Neurochemical effects of ethylhexyl nitrate in rats.

Abstract:

:Rats injected i.p. with 100 mg ethylhexyl nitrate/kg body wt excreted 0.3% of the dose in the urine within 24 h. No urinary nitrite was found within 5 postinjection hours while an output of 26.9 +/- 15.8 micrograms nitrite/h X kg body wt. was detected between 5-24 h. Cerebral glutathione concentration was below the control level after 1 day but returned to control value after 3 and 7 days postinjection. Brain acetylcholine esterase activity was marginally decreased after 1 day while RNA and succinate dehydrogenase assay excluded major structural damage. It seems that the mechanism of clinical symptoms experienced by exposed workers are comparable to those exposed to dynamite and are largely functional.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Someroja S,Savolainen H

doi

10.1016/0378-4274(83)90281-3

subject

Has Abstract

pub_date

1983-10-01 00:00:00

pages

189-93

issue

1-2

eissn

0378-4274

issn

1879-3169

pii

0378-4274(83)90281-3

journal_volume

19

pub_type

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