Effect of saccharin on the induction of chromosomal translocations in male mice and their F1 offspring.

abstract：:Oleanolic acid is a triterpenoid compound that has been shown to protect against liver injury produced by some hepatotoxicants. This study was designed to characterize the protective effects of oleanolic acid on carbon tetrachloride-induced hepatotoxicity, and the role of metallothionein in the protection. Oleanolic a...

journal_title：Toxicology letters

authors： Liu Y,Hartley DP,Liu J

更新日期：1998-03-31 00:00:00

abstract：:Sensitivity to chemicals is a toxicological concept, contained in the dose-response relationship. Sensitivity also includes the concept of hypersensitivity, although controversy surrounds the nature of effects from very low exposures. The term multiple chemical sensitivity has been used to describe individuals with a ...

journal_title：Toxicology letters

authors： Winder C

更新日期：2002-03-10 00:00:00

abstract：:Acetaminophen is a widely used analgesic, which has exhibited evidence of estrogenic activity in estrogen-receptor positive human breast cancer cells. However, there is limited in vivo experimentation regarding the estrogenicity of acetaminophen. Therefore, the present study examined the in vivo estrogenic potential o...

journal_title：Toxicology letters

authors： Patel R,Rosengren RJ

更新日期：2001-05-31 00:00:00

abstract：:The data obtained from in vitro systems utilizing human cells and tissues should form a basic part of the information necessary for risk assessment. The most important thing for such systems is, therefore, to simulate the structures and functions of cells and tissues in the native organ as closely as possible. In desi...

journal_title：Toxicology letters

authors： Emura M,Ochiai A,Hirohashi S

更新日期：1996-11-01 00:00:00

abstract：:At the present work, different groups of rainbow trouts have been intraperitoneally treated with a polychlorinated biphenyls commercial mixture (Arochlor-1254) at three doses (5, 20 and 70 mg PCBs/ kg body weight) and they have been sampled at 0 (injection moment), 3, 6 and 9 weeks after xenobiotic exposure. Purificat...

journal_title：Toxicology letters

authors： Pérez-López M,Nóvoa-Valiñas MC,Melgar-Riol MJ

更新日期：2002-12-15 00:00:00

abstract：BACKGROUND:Oxidative stress is one of the main pathogenic mechanisms in vancomycin-induced nephrotoxicity (VIN). Some studies suggest proximal renal tubular cell necrosis by vancomycin accumulation as a mechanism of nephrotoxicity, and other studies demonstrate that cilastatin has protective effects against drug-induce...

journal_title：Toxicology letters

authors： Im DS,Shin HJ,Yang KJ,Jung SY,Song HY,Hwang HS,Gil HW

更新日期：2017-08-05 00:00:00

abstract：:This study aims to determine whether quercetin elicits a protective effect against the toxicity of chronic exposure to low-level DDVP using metabonomic technology. Rats were randomly assigned into the control, DDVP-treated, quercetin-treated, and quercetin plus DDVP-treated groups. DDVP and quercetin were given to rat...

journal_title：Toxicology letters

authors： Wang H,Li S,Qi L,Xu W,Zeng Y,Hou Y,Zhao X,Sun C

更新日期：2014-03-03 00:00:00

abstract：:Occupational and environmental exposure to pesticides has been associated with thyroid dysfunction, particularly changes in circulating thyroid hormone levels (T3, T4) and thyroid stimulating hormone (TSH). This study assessed the association between environmental exposure to pesticides and the risk of developing thyr...

journal_title：Toxicology letters

authors： Requena M,López-Villén A,Hernández AF,Parrón T,Navarro Á,Alarcón R

更新日期：2019-10-15 00:00:00

abstract：:Rates of alkaline hydrolysis of 18 natural or semisynthetic pyrrolizidine alkaloids, all retronecine diesters, have been compared. Steric hindrance around the ester groups was the major factor inhibiting hydrolysis. Relative rates of hydrolysis by esterases in a rat liver homogenate were also dependent on steric hindr...

journal_title：Toxicology letters

authors： Mattocks AR

更新日期：1982-11-01 00:00:00

abstract：:The HER2 pathway plays a pivotal role in cell proliferation and differentiation, while the receptor overexpression caused by amplification of HER2 gene is associated with the growth of several tumors. Previously published clinical trials have demonstrated that antibody-conjugated drugs (ADCs) remarkably improved clini...

journal_title：Toxicology letters

authors： Jiang J,Li S,Shan X,Wang L,Ma J,Huang M,Dong L,Chen F

更新日期：2020-05-15 00:00:00

abstract：:3-Bromopyruvate (3-BrPA) is a promising agent that has been widely studied in the treatment of cancer and pulmonary hypertension. Rotenone is a pesticide commonly used on farms and was shown to have anti-cancer activity and delay fibrosis progression in chronic kidney disease in a recent study. However, there are few ...

