by hy...

journal_title：Toxicology letters

authors： Nowak G,Grant DF,Moran JH

更新日期：2004-03-01 00:00:00

abstract：:Between 1997 and 2011, more than 200 new substances were notified through the early-warning system, with the record number of 49 novel molecules reported in 2011. The pattern of acute toxicity associated with the consumption of these new substances is generally similar to that seen with traditional drugs of abuse. Rec...

journal_title：Toxicology letters

authors： Coppola M,Mondola R

更新日期：2012-07-07 00:00:00

abstract：:Tubule segments from defined stages of the mouse seminiferous epithelium were incubated for 4, 8 and 24 h in the presence of different concentrations of mono-2-ethylhexyl phthalate (MEHP), adriamycin, and N-ethyl-N-nitrosourea (ENU) to study the effects of these chemicals on germ cell apoptosis and DNA synthesis. Apop...

journal_title：Toxicology letters

authors： Suominen JS,Linderborg J,Nikula H,Hakovirta H,Parvinen M,Toppari J

更新日期：2003-07-20 00:00:00

abstract：:Toxicity of a compound for an organism is dependent on the route of exposure, the amount (or concentration), the way in which the compound is taken up, distributes and is eliminated from the organism (ADME, kinetics) and the intrinsic properties (reactivity; mode of action, dynamics) of the compound towards the organi...

journal_title：Toxicology letters

authors： Blaauboer BJ

更新日期：2003-02-18 00:00:00

abstract：:Mutagenic activity of aflatoxin B1 (AFB1) was followed in the Ames Salmonella/microsome test using liver S-9 from control and partially hepatectomized (PH) mice. The S-9 preparations from the PH mice were capable of inducing significantly greater AFB1 mutagenic activity to strain TA100 than S-9 preparations from eithe...

journal_title：Toxicology letters

authors： Vandewaa EA,Barney CC,Gentile JM

更新日期：1982-12-01 00:00:00

abstract：:288 BALB/c male mice were allocated to: Group 1-control; Group 2-500 ppm of 2-acetylaminofluorene (2-AAF) in the food, with control water; Group 4-500 ppm of 2-AAF in the food and 250 mg/100 ml of vitamin C in the water; and Group 3-control food and 250 mg% of vitamin C in the water. Major histopathologic changes at t...

journal_title：Toxicology letters

authors： Frith CH,Rule J,Kodell RL

更新日期：1980-09-01 00:00:00

abstract：:Reactivity of phenoxyl radicals towards biomolecules (proteins, nucleic acids and lipids) is essential for antioxidant (protective) versus prooxidant (cytotoxic) effects of phenolic compounds (antioxidants, phytochemicals, environmental pollutants and toxic chemicals). The present study demonstrates for the first time...

journal_title：Toxicology letters

authors： Ritov VB,Menshikova EV,Goldman R,Kagan VE

更新日期：1996-10-01 00:00:00

abstract：:This paper reviews the results from past regulatory and mechanistic inhalation studies in rats with the type II pyrethroid Cyfluthrin. Apart from many chemical irritants, Cyfluthrin was shown to be a neuroexcitatory agent without any inherent tissue-destructive or irritant property. Thus, any Cyfluthrin-induced neuroe...

journal_title：Toxicology letters

authors： Pauluhn J

更新日期：2018-01-05 00:00:00

abstract：:Nerve agent toxicity is primarily due to the synaptic build up of toxic levels of acetylcholine. The acute lethal effects of the nerve agents are generally attributed to respiratory failure caused by a combination of effects at both central and peripheral levels and are further complicated by copious secretions, muscl...

journal_title：Toxicology letters

authors： RamaRao G,Bhattacharya BK

更新日期：2012-01-05 00:00:00

abstract：:Subchronic oral toxicity of turmeric and ethanolic turmeric extract was studied in female Swiss mice and Wistar rats fed turmeric (0, 1 and 5%) and ethanolic turmeric extract (0, 0.05 and 0.25%) through diet for 14 and/or 90 days. The administration of a high dose of turmeric (5%) for longer duration (90 days) showed ...

journal_title：Toxicology letters

authors： Deshpande SS,Lalitha VS,Ingle AD,Raste AS,Gadre SG,Maru GB

更新日期：1998-05-01 00:00:00

abstract：:A lack of well-established parameters and assessment values currently impairs biomonitoring of n-heptane exposure. Using controlled inhalation experiments, we collected information on urinary n-heptane metabolite concentrations and the time course of metabolite excretion. Relationships between external and internal ex...

