Lead given systemically to mice in experimental delay of implantation increases the oxygen consumption of delayed blastocysts.

Abstract:

:The metabolic activity of pre-implantation blastocysts recovered from delayed mice before and after administration of lead was estimated by measuring their oxygen consumption using a spectrophotometer technique. Normal blastocysts, activated for implantation, increased their oxygen consumption by about 50% compared with inactive, delayed blastocysts. Inactive, delayed blastocysts from lead-injected mice reached the same level of oxygen consumption even without oestrogen administration. Oestrogen given to the lead-injected mice did not further increase the oxygen consumption of their blastocysts. It is concluded that administration of lead to pre-implantation mice resulted in increased metabolic activity of their blastocysts due either to a direct effect of lead or to an indirect effect, caused by changed composition of the uterine secretion.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Nilsson BO,Einarsson B,Magnusson C

doi

10.1016/0378-4274(91)90163-z

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

349-53

issue

3

eissn

0378-4274

issn

1879-3169

pii

0378-4274(91)90163-Z

journal_volume

56

pub_type

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