Effect of ethanol on the in vivo covalent binding and in vitro metabolism of aflatoxin B1 in rats.

Abstract:

:The binding of [3H]aflatoxin B1 (AFB1) to the DNA, RNA and protein of liver after i.p. administration to rats with and without ethanol pretreatment was studied. The quantities of AFB1 binding to DNA and RNA were significantly increased by ethanol pretreatment but the formation of protein adducts was not affected. AFB1 metabolism by hepatic microsomes from ethanol-treated rats to aflatoxins M1 (AFM1) and Q1 (AFQ1) was increased when compared to those of control microsomes. These results suggest that an increase in AFB1 binding to liver nucleic acids and AFB1 metabolism after pretreatment of ethanol resulted from an increase in hepatic mixed-function oxidases and a possible decrease in hepatic glutathione (GSH) content which subsequently lead to an increase in hepatotoxicity of AFB1.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Toskulkao C,Glinsukon T

doi

10.1016/0378-4274(86)90097-4

subject

Has Abstract

pub_date

1986-02-01 00:00:00

pages

151-7

issue

2

eissn

0378-4274

issn

1879-3169

pii

0378-4274(86)90097-4

journal_volume

30

pub_type

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