Interactions by carcinogenic metal compounds with DNA repair processes: toxicological implications.


:Even though compounds of nickel, arsenic, cobalt and cadmium are carcinogenic, their mutagenic potentials are rather weak. In contrast, they exert pronounced comutagenic effects, which may be explained by disturbances of different DNA repair systems. Thus, cobalt, arsenic, nickel and cadmium interfere with base and nucleotide excision repair, even though they affect different steps of the respective repair systems and act by different, not yet completely understood mechanisms. Potential target molecules for some metal ions are so-called zinc finger structures in DNA repair proteins, but each zinc finger protein exerts its own sensitivity towards toxic metal ions. Possible consequences of repair inhibitions are discussed in more detail for soluble and particulate nickel compounds, which have recently been shown to interfere with the repair of stable DNA adducts induced by benzo[a]pyrene (B[a]P). Since nickel compounds and polycyclic aromatic hydrocarbons such as B[a]P are frequently associated in the ambient air, in cigarette smoke and at many workplaces, an impaired removal of B[a]P-derived DNA adducts will lead to persistent DNA damage and thus increase the risk of mutations and tumor formation.


Toxicol Lett


Toxicology letters


Hartwig A,Schwerdtle T





Has Abstract


2002-02-28 00:00:00














  • An assessment of the genotoxicity of vanadium.

    abstract::The activities of vanadium oxide (V2O3), vanadyl sulfate (VOSO4) and ammonium metavanadate (NH4VO3) in inducing sister chromatid exchange (SCE) and chromosomal aberrations (CAb) were assayed in Chinese hamster ovary cells. The toxic concentrations (TC50) for these compounds were found to be 25, 23 and 16 micrograms el...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Owusu-Yaw J,Cohen MD,Fernando SY,Wei CI

    更新日期:1990-02-01 00:00:00

  • Differences in butadiene adduct formation between rats and mice not due to selective inhibition of CYP2E1 by butadiene metabolites.

    abstract::CYP2E1 metabolizes 1,3-butadiene (BD) into genotoxic and possibly carcinogenic 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane (DEB), and 1,2-epoxy-3,4-butanediol (EB-diol). The dose response of DNA and protein adducts derived from BD metabolites increases linearly at low BD exposures and then saturates at higher expos...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Pianalto KM,Hartman JH,Boysen G,Miller GP

    更新日期:2013-11-25 00:00:00

  • Hydrolysis and hepatotoxicity of retronecine diesters.

    abstract::Rates of alkaline hydrolysis of 18 natural or semisynthetic pyrrolizidine alkaloids, all retronecine diesters, have been compared. Steric hindrance around the ester groups was the major factor inhibiting hydrolysis. Relative rates of hydrolysis by esterases in a rat liver homogenate were also dependent on steric hindr...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Mattocks AR

    更新日期:1982-11-01 00:00:00

  • Influence of methylglyoxal on antioxidant enzymes and oxidative damage.

    abstract::The effect of different doses of methylglyoxal (50-400 mg/kg body wt.) were examined using enzymes involved in the antioxidant function, glutathione (GSH) content and lipid peroxidation in the liver and spleen of Swiss albino mice (7-8 week old) after 6, 12 and 24 h. Significant changes were observed predominantly in ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Choudhary D,Chandra D,Kale RK

    更新日期:1997-12-01 00:00:00

  • Chloroacetonitrile induces oxidative stress and apoptosis in mouse fetal liver.

    abstract::Chloroacetonitrile (CAN) is a disinfection by-product of chlorination of drinking water. The present study was designed to investigate the potential adverse effects of maternal exposure to CAN on fetal liver in mice. Based on an initial dose-response experiment, CAN (25mg/(kgday)) was given orally to pregnant mice at ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Abdel-Naim AB,Nagy AA,Mohamadin AM,El-Mazar HM,Ahmed AE

    更新日期:2009-10-28 00:00:00

  • Acute exposure to cobalt induces transient methemoglobinuria in rats.

    abstract::We observed transient excretion of dark-brown urine after acute exposure to cobalt in rats and investigated the mechanism of it. We injected cobalt into rats s.c. at a dose of 15 mg/kg and collected urine, peripheral blood, and organ samples at the indicated times after injection. Biochemical and histopathological exa...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Horiguchi H,Oguma E,Nomoto S,Arao Y,Ikeda K,Kayama F

