Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver fibrosis in rats.

abstract：:The phthalates di(2-ethylhexyl)phthalate (DEHP) and di-n-butyl phthalate (DBP) are environmental contaminants with significant human exposures. Both compounds are known reproductive toxins in rodents and DEHP also induces rodent hepatocarcinogenesis in a process believed to be mediated via the peroxisome proliferator-...

journal_title：Toxicology letters

authors： Venkata NG,Robinson JA,Cabot PJ,Davis B,Monteith GR,Roberts-Thomson SJ

更新日期：2006-06-01 00:00:00

abstract：:It is known in humans and mouse models, that drinking water exposures to arsenite (As+3) leads to immunotoxicity. Previously, our group showed that certain types of immune cells are extremely sensitive to arsenic induced genotoxicity. In order to see if cells from different immune organs have differential sensitivitie...

journal_title：Toxicology letters

authors： Xu H,McClain S,Medina S,Lauer FT,Douillet C,Liu KJ,Hudson LG,Stýblo M,Burchiel SW

更新日期：2016-11-16 00:00:00

abstract：:Victims of nerve agents basically require antidotal treatment. There is need for novel antidotes and for therapeutic procedures that are specifically adapted to these patients. To cope with this challenge, in vitro test systems which are easy to handle and allow for conducting long-term studies would be of great benef...

journal_title：Toxicology letters

authors： Drexler B,Seeger T,Grasshoff C,Thiermann H,Antkowiak B

更新日期：2011-09-25 00:00:00

abstract：:Staphylococcal enterotoxin A (SEA) is a potent stimulator of CD4+ and CD8+ T cells, the immunotoxic action of which remains unclear. We investigated the in vitro effects of SEA on freshly isolated human peripheral blood lymphocytes depleted of CD8+ T cells. Proliferation and flow cytometry analysis indicated that SEA ...

journal_title：Toxicology letters

authors： Porichis F,Morou A,Baritaki S,Spandidos DA,Krambovitis E

更新日期：2008-01-04 00:00:00

abstract：:Effects of sublethal concentration (0.8 of LC50 96 h) of nickel sulphate (NiSO4 X 7H2O) on muscle glycogen and blood lactic acid levels of a freshwater teleost, Colisa fasciatus, at time intervals from 3-96 h have been recorded. Muscle glycogen levels showed a general decrease at all time intervals compared with contr...

journal_title：Toxicology letters

authors： Chaudhry HS

更新日期：1984-01-01 00:00:00

abstract：:The acute toxicity of fullerenol-1 was determined using mice pretreated intraperitoneally (i.p.) with polyhydroxylated C60 derivatives. The LD50 value of fullerenol-1 was estimated to be 1.2 g/kg. Pretreatments with 0.5 and 1.0 g/kg fullerenol-1 decreased cytochromes P450 and b5 contents, and NADPH-cytochrome P450 red...

journal_title：Toxicology letters

authors： Ueng TH,Kang JJ,Wang HW,Cheng YW,Chiang LY

更新日期：1997-09-19 00:00:00

abstract：:Sertoli cells play a pivotal role in supporting proliferation of germ cells and differentiation during spermatogenesis in mammals. Nanomolar concentrations of Bisphenol A (BPA) can significantly stimulate the proliferation of mouse immature Sertoli (TM4) cells. However, mechanisms by which BPA caused these effects wer...

journal_title：Toxicology letters

authors： Ge LC,Chen ZJ,Liu HY,Zhang KS,Liu H,Huang HB,Zhang G,Wong CK,Giesy JP,Du J,Wang HS

更新日期：2014-04-07 00:00:00

abstract：:Saikosaponin-d (SSd), one of the main constituents of the total saikosaponins extracted from Bupleurum falcatum L, possesses anti-inflammatory and anti-apoptosis effect. Recently, SSd was proved to improve depressive symptoms although exhibit hepatotoxicity in animals, but the central nervous system (CNS) toxicity of ...

journal_title：Toxicology letters

authors： Lixing X,Zhouye J,Liting G,Ruyi Z,Rong Q,Shiping M

更新日期：2018-03-01 00:00:00

abstract：:Previous studies have suggested that elevated blood homocysteic acid (HCA) levels increased the risk of Alzheimer's disease (AD), but the underlying mechanisms are unclear. Herein, we studied the neuronal toxicity of HCA and the underlying mechanisms in HT-22 cells. Results showed that HCA induced cell death in concen...

journal_title：Toxicology letters

authors： Tan M,Ouyang Y,Jin M,Chen M,Liu P,Chao X,Chen Z,Chen X,Ramassamy C,Gao Y,Pi R

更新日期：2013-10-23 00:00:00

abstract：:Methoxetamine is one of the constantly growing group of novel psychoactive substances that has emerged in recent years. The compound belongs to the arylcyclohexylamine class, which is used for its recreational and psychedelic effects. Methoxetamine is a structural analogue of ketamine, with a much longer duration of a...

