7-Methyldeoxyguanosine as a marker of exposure to environmental methylating agents.

abstract：:Paracetamol (acetaminophen, APAP) is the most frequently used analgesic drug worldwide. However, patients in several specific populations can have an increased exposure to toxic APAP metabolites. Therefore, APAP-protein adducts have been proposed as an alternative marker for the assessment of APAP intoxications and as...

journal_title：Toxicology letters

authors： Delahaye L,Dhont E,De Cock P,De Paepe P,Stove CP

更新日期：2020-05-15 00:00:00

abstract：:Autophagy, which works to remove stress and maintain cellular homeostasis, is usually considered a "pro-survival" signal. Contrarily, apoptosis is programmed "pro-death" machinery. Polychlorinated biphenyls (PCBs) are a group of ubiquitous industrial pollutants. Our previous studies illustrated that a PCB quinone meta...

journal_title：Toxicology letters

authors： Shi Q,Wang Y,Dong W,Song E,Song Y

更新日期：2019-05-15 00:00:00

abstract：:Between 1997 and 2011, more than 200 new substances were notified through the early-warning system, with the record number of 49 novel molecules reported in 2011. The pattern of acute toxicity associated with the consumption of these new substances is generally similar to that seen with traditional drugs of abuse. Rec...

journal_title：Toxicology letters

authors： Coppola M,Mondola R

更新日期：2012-07-07 00:00:00

abstract：:The effect of two herbicides (paraquat and 2,4-dichlorophenoxybutyric acid) and two fungicides (mancozeb and captafol) was studied on the growth of Flagellospora penicillioides, Lunulospora curvula and Phalangispora constricta using the poisoned-food technique. The pesticides did not produce any inhibition of growth a...

journal_title：Toxicology letters

authors： Chandrashekar KR,Kaveriappa KM

更新日期：1989-09-01 00:00:00

abstract：:Activity of telomerase, the enzyme that synthesizes the telomere ends of linear eukaryotic chromosomes, is repressed in most normal human somatic cells but induced in most human cancers. Normal human cells that lack telomerase activity progressively lose telomere sequences. In contrast, most immortalized cell lines an...

journal_title：Toxicology letters

authors： Meyerson M

更新日期：1998-12-28 00:00:00

abstract：:Benzidine dihydrochloride administered in water at 0, 30, 60, 120, 200 or 400 ppm to 1664 mice induced a total of 368 hepatocellular carcinomas, of which 34 or 9.2% metastasized to the lungs. Liver tumors which were larger and heavier were more prone to metastasize and all that metastasized contained areas of prominen...

journal_title：Toxicology letters

authors： Frith CH,Baetcke KP,Nelson CJ,Schieferstein G

更新日期：1980-12-01 00:00:00

abstract：:The anesthetic potencies of n-alcohols increase progressively with lengthening of the carbon chain and then disappear at a cut-off point of a longer-chain n-alcohol. In order to assess the mechanisms for cut-off in mammalian central nervous system, the effects of a series of n-alcohols (C(2)-C(11)) were examined on th...

journal_title：Toxicology letters

authors： Takehana K,Hirota K,Roth SH,Masuda A,Ito Y

更新日期：2000-05-19 00:00:00

abstract：:Nano-materials are currently being used in a variety of fields. One of the concerns associated with their use is their potential to harm human health. In an attempt to identify genes expressed differently in human lung cells (WI-26 VA4) exposed to nanosized (45 nm in diameter) PAMAM (polyamidoamine) dendrimers, we obs...

journal_title：Toxicology letters

authors： Lee JH,Cha KE,Kim MS,Hong HW,Chung DJ,Ryu G,Myung H

更新日期：2009-10-28 00:00:00

abstract：:Rates of alkaline hydrolysis of 18 natural or semisynthetic pyrrolizidine alkaloids, all retronecine diesters, have been compared. Steric hindrance around the ester groups was the major factor inhibiting hydrolysis. Relative rates of hydrolysis by esterases in a rat liver homogenate were also dependent on steric hindr...

journal_title：Toxicology letters

authors： Mattocks AR

更新日期：1982-11-01 00:00:00

abstract：:(1) Local anaesthetics (LA) rely for their clinical actions on state-dependent inhibition of voltage-dependent sodium channels. (2) Single, batrachoxin-modified sodium channels in planar lipid bilayers allow direct observation of drug-channel interactions. Two modes of inhibition of single-channel current are observed...