    更新日期:2004-08-01 00:00:00

  • Interlaboratory evaluation of a cow's milk allergy mouse model to assess the allergenicity of hydrolysed cow's milk based infant formulas.

    abstract::This study describes two phases of a multi-phase project aiming to validate a mouse model for cow's milk allergy to assess the potential allergenicity of hydrolysed cow's milk based infant formulas (claim support EC-directive 2006/141/E). The transferability and the discriminatory power of this model was evaluated in ...

    journal_title:Toxicology letters

    pub_type: 杂志文章,多中心研究


    authors: van Esch BC,van Bilsen JH,Jeurink PV,Garssen J,Penninks AH,Smit JJ,Pieters RH,Knippels LM

    更新日期:2013-06-20 00:00:00

  • The effects of n-alcohols on evoked synaptic potentials in rat hippocampal slices: Hill coefficients account for the cut-off phenomenon.

    abstract::The anesthetic potencies of n-alcohols increase progressively with lengthening of the carbon chain and then disappear at a cut-off point of a longer-chain n-alcohol. In order to assess the mechanisms for cut-off in mammalian central nervous system, the effects of a series of n-alcohols (C(2)-C(11)) were examined on th...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Takehana K,Hirota K,Roth SH,Masuda A,Ito Y

    更新日期:2000-05-19 00:00:00

  • Comparison between oral and dermal bioavailability of soil-adsorbed phenanthrene in female rats.

    abstract::Phenathrene is a major coal tar component found in hazardous waste disposal sites. The purpose of this study was to evaluate the extent to which phenanthrene adsorption to either of 2 different soils affects the manner in which phenanthrene is subsequently handled in orally and dermally exposed adult female rats. Abso...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Kadry AM,Skowronski GA,Turkall RM,Abdel-Rahman MS

    更新日期:1995-07-01 00:00:00

  • Cadmium-binding proteins in human organs.

    abstract::Cadmium-binding proteins (CdBPs) in the cytosol fractions from several organs of man orally exposed to cadmium (Cd) were examined by gel chromatography. In kidney and liver most of the cadmium (76-87%) in the cytosols was bound to metallothionein, and hepatic metallothionein contained zinc also at a similar level. The...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Sato M,Takizawa Y

    更新日期:1982-05-01 00:00:00

  • Protection against mercuric chloride nephrotoxicity by cold exposure in rats.

    abstract::The influence of cold exposure (+ 1 degree C for 24 h) was studied in rats dosed i.p. with 0, 2.5 or 5.0 mumol HgCl2/kg. Cold exposure of controls caused an increased diuresis and solute elimination, except sodium, with almost no variations in urine alkaline phosphatase (ALP) and gammaglutamyl transferase (GGT). Proxi...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Burgat-Sacaze V,Braun JP,Benard P,Eghbali B,Rico A

    更新日期:1982-02-01 00:00:00

  • In vitro prenatal developmental toxicity induced by some petroleum substances is mediated by their 3- to 7-ring PAH constituent with a potential role for the aryl hydrocarbon receptor (AhR).

    abstract::To test the hypothesis that 3-7 ring polycyclic aromatic hydrocarbons (PAHs) are responsible for the prenatal developmental toxicity (PDT) as observed with some petroleum substances (PS), the present study evaluates the PDT potency of DMSO-extracts of 7 heavy fuel oils (HFO), varying in their PAH content, and 1 highly...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Kamelia L,de Haan L,Ketelslegers HB,Rietjens IMCM,Boogaard PJ

    更新日期:2019-10-15 00:00:00

  • Dimethocaine, a synthetic cocaine derivative: studies on its in vitro metabolism catalyzed by P450s and NAT2.

    abstract::Dimethocaine (DMC), a synthetic derivative of cocaine, is distributed and consumed as "new psychoactive substance" (NPS) without any safety testing at the forefront. It is mainly metabolized by N-acetylation, N-deethylation or hydroxylation. Therefore, the aim of the presented study was to determine the human NAT and ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Meyer MR,Lindauer C,Maurer HH

    更新日期:2014-02-10 00:00:00

  • Safrole-DNA adduct in hepatocellular carcinoma associated with betel quid chewing.

