Abstract:
:The anesthetic potencies of n-alcohols increase progressively with lengthening of the carbon chain and then disappear at a cut-off point of a longer-chain n-alcohol. In order to assess the mechanisms for cut-off in mammalian central nervous system, the effects of a series of n-alcohols (C(2)-C(11)) were examined on the evoked synaptic potentials of the rat hippocampal preparation in vitro. The n-alcohols (C(2)-C(10)) reduced the slope of the excitatory post-synaptic potential in a concentration-dependent manner, and the inhibitory potencies enhanced as a function of carbon chain length. The effect disappeared at n-undecanol (C(11)). The Hill coefficients of the concentration-response curves of the n-alcohols negatively correlated with the number of carbon atoms. The decrease in the Hill coefficient could account for the cut-off phenomenon, indicating that the results can support the anesthetic pocket hypothesis.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Takehana K,Hirota K,Roth SH,Masuda A,Ito Ydoi
10.1016/s0378-4274(00)00186-7keywords:
subject
Has Abstractpub_date
2000-05-19 00:00:00pages
149-52issue
2eissn
0378-4274issn
1879-3169pii
S0378-4274(00)00186-7journal_volume
115pub_type
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