journal_title：Toxicology letters

authors： French RJ,Zamponi GW,Sierralta IE

更新日期：1998-11-23 00:00:00

abstract：:According to European laws animal testing in cosmetic industry will be prohibited in a few years and it will be replaced by alternative methods based on cell and tissue culture. Many ingredients of cosmetic formulations are potentially causes of skin inflammation and sensibilization. Since cytotoxicity is known, among...

journal_title：Toxicology letters

authors： Parodi A,Sanguineti R,Catalano M,Penco S,Pronzato MA,Scanarotti C,Bassi AM

更新日期：2010-02-01 00:00:00

abstract：:Cadmium is a toxic heavy metal which has been shown to be a possible risk factor of atherosclerosis in epidemiological and experimental studies. Since intimal hyperplasia in vascular tissue is an important component of atherosclerosis, we examined the effect of cadmium on the proliferation of vascular smooth muscle ce...

journal_title：Toxicology letters

authors： Fujiwara Y,Watanabe S,Kaji T

更新日期：1998-02-01 00:00:00

abstract：:On chronic administration of 20 microliter of chilli extract to the cheek pouch of hamsters till death, 23% of the hamsters developed shrunken eye balls and closing of the eyelids. This effect was not observed in hamsters which received a single application of the potent carcinogen methylacetoxymethyl nitrosamine (DMN...

journal_title：Toxicology letters

authors： Agrawal RC,Sarode AV,Lalitha VS,Bhide SV

更新日期：1985-10-01 00:00:00

abstract：:The present study was carried out in order to investigate the effects of inhaled volatile anesthetic gases in subanesthetic concentrations on circulating hormones essential for normal male reproduction. Male mature rats were exposed daily, up to 11 days, to halothane or enflurane in concentrations up to 500 and 1000 p...

journal_title：Toxicology letters

authors： Cameron AM,Dale O,Haug E,Nilsen OG

更新日期：1983-12-01 00:00:00

abstract：:A low-Mr copper (Cu) and zinc (Zn)-binding protein was present in the liver of a control water lizard Triturus pyrrhogaster. Cadmium (Cd) accumulated in the liver of the animals after intramuscular injections of Cd salt and was bound to Cu- and Zn-binding protein of a single isoform that had properties characteristic ...

journal_title：Toxicology letters

authors： Suzuki KT,Akitomi H,Kawamura R

更新日期：1984-05-01 00:00:00

abstract：:Chronic exposure of humans to fluorine compounds in the air, water and food may be atherogenic via the activation of oxidative stress and increased ROS production. The most important factor that promotes the formation of ROS seems to be the oxidoreduction of electron carriers in the critical points of the respiratory ...

journal_title：Toxicology letters

authors： Gutowska I,Baranowska-Bosiacka I,Baśkiewicz M,Milo B,Siennicka A,Marchlewicz M,Wiszniewska B,Machaliński B,Stachowska E

更新日期：2010-07-01 00:00:00

abstract：:In the present study experiments are described, which indicate that the exposure of normal human skin fibroblasts (HSFs) to a low-frequency electromagnetic field of 20 Hz and 7-8 mT does induce terminal differentiation within 14 days of daily exposure of 12 h. As demonstrated by the analysis of the expression level of...

journal_title：Toxicology letters

authors： Löschinger M,Thumm S,Hämmerle H,Rodemann HP

更新日期：1998-08-01 00:00:00

abstract：:Male rats are the most frequently used experimental animals in drug toxicity tests. However, there are clear sex-related differences in toxicity of various drugs and chemicals in rats. These differences, in most cases, are closely connected with the sex-related differences in hepatic drug metabolisms. Recent studies i...

journal_title：Toxicology letters

authors： Kato R,Yamazoe Y

更新日期：1992-12-01 00:00:00

abstract：:Identification of genetic polymorphisms responsible for reduced DNA repair capacity may allow better cancer prevention. We examined whether variations in genes involved in base-excision (hOGG1, XRCC1) and double strand break (XRCC3) DNA repair contribute to inter-individual differences in genotoxic effects induced in ...

journal_title：Toxicology letters

authors： Mateuca R,Aka PV,De Boeck M,Hauspie R,Kirsch-Volders M,Lison D

更新日期：2005-04-10 00:00:00

abstract：:The objective of the present study was to identify the polychlorinated biphenyl congeners of Aroclor 1254 that are responsible for the induction of the cytosolic bioactivation of aromatic amines. Various chlorobiphenyls, ranging from di- to hexa-substituted, were administered to rats and the ability of the hepatic cyt...

journal_title：Toxicology letters

authors： Marczylo T,Ioannides C

更新日期：1997-07-21 00:00:00

abstract：:A detailed characterisation of the biotransformation pathways followed by the chemical of interest is, evidently, of primordial importance to design reliable biomonitoring programs. This short overview discusses some recent studies that are of potential interest for the development of new avenues of research. Four top...