    abstract::Betel quid chewing, which contributes high concentration of safrole in saliva, is a popular oral habit in Taiwan. Safrole is a documented rodent hepatocarcinogen, yet its hepatocarcinogenic potential in human is not known. Here, we used LC/ESI-ITMS(n) and LC/QTOF-MS confirmed safrole-dGMP as reference standard to dete...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Chung YT,Chen CL,Wu CC,Chan SA,Chi CW,Liu TY

    更新日期:2008-12-15 00:00:00

  • Impact of carbon nanotube exposure, dosage and aggregation on smooth muscle cells.

    abstract::Carbon nanotubes (CNT), despite their diverse application potential, have demonstrated adverse impacts in vitro and in vivo. Previous studies have focused on the combined in vitro cytotoxic impact of CNT aggregates and associated nanoparticulate impurities. However, the isolated effect of CNT aggregates and associated...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Raja PM,Connolley J,Ganesan GP,Ci L,Ajayan PM,Nalamasu O,Thompson DM

    更新日期:2007-02-28 00:00:00

  • Environmental contaminants and human health in the Arctic.

    abstract::Monitoring of human exposure to persistent organic pollutants POPs and heavy metals have taken place since 1994 in a circumpolar study conducted under the Arctic monitoring and assessment programme (AMAP). The study has confirmed that Arctic populations relying on marine food (Inuit) have an exposure level of POPs and...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Hansen JC

    更新日期:2000-03-15 00:00:00

  • Efficacies of tea components on doxorubicin induced antitumor activity and reversal of multidrug resistance.

    abstract::Considering of novel biochemical modulation by some foods and beverages, we have performed screening for green tea components that have enhancing effects on doxorubicin (DOX) induced antitumor activity. Components, such as caffeine, theanine, (-)-epigallocatechin gallate (EGCG) and flavonoids have inhibitory effects o...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Sadzuka Y,Sugiyama T,Sonobe T

    更新日期:2000-04-03 00:00:00

  • Induction of renin release from isolated glomeruli by inorganic mercury(II).

    abstract::Mercury(II) ions are known to accumulate in the kidney and their effect upon the renin-angiotensin system has also been described. The question, however, whether mercury(II) also exerts direct effect on the juxtaglomerular cells (JGC) to induce renin release remained to be answered. Suspension of isolated glomeruli wa...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Kozma L,Lenkey A,Varga E,Gomba S

    更新日期:1996-04-01 00:00:00

  • Effects of cyanobacteria Oscillatoria sp. lipopolysaccharide on B cell activation and Toll-like receptor 4 signaling.

    abstract::Cyanobacteria ("blue-green algae"), such as Oscillatoria sp., are a ubiquitous group of bacteria found in freshwater systems worldwide that are linked to illness and in some cases, death among humans and animals. Exposure to cyanobacteria occurs via ingestion of contaminated water or food-products. Exposure of the gut...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Swanson-Mungerson M,Incrocci R,Subramaniam V,Williams P,Hall ML,Mayer AMS

    更新日期:2017-06-05 00:00:00

  • The use of toxicodynamics in risk assessment.

    abstract::Risk assessment of xenobiotics is a qualitative and quantitative assessment of toxic properties conventionally based on data resulting from tests in animals exposed to the substance. The assessment of dose-effect relationship includes evaluation of exposure at the site of action. More recently, emphasis is put on unde...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Heinrich-Hirsch B,Madle S,Oberemm A,Gundert-Remy U

    更新日期:2001-03-31 00:00:00

  • Saikosaponin-d-mediated downregulation of neurogenesis results in cognitive dysfunction by inhibiting Akt/Foxg-1 pathway in mice.

    abstract::Saikosaponin-d (SSd), one of the main constituents of the total saikosaponins extracted from Bupleurum falcatum L, possesses anti-inflammatory and anti-apoptosis effect. Recently, SSd was proved to improve depressive symptoms although exhibit hepatotoxicity in animals, but the central nervous system (CNS) toxicity of ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Lixing X,Zhouye J,Liting G,Ruyi Z,Rong Q,Shiping M

    更新日期:2018-03-01 00:00:00

  • Monitoring internal exposure to metals and organic substances in workers at a hazardous waste incinerator after 3 years of operation.

    abstract::The potential adverse effects of hazardous waste incinerators (HWI) continue to be a subject of worry. The construction of the first and up till now only HWI in Spain finished in 1999. Twenty-six subjects employed at this HWI were divided into three groups: plant, laboratory and administration. Plasma analyses of HCB,...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Carmen Agramunt M,Domingo A,Domingo JL,Corbella J

