Abstract：
:Administration of [14C]chlorferron in a single oral dose of 0.5 and 20 mg/kg body weight to female rats resulted in a urinary excretion of greater than 74% of the given dose during the first 24 h. Approx. 8% of the dose was eliminated in faeces within 7 days. 7 days after dosing, very low levels of [14C]chlorferron-derived residues were detected in all analyzed organs. These findings indicated that chlorferron was absorbed from the gastro-intestinal tract in appreciable quantities, but was rapidly excreted mainly via the urine with small amounts only in the faeces.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Malik JK,Lay JP,Klein W,Korte Fdoi
10.1016/0378-4274(81)90091-6subject
Has Abstractpub_date
1981-03-01 00:00:00pages
449-52issue
6eissn
0378-4274issn
1879-3169pii
0378-4274(81)90091-6journal_volume
7pub_type
杂志文章abstract：:We have studied the effects of chronic slight to moderate lead exposure on the renin-angiotensin-aldosterone system in normotensive man. Plasma renin activity (PRA), blood angiotensin I (AI) concentration, angiotensin converting enzyme (ACE) activity and aldosterone concentration were measured in 33 normotensive men, ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(85)90096-7
更新日期：1985-04-01 00:00:00
abstract：:Subchronic oral toxicity of turmeric and ethanolic turmeric extract was studied in female Swiss mice and Wistar rats fed turmeric (0, 1 and 5%) and ethanolic turmeric extract (0, 0.05 and 0.25%) through diet for 14 and/or 90 days. The administration of a high dose of turmeric (5%) for longer duration (90 days) showed ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(98)00035-6
更新日期：1998-05-01 00:00:00
abstract：:Adrenal weight and the concentration of corticosterone and glucose in plasma of male Wistar rats, dosed orally with fenitrothion (7.25 or 14.5 mg/kg/day) for 28 days were investigated. A significant increase in the relative weight of adrenals was observed 2 weeks after treatment commenced, but was preceded by an incre...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(82)90126-6
更新日期：1982-04-01 00:00:00
abstract：:Pyrethroids, a group of insecticides with high efficiency, low toxicity and wide spectrum, are used for pest control in agriculture. Here, we administered two representative pyrethroids (cypermethrin and deltamethrin) and an equal volume of vehicle (corn oil) to the pregnant ICR mice. This study investigated the effec...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2018.01.019
更新日期：2018-05-01 00:00:00
abstract：:In the present study, the emetic effect of the anticancer drug cisplatin, and protective effects of 5-HT3 receptor antagonists against cisplatin emesis were investigated in the pigeon. The experimental setting involved the i.v. administration of drugs and subsequent observation of the percentage of vomiting animals an...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(92)90256-j
更新日期：1992-12-01 00:00:00
abstract：:Children may be inherently more vulnerable than adults to the lethal effects associated with chemical warfare nerve agent (CWNA) exposure because of their closer proximity to the ground, smaller body mass, higher respiratory rate, increased skin permeability and immature metabolic systems. Unfortunately, there have on...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2015.11.023
更新日期：2016-01-22 00:00:00
abstract：:The study was designed to conduct human in vivo and in vitro studies on the gastrointestinal absorption of nanoparticles, using titanium dioxide as a model compound, and to compare nanoparticle behaviour with that of larger particles. A supplier's characterisation data may not fully describe a particle formulation. Mo...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2014.12.005
更新日期：2015-03-04 00:00:00
abstract：:Effective emergency preparedness and response planning are needed to assist responders in making sound decisions under the stressful and confusing conditions accompanying a major accidental release of hazardous materials. One of the most important decisions to be made is the extent and duration of the evacuation of pe...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/0378-4274(89)90043-x
更新日期：1989-12-01 00:00:00
abstract：:When used in the risk assessment process, the output from physiologically based pharmacokinetic (PBPK) models has usually been considered as an exact estimate of dose, ignoring uncertainties in the parameter values used in the model and their impact on model predictions. We have collected experimental data on the vari...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(93)90126-i
更新日期：1993-05-01 00:00:00
abstract：:Haemolysis by chrysotile fibres may be related to an adsorption of the red blood cell (RBC) membranes on the fibres and not to an interaction between magnesium (Mg) from the fibres and sialic acid from RBC. This was demonstrated using neuraminidase (NANASE)-treated RBC and Mg-depleted chrysotile fibres. The mechanism ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(83)90217-5
