Cholestyramine as an antidote against paracetamol-induced hepato- and nephrotoxicity in the rat.

Abstract:

:Besides hepatotoxicity, paracetamol may exert nephrotoxic effects in experimental animals and man. The present study in rats shows that cholestyramine given 4 and 24 h after paracetamol provided protection against both hepato- and nephrotoxicity; this was evidenced by reduced increments in plasma enzyme activities (SDH, GPT), indicating liver damage, and diminished retention of plasma and creatinine, indicating renal failure. The recovery of paracetamol and its conjugates in urine was markedly reduced by cholestyramine at 24-48 h after treatment. The protective effects of cholestyramine are explained by adsorption of paracetamol and conjugates in the intestine undergoing biliary excretion and enterohepatic circulation.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Siegers CP,Möller-Hartmann W

doi

10.1016/0378-4274(89)90073-8

subject

Has Abstract

pub_date

1989-05-01 00:00:00

pages

179-84

issue

2

eissn

0378-4274

issn

1879-3169

pii

0378-4274(89)90073-8

journal_volume

47

pub_type

杂志文章
  • Genotoxicity studies of benzofuran dioxetanes and epoxides with isolated DNA, bacteria and mammalian cells.

    abstract::1,2-Dioxetanes, very reactive and high energy molecules, are involved as labile intermediates in dioxygenase-activated aerobic metabolism and in physiological processes. Various toxicological tests reveal that dioxetanes are indeed genotoxic. In supercoiled DNA of bacteriophage PM2 they induce endonuclease-sensitive s...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(93)90045-y

    authors: Adam W,Ahrweiler M,Saha-Möller CR,Sauter M,Schönberger A,Epe B,Müller E,Schiffmann D,Stopper H,Wild D

    更新日期:1993-04-01 00:00:00

  • The effect of BCNU (carmustine) on tissue glutathione reductase activity.

    abstract::A single, 50 mg/kg i.p. dose of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) to mice significantly inhibited glutathione reductase activity in liver within 10 min, and in lung and heart within 30 min. Maximal inhibition was reached at 4 h in all tissues and glutathione reductase activity remained significantly depress...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(83)90036-x

    authors: Kehrer JP

    更新日期:1983-06-01 00:00:00

  • The pentachlorophenol metabolite tetrachloro-p-hydroquinone induces the formation of 8-hydroxy-2-deoxyguanosine in liver DNA of male B6C3F1 mice.

    abstract::Tetrachloro-p-hydroquinone (TCHQ), the major metabolite of pentachlorophenol (PCP) in mammalian systems, is known to autoxidize to its semiquinone radical under physiological conditions. In this way, PCP could present a potent source of reactive oxygen species (ROS) during metabolization. ROS contribute to numerous mo...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(94)90085-x

    authors: Dahlhaus M,Almstadt E,Appel KE

    更新日期:1994-12-01 00:00:00

  • Gene expression profile and cytotoxicity of human bronchial epithelial cells exposed to crotonaldehyde.

    abstract::Crotonaldehyde is an environment pollutant and lipid peroxidation product. Crotonaldehyde produces adverse effects to humans and serves as a risk factor for human pulmonary diseases. Like acrolein and 4-hydroxynonenal, crotonaldehyde seems likely to alter many cell signaling cascades, including inflammatory responses....

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2010.05.005

    authors: Liu XY,Yang ZH,Pan XJ,Zhu MX,Xie JP

    更新日期:2010-08-16 00:00:00

  • Bisphenol A and its derivatives tetrabromobisphenol A and tetrachlorobisphenol A induce apelin expression and secretion in ovarian cancer cells through a peroxisome proliferator-activated receptor gamma-dependent mechanism.

    abstract::Epidemiological studies have reported that humans have detectable levels of not only bisphenol A (BPA), but also its halogenated derivatives tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA), in the serum. Our previous study showed that BPA promotes ovarian cancer progression by directly inducing cell p...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2017.01.006

    authors: Hoffmann M,Fiedor E,Ptak A

    更新日期:2017-03-05 00:00:00

  • Differentiation of skin sensitizers from irritant chemicals by interleukin-1α and macrophage inflammatory protein-2 in murine keratinocytes.

    abstract::The development of novel alternative testing methods is required to identify the sensitizing capacity of chemicals as a replacement for animal experimentation. We aimed to evaluate in vitro assays as screening tools for detecting skin sensitizers. The murine epidermal keratinocyte cell line HEL-30 was exposed to 16 re...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2012.10.017

    authors: Son D,Na Y,Cho WS,Lee BH,Heo Y,Park JH,Seok SH

    更新日期:2013-01-10 00:00:00

  • Application of the kinetic of RNA synthesis on Hep 3B cells. Study of the medium-term cytotoxicity of atrazine.

