The involvement of mitochondrial apoptotic pathway in eugenol-induced cell death in human glioblastoma cells.

abstract：:An atomic absorption spectrophotometric (AAS) method was successfully applied to analysis of urine for arsenic (As) as a measure of biological monitoring of occupational exposure to As in Vietnam. The application of the method to urine samples from 75 non-exposed control urbanites (after 2-day abstinence from sea food...

journal_title：Toxicology letters

authors： Dang TM,Tran QT,Vu KV

更新日期：1999-09-05 00:00:00

abstract：:The binding of [3H]aflatoxin B1 (AFB1) to the DNA, RNA and protein of liver after i.p. administration to rats with and without ethanol pretreatment was studied. The quantities of AFB1 binding to DNA and RNA were significantly increased by ethanol pretreatment but the formation of protein adducts was not affected. AFB1...

journal_title：Toxicology letters

authors： Toskulkao C,Glinsukon T

更新日期：1986-02-01 00:00:00

abstract：:Several studies have demonstrated that bisphenol A (BPA) exhibited weak estrogenic activity in the 3-day uterotrophic assay using ovariectomized (OVX) and immature rats (Toxicol. Lett. 115 (2000) 231; Regul. Toxicol. Pharmacol. 32 (2000) 118; J. Toxicol. Sci. 26 (2001) 111) and BPA also possessed anti-androgenic activ...

journal_title：Toxicology letters

authors： Kim HS,Han SY,Kim TS,Kwack SJ,Lee RD,Kim IY,Seok JH,Lee BM,Yoo SD,Park KL

更新日期：2002-09-05 00:00:00

abstract：:The influence of cold exposure (+ 1 degree C for 24 h) was studied in rats dosed i.p. with 0, 2.5 or 5.0 mumol HgCl2/kg. Cold exposure of controls caused an increased diuresis and solute elimination, except sodium, with almost no variations in urine alkaline phosphatase (ALP) and gammaglutamyl transferase (GGT). Proxi...

journal_title：Toxicology letters

authors： Burgat-Sacaze V,Braun JP,Benard P,Eghbali B,Rico A

更新日期：1982-02-01 00:00:00

abstract：:A rat bioassay has been developed to provide an objective approach for the identification and classification of upper and lower respiratory tract irritants, with particular emphasis on the concentration-dependent induction and regression of lesions characteristic of asthma, such as persisting non-specific airway hyper...

journal_title：Toxicology letters

authors： Pauluhn J

更新日期：1996-08-01 00:00:00

abstract：:Paraquat is a widely used herbicide which has been involved in many accidental and intentional deaths. Nephrotoxicity is common in severe acute paraquat poisoning. We examined seven renal injury biomarkers, including cystatin-C, kidney injury molecule-1, β2-microglobulin, clusterin, albumin, neutrophil gelatinase-asso...

journal_title：Toxicology letters

authors： Wunnapuk K,Liu X,Peake P,Gobe G,Endre Z,Grice JE,Roberts MS,Buckley NA

更新日期：2013-10-09 00:00:00

abstract：:To test the toxicity of some substances, known to affect the nervous system i.e. organic solvents, heavy metals and DDT, their ability to cause cell detachment of cultured mouse neuroblastoma cells was investigated. A TD25 value was obtained by graphic estimation of the concentration needed to cause 25% of the total c...

journal_title：Toxicology letters

authors： Peterson A,Lewné M,Walum E

更新日期：1981-10-01 00:00:00

abstract：:In vivo effects of model cadmium-containing silica nanoparticles (SiNPs-Cd, 1 mg/rat) were investigated by i.t. instillation in rats to evaluate potential effects on secondary target organ, e.g., kidney. Specific endpoints and pathological outcomes were focused to assess inflammation and fibrosis in renal tissue, 7 an...

journal_title：Toxicology letters

authors： Coccini T,Barni S,Mustarelli P,Locatelli C,Roda E

更新日期：2015-01-22 00:00:00

abstract：:Cholestasis represents pathophysiologic syndromes defined as impaired bile flow from the liver. As an outcome, bile acids accumulate and promote hepatocyte injury, followed by liver cirrhosis and liver failure. Glycochenodeoxycholic acid (GCDCA) is relatively toxic and highly concentrated in bile and serum after chole...

journal_title：Toxicology letters

authors： Lan W,Chen Z,Chen Y,Tan M,Chen Y,Chen J,Chi X,Chen Y

更新日期：2020-10-01 00:00:00

abstract：:Aliesterases (carboxylesterases, EC 3.1.1.1) are serine esterases which may protect acetylcholinesterase during organophosphorus insecticide intoxication by providing alternative phosphorylation sites. Levels of hepatic aliesterase activity were investigated after the intraperitoneal administration of beta-naphthoflav...

