Effect of the cephalosporin cefepime on hepatic drug metabolising enzyme activity in rats.

Abstract:

:Oral doses of the new cephalosporin cefepime administered to rats for 14 days (40 mg/kg/day) did not affect the activities of the hepatic drug metabolising enzymes measured. By contrast there were highly statistically significant increases in all measured parameters in rats treated with phenobarbitone (80 mg/kg/day), the positive control. Control activities in male rats exceeded those in females by about 2-3 fold.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Jordan MC,Waller AR,Chasseaud LF,Barbhaiya RH

doi

10.1016/0378-4274(94)90199-6

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

63-7

issue

1

eissn

0378-4274

issn

1879-3169

pii

0378-4274(94)90199-6

journal_volume

71

pub_type

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