Abstract:
:Goniothalamin, a styryllactone, has been shown to induce cytotoxicity via apoptosis in several tumor cell lines. In this study, we have examined the potential role of several genes, which were stably transfected into T-cell lines and which regulate apoptosis in different ways, on goniothalamin-induced cell death. Overexpression of full-length receptor for activated protein C-kinase 1 (RACK-1) and pc3n3, which up-regulates endogenous RACK-1, in both Jurkat and W7.2 T cells resulted in inhibition of goniothalamin-induced cell death as assessed by MTT and clonogenic assays. However, overexpression of rFau (antisense sequence to Finkel-Biskis-Reilly murine sarcoma virus-associated ubiquitously expressed gene) in W7.2 cells did not confer resistance to goniothalamin-induced cell death. Etoposide, a clinically used cytotoxic agent, was equipotent in causing cytotoxicity in all the stable transfectants. Assessment of DNA damage by Comet assay revealed goniothalamin-induced DNA strand breaks as early as 1 h in vector control but this effect was inhibited in RACK-1 and pc3n3 stably transfected W7.2 cells. This data demonstrate that RACK-1 plays a crucial role in regulating cell death signalling pathways induced by goniothalamin.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Inayat-Hussain SH,Wong LT,Chan KM,Rajab NF,Din LB,Harun R,Kizilors A,Saxena N,Mourtada-Maarabouni M,Farzaneh F,Williams GTdoi
10.1016/j.toxlet.2009.08.012subject
Has Abstractpub_date
2009-12-15 00:00:00pages
118-22issue
2-3eissn
0378-4274issn
1879-3169pii
S0378-4274(09)01396-4journal_volume
191pub_type
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