Reactive oxygen species production by BP-1,6-quinone and its effects on the endothelial dysfunction: Involvement of the mitochondria.

abstract：:We previously reported that NR2E3, an orphan nuclear receptor, plays an important role in maintaining the basal expression of estrogen receptor α (ER) and that the NR2E3 level is highly correlated with the relapse-free survival of breast cancer patients. Here, we investigated the role of NR2E3 in benzo(a)pyrene (BaP)-...

journal_title：Toxicology letters

authors： Khanal T,Kim D,Johnson A,Choubey D,Kim K

更新日期：2015-09-17 00:00:00

abstract：:Toluene diisocyanate (TDI), a highly reactive industrial chemical is a leading cause of occupational asthma in westernized countries. It has also been reported to be a skin sensitizer in mice and guinea pigs although instances of skin sensitivity in humans are rare. It is uncertain if skin-contact is necessary to init...

journal_title：Toxicology letters

authors： Ebino K,Ueda H,Kawakatsu H,Shutoh Y,Kosaka T,Nagayoshi E,Lemus R,Karol MH

更新日期：2001-04-08 00:00:00

abstract：:Eugenol, a natural phenolic constituent of clove oil, has a wide range of applications in medicine as a local antiseptic and anesthetic. However, the effect of eugenol on human glioblastoma is unclear. This study examined whether eugenol elevated intracellular free Ca(2+) levels ([Ca(2+)]i) and induced apoptosis in DB...

journal_title：Toxicology letters

authors： Liang WZ,Chou CT,Hsu SS,Liao WC,Shieh P,Kuo DH,Tseng HW,Kuo CC,Jan CR

更新日期：2015-01-05 00:00:00

abstract：:A partially purified toxin fraction and lantadene A were obtained from Lantana camara L. leaves by batch extraction, column chromatography and fractional crystallization. Toxicity was tested in guinea pigs. The total number of chemical entities in the partially purified toxin preparation was 7, the 2 major ones being ...

journal_title：Toxicology letters

authors： Sharma OP,Dawra RK,Makkar HP

更新日期：1987-07-01 00:00:00

abstract：:We have studied the effects of chronic slight to moderate lead exposure on the renin-angiotensin-aldosterone system in normotensive man. Plasma renin activity (PRA), blood angiotensin I (AI) concentration, angiotensin converting enzyme (ACE) activity and aldosterone concentration were measured in 33 normotensive men, ...

journal_title：Toxicology letters

authors： Campbell BC,Meredith PA,Scott JJ

更新日期：1985-04-01 00:00:00

abstract：:This study was designed to compare the pulmonary cellular proliferative effects of inhaled, size-separated preparations of chrysotile asbestos fibres with similar aerosol fibre concentrations of para-aramid fibrils. Following fibre preparation, rats were exposed for 2 weeks to aerosols of p-aramid fibrils or chrysotil...

journal_title：Toxicology letters

authors： Warheit DB,Hartsky MA,Frame SR

更新日期：1996-11-01 00:00:00

abstract：:Intraperitoneal injection of the iron-complex, ferric-nitrilotriacetate (Fe-NTA), induces renal proximal tubular damage associated with oxidative damage in vivo. Fe-NTA induced a time-dependent decrease of several polyunsaturated fatty acids (PUFA), together with increased conjugated diene values and decreased cellula...

journal_title：Toxicology letters

authors： Deiana M,Aruoma OI,Rosa A,Crobu V,Casu V,Piga R,Dessi MA

更新日期：2001-09-15 00:00:00

abstract：:Accumulation of N2-(trans-isoestragol-3'-yl)-2'-deoxyguanosine (E-3'-N2-dG) DNA adducts derived from the alkenylbenzene estragole upon repeated dose exposure was investigated since the repair of this adduct was previously shown to be inefficient. To this end human HepaRG cells were exposed to repeating cycles of 2 h e...

journal_title：Toxicology letters

authors： Yang S,Wesseling S,Rietjens IMCM

更新日期：2021-02-01 00:00:00

abstract：:The proceedings in this volume suggest several important future research needs. Research is needed to validate modeling in toxicology in order to support the use of the general approach of modeling, either for structure-activity relationships (SAR) or physiologically based pharmacokinetics (PBPK), by regulators. Resea...

journal_title：Toxicology letters

authors： Menzel DB

更新日期：1995-09-01 00:00:00

abstract：:Autophagy, which works to remove stress and maintain cellular homeostasis, is usually considered a "pro-survival" signal. Contrarily, apoptosis is programmed "pro-death" machinery. Polychlorinated biphenyls (PCBs) are a group of ubiquitous industrial pollutants. Our previous studies illustrated that a PCB quinone meta...