journal_title：Toxicology letters

authors： Zawilska JB

更新日期：2014-11-04 00:00:00

abstract：:Interactions of chemicals with cerebral neurotransmitters, receptors, and second messenger systems are often accompanied by similar changes involving components in non-neural tissues. On this basis, indirect strategies have been developed to investigate neural cell function parameters by methods using accessible cells...

journal_title：Toxicology letters

authors： Manzo L,Castoldi AF,Coccini T,Rossi AD,Nicotera P,Costa LG

更新日期：1995-05-01 00:00:00

abstract：:An in vivo intestinal perfusion technique was used to measure the absorption rates of five Cr compounds in black ducks. Cr was absorbed from saline solutions of KCr(SO4)2 and CrO3 at a rate about 1.5 to 2.0 times greater than from solutions of Cr, Cr(NO3)3, and Cr(C5H7O2)3. These results suggest the ionic form of Cr i...

journal_title：Toxicology letters

authors： Eastin WC Jr,Haseltine SD,Murray HC

更新日期：1980-08-01 00:00:00

abstract：:Trihalomethanes (THMs; chloroform, bromoform, bromodichloromethane, dibromochloromethane), formed as by-products of chlorine disinfection, are found to occur in combination in drinking water supplies. THMs are metabolized by cytochromes P-450 and are likely substrates of CYP2E1. Therefore, it is possible that mixed ex...

journal_title：Toxicology letters

authors： Luciene da Silva M,Charest-Tardif G,Krishnan K,Tardif R

更新日期：1999-05-20 00:00:00

abstract：:Using the comet assay technique, this paper examines the protection from the cisplatin-induced genetic damage in mouse bone marrow cells provided by cedron-leaf infusion. Animals were separated into six groups: (I) untreated, (II) negative control, (III) treated with cedron-leaf infusion (5%), (IV) treated with cispla...

journal_title：Toxicology letters

authors： Zamorano-Ponce E,Fernández J,Vargas G,Rivera P,Carballo MA

更新日期：2004-08-30 00:00:00

abstract：:Triptolide (TP) is the main ingredient of Chinese herb Tripterygium wilfordii Hook f. (TWHF). Despite of its multifunction in pharmaceutics, accumulating evidences showed that TP caused obvious hepatotoxicity in clinic. The current study investigated the role of Notch1 signaling in TP-induced hepatotoxicity. Our data ...

journal_title：Toxicology letters

authors： Shen F,Xiong Z,Kong J,Wang L,Cheng Y,Jin J,Huang Z

更新日期：2019-01-01 00:00:00

abstract：:The genotoxicity of polycyclic aromatic hydrocarbons (PAHs) and nitrated PAHs may be influenced by the interaction of the compounds. In this study, our data showed that benzo[a]pyrene (BaP)-DNA adduct levels were decreased in a dose-dependent manner when the human hepatoma cell line HepG2 simultaneously treated with B...

journal_title：Toxicology letters

authors： Cherng SH,Hsu SL,Yang JL,Yu CT,Lee H

更新日期：2006-03-01 00:00:00

abstract：:The effects of selenium on cellular toxicity and histochemical distribution of mercury were examined in a cell culture system of mouse peritoneal macrophages. Selenium protected against the toxicity of mercury in cultures exposed to 4 microM of mercuric chloride. Selenomethionine caused a significant increase in cell ...

journal_title：Toxicology letters

authors： Christensen M,Rungby J,Mogensen SC

更新日期：1989-06-01 00:00:00

abstract：:The effect of endotoxin pretreatment (1 mg/kg body weight, i.p., once daily for 2 days) on the gastric mucosal damage induced by aspirin, phenylbutazone and reserpine has been studied in albino rats. When given alone, endotoxin did not produce any visibly discernible gastric lesions. It produced a significant augmenta...

journal_title：Toxicology letters

authors： Tariq M

更新日期：1987-06-01 00:00:00

abstract：:Inorganic arsenic, an early life carcinogen in humans and mice, can initiate lesions promotable by other agents in later life. The biomethylation product of arsenic, dimethylarsinic acid (DMA), is a multi-site tumor promoter. Thus, pregnant CD1 mice were given drinking water (0 ppm or 85 ppm arsenic) from gestation da...

journal_title：Toxicology letters

authors： Tokar EJ,Diwan BA,Waalkes MP

更新日期：2012-03-07 00:00:00

abstract：:We have previously shown that rituximab has a significant radiosensitizing effect on Raji cells in vitro. To investigate whether calcium signals participate in rituximab- and radiation-induced cell death in Raji cells, confocal laser scanning microscopy was used to detect kinetic changes in intracellular free calcium ...

journal_title：Toxicology letters

authors： Fengling M,Qingxiang G,Lijia Z,Wei Z

更新日期：2012-03-25 00:00:00

abstract：:To elucidate relevance of estrogens to immune responses, we investigated whether estrogen receptor alpha (ERalpha) exists in mouse splenic B cells and T cells and the effect of 17beta-estradiol and endocrine disrupting chemicals (EDCs) on lymphocyte mitogenesis. ERalpha was identified in both male and female mouse spl...

