Protection against mercuric chloride nephrotoxicity by cold exposure in rats.

abstract：:A teratological test was carried out on triphenyltin acetate (TPTA) used as a fungicide and antifouling agent. Pregnant Wistar rats were treated orally with TPTA at dose levels of 0, 1.5, 3.0, 6.0, 9.0 and 12.0 mg/kg/d during days 7-17 of gestation. Cesarean sections were performed on day 20 of gestation. In the pregn...

journal_title：Toxicology letters

authors： Noda T,Morita S,Yamano T,Shimizu M,Yamada A

更新日期：1991-04-01 00:00:00

abstract：:Aflatoxin is a fungal secondary metabolite with high toxicity that is capable of contaminating various types of food crops. It has been identified as a Group 1 human carcinogen by the International Agency for Research on Cancer. Chronic aflatoxin exposure has caused worldwide concern as a matter of public food safety....

journal_title：Toxicology letters

authors： Wang X,You SH,Lien KW,Ling MP

更新日期：2019-10-10 00:00:00

abstract：:Benzodiazepines have wide-spread used in pharmacotherapy for their anxiolytic, myorelaxant, hypnotic, amnesic and anticonvulsive properties. Despite benzodiazepines are used in clinics over 50 years, they have not been surprisingly tested for capability to induce major drug-metabolizing cytochromes P450. In the curren...

journal_title：Toxicology letters

authors： Vrzal R,Kubesova K,Pavek P,Dvorak Z

更新日期：2010-03-15 00:00:00

abstract：:Cholestasis represents pathophysiologic syndromes defined as impaired bile flow from the liver. As an outcome, bile acids accumulate and promote hepatocyte injury, followed by liver cirrhosis and liver failure. Glycochenodeoxycholic acid (GCDCA) is relatively toxic and highly concentrated in bile and serum after chole...

journal_title：Toxicology letters

authors： Lan W,Chen Z,Chen Y,Tan M,Chen Y,Chen J,Chi X,Chen Y

更新日期：2020-10-01 00:00:00

abstract：:Various hypotheses on the origin of cancer stem cells (CSCs) exist, including that CSCs develop from transformed human bone marrow mesenchymal stem cells (hBMSC). Since the polyether antibiotic salinomycin selectively kills CSCs, the present study aims to elucidate the effects of salinomycin on normal hBMSC. The immun...

journal_title：Toxicology letters

authors： Scherzed A,Hackenberg S,Froelich K,Rak K,Technau A,Radeloff A,Nöth U,Koehler C,Hagen R,Kleinsasser N

更新日期：2013-04-26 00:00:00

abstract：:Male Swiss Webster mice were given an intravenous dose of 50 mg/kg, or an oral gavage dose of 5, 50 or 500 mg/kg [1, 2-(14)C]-ethylenediamine dihydrochloride, and its fate was followed for 48 h. Ethylenediamine (EDA) was readily absorbed from the gut (bioavailability, 87% measured at 50 mg/kg). Absorption was rapid as...

journal_title：Toxicology letters

authors： Leung HW

更新日期：2000-09-30 00:00:00

abstract：:There are multiple lines of evidence showing that environmental toxicants including pesticides may contribute to neuronal cell death. Fipronil (FPN) is a phenylpyrazole insecticide that acts on insect GABA receptors. Although the action of FPN is restricted to insect neuronal or muscular transmitter systems, a few stu...

journal_title：Toxicology letters

authors： Ki YW,Lee JE,Park JH,Shin IC,Koh HC

更新日期：2012-05-20 00:00:00

abstract：:Short-term exposure to elevated levels of particulate matter is associated with increased respiratory and cardiovascular mortality and morbidity. However, the mechanisms underlying these effects are still unclear. Recent studies have suggested that inhaled ultrafine particles are able to translocate into the bloodstre...

journal_title：Toxicology letters

authors： Nemmar A,Inuwa IM

更新日期：2008-01-04 00:00:00

abstract：:There are reports of fluorochloridone (FLC)-induced male reproductive toxicity, but the underlying toxicological mechanisms remain unknown. In this study, we looked at how FLC exposure affected the integrity of the blood-testis barrier (BTB) and the Sertoli cell barrier and studied the molecular mechanisms. Male rats ...

journal_title：Toxicology letters

authors： Liu L,Zhang Y,Chang X,Li R,Wu C,Tang L,Zhou Z

更新日期：2018-10-01 00:00:00

abstract：:The activity of femoral-epiphyseal acid phosphatase, a marker enzyme of bone resorption induced by parathyroid hormone, was increased by a single oral dose of Zn 100 mg/kg to rats. This increase was completely inhibited by calcitonin which has antagonistic effect on the action of parathyroid hormone on bone, thus supp...