journal_title：Toxicology letters

authors： Shi Q,Wang Y,Dong W,Song E,Song Y

更新日期：2019-05-15 00:00:00

abstract：:Safety assessment procedures still rely heavily if not exclusively on the results of tests carried out in laboratory animals, then extrapolated to man. There are few examples of environmental compounds examined extensively enough in both man and animals to permit a critical comparison of the accuracy of such risk asse...

journal_title：Toxicology letters

authors： Guzelian PS

更新日期：1992-12-01 00:00:00

abstract：:The possible role of acetylcholine receptors on the HgCl(2)-induced dopamine (DA) release from rat striatum was investigated by using in vivo brain microdialysis technique after administration of selective nicotinic and muscarinic receptor antagonists, mecamylamine and atropine, respectively. Intrastriatal infusion of...

journal_title：Toxicology letters

authors： Vidal L,Durán R,Faro LR,Alfonso M

更新日期：2008-05-30 00:00:00

abstract：:Retinoic acid, an oxidative metabolite of vitamin A, is involved in the control of many biological processes including embryonic development and excess as well as deficiency of retinoids has been found to be teratogenic. The effects of retinoids in normal as well as abnormal development may be mediated by two members ...

journal_title：Toxicology letters

authors： Nau H

更新日期：1995-12-01 00:00:00

abstract：:Recently, spermatogenic cell apoptosis was shown to play a key role in the induction of testicular atrophy by dibutyl phthalate (DBP), thus causing reproductive toxicology. However, the molecular events induced by DBP in apoptotic germ cells remain unclear. In the present study, the mouse spermatocyte-derived GC-2 cel...

journal_title：Toxicology letters

authors： Zhang G,Liu K,Ling X,Wang Z,Zou P,Wang X,Gao J,Yin L,Zhang X,Liu J,Ao L,Cao J

更新日期：2016-03-14 00:00:00

abstract：:Apoptosis is a type of programmed cell death involved in growth control of tissues. It is considered as a cellular suicide functionally opposite to mitosis. It may serve to remove "unwanted" damaged or dangerous, e.g. precancerous, cells. Chemical compounds can interfere with the regulatory network which controls apop...

journal_title：Toxicology letters

authors： Schulte-Hermann R,Bursch W,Kraupp-Grasl B,Oberhammer F,Wagner A

更新日期：1992-12-01 00:00:00

abstract：:Palytoxins (PLTXs) are known seafood contaminants and their entrance into the food chain raises concern about possible effects on human health. The increasing number of analogs being identified in edible marine organisms complicates the estimation of the real hazard associated with the presence of PLTX-like compounds....

journal_title：Toxicology letters

authors： Del Favero G,Sosa S,Poli M,Tubaro A,Sbaizero O,Lorenzon P

更新日期：2014-03-03 00:00:00

abstract：:Traditional Chinese medicine (TCM) has become a crucial cause of drug-induced liver injury (DILI). Differ from chemical medicines, TCM feature more complex and mostly indefinite components. This review aimed to clarify the classification, underlying mechanisms and targets of the risk components in TCM-induced liver in...

journal_title：Toxicology letters

authors： Pan X,Zhou J,Chen Y,Xie X,Rao C,Liang J,Zhang Y,Peng C

更新日期：2020-05-01 00:00:00

abstract：:Sex difference was observed in the aryl hydrocarbon hydroxylase (AHH) activity of liver in the C3H/He strain of mice. Treatment with estradiol showed an increase in AHH activity in gonadectomized female mice, but not in males. Testosterone, however, lowered AHH activity in both the gonadectomized male and female. Foll...

journal_title：Toxicology letters

authors： Watanabe M,Tamura Y,Abe T

更新日期：1980-01-01 00:00:00

abstract：:The effect of carbon monoxide (CO) on pulmonary glutathione-S-transferase (GST) activity was investigated using the isolated perfused rabbit lung (IPRL) preparation. CO at a concentration of 7.5% did not alter the conjugation of glutathione (GSH) with 1,2-epoxy-(p-nitrophenoxy)propane (ENP) in the IPRL. The rate of GS...

journal_title：Toxicology letters

authors： Yang CM,Carlson GP

更新日期：1990-06-01 00:00:00

abstract：:In this work the in vitro reactions of phosphine with intact red blood cells and membrane-free hemoglobin extracts are reported. We demonstrate that phosphine or phosphine derivatives induce dense aggregates of denatured hemoglobin known as 'Heinz bodies' in intact red blood cells. The reaction products include irreve...

journal_title：Toxicology letters

authors： Potter WT,Rong S,Griffith J,White J,Garry VF

更新日期：1991-06-01 00:00:00

abstract：:Di-(2-propylheptyl) phthalate (DPHP) is used as a plasticizer for polyvinyl chloride products. A tolerable daily intake of DPHP of 0.2 mg/kg body weight has been derived from rat data. Because toxicokinetic data of DPHP in humans were not available, it was the aim of the present work to monitor DPHP and selected metab...