更新日期：1983-02-01 00:00:00
abstract：:The modern environmental awareness leads to the realisation that the human metabolism is stressed by a huge number of chemical substances. Generally, these background exposures, consisting predominantly from natural and partly from industrial as well as life style sources, are tolerated without any adverse effects. Pe...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(99)00040-5
更新日期：1999-06-30 00:00:00
abstract：:The adverse effects on the immune system resulting from acute and subchronic exposure to immunotoxic compounds can be divided into the following three categories. One is the tissue manifestations induced by either immunosuppressive or immunomodulative compounds through the interactions of the drug or its metabolites w...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(92)90177-l
更新日期：1992-12-01 00:00:00
abstract：:The gut microbiome has tremendous potential to impact health and disease. Various environmental toxicants, including insecticides, have been shown to alter gut microbiome community structures. However, the mechanism that compositionally and functionally regulates gut microbiota remains unclear. Quorum sensing is known...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2017.10.023
更新日期：2018-02-01 00:00:00
abstract：:Carbon nanotubes (CNT), despite their diverse application potential, have demonstrated adverse impacts in vitro and in vivo. Previous studies have focused on the combined in vitro cytotoxic impact of CNT aggregates and associated nanoparticulate impurities. However, the isolated effect of CNT aggregates and associated...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2006.12.003
更新日期：2007-02-28 00:00:00
abstract：:This paper is a review of epidemiological studies in which sensitive markers of nephrotoxicity have been used to detect the early effects of chemicals on the kidney. Most of the studies are cross-sectional, and their objective was either to identify potentially nephrotoxic chemicals (organic solvents, heavy metals) in...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(89)90137-9
更新日期：1989-03-01 00:00:00
abstract：:Malathion was applied to roses in three Finnish greenhouses by hand held lance sprayers. The potential dermal exposure of applicators to this insecticide was measured. Total urine production of each applicator was also collected up to 24 h post application. In the urine samples the specific metabolite of malathion, ma...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(02)00181-9
更新日期：2002-08-05 00:00:00
abstract：:Mitochondrial enzymes are targets of newly synthesized drugs being tested for the treatment of neurodegenerative disorders, such as Alzheimer's disease (AD). The enzyme 17β-hydroxysteroid dehydrogenase type 10 (HSD10) is a multifunctional mitochondrial protein that is thought to play a role in the pathophysiology of A...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2020.12.012
更新日期：2021-03-15 00:00:00
abstract：:Nitropyrene (1-NP) is classified as Group 2B carcinogen and is one of the main components of diesel exhaust particles (DEP), which are generated from incomplete combustion of automobile engines to cause human cancer or inflammatory diseases. Although many reports on the mutagenesis or carcinogenesis of 1-NP have been ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2008.10.028
更新日期：2009-01-30 00:00:00
abstract：:Because coarse mode particles are rarely studied in their existing size ranges (greatest mass about 5-7 microns, aerodynamic diameter), we investigated the effects of four such particles, quartz, ferric oxide, calcium carbonate, and sodium feldspar, on host defenses against bacterial pulmonary infection. Mice which re...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(83)90263-1
更新日期：1983-10-01 00:00:00
abstract：:Exposure of C57Bl mice to 10 ppm benzene (the current occupational exposure limit) for 6 h/day, 5 days/week causes a progressive depression in the in vitro colony forming ability of one of the erythroid progenitor cells, the colony-forming unit-erythroid (CFU-E). Colony growth of cells from exposed mice was only 5% of...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(84)90169-3
更新日期：1984-03-01 00:00:00
abstract：:A group of 20 female albino rats was exposed to mosquito coil smoke, 8 h a day, 6 days per week, for 60 days. An additional group receiving air exposure served as control. The smoke-exposed animals had a lower body weight than the controls. Smoke-induced histopathological lesions, including an inflammation of the trac...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(87)90238-4
更新日期：1987-12-01 00:00:00
abstract：UNLABELLED:The Mre11, Rad50, and Nbs1 (MRN) complex is a DNA double-strand break sensor involved in DNA damage repair. Herein, we explored whether deletion of NAD(P)H:quinone oxidoreductase 1 (NQO1), a cytoprotective gene, affected MRN complex expression in the kidney after cisplatin-induced acute kidney injury (AKI)....