    更新日期:2003-12-15 00:00:00

  • Toluene exposure during brain growth spurt and adolescence produces differential effects on N-methyl-D-aspartate receptor-mediated currents in rat hippocampus.

    abstract::Toluene, an industrial organic solvent, is voluntarily inhaled as drug of abuse. Because inhibition of N-methyl-d-aspartate (NMDA) receptors is one of the possible mechanisms underlying developmental neurotoxicity of toluene, the purpose of the present study was to examine the effects of toluene exposure during two ma...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Chen HH,Lin YR,Chan MH

    更新日期:2011-09-10 00:00:00

  • Toxic effect of nickel in an in vitro model of human oral epithelium.

    abstract::Nickel is a metal widely employed in dental alloys, and due to peculiar properties of certain nickel-based materials, it cannot be substituted with other metals in some applications. The release of nickel ions from dental alloys placed into long-term contact with mouth soft tissues is alarming because of the toxic, im...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Trombetta D,Mondello MR,Cimino F,Cristani M,Pergolizzi S,Saija A

    更新日期:2005-12-15 00:00:00

  • Methylmercury chloride induces alveolar type II epithelial cell damage through an oxidative stress-related mitochondrial cell death pathway.

    abstract::Mercury, one of the widespread pollutants in the world, induces oxidative stress and dysfunction in many cell types. Alveolar type II epithelial cells are known to be vulnerable to oxidative stress. Alveolar type II epithelial cells produce and secrete surfactants to maintain morphological organization, biophysical fu...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Lu TH,Chen CH,Lee MJ,Ho TJ,Leung YM,Hung DZ,Yen CC,He TY,Chen YW

    更新日期:2010-05-04 00:00:00

  • Research chemicals marketed as legal highs: the case of pipradrol derivatives.

    abstract::Between 1997 and 2011, more than 200 new substances were notified through the early-warning system, with the record number of 49 novel molecules reported in 2011. The pattern of acute toxicity associated with the consumption of these new substances is generally similar to that seen with traditional drugs of abuse. Rec...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Coppola M,Mondola R

    更新日期:2012-07-07 00:00:00

  • Acrylamide increases dopamine levels by affecting dopamine transport and metabolism related genes in the striatal dopaminergic system.

    abstract::Dopaminergic system dysfunction is proved to be a possible mechanism in acrylamide (ACR) -induced neurotoxicity. The neurotransmitter dopamine (DA) has an increasingly important role in the dopaminergic system. Thus, the goal of this study is to evaluate effects of ACR on dopamine and its metabolite levels, dopamine t...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Pan X,Guo X,Xiong F,Cheng G,Lu Q,Yan H

    更新日期:2015-07-02 00:00:00

  • The effect of α-synuclein and Tau in methamphetamine induced neurotoxicity in vivo and in vitro.

    abstract::The upregulated α-synuclein (α-syn) and Tau co-occur in methamphetamine (METH) abusers' brains. Here, we designed experiments mainly to investigate whether α-syn and Tau interact in METH exposure. We detected the expression of α-syn, total Tau, and phosphorylation of Tau at Serine 396 (pSer396 Tau) under in vitro and ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Ding J,Lian Y,Meng Y,He Y,Fan H,Li C,Qiu P

    更新日期:2020-02-01 00:00:00

  • Cholestyramine as an antidote against paracetamol-induced hepato- and nephrotoxicity in the rat.

    abstract::Besides hepatotoxicity, paracetamol may exert nephrotoxic effects in experimental animals and man. The present study in rats shows that cholestyramine given 4 and 24 h after paracetamol provided protection against both hepato- and nephrotoxicity; this was evidenced by reduced increments in plasma enzyme activities (SD...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Siegers CP,Möller-Hartmann W

    更新日期:1989-05-01 00:00:00

  • Influx of extracellular calcium participates in rituximab-enhanced ionizing radiation-induced apoptosis in Raji cells.

    abstract::We have previously shown that rituximab has a significant radiosensitizing effect on Raji cells in vitro. To investigate whether calcium signals participate in rituximab- and radiation-induced cell death in Raji cells, confocal laser scanning microscopy was used to detect kinetic changes in intracellular free calcium ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Fengling M,Qingxiang G,Lijia Z,Wei Z

    更新日期:2012-03-25 00:00:00