journal_title：Toxicology letters

authors： Zhan C,Liu G,Li J,Li G,Li T,Zhao H,Li L,Yang W,Bai N,Zheng M,Yang J,Li W

更新日期：2020-01-01 00:00:00

abstract：:The early histologic lesions and sequential changes in the development of mirex-induced cataracts were studied in the offspring of lactating female Sherman rats given oral doses of mirex for 5 consecutive days post partum. The earliest histologic change, seen at neonatal day 7, was slight swelling of the individual co...

journal_title：Toxicology letters

authors： Scotti TM,Chernoff N,Linder R,McElroy WK

更新日期：1981-11-01 00:00:00

abstract：:The environmental neurotoxin β-N-methylamino-L-alanine (BMAA) is not an amino acid that is normally found in proteins. Our previous autoradiographic study of (3)H-labeled BMAA in adult mice unexpectedly revealed a tissue distribution similar to that of protein amino acids. The aim of this study was to characterize the...

journal_title：Toxicology letters

authors： Karlsson O,Jiang L,Andersson M,Ilag LL,Brittebo EB

更新日期：2014-04-07 00:00:00

abstract：:Asthma is a common chronic inflammatory disease which severely reduces the quality of life in patients. Studies have demonstrated that both PM2.5 and cold stress contribute to the development of asthma. However, the combined effects of these two risking factors are unknown. In this study, we investigated the combined ...

journal_title：Toxicology letters

authors： Zhou J,Geng F,Xu J,Peng L,Ye X,Yang D,Zhao J,Sun Q

更新日期：2019-11-01 00:00:00

abstract：:Exposure to high levels of persistent pollutants, such as metal mixtures, is commonly encountered by the general population especially in industrialized countries. The aim of this work was to evaluate how metal pollution in contaminated areas is reflected in terms of biomarkers (BMs) of exposure and effect in human su...

journal_title：Toxicology letters

authors： de Andrade VL,Cota M,Serrazina D,Mateus ML,Aschner M,Dos Santos APM

更新日期：2020-05-15 00:00:00

abstract：:The effects of zinc on the lipid components of carp erythrocytes (Cyprinus carpio L.) were studied on red blood cells exposed to ZnSO4 (0.01-1 mM) for 20 h. The temperatures of the incubation medium were 5 and 20 degrees C for carp collected in winter and summer, respectively. It was observed that increase in the conc...

journal_title：Toxicology letters

authors： Teresa G,Anna A,Maria P,Zofia J,Gerard B

更新日期：2002-06-07 00:00:00

abstract：:Work with sub-natural levels of deuterium (D) in animals has demonstrated an anti-cancer effect of low D-concentration in water. Our objective was to investigate whether deuterium-depleted water (DDW) can overturn reverse manganese (Mn)-induced reduction in life span, using the Caenorhabditis elegans (C. elegans) as a...

journal_title：Toxicology letters

authors： Avila DS,Somlyai G,Somlyai I,Aschner M

更新日期：2012-06-20 00:00:00

abstract：:Troglitazone (TGZ) is an orally active hypoglycemic agent which is used for the treatment of non-insulin-dependent diabetes mellitus. It had been associated with severe drug-induced liver failure which resulted in its withdrawal from the market in 2000. While the exact mechanism of its toxicity remains unknown, it has...

journal_title：Toxicology letters

authors： Saha S,New LS,Ho HK,Chui WK,Chan EC

更新日期：2010-02-01 00:00:00

abstract：:The antioxidant activity of genistein is associated with preventing atherosclerosis; however, the underlying mechanisms are not fully understood. In this study, human umbilical vein endothelial cells (HUVECs) were pretreated with genistein at different concentrations (10nM, 100nM and 1000nM) for 6h and then exposed to...

journal_title：Toxicology letters

authors： Zhang H,Zhao Z,Pang X,Yang J,Yu H,Zhang Y,Zhou H,Zhao J

更新日期：2017-08-05 00:00:00

abstract：:The blood-brain barrier (BBB) is critical to maintain cerebral homeostasis. In this study, we examined the effects of exposure to electromagnetic pulse (EMP) on the functional integrity of BBB and, on the localization and expression of tight junction (TJ) proteins (occludin and ZO-1) in rats. Animals were sham or whol...

journal_title：Toxicology letters

authors： Ding GR,Qiu LB,Wang XW,Li KC,Zhou YC,Zhou Y,Zhang J,Zhou JX,Li YR,Guo GZ

