Stimulation of protein kinase A activity and induced terminal differentiation of human skin fibroblasts in culture by low-frequency electromagnetic fields.

Abstract:

:In the present study experiments are described, which indicate that the exposure of normal human skin fibroblasts (HSFs) to a low-frequency electromagnetic field of 20 Hz and 7-8 mT does induce terminal differentiation within 14 days of daily exposure of 12 h. As demonstrated by the analysis of the expression level of the proto-oncogene c-myc, the induction of terminal differentiation of progenitor fibroblasts to postmitotic fibrocytes does most likely not involve changes in the c-myc protein. As one possible candidate being involved in the ELF-EMF-mediated inhibition of fibroblast growth and the subsequent induction of terminal differentiation the cyclic AMP-dependent protein kinase A (PKA) could be characterised. Thus, the data presented clearly indicate that the specific EMF field of 20 Hz and 7-8 mT significantly interfere with regulatory processes of fibroblast proliferation and differentiation.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Löschinger M,Thumm S,Hämmerle H,Rodemann HP

doi

10.1016/s0378-4274(98)00095-2

subject

Has Abstract

pub_date

1998-08-01 00:00:00

pages

369-76

eissn

0378-4274

issn

1879-3169

pii

S0378-4274(98)00095-2

journal_volume

96-97

pub_type

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