Abstract：
OBJECTIVE:To evaluate manganese in exhaled breath condensate (Mn-EBC) as an indicator of exposure to fumes from metal inert gas welding process. METHODS:We collected EBC and urine from 17 welders and 16 unexposed control subjects after 5 days exposure. Concentrations of manganese (Mn), nickel (Ni), iron (Fe) and chromium (Cr) were measured in EBC and urine samples and correlated with cumulative exposure indices for the working week (CIW) and for the total welding years (WY), based on duration of welding activity and atmospheric metal measurements. RESULTS:Concentrations of Mn and Ni in EBC were significantly higher among welders than controls whereas this difference was not significant for Mn in urine. Levels of Mn and Ni in EBC were not correlated with their respective levels in urine. The linear regressions found significant positive coefficients between Mn-EBC, Ni-EBC, Ni-U and Cr-U concentrations and the cumulative exposure indices. Taking into account tobacco use, statistical analysis showed the same trends except for the relationship between Mn-U and CIW. CONCLUSION:This pilot study showed that Mn-EBC, as well as Ni-EBC, can serve as reliable indices of occupational exposure to welding fumes and provide complimentary toxicokinetic information to that provided by urine analyses.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Hulo S,Chérot-Kornobis N,Howsam M,Crucq S,de Broucker V,Sobaszek A,Edme JLdoi
10.1016/j.toxlet.2014.01.034subject
Has Abstractpub_date
2014-04-07 00:00:00pages
63-9issue
1eissn
0378-4274issn
1879-3169pii
S0378-4274(14)00054-Xjournal_volume
226pub_type
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