Abstract:
:Fatty acid composition was studied in milk at day 14 and in liver at day 24 after parturition of lactating rats exposed to 0 ppm, 5 ppm or 25 ppm cadmium (Cd) via drinking water for 17 days during lactation, and in the brain of their offspring at day 19 after birth. In the liver phospholipid fraction, 22:5(n-3) was significantly higher, while in the triacylglycerol fraction 22:6(n-3)/20:5(n-3) ratio was significantly lower in the 25 ppm group compared to the controls. Significantly higher proportions of 16:0 and lower proportions of medium-chain fatty acids, 8:0-14:0, were observed in milk of dams in the 25 ppm group, indicating decreased enzymatic activity of thiotransferase II in the mammary gland. Slightly increased levels of 20:3(n-6) were observed in brains of pups in the 25 ppm group compared to control. The results indicate that Cd exposure influences fatty acid metabolism in lactating rats.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Grawé KP,Pickova J,Dutta PC,Oskarsson Adoi
10.1016/j.toxlet.2003.12.012keywords:
subject
Has Abstractpub_date
2004-03-14 00:00:00pages
73-82issue
1-2eissn
0378-4274issn
1879-3169pii
S0378427403004740journal_volume
148pub_type
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