journal_title：Toxicology letters

authors： Watson AM,Chambers H,Chambers JE

更新日期：1994-05-01 00:00:00

abstract：:The skin is highly sensitive to the chemical warfare agent in mustard gas, sulfur mustard (SM) that initiates a delayed injury response characterized by erythema, inflammation and severe vesication (blistering). Although SM poses a continuing threat, used as recently as in the Syrian conflict, no mechanism-based antid...

journal_title：Toxicology letters

authors： Achanta S,Chintagari NR,Brackmann M,Balakrishna S,Jordt SE

更新日期：2018-09-01 00:00:00

abstract：:The development of three generic multi-compartment physiologically based kinetic (PBK) models is described for farm animal species, i.e. cattle, sheep, and swine. The PBK models allow one to quantitatively link external dose and internal dose for risk assessment of chemicals relevant to food and feed safety. Model per...

journal_title：Toxicology letters

authors： Lautz LS,Hoeks S,Oldenkamp R,Hendriks AJ,Dorne JLCM,Ragas AMJ

更新日期：2020-01-01 00:00:00

abstract：:cis-Diamminedichloroplatinum(II) (cisplatin) is one of the most effective antitumor agents currently available for cancer chemotherapy. Unfortunately, its clinical use is severely limited by its dose-dependent nephrotoxicity. Recently, it has been reported that this nephrotoxicity is associated with an increase in lip...

journal_title：Toxicology letters

authors： Sadzuka Y,Shoji T,Takino Y

更新日期：1991-07-01 00:00:00

abstract：:There have been many concerns about the possible adverse effects of thyroid hormone-disrupting chemicals in the environment. Because thyroid hormones are essential for regulating the growth and differentiation of many tissues, disruption of thyroid hormones during the neonatal period of an organism might lead to perma...

journal_title：Toxicology letters

authors： Fujimoto N,Kitamura S,Uramaru N,Miyagawa S,Iguchi T

更新日期：2018-04-01 00:00:00

abstract：:Activation of the cold-receptor TRPM8 by menthol or other tobacco additives can suppress natural defense reactions such as coughing that usually would become effective as involuntary resistance against the inhalation of fumes. In Europe menthol is only regulated as flavor, but can be used as additive as long as no cha...

journal_title：Toxicology letters

authors： Paschke M,Tkachenko A,Ackermann K,Hutzler C,Henkler F,Luch A

更新日期：2017-04-05 00:00:00

abstract：:Harmonisation of risk assessment (RA) is one of the priorities for sound chemical management set by Chapter 19, Agenda 21 of the United Nations Conference on the Environment and Development (UNCED) 1992 Earth Summit. The benefits of harmonisation are self evident and include transportability and consistency of RA outc...

journal_title：Toxicology letters

authors： Di Marco PN,Priestly BG,Buckett KJ

更新日期：1998-12-28 00:00:00

abstract：:Intraperitoneal (i.p.) administration of a cadmium (Cd) salt at concentrations of 1.0, 2.5 and 4.0 mg CdCl2/kg body wt. caused severe liver injury in rats 24 h after administration. The toxic effects were most evident in the intermediate dose of 2.5 mg. Thymidine kinase (TK), the key enzyme of the salvage pathway of D...

journal_title：Toxicology letters

authors： Theocharis SE,Margeli AP,Ghiconti IK,Varonos D

更新日期：1992-11-01 00:00:00

abstract：:Cocaine remains a widely abused substance. While most addicts take cocaine intranasally, a considerable number abuse cocaine by mouth. It has been assumed that after oral exposure cocaine is hydrolyzed in the stomach rendering it ineffective. This study investigated the effect of orally administered cocaine on liver f...

journal_title：Toxicology letters

authors： Labib R,Turkall R,Abdel-Rahman MS

更新日期：2001-12-15 00:00:00

abstract：:Long-term excessive intake of fluoride (F) could lead to chronic fluorosis. To explore the underlying molecular mechanisms, present study is designed to elucidate the effect of fluoride on proteome expression of bone in sodium fluoride (NaF)-treated SD rats. Hematoxylin and eosin (H&E) staining was used to determine t...

journal_title：Toxicology letters

authors： Wei Y,Zeng B,Zhang H,Chen C,Wu Y,Wang N,Wu Y,Zhao D,Zhao Y,Iqbal J,Shen L

更新日期：2018-07-01 00:00:00

abstract：:Hepatic and renal microsomal electron transport components and erythrocyte delta-aminolevulinate dehydratase were investigated in adult male rats exposed to 0, 50, 200 and 600 ppm tetrachloroethylene for 4 weeks. Body weight and liver weight showed a significant decrease only in the 600 ppm group. A dose-dependent dec...