    abstract::The test based on measuring the RNA synthesis rate, already described on Hela S3 in culture (Fauris et al., Les colloques de l'INSERM 106 (1981) 455-463), has been adapted to a human hepatoma cell line Hep 3B which retains a certain capacity towards metabolising. These modifications make it easier to point to the pres...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(94)90090-6

    authors: Descampiaux B,Herno V,Brice A,Erb F

    更新日期:1994-11-01 00:00:00

  • Relationship between oxidative metabolites of hydrazine and hydrazine-induced mutagenicity.

    abstract::Hydrazine (Hz) mutagenicity was observed in a test using Escherichia coli B/r strain, WP2 uvrA and was enhanced by the addition of rat liver microsomal fraction containing a generating system, while the enhanced mutagenicity was diminished by the addition of metyrapone to the microsome-free levels. On the other hand, ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(86)90006-8

    authors: Noda A,Ishizawa M,Ohno K,Sendo T,Noda H

    更新日期:1986-05-01 00:00:00

  • Kahweol blocks STAT3 phosphorylation and induces apoptosis in human lung adenocarcinoma A549 cells.

    abstract::Kahweol, the coffee-specific diterpene, has been reported to have anti-carcinogenic properties. Animal data support such a chemopreventive effect of coffee. However, the precise underlying protective mechanisms are poorly understood. In this study, the apoptotic effect of kahweol in human lung adenocarcinoma A549 cell...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2009.01.022

    authors: Kim HG,Hwang YP,Jeong HG

    更新日期:2009-05-22 00:00:00

  • Extrapolation from rat studies with environmental tobacco smoke (ETS) to humans: comparison of particle mass deposition and of clearance behavior of ETS compounds.

    abstract::The relative deposition of inhaled heterodisperse particles of the size of environmental tobacco smoke (ETS, mass median aerodynamic diameter 0.2 micron, geometric standard deviation 1.5) is about the same in the tracheobronchial tree and is lower in the pulmonary region of the rat than in the same regions of humans. ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(87)90093-2

    authors: Oberdörster G,Pott F

    更新日期:1987-01-01 00:00:00

  • Stimulation of protein kinase A activity and induced terminal differentiation of human skin fibroblasts in culture by low-frequency electromagnetic fields.

    abstract::In the present study experiments are described, which indicate that the exposure of normal human skin fibroblasts (HSFs) to a low-frequency electromagnetic field of 20 Hz and 7-8 mT does induce terminal differentiation within 14 days of daily exposure of 12 h. As demonstrated by the analysis of the expression level of...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(98)00095-2

    authors: Löschinger M,Thumm S,Hämmerle H,Rodemann HP

    更新日期:1998-08-01 00:00:00

  • Effects of pretreatment with SKF-525A on triphenyltin metabolism and toxicity in mice.

    abstract::The effects of cytochrome P-450 inhibition by alpha-phenyl-alpha-propylbenzeneacetic acid 2-[diethylamino]-ethyl ester hydrochloride (SKF-525A), which inhibits the activity of a number of cytochrome P-450s, on triphenyltin metabolism and toxicity in mice were studied. At 24 h after triphenyltin administration, the tri...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(00)00255-1

    authors: Ohhira S,Matsui H,Watanabe K

    更新日期:2000-11-20 00:00:00

  • In vitro reconstituted tissue as an alternative to human respiratory tract.

    abstract::The data obtained from in vitro systems utilizing human cells and tissues should form a basic part of the information necessary for risk assessment. The most important thing for such systems is, therefore, to simulate the structures and functions of cells and tissues in the native organ as closely as possible. In desi...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(96)03721-6

    authors: Emura M,Ochiai A,Hirohashi S

    更新日期:1996-11-01 00:00:00

  • Bio-effect monitoring using a [(15)N]methacetin test as diagnostic tool to monitor remediation effects in an industrially polluted region.

    abstract::The classical way to demonstrate the efficiency of remediation is measuring the reduction of toxic compounds in the environment. Nevertheless, more important is the risk reduction in human health. To determine changing health effects, exposure and bio-effects have to be monitored at time of and during remediation. Kin...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2005.09.017

    authors: Rolle-Kampczyk UE,Rehwagen M,Franck U,Weiss H,Krumbiegel P,Herbarth O

    更新日期:2006-04-10 00:00:00

  • Multi-walled carbon nanotube inhibits CA1 glutamatergic synaptic transmission in rat's hippocampal slices.