journal_title：Toxicology letters

authors： Yamaguchi M,Takahashi K

更新日期：1983-10-01 00:00:00

abstract：:The aim of our study was to determine agonist- and time-dependent phosphorylation of distinct proteins in bovine alveolar macrophages after activation with quartz dusts and heavy metal-coated silica particles. Silica particles were coated with vanadium oxide or cadmium oxide. Separation of proteins was achieved by one...

journal_title：Toxicology letters

authors： Radloff M,Delling M,Gercken G

更新日期：1998-08-01 00:00:00

abstract：:Elevated urinary trehalase activity was observed in the inhabitants of the Jinzu River basin. Urinary trehalase activity was correlated with other urinalysis components, such as beta 2-microglobulin, glucose, amino nitrogen, and cadmium, of which a high level was observed in cadmium-polluted areas as compared with the...

journal_title：Toxicology letters

authors： Nakano M,Aoshima K,Katoh T,Teranishi H,Kasuya M

更新日期：1986-12-01 00:00:00

abstract：:The chronic toxic effects of chromium (2.6 mg/1) on the carbohydrate metabolism of a teleost fish, Channa punctatus were examined after 60 and 120 days of exposure. After 60 days the lactic acid content of blood and muscles was increased but liver lactic acid content decreased. Liver glycogen was also depleted. The ac...

journal_title：Toxicology letters

authors： Sastry KV,Sunita K

更新日期：1983-04-01 00:00:00

abstract：:Exposure to high levels of persistent pollutants, such as metal mixtures, is commonly encountered by the general population especially in industrialized countries. The aim of this work was to evaluate how metal pollution in contaminated areas is reflected in terms of biomarkers (BMs) of exposure and effect in human su...

journal_title：Toxicology letters

authors： de Andrade VL,Cota M,Serrazina D,Mateus ML,Aschner M,Dos Santos APM

更新日期：2020-05-15 00:00:00

abstract：:Nonylphenol (NP) is a representative endocrine disruptor that has an adverse effect on male reproduction and posses direct hazard to Sertoli cells, but the mechanism remains incompletely elucidated. In the present study, based on the structural comparability and high affinity between NP and membrane phospholipid molec...

journal_title：Toxicology letters

authors： Gong Y,Pan X,Huang Y,Gao Z,Yu H,Han X

更新日期：2008-12-15 00:00:00

abstract：RATIONALE:The popularity of new and emerging tobacco products such as E-cigarettes (E-cigs) is rapidly expanding worldwide. However, uncertainties surrounding the potential health consequences due to the use of such products exist and warrant further study. METHODS:Cultured A549 and Calu-3 airway epithelia were expose...

journal_title：Toxicology letters

authors： Zhang R,Jones MM,Dornsife RE,Wu T,Sivaraman V,Tarran R,Onyenwoke RU

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVES:Determine uptake of furan, a potential human carcinogen, in waterpipe tobacco (WPT) smokers in home settings. METHODS:We analysed data from a US convenience sample of 50 exclusive WPT smokers, mean age 25.3 years, and 25 non-smokers, mean age 25.5 years. For WPT smokers, data were collected at a home visit ...

journal_title：Toxicology letters

authors： Kassem NOF,Peterson LA,Liles S,Kassem NO,Zaki FK,Lui KJ,Vevang KR,Dodder NG,Hoh E,Hovell MF

更新日期：2020-10-15 00:00:00

abstract：:Even though compounds of nickel, arsenic, cobalt and cadmium are carcinogenic, their mutagenic potentials are rather weak. In contrast, they exert pronounced comutagenic effects, which may be explained by disturbances of different DNA repair systems. Thus, cobalt, arsenic, nickel and cadmium interfere with base and nu...

journal_title：Toxicology letters

authors： Hartwig A,Schwerdtle T

更新日期：2002-02-28 00:00:00

abstract：:Elevated intracellular Ca(2+) content is implicated in ethanol-induced hepatocyte apoptosis and necrosis. Extracellular Ca(2+) influx has been suggested to play a role in this process. However, the exact Ca(2+)-permeable channel involved in the plasma membrane is still unclear. This study investigated the role of stor...

journal_title：Toxicology letters

authors： Liu H,Jia X,Luo Z,Guan H,Jiang H,Li X,Yan M

更新日期：2012-02-05 00:00:00

abstract：:New psychoactive substances (NPS) are an emerging topic amongst abused compounds. New varieties appear constantly on the market, without any knowledge about their toxicodynamic and/or -kinetic properties and knowledge of their metabolism is crucial for the development of analytical methods employed for their detection...

journal_title：Toxicology letters

authors： Richter LHJ,Herrmann J,Andreas A,Park YM,Wagmann L,Flockerzi V,Müller R,Meyer MR

