Abstract:
:In the present study experiments are described, which indicate that the exposure of normal human skin fibroblasts (HSFs) to a low-frequency electromagnetic field of 20 Hz and 7-8 mT does induce terminal differentiation within 14 days of daily exposure of 12 h. As demonstrated by the analysis of the expression level of the proto-oncogene c-myc, the induction of terminal differentiation of progenitor fibroblasts to postmitotic fibrocytes does most likely not involve changes in the c-myc protein. As one possible candidate being involved in the ELF-EMF-mediated inhibition of fibroblast growth and the subsequent induction of terminal differentiation the cyclic AMP-dependent protein kinase A (PKA) could be characterised. Thus, the data presented clearly indicate that the specific EMF field of 20 Hz and 7-8 mT significantly interfere with regulatory processes of fibroblast proliferation and differentiation.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Löschinger M,Thumm S,Hämmerle H,Rodemann HPdoi
10.1016/s0378-4274(98)00095-2subject
Has Abstractpub_date
1998-08-01 00:00:00pages
369-76eissn
0378-4274issn
1879-3169pii
S0378-4274(98)00095-2journal_volume
96-97pub_type
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