    abstract::The purpose of the study was to investigate the neurotoxic effect of multi-walled carbon nanotubes (MWCNTs) on the properties of glutamatergic synaptic transmission in rat's hippocampal slices using whole-cell patch clamp technique. The amplitude and frequency of excitatory postsynaptic current (EPSC) were accessed on...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2014.06.036

    authors: Chen T,Yang J,Zhang H,Ren G,Yang Z,Zhang T

    更新日期:2014-09-17 00:00:00

  • Chicken IgY facilitates allergic airway inflammation in a chemical-induced murine asthma model by potentiating IL-4 release.

    abstract::High mobility group box 1 (HMGB1) is a DNA-binding protein that is abundantly expressed in most tissues. Recently, HMGB1 has gained much attention for its regulation of immunity and inflammation. Yet its role in toluene diisocyanate (TDI)-induced asthma still remains poorly characterized. In this study, mice were sens...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2015.08.1108

    authors: Yao L,Zhao H,Tang H,Song J,Dong H,Zou F,Cai S

    更新日期:2015-11-19 00:00:00

  • Improving toxicology testing protocols using computer simulations.

    abstract::Computer simulation can be used to integrate existing toxicity information within a biologically realistic framework. Simulation models calculate relevant measures of target tissue dose based on physiological, biochemical and physicochemical properties and readily support the dose, route, species and interchemical ext...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/0378-4274(89)90029-5

    authors: Clewell HJ 3rd,Andersen ME

    更新日期:1989-12-01 00:00:00

  • Dioxins, dioxin-like PCBs and non-dioxin-like PCBs in foodstuffs: occurrence and dietary intake in The Netherlands.

    abstract::Data on occurrence of dioxins (polychlorinated dibenzo-p-dioxins [PCDDs] and dibenzofurans [PCDFs]), dioxin-like PCBs (polychlorinated non-ortho and mono-ortho biphenyls) and non-dioxin-like PCBs (as represented by the so-called indicator-PCBs: congeners 28, 52, 101, 118, 138, 153 and 180) in food products consumed in...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2004.01.028

    authors: Baars AJ,Bakker MI,Baumann RA,Boon PE,Freijer JI,Hoogenboom LA,Hoogerbrugge R,van Klaveren JD,Liem AK,Traag WA,de Vries J

    更新日期:2004-06-15 00:00:00

  • Cisplatin transiently up-regulates hHR23 expression through enhanced translational efficiency in A549 adenocarcinoma cells.

    abstract::DNA-damaging agents are commonly used as anticancer therapeutics. Unfortunately, such drugs induced DNA damages as well as DNA repair are important in mediating drug resistance to cancer treatments. To evaluate changes in DNA repair proteins that occur in DNA damage agent treatment, we challenged human A549 lung adeno...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2011.06.028

    authors: Shen YH,Chen BR,Cherng SH,Chueh PJ,Tan X,Lin YW,Lin JC,Chuang SM

    更新日期:2011-09-10 00:00:00

  • Sister-chromatid exchanges in the lymphocytes of people exposed to environmental cadmium.

    abstract::Sister-chromatid exchanges (SCEs) were analyzed from peripheral lymphocyte cultures of 8 men and 16 women who had been exposed to environmental cadmium (Cd), and 6 controls. Average Cd concentrations in blood of the Cd-polluted group were 8.9 micrograms/l for men and 10.0 micrograms/l for women. These were no signific...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(86)90120-7

    authors: Nogawa K,Tsuritani I,Yamada Y,Kido T,Honda R,Ishizaki M,Kurihara T

    更新日期:1986-09-01 00:00:00

  • Role of corticosterone in ethyl carbamate-induced immunosuppression in female BALB/c mice.

    abstract::We have recently demonstrated that the antibody response to the T-cell-dependent antigen, sheep red blood cells (SRBCs), was suppressed by ethyl carbamate in female BALB/c mice. At the same doses, ethyl carbamate decreased in the numbers of splenic macrophages, B cells, total T cells, CD4(+) T cells and CD8(+) T cells...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(00)00306-4

    authors: Cha SW,Lee HJ,Cho MH,Lee MH,Koh WS,Han S,Kim J,Lee E,Nam D,Jeong TC

    更新日期:2001-03-08 00:00:00

  • Dietary pyrrolizidine (Senecio) alkaloids and tissue distribution of copper and vitamin A in broiler chickens.

    abstract::The effect of feeding a diet containing 5% tansy ragwort (TR) (Senecio jacobaea), a poisonous plant containing pyrrolizidine alkaloids (PA), on the blood and liver levels of copper, zinc, iron and vitamin A in broiler chicks was examined. Serum and liver copper and liver iron concentrations were increased in chicks fe...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(92)90017-e

    authors: Huan J,Cheeke PR,Lowry RR,Nakaue HS,Snyder SP,Whanger PD

    更新日期:1992-09-01 00:00:00

  • Chilli extract treatment and induction of eye lesions in hamsters.

