Abstract:
:Rats were treated with LiCl or RbCl in drinking water for 65 days. Spleen cells from both treated groups exhibited significantly greater proliferative responses to lipopolysaccharide (LPS) than those from untreated controls. Responses to concanavalin A (Con A) were not affected. Cytotoxic activities of natural killer (NK) cells from both treated groups were significantly less than those from untreated controls. In vitro, Li augmented responses of spleen cells to LPS, but the same doses of Rb suppressed the responses. Effects on responses to Con A were variable. Both Li and Rb alone had a small mitogenic effect on spleen cells.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Jones JM,Yeralan O,Hines G,Maher M,Roberts DW,Benson RWdoi
10.1016/0378-4274(90)90150-ksubject
Has Abstractpub_date
1990-07-01 00:00:00pages
163-8issue
2eissn
0378-4274issn
1879-3169pii
0378-4274(90)90150-Kjournal_volume
52pub_type
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