更新日期：2019-05-01 00:00:00

abstract：:The skin is highly sensitive to the chemical warfare agent in mustard gas, sulfur mustard (SM) that initiates a delayed injury response characterized by erythema, inflammation and severe vesication (blistering). Although SM poses a continuing threat, used as recently as in the Syrian conflict, no mechanism-based antid...

journal_title：Toxicology letters

authors： Achanta S,Chintagari NR,Brackmann M,Balakrishna S,Jordt SE

更新日期：2018-09-01 00:00:00

abstract：:In August 2003, 44 victims were poisoned by chemical warfare agents (CWAs) leaked from five drums that were excavated at a construction site in Qiqihar, Northeast China. The drums were abandoned by the former Japanese imperial army during World War II and contained a mixture of Sulfur mustard (SM) and Lewisite. We car...

journal_title：Toxicology letters

authors： Isono O,Kituda A,Fujii M,Yoshinaka T,Nakagawa G,Suzuki Y

更新日期：2018-09-01 00:00:00

abstract：:Although building constructions are a recurring part of urbanization, the health risk of particulate matters (PM) originating from such activities have seldom been subjected to detailed studies. We sought to characterize the relative risk of air borne PM collected from different heights (ground and top floor) of a bui...

journal_title：Toxicology letters

authors： Li H,Fang CH,Shi W,Gurusamy S,Li S,Krishnan MN,George S

更新日期：2015-11-04 00:00:00

abstract：:We examined the ability of the multidrug resistance-associated protein 1 (MRP1/ABCC1) to transport pesticides, as this transporter mediates the cellular efflux of a variety of xenobiotics, typically as glucuronide, sulfate, or glutathione conjugates. NIH3T3 cells stably expressing MRP1 were 3.37-fold more resistant to...

journal_title：Toxicology letters

authors： Tribull TE,Bruner RH,Bain LJ

更新日期：2003-04-30 00:00:00

abstract：:Aluminum (Al) is a toxic metal, and excessive Al accumulation causes immunosuppression. Deferiprone (DFP) is a well-known chelator and used in dialysis patients for removing Al from tissues. The present study aimed to investigate whether DFP treatment can attenuate immunotoxicity induced by aluminum chloride (AlCl3) i...

journal_title：Toxicology letters

authors： Zhuang C,She Y,Zhang H,Song M,Han Y,Li Y,Zhu Y

更新日期：2018-03-15 00:00:00

abstract：:Hydrochlorofluorocarbon 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123), a close structural analogue of the hepatotoxic anaesthetic halotane and a replacement for some ozone-depleting chlorofluorocarbons, is metabolized by liver cytochrome P450 (P450), both in vitro and in vivo. P450 activates HCFC-123, both oxidatively...

journal_title：Toxicology letters

authors： Zanovello A,Ferrara R,Manno M

更新日期：2003-09-15 00:00:00

abstract：:Chronic exposure to arsenic, a potent carcinogen and toxicant, via drinking water is a worldwide public health problem. Because little is known about early-life effects of arsenic on immunity, we evaluated the impact of in utero exposure on infant immune parameters and morbidity in a pilot study. Pregnant women were e...

journal_title：Toxicology letters

authors： Raqib R,Ahmed S,Sultana R,Wagatsuma Y,Mondal D,Hoque AM,Nermell B,Yunus M,Roy S,Persson LA,Arifeen SE,Moore S,Vahter M

更新日期：2009-03-28 00:00:00

abstract：:Zinc oxide NPs (ZnO) have been recently proposed as novel candidates for the treatment of allergic inflammatory diseases. Paradoxically, recent data suggested that ZnO could cause eosinophilic airway inflammation in rodents. Despite the above observations, there are currently no studies reporting direct interaction be...

journal_title：Toxicology letters

authors： Silva LR,Girard D

更新日期：2016-09-30 00:00:00

abstract：:Rates of alkaline hydrolysis of 18 natural or semisynthetic pyrrolizidine alkaloids, all retronecine diesters, have been compared. Steric hindrance around the ester groups was the major factor inhibiting hydrolysis. Relative rates of hydrolysis by esterases in a rat liver homogenate were also dependent on steric hindr...

journal_title：Toxicology letters

authors： Mattocks AR

更新日期：1982-11-01 00:00:00

abstract：:Male Sprague-Dawley rats were treated i.p. with different doses of bromobenzene (0, 0.1, 0.2, 0.3 and 0.5 mmol/kg) in corn oil for 4 weeks. The animals were killed 24 h after the end of the treatment for hepatic drug metabolism studies. A significant induction of the activities of microsomal aniline hydroxylase (51%) ...

journal_title：Toxicology letters

authors： Chakrabarti S

更新日期：1984-01-01 00:00:00