    abstract::On chronic administration of 20 microliter of chilli extract to the cheek pouch of hamsters till death, 23% of the hamsters developed shrunken eye balls and closing of the eyelids. This effect was not observed in hamsters which received a single application of the potent carcinogen methylacetoxymethyl nitrosamine (DMN...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(85)90002-5

    authors: Agrawal RC,Sarode AV,Lalitha VS,Bhide SV

    更新日期:1985-10-01 00:00:00

  • Adduct levels from benzo[a]pyrenediol epoxide: Relative formation to histidine in serum albumin and to deoxyguanosine in DNA in vitro and in vivo in mice measured by LC/MS-MS methods.

    abstract::Stable and specific biomacromolecular adducts can be used to measure in vivo doses of reactive compounds. An LC/MS-MS method to measure adducts from the benzo[a]pyrene (BP) metabolite (±)-anti-BP-7,8-diol-9,10-epoxide ((±)-anti-BPDE) to His(146) in serum albumin (SA), earlier evaluated on in vitro alkylated human SA, ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2014.09.019

    authors: Westberg EA,Singh R,Hedebrant U,Koukouves G,Souliotis VL,Farmer PB,Segerbäck D,Kyrtopoulos S,Törnqvist MÅ

    更新日期:2015-01-05 00:00:00

  • UVA-induced cyototoxicity and DNA damaging potential of benz (e) acephenanthrylene.

    abstract::The toxicity of benz (e) acephenanthrylene (BeA) has been studied earlier with regard to the carcinogenicity of its metabolites, but its phototogenotoxicity is not well understood. Present study aimed to analyze the photodynamic response of BeA in human skin cell line (A375) under ambient environmental intensity of UV...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2010.08.023

    authors: Ali D,Ray RS,Hans RK

    更新日期:2010-11-30 00:00:00

  • Acid rain: effects on arachidonic acid metabolism in perfused and ventilated guinea-pig lung.

    abstract::Isolated, perfused and ventilated guinea-pig lungs were exposed for 10 min to acid (sulphuric + nitric acid) aerosol mimicking acid rain at pH 4.5 or 2.5, as well as to a control distilled water aerosol (pH 6.0-6.5). Lung perfusing solution was recovered and thromboxane (TX) B2 and leukotriene (LT) B4 were measured by...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(87)90262-1

    authors: Preziosi P,Ciabattoni G

    更新日期:1987-11-01 00:00:00

  • A vasoactive serum component and reactivity of isolated rat aorta after chronic alcohol administration.

    abstract::Norepinephrine-induced contractility and relaxation to acetylcholine of isolated aortas taken from normal and chronic alcoholic rats were measured. Similar experiments were performed adding serum from normal (NS) or alcoholic rats (AS), with or without norepinephrine and acetylcholine. Responses of normal and alcoholi...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(94)03180-0

    authors: Baños G,Lopez-Zetina P,Franco M

    更新日期:1995-02-01 00:00:00

  • Generally recognized as safe (GRAS): history and description.

    abstract::Generally recognized as safe (GRAS), a system for review and approval of ingredients for addition to food, was conceived at a time when the need for a less doctrinaire review of food ingredients was critical. The GRAS approval process for a food ingredient relies on the judgment of "...experts qualified by scientific ...

    journal_title:Toxicology letters

    pub_type: 历史文章,杂志文章,评审

    doi:10.1016/j.toxlet.2003.07.004

    authors: Burdock GA,Carabin IG

    更新日期:2004-04-15 00:00:00

  • Differential effects on the cyanogenic glycoside content of fermenting cassava root pulp by beta-glucosidase and microbial activities.

    abstract::The degradation of cyanogenic glycosides was studied in spontaneously fermenting cassava root pulp and in fresh pulp samples pretreated to prevent either endogenous beta-glycosidase activity, fermentation, or both. The rate of disappearance of the glycosides, as measured by hydrocyanic acid (HCN) production in situ, i...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(83)90153-4

    authors: Maduagwu EN

    更新日期:1983-03-01 00:00:00

  • Effect of diet on colonic-programmed cell death: molecular mechanism of action.

    abstract::Colon cancer evolves from a progressive inhibition of apoptosis and is influenced strongly by diet. Among dietary factors, butyrate (derived from fermentable fibers) may have utility as a chemopreventive agent because of its ability to promote apoptosis. Because CD95 (APO-1/Fas) transduces signals resulting in apoptos...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-4274(99)00263-5

    authors: Chapkin RS,Fan Y,Lupton JR

    更新日期:2000-03-15 00:00:00