更新日期：2010-07-15 00:00:00

abstract：:The effect of sorbic acid alone and in combination with sodium nitrite has been studied on bone marrow chromosomes of mice following 30 days oral treatment. Bone marrow of mice exposed to sorbic acid (15 mg/kg) and sorbic acid nitrite (7.5-1 mg/kg) showed an increase in mitotic index indicating that the drugs had an e...

journal_title：Toxicology letters

authors： Banerjee TS,Giri AK

更新日期：1986-05-01 00:00:00

abstract：:Sulfur dioxide (SO2) is a ubiquitous air pollutant, presents in low concentrations in the urban air, and in higher concentrations in the working environment. In the present study, male Wistar rats were housed in exposure chambers and treated with 14.00+/-1.53, 28.00+/-2.12 and 56.00+/-4.28 mg/m3 SO2 for 6 h/day for 7 ...

journal_title：Toxicology letters

authors： Qin G,Meng Z

更新日期：2005-12-30 00:00:00

abstract：:Two groups of C57BL/6J mice received a single oral dose of 1 nmol/kg 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin (TCDD) alone or in combination with 300 mumol/kg 2,2',4,4',5,5'-hexachlorobiphenyl (HxCB). The disposition of TCDD in liver, fat, skin, spleen, lung and blood was studied at days 3, 7, 13 and 34 after dosage. H...

journal_title：Toxicology letters

authors： De Jongh J,DeVito M,Diliberto J,Van den Berg M,Birnbaum L

更新日期：1995-10-01 00:00:00

abstract：:Dietary administration of di-2-ethylhexyl phthalate (DEHP; 2%) to male rats caused testicular atrophy. Serum non-esterified fatty acid increased while cholesterol, triglyceride and phospholipid decreased in treated rats. Testicular concentration of cholesterol and non-esterified fatty acid increased in DEHP-treated ra...

journal_title：Toxicology letters

authors： Oishi S

更新日期：1984-10-01 00:00:00

abstract：:Diclofenac is a widely prescribed NSAID that causes severe idiosyncratic drug induced liver injury (IDILI) in a small part of the patient population. Formation of protein-reactive metabolites is considered to play a role in the development of diclofenac-induced IDILI. Therefore, a high hepatic activity of enzymes invo...

journal_title：Toxicology letters

authors： den Braver MW,Zhang Y,Venkataraman H,Vermeulen NP,Commandeur JN

更新日期：2016-07-25 00:00:00

abstract：:Accumulation of macrophages and neutrophil granulocytes in the lung are key events in the inflammatory response to inhaled particles. The present study aims at the time course of chemotaxis in vitro in response to the challenge of various biopersistent particles and its functional relation to the transcription of infl...

journal_title：Toxicology letters

authors： Schremmer I,Brik A,Weber DG,Rosenkranz N,Rostek A,Loza K,Brüning T,Johnen G,Epple M,Bünger J,Westphal GA

更新日期：2016-11-30 00:00:00

abstract：:Induction of endotoxin tolerance in rats led to reductions in bile flow and BSP excretion. BSP serum retention or storage of BSP in the liver was not affected. Although serum alanine aminotransferase (ALT) activity was slightly elevated in endotoxin-tolerant rats, the levels of serum aspartate amino-transferase (AST) ...

journal_title：Toxicology letters

authors： Boelsterli UA,Abernathy CO,Balazs T,Zimmerman HJ

更新日期：1982-05-01 00:00:00

abstract：:Intraperitoneal injection of the iron-complex, ferric-nitrilotriacetate (Fe-NTA), induces renal proximal tubular damage associated with oxidative damage in vivo. Fe-NTA induced a time-dependent decrease of several polyunsaturated fatty acids (PUFA), together with increased conjugated diene values and decreased cellula...

journal_title：Toxicology letters

authors： Deiana M,Aruoma OI,Rosa A,Crobu V,Casu V,Piga R,Dessi MA

更新日期：2001-09-15 00:00:00

abstract：:Amitriptyline hydrochloride, an antidepressant drug, was tested in mice for mutagenic effects in the somatic cells by the micronucleus test and in the germ cells by the air drying technique of Evans et al. Mice were treated orally with the drug at a dose of 70, 140 and 210 mg/kg body weight. The results indicate that ...

journal_title：Toxicology letters

authors： Chowdary PS,Rao MS

更新日期：1987-12-01 00:00:00

abstract：:Indomethacin (IND) suppresses the T-dependent antibody response (TDAR) in juvenile males when it is administered to pregnant rats during late gestation. In this study, the effect of IND on cytokine production in juvenile rats was examined to investigate the mechanism behind the suppression of antibody production. IND ...

journal_title：Toxicology letters

authors： Kushima K,Sakuma S,Furusawa S,Fujiwara M

更新日期：2009-02-25 00:00:00