journal_title：Toxicology letters

authors： Lison D

更新日期：1999-09-05 00:00:00

abstract：:Ethanolamine, a positively charged hydrophilic component of the phosphatidylethanolamine (PE) which is also a precursor of phosphatidylcholine (PC), enhances the repair processes 24 h after carbon tetrachloride (CCl4) intoxication of mouse liver. Ethanolamine quickly reduced aminotransferase activity released in the s...

journal_title：Toxicology letters

authors： Murakami T,Nagamura Y,Hirano K

更新日期：1998-01-31 00:00:00

abstract：:The aim of the current HBM-study is to further the understanding of the impact of inter- and intra-individual variability in HBM surveys as it may have implications for the design and interpretation of the study outcomes. As spot samples only provide a snapshot in time of the concentrations of chemicals in an individu...

journal_title：Toxicology letters

authors： Smolders R,Koch HM,Moos RK,Cocker J,Jones K,Warren N,Levy L,Bevan R,Hays SM,Aylward LL

更新日期：2014-12-01 00:00:00

abstract：:Hexachlorobenzene (HCB) is an organochlorine pesticide widely distributed in the biosphere. ERalpha regulates the expression of genes involved in growth and development, and plays an important role in breast cancer. The present study focuses attention on the effect of HCB (0.005, 0.05, 0.5, 5 microM) on cell prolifera...

journal_title：Toxicology letters

authors： García MA,Peña D,Alvarez L,Cocca C,Pontillo C,Bergoc R,de Pisarev DK,Randi A

更新日期：2010-02-01 00:00:00

abstract：:It has reported that many environmental compounds may display estrogenic actions and these findings led to researchers to associate breast cancer risk with the use of some pesticides. The aim of this work was to investigate the effect of chlorpyrifos (CPF) on cell proliferation and the ERα-dependence of this action em...

journal_title：Toxicology letters

authors： Ventura C,Núñez M,Miret N,Martinel Lamas D,Randi A,Venturino A,Rivera E,Cocca C

更新日期：2012-09-03 00:00:00

abstract：:Trichothecenes are mycotoxins which produce lethal toxicosis in humans and animals, yet no adequate therapeutic regimen has been developed. This study provides evidence that the selective platelet activating factor (PAF) antagonist, BN 52021 (5-15 mg/kg i.v.) can prolong the survival of conscious rats exposed to a hig...

journal_title：Toxicology letters

authors： Feuerstein G,Leader P,Siren AL,Braquet P

更新日期：1987-10-01 00:00:00

abstract：:The industrial solvent dioxane (1,4-diethylene dioxide) was evaluated for teratogenic potential in Sprague-Dawley rats. The compound was administered on days 6-15 of gestation by gavage (0, 0.25, 0.5 and 1.0 ml/kg/day). A slight maternal toxicity, as evidenced by reduced weight gain, was observed with 1.0 ml/kg. Anima...

journal_title：Toxicology letters

authors： Giavini E,Vismara C,Broccia ML

更新日期：1985-07-01 00:00:00

abstract：:Rhesus monkeys exposed to marijuana smoke either 7 or 2 days/weeks (HI and LO groups, respectively), or ethanol-extracted marijuana smoke for 7 days/week (EM) or sham treatment (SH) for 1 year were sacrificed 7 months following the last exposure. Pulmonary levels of carcinogen-DNA adducts were determined. Although mea...

journal_title：Toxicology letters

authors： Talaska G,Schamer M,Bailey JR,Ali SF,Scallet AC,Slikker W Jr,Paule MG

更新日期：1992-12-01 00:00:00

abstract：:Considering of novel biochemical modulation by some foods and beverages, we have performed screening for green tea components that have enhancing effects on doxorubicin (DOX) induced antitumor activity. Components, such as caffeine, theanine, (-)-epigallocatechin gallate (EGCG) and flavonoids have inhibitory effects o...

journal_title：Toxicology letters

authors： Sadzuka Y,Sugiyama T,Sonobe T

更新日期：2000-04-03 00:00:00

abstract：:In vivo experiments are still widely used for the testing of lung toxicity but there is an ethical and legal obligation to replace, reduce and refine animal testing. Lung A549 cells could serve as an in vitro indicator for acute lung toxicity but little data about the correlation of the cytotoxicity in A549 cells and ...

journal_title：Toxicology letters

authors： Gohlsch K,Mückter H,Steinritz D,Aufderheide M,Hoffmann S,Gudermann T,Breit A

更新日期：2019-11-01 00:00:00