Abstract:
:Besides hepatotoxicity, paracetamol may exert nephrotoxic effects in experimental animals and man. The present study in rats shows that cholestyramine given 4 and 24 h after paracetamol provided protection against both hepato- and nephrotoxicity; this was evidenced by reduced increments in plasma enzyme activities (SDH, GPT), indicating liver damage, and diminished retention of plasma and creatinine, indicating renal failure. The recovery of paracetamol and its conjugates in urine was markedly reduced by cholestyramine at 24-48 h after treatment. The protective effects of cholestyramine are explained by adsorption of paracetamol and conjugates in the intestine undergoing biliary excretion and enterohepatic circulation.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Siegers CP,Möller-Hartmann Wdoi
10.1016/0378-4274(89)90073-8subject
Has Abstractpub_date
1989-05-01 00:00:00pages
179-84issue
2eissn
0378-4274issn
1879-3169pii
0378-4274(89)90073-8journal_volume
47pub_type
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journal_title:Toxicology letters
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更新日期:1993-04-01 00:00:00
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journal_title:Toxicology letters
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更新日期:1983-06-01 00:00:00
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更新日期:1994-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-08-16 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2017.01.006
更新日期:2017-03-05 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2013-01-10 00:00:00
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journal_title:Toxicology letters
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更新日期:1994-11-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(86)90006-8
更新日期:1986-05-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2009.01.022
更新日期:2009-05-22 00:00:00
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journal_title:Toxicology letters
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更新日期:1987-01-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1998-08-01 00:00:00
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journal_title:Toxicology letters
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更新日期:2000-11-20 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(96)03721-6
更新日期:1996-11-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2006-04-10 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2014-09-17 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2015.08.1108
更新日期:2015-11-19 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章,评审
doi:10.1016/0378-4274(89)90029-5
更新日期:1989-12-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2004-06-15 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2011-09-10 00:00:00
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journal_title:Toxicology letters
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更新日期:1986-09-01 00:00:00
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更新日期:2001-03-08 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1992-09-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(85)90002-5
更新日期:1985-10-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2014.09.019
更新日期:2015-01-05 00:00:00
abstract::The toxicity of benz (e) acephenanthrylene (BeA) has been studied earlier with regard to the carcinogenicity of its metabolites, but its phototogenotoxicity is not well understood. Present study aimed to analyze the photodynamic response of BeA in human skin cell line (A375) under ambient environmental intensity of UV...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2010.08.023
更新日期:2010-11-30 00:00:00
abstract::Isolated, perfused and ventilated guinea-pig lungs were exposed for 10 min to acid (sulphuric + nitric acid) aerosol mimicking acid rain at pH 4.5 or 2.5, as well as to a control distilled water aerosol (pH 6.0-6.5). Lung perfusing solution was recovered and thromboxane (TX) B2 and leukotriene (LT) B4 were measured by...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(87)90262-1
更新日期:1987-11-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(94)03180-0
更新日期:1995-02-01 00:00:00
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journal_title:Toxicology letters
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.toxlet.2003.07.004
更新日期:2004-04-15 00:00:00
abstract::The degradation of cyanogenic glycosides was studied in spontaneously fermenting cassava root pulp and in fresh pulp samples pretreated to prevent either endogenous beta-glycosidase activity, fermentation, or both. The rate of disappearance of the glycosides, as measured by hydrocyanic acid (HCN) production in situ, i...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(83)90153-4
更新日期:1983-03-01 00:00:00
abstract::Colon cancer evolves from a progressive inhibition of apoptosis and is influenced strongly by diet. Among dietary factors, butyrate (derived from fermentable fibers) may have utility as a chemopreventive agent because of its ability to promote apoptosis. Because CD95 (APO-1/Fas) transduces signals resulting in apoptos...
journal_title:Toxicology letters
pub_type: 杂志文章,评审
doi:10.1016/s0378-4274(99)00263-5
更新日期:2000-03-15 00:00:00