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2015.12.004
更新日期：2016-01-22 00:00:00
abstract：:N-cadherin has known to be involved in tumor progression and metastasis. However, it is still obscure about the signaling pathway involving in the processing of N-cadherin. Thus, we examined which signaling pathway plays a major role in the processing of N-cadherin in C6 glioma cells following treatment of cadmium (Cd...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2013.07.015
更新日期：2013-10-24 00:00:00
abstract：:Inorganic arsenic has strong human carcinogenic potential, but the availability of an animal model to study toxicity is extremely limited. Here, we used the transgenic zebrafish line Tg(k18(2.9):RFP) as an animal model to study arsenite toxicity. This line was chosen because the red fluorescent protein (RFP) is expres...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2005.10.024
更新日期：2006-06-01 00:00:00
abstract：:Cultured Chinese hamster ovary (CHO) cells were incubated with dilutions of natural or synthetic crude oils and subsequently exposed to near ultraviolet light (NUV). Although the magnitude of photo-induced cytotoxicity in CHO was essentially independent of the source of the oil (within a factor of two), two shale oils...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(82)90205-3
更新日期：1982-10-01 00:00:00
abstract：:The phthalates di(2-ethylhexyl)phthalate (DEHP) and di-n-butyl phthalate (DBP) are environmental contaminants with significant human exposures. Both compounds are known reproductive toxins in rodents and DEHP also induces rodent hepatocarcinogenesis in a process believed to be mediated via the peroxisome proliferator-...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2005.11.001
更新日期：2006-06-01 00:00:00
abstract：:Impairments induced by sublethal doses of two pesticides Carbaryl and Endosulfan have been studied on the ovaries of a freshwater teleost Channa striatus by exposing the fish for a period of 2 to 30 days during the spawning season. The pesticide exposure produced reduction in the number of oocytes, reduction in size a...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(84)90189-9
更新日期：1984-01-01 00:00:00
abstract：:Although formaldehyde (FA) has been classified as a human leukemogen, the mechanisms of leukemogenesis remain elusive. Previously, using colony-forming assays in semi-solid media, we showed that FA exposure in vivo and in vitro was toxic to human hematopoietic stem/progenitor cells. In the present study, we have appli...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2013.10.028
更新日期：2014-01-13 00:00:00
abstract：:The main objective of this work was to assess the potentiality of in vitro models to study and understand the uranium-induced cytotoxicity on renal cells. Cytotoxicity and morphological studies were performed in a tubular proximal original established cell line (LLC-PK1 cell line). Dose-dependent cytotoxicity response...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(98)00371-3
更新日期：1999-02-22 00:00:00
abstract：:The molecular basis of the interindividual differences of normal individuals to ionizing radiation is poorly understood. Several studies in telomerase KO mice with short telomeres have uncovered an inverse relationship between telomere length and radiation sensitivity. The present work aims to determine if chromosome ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2007.05.012
更新日期：2007-07-30 00:00:00