journal_title：Toxicology letters

authors： Rossbach B,Kegel P,Letzel S

更新日期：2018-12-01 00:00:00

abstract：:Tetramethylenedisulfotetramine (TMDT) is a synthetic neurotoxic rodenticide and potential chemical threat agent. Signs of TMDT poisoning include convulsions which can progress into status epilepticus and death. Although clinical reports clearly show that poisoning via food and drink is the main route of exposure, expe...

journal_title：Toxicology letters

authors： Lauková M,Pervez S,Rosman R,Velíšková J,Velíšek L,Shakarjian MP

更新日期：2019-06-15 00:00:00

abstract：:Various hypotheses on the origin of cancer stem cells (CSCs) exist, including that CSCs develop from transformed human bone marrow mesenchymal stem cells (hBMSC). Since the polyether antibiotic salinomycin selectively kills CSCs, the present study aims to elucidate the effects of salinomycin on normal hBMSC. The immun...

journal_title：Toxicology letters

authors： Scherzed A,Hackenberg S,Froelich K,Rak K,Technau A,Radeloff A,Nöth U,Koehler C,Hagen R,Kleinsasser N

更新日期：2013-04-26 00:00:00

abstract：:Colon cancer evolves from a progressive inhibition of apoptosis and is influenced strongly by diet. Among dietary factors, butyrate (derived from fermentable fibers) may have utility as a chemopreventive agent because of its ability to promote apoptosis. Because CD95 (APO-1/Fas) transduces signals resulting in apoptos...

journal_title：Toxicology letters

authors： Chapkin RS,Fan Y,Lupton JR

更新日期：2000-03-15 00:00:00

abstract：:Environmental toxicants such as methylmercury play a critical role in the pathogenesis of many neurodevelopmental disorders. Environmental exposure to methylmercury frequently occurs at low doses, most frequently through fish consumption. Although the general population is at risk for exposure, pregnant women and youn...

journal_title：Toxicology letters

authors： Patel E,Reynolds M

更新日期：2013-10-09 00:00:00

abstract：:Propylene oxide (PO) concentrations >or=300 ppm induced cell proliferation and tumors in rat nasal respiratory epithelium (NRE). Cell proliferation was suggested to result from depletion of glutathione (GSH) in NRE. In order to substantiate this hypothesis, cell proliferation - measured by bromodeoxyuridine incorporat...

journal_title：Toxicology letters

authors： Khan MD,Klein D,Mossbrugger I,Oesterle D,Csanády GA,Quintanilla-Martinez L,Filser JG

更新日期：2009-03-28 00:00:00

abstract：:Elevated urinary trehalase activity was observed in the inhabitants of the Jinzu River basin. Urinary trehalase activity was correlated with other urinalysis components, such as beta 2-microglobulin, glucose, amino nitrogen, and cadmium, of which a high level was observed in cadmium-polluted areas as compared with the...

journal_title：Toxicology letters

authors： Nakano M,Aoshima K,Katoh T,Teranishi H,Kasuya M

更新日期：1986-12-01 00:00:00

abstract：:Effective treatments for esophageal squamous cell carcinoma (ESCC), one of the most common cancers in China, are lacking. Longikaurin A (LK-A), an ent-kauranoid diterpenoid isolated from Isodon ternifolius, has been shown to have potent cytotoxic effects on ESCC cells both in vivo and in vitro, mainly by inducing apop...

journal_title：Toxicology letters

authors： Che Y,Wang J,Yuan Z,Li Y,Lu Z,Zhang Z,Zhang J,Wan J,Sun H,Chen Z,Pu J,He J

更新日期：2017-10-05 00:00:00

abstract：:In recent years, interesterified fat (IF) has been used to replace hydrogenated vegetable fat (HVF), rich in trans isomers, being found in processed foods. Studies involving IF have shown deleterious influences on the metabolic system, similarly to HVF, whereas no studies regarding its influence on the central nervous...

journal_title：Toxicology letters

authors： D'avila LF,Dias VT,Vey LT,Milanesi LH,Roversi K,Emanuelli T,Bürger ME,Trevizol F,Maurer HL

更新日期：2017-07-05 00:00:00

abstract：:The binding of [3H]aflatoxin B1 (AFB1) to the DNA, RNA and protein of liver after i.p. administration to rats with and without ethanol pretreatment was studied. The quantities of AFB1 binding to DNA and RNA were significantly increased by ethanol pretreatment but the formation of protein adducts was not affected. AFB1...

journal_title：Toxicology letters

authors： Toskulkao C,Glinsukon T

更新日期：1986-02-01 00:00:00