journal_title：Toxicology letters

authors： Sakazaki H,Ueno H,Nakamuro K

更新日期：2002-07-21 00:00:00

abstract：:Stable and specific biomacromolecular adducts can be used to measure in vivo doses of reactive compounds. An LC/MS-MS method to measure adducts from the benzo[a]pyrene (BP) metabolite (±)-anti-BP-7,8-diol-9,10-epoxide ((±)-anti-BPDE) to His(146) in serum albumin (SA), earlier evaluated on in vitro alkylated human SA, ...

journal_title：Toxicology letters

authors： Westberg EA,Singh R,Hedebrant U,Koukouves G,Souliotis VL,Farmer PB,Segerbäck D,Kyrtopoulos S,Törnqvist MÅ

更新日期：2015-01-05 00:00:00

abstract：:Rats injected i.p. with 100 mg ethylhexyl nitrate/kg body wt excreted 0.3% of the dose in the urine within 24 h. No urinary nitrite was found within 5 postinjection hours while an output of 26.9 +/- 15.8 micrograms nitrite/h X kg body wt. was detected between 5-24 h. Cerebral glutathione concentration was below the co...

journal_title：Toxicology letters

authors： Someroja S,Savolainen H

更新日期：1983-10-01 00:00:00

abstract：:Eugenol, a natural phenolic constituent of clove oil, has a wide range of applications in medicine as a local antiseptic and anesthetic. However, the effect of eugenol on human glioblastoma is unclear. This study examined whether eugenol elevated intracellular free Ca(2+) levels ([Ca(2+)]i) and induced apoptosis in DB...

journal_title：Toxicology letters

authors： Liang WZ,Chou CT,Hsu SS,Liao WC,Shieh P,Kuo DH,Tseng HW,Kuo CC,Jan CR

更新日期：2015-01-05 00:00:00

abstract：:Lead (Pb) alters the susceptibility to different pathogens suggesting that macrophage-mediated defense mechanisms, through activation of toll-like receptors (TLRs), may be affected by Pb. The aim of this study was to test whether activation of TLR4 is a targeted molecule to the effect of environmentally relevant Pb co...

journal_title：Toxicology letters

authors： Luna AL,Acosta-Saavedra LC,Martínez M,Torres-Avilés N,Gómez R,Calderón-Aranda ES

更新日期：2012-11-15 00:00:00

abstract：:An intensive study was conducted to provide data on intra- and inter-individual variation in urinary excretion of a series of ingredients in personal care products (parabens, triclosan, benzophenones) and bisphenol A (BPA, not expected to be an ingredient) in 8 volunteers over 6 days. Exposure diaries recorded use of ...

journal_title：Toxicology letters

authors： Koch HM,Aylward LL,Hays SM,Smolders R,Moos RK,Cocker J,Jones K,Warren N,Levy L,Bevan R

更新日期：2014-12-01 00:00:00

abstract：:The metabolic activity of pre-implantation blastocysts recovered from delayed mice before and after administration of lead was estimated by measuring their oxygen consumption using a spectrophotometer technique. Normal blastocysts, activated for implantation, increased their oxygen consumption by about 50% compared wi...

journal_title：Toxicology letters

authors： Nilsson BO,Einarsson B,Magnusson C

更新日期：1991-05-01 00:00:00

abstract：:The upregulated α-synuclein (α-syn) and Tau co-occur in methamphetamine (METH) abusers' brains. Here, we designed experiments mainly to investigate whether α-syn and Tau interact in METH exposure. We detected the expression of α-syn, total Tau, and phosphorylation of Tau at Serine 396 (pSer396 Tau) under in vitro and ...

journal_title：Toxicology letters

authors： Ding J,Lian Y,Meng Y,He Y,Fan H,Li C,Qiu P

更新日期：2020-02-01 00:00:00

abstract：:The in vitro N-methylating capability of rabbit tissue cytosolic preparations, utilizing S-adenosyl-L-[methyl-3H]methionine as methyl donor, is described. Dialysed preparations from the lung, liver and kidney are capable of N-methylating 3- and 4-phenylpyridines and 3,3'- and 4,4'-bispyridyls; the corresponding 2-subs...

journal_title：Toxicology letters

authors： Godin CS,Crooks PA,Damani LA

更新日期：1986-12-01 00:00:00

abstract：:The aim of the current HBM-study is to further the understanding of the impact of inter- and intra-individual variability in HBM surveys as it may have implications for the design and interpretation of the study outcomes. As spot samples only provide a snapshot in time of the concentrations of chemicals in an individu...

journal_title：Toxicology letters

authors： Smolders R,Koch HM,Moos RK,Cocker J,Jones K,Warren N,Levy L,Bevan R,Hays SM,Aylward LL

更新日期：2014-12-01 00:00:00