journal_title：Toxicology letters

authors： Soni M,Nomiyama H,Nomiyama K

更新日期：1990-12-01 00:00:00

abstract：:The effect of tri- and hexavalent chromium after intraperitoneal administration for 5 consecutive days on testicular histopathology and epididymal sperm number was assessed. Treatment with hexavalent chromium induced testicular atrophy and a reduction in epididymal sperm number after 60 days. No effect was seen after ...

journal_title：Toxicology letters

authors： Ernst E

更新日期：1990-05-01 00:00:00

abstract：:Mouse neuroblastoma cells exposed to 2.5 and 5.0 microM methylmercury for 24 h appeared rounded with the loss of processes. Immunohistochemical staining directed against beta-tubulin revealed severe alterations in microtubular architecture. Non-membrane-bound condensation product was visualized ultrastructurally in th...

journal_title：Toxicology letters

authors： Kromidas L,Trombetta LD,Jamall IS

更新日期：1990-03-01 00:00:00

abstract：:Fenitrothion (FNT) is used worldwide in agricultural and public health settings. Spermatogenesis is a toxicological target of FNT under high-dose exposure. Although anti-androgenic action is postulated to be the mechanism associated with this toxicity, few studies have examined histopathology of androgen-dependent mal...

journal_title：Toxicology letters

authors： Miyake M,Ito Y,Suzuki H,Tomizawa M,Sato H,Liu M,Okamura A,Nakajima T,Ohtani K,Takino H,Inagaki H,Kamijima M

更新日期：2018-03-15 00:00:00

abstract：:To understand environmental causes of disease, unbiased methods are needed to characterize the human exposome, which represents all toxicants to which people are exposed from both exogenous and endogenous sources. Because they directly modify DNA and important proteins, reactive electrophiles are probably the most imp...

journal_title：Toxicology letters

authors： Rappaport SM,Li H,Grigoryan H,Funk WE,Williams ER

更新日期：2012-08-13 00:00:00

abstract：:Coumarin and its derivatives are widely employed as a fragrance in cosmetics and skin care products. The skin absorption level and possible disruption to the skin by topical application of coumarins were evaluated in this study. Percutaneous absorption of osthole, daphnoretin, coumarin, byakangelicin, and 7-hydroxycou...

journal_title：Toxicology letters

authors： Pan TL,Wang PW,Aljuffali IA,Leu YL,Hung YY,Fang JY

更新日期：2014-04-21 00:00:00

abstract：:Transcription factor activator protein (AP)-1 can be activated in nitrogen-mustard-injured mouse skin, and is thought to participate in the inflammatory response. AP-1 consists of homo- or heterodimers of Fos [c-Fos, Fos-B, fos-related antigen (Fra)-1 and Fra-2] and Jun (c-Jun, JunB and JunD) family members, and infor...

journal_title：Toxicology letters

authors： Ye F,Zeng Q,Dan G,Dong X,Chen M,Sai Y,Lin H,Zou Z

更新日期：2020-02-01 00:00:00

abstract：:Conversion of hepatic stellate cells (HSCs) into hepatic myofibroblasts is a necessary event during the development of liver fibrosis. DNA methyltransferase 1 (DNMT1), which catalyzes DNA methylation and subsequently leads to the transcriptional repression of profibrotic genes, is selectively induced in myofibroblasts...

journal_title：Toxicology letters

authors： Bian EB,Huang C,Wang H,Chen XX,Zhang L,Lv XW,Li J

更新日期：2014-01-13 00:00:00

abstract：OBJECTIVE:To evaluate manganese in exhaled breath condensate (Mn-EBC) as an indicator of exposure to fumes from metal inert gas welding process. METHODS:We collected EBC and urine from 17 welders and 16 unexposed control subjects after 5 days exposure. Concentrations of manganese (Mn), nickel (Ni), iron (Fe) and chrom...

journal_title：Toxicology letters

authors： Hulo S,Chérot-Kornobis N,Howsam M,Crucq S,de Broucker V,Sobaszek A,Edme JL

更新日期：2014-04-07 00:00:00

abstract：:Administration of [14C]chlorferron in a single oral dose of 0.5 and 20 mg/kg body weight to female rats resulted in a urinary excretion of greater than 74% of the given dose during the first 24 h. Approx. 8% of the dose was eliminated in faeces within 7 days. 7 days after dosing, very low levels of [14C]chlorferron-de...

journal_title：Toxicology letters

authors： Malik JK,Lay JP,Klein W,Korte F

更新日期：1981-03-01 00:00:00

abstract：:In order to study the effect of arsenic on DNA damage, Sprague-Dawley rats were dosed with sodium arsenite (10 mg/kg) with or without 800 microg of benzo(a)pyrene (BP) by intramammilary injection. The animals were sacrificed on day 1, 3, 5, 10 and 27 and the mammary gland tissues were collected for DNA adduct measurem...

journal_title：Toxicology letters

authors： Tran HP,Prakash AS,Barnard R,Chiswell B,Ng JC

更新日期：2002-07-07 00:00:00