Abstract:
:The binding of [3H]aflatoxin B1 (AFB1) to the DNA, RNA and protein of liver after i.p. administration to rats with and without ethanol pretreatment was studied. The quantities of AFB1 binding to DNA and RNA were significantly increased by ethanol pretreatment but the formation of protein adducts was not affected. AFB1 metabolism by hepatic microsomes from ethanol-treated rats to aflatoxins M1 (AFM1) and Q1 (AFQ1) was increased when compared to those of control microsomes. These results suggest that an increase in AFB1 binding to liver nucleic acids and AFB1 metabolism after pretreatment of ethanol resulted from an increase in hepatic mixed-function oxidases and a possible decrease in hepatic glutathione (GSH) content which subsequently lead to an increase in hepatotoxicity of AFB1.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Toskulkao C,Glinsukon Tdoi
10.1016/0378-4274(86)90097-4subject
Has Abstractpub_date
1986-02-01 00:00:00pages
151-7issue
2eissn
0378-4274issn
1879-3169pii
0378-4274(86)90097-4journal_volume
30pub_type
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journal_title:Toxicology letters
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