journal_title：Toxicology letters

authors： Klein D,Kessler W,Pütz C,Semder B,Kirchinger W,Langsch A,Gries W,Otter R,Gallien AKE,Wurzenberger X,Filser JG

更新日期：2018-09-15 00:00:00

abstract：:The genotoxicity of cypermethrin, a synthetic pyrethroid insecticide, has been studied in vivo in mice. Bone marrow chromosome aberrations were not dose, time or route dependent, but most of the results differed significantly from controls except after 6 and 24 h of treatment using the i.p. and s.c. routes, respective...

journal_title：Toxicology letters

authors： Bhunya SP,Pati PC

更新日期：1988-06-01 00:00:00

abstract：:The effect of sodium selenite administered acutely or repeatedly on the biochemical components of the hepatic microsomal monooxygenase enzyme system was examined in male rats. 72 h following acute administration of selenium (2.4 mg Se/kg, i.p.), there was a significant decrease in ethylmorphine-N-demethylase activity ...

journal_title：Toxicology letters

authors： Schnell RC,Early JL,Deimling MJ,Merrick BA,Davies MH

更新日期：1983-06-01 00:00:00

abstract：:L-Carnitine is a critical metabolite indispensable for the metabolism of lipids as it facilitates fatty acid transport into the mitochondrion where β-oxidation occurs. Human astrocytes (CCF-STTG1 cells) and hepatocytes (HepG2 cells) exposed to aluminum (Al) and hydrogen peroxide (H₂O₂), were characterized with lower l...

journal_title：Toxicology letters

authors： Lemire J,Mailloux R,Darwich R,Auger C,Appanna VD

更新日期：2011-06-24 00:00:00

abstract：:Sulfur dioxide (SO2) is one of potential risk factors for induction and/or exacerbation of asthma, but the underlying mechanisms are not well understood. In this study, we investigate the role of SO2 in asthma using a classical asthmatic model with allergic airway inflammation by treating C57BL/6 mice with ovalbumin (...

journal_title：Toxicology letters

authors： Li X,Huang L,Wang N,Yi H,Wang H

更新日期：2018-03-15 00:00:00

abstract：:A low-Mr copper (Cu) and zinc (Zn)-binding protein was present in the liver of a control water lizard Triturus pyrrhogaster. Cadmium (Cd) accumulated in the liver of the animals after intramuscular injections of Cd salt and was bound to Cu- and Zn-binding protein of a single isoform that had properties characteristic ...

journal_title：Toxicology letters

authors： Suzuki KT,Akitomi H,Kawamura R

更新日期：1984-05-01 00:00:00

abstract：:Since a number of food and food products contain 2,4-hexadienal (HX), an unsaturated aldehyde, human exposure to HX is likely. Long term HX feeding to rodents induces forestomach cancers. Aldehyde dehydrogenases (ALDH) are key enzymes in the stomach for the metabolism of aldehydes. We examined the effect of short term...

journal_title：Toxicology letters

authors： Lee PC,Picchiottino C

更新日期：2003-01-13 00:00:00

abstract：:Sublethal exposure to the organochlorine pesticide, dieldrin, decreased the T-cell immune response in mice. Indeed, a transient inhibition of the mixed lymphocyte reactivity (MLR) was noted at 7 days after intraperitoneal exposure to 0.6 LD50 dieldrin. The present study was undertaken to further investigate the effect...

journal_title：Toxicology letters

authors： Hugo P,Bernier J,Krzystyniak K,Potworowski EF,Fournier M

更新日期：1988-04-01 00:00:00

abstract：:Aflatoxin is a fungal secondary metabolite with high toxicity that is capable of contaminating various types of food crops. It has been identified as a Group 1 human carcinogen by the International Agency for Research on Cancer. Chronic aflatoxin exposure has caused worldwide concern as a matter of public food safety....

journal_title：Toxicology letters

authors： Wang X,You SH,Lien KW,Ling MP

更新日期：2019-10-10 00:00:00

abstract：UNLABELLED:The Mre11, Rad50, and Nbs1 (MRN) complex is a DNA double-strand break sensor involved in DNA damage repair. Herein, we explored whether deletion of NAD(P)H:quinone oxidoreductase 1 (NQO1), a cytoprotective gene, affected MRN complex expression in the kidney after cisplatin-induced acute kidney injury (AKI)....

journal_title：Toxicology letters

authors： Kim YJ,Kim TW,Park SR,Kim HT,Jung DY,Ryu SY,Jung JY

更新日期：